Abstract:
OBJECTIVE:To determine the extent, epidemiological and clinical features of an epidemic of non-inflammatory encephalopathy in northern region of India. DESIGN:Surveillance of referred cases having unconsciousness after a short bout of fever during October and November 1997. Case control study in 7 most affected villages. METHODS:Active case finding was done to assess the extent and severity of the epidemic by interviewing health professionals and by reviewing mortality records in 10 districts of Haryana, Punjab and Chandigarh. A house to house survey was conducted in seven most affected villages. A case was defined as any child of less than 15 years of age, who had prodromal fever followed by vomiting and unconsciousness with subsequent recovery or death. Two age and sex matched controls who had fever without unconsciousness were taken for each case, one from nearby house and another staying furthest from the affected house. These groups were compared for various epidemiologic factors, clinical features and treatment pattern. Residual medicines used by affected patients were tested for presence of salicylate. Local village practitioners were interviewed for their knowledge and attitude towards use of aspirin in a febrile child. RESULTS:Information regarding 129 affected children (M: F=1 : 1) could be obtained. Age ranged between 1 to 12 years (mean 5.8 years). Most were from rural or semi-suburban areas. Attack rate was 5.4/1000 and case fatality rate was 72%. Multiple sibs were affected in 9.3%. History of fever was reported by 83%, vomiting preceding unconsciousness by 83% and abnormal behavior by 65%. Abnormal posturing was reported in 55%. Seventeen (61%) of 28 samples had IgM antibodies in serum/CSF against measles. Twelve (36%) of 33 serum samples tested positive for Varicella zoster virus. None gave history of aspirin intake and 10 samples of residual drugs did not contain salicylate. However, 6 out of 19 blood samples taken from affected patients contained salicylate. Environmental factors were in favor of Japanese encephalitis (JE) but brain biopsy and serology disproved it. Based on earlier report of JE from this area, the cases in present epidemic were being reported as JE before this study was undertaken. Intensive fogging with malathion was being undertaken as antimosquito measure, specially around the affected houses. Local village practitioners (n = 37) were unaware of contraindications of aspirin in a febrile child. CONCLUSION:Measles and varicella zoster emerged as the probable etiologies for the viral prodrome precipitating these cases of Reye's syndrome. Aspirin might have a contributory role. Malathion is another putative cofactor.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Ghosh D,Dhadwal D,Aggarwal A,Mitra S,Garg SK,Kumar R,Kaur Bkeywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1097-106issue
11eissn
0019-6061issn
0974-7559journal_volume
36pub_type
杂志文章abstract::A case control study was conducted in a referral and teaching hospital in North India on children aged 2 months to 5 years, to compare blood zinc levels in 50 cases of severe pneumonia and 50 age,sex and nutritional status matched controls. Mean blood Zinc levels in cases and controls was 376.1 ug/dL + 225.73 and 538....
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To determine the health-related quality of life in children with cerebral palsy and their families. METHODS:One hundred children (3-10 years of age) receiving regular rehabilitation therapy for cerebral palsy for last 1 year at a Child Development Centrer were enrolled and the Lifestyle assessment questionna...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0414-z
更新日期:2014-05-01 00:00:00
abstract::We report Hemolytic Uremic Syndrome (HUS) induced by Streptococcus pneumoniae in a 20 month-old girl. She responded well to hemodialysis. ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare genetic disorder characterized by lipoatrophy, hypertriglyceridemia, hepatomegaly and acromegaloid features. On the basis of mutational and haplotype analysis, BSCL families have been classified into three types BSCL 1, BSCL2 and BSCLX. We report Berardi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Seventy five mothers with lactation failure were studied, whose less than 4-month-old babies were admitted to the hospital. Partial lactational failure (94.7%) was noted more often than complete lactational failure (5.3%). Initiation of breastfeeding was delayed for 2 to 5 days usually for traditional reasons (77.3%) ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::A retrospective analysis was carried out to identify factors associated with delay in diagnosis of Kawasaki disease in a tertiary care pediatric hospital setting in Chennai, India. Over a period of 2 years, a total of 37 cases were studied. The cases were divided into Early Diagnosis Group (EDG) and Delayed Diagnosis ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0130-5
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To study the clinical spectrum and management of choledochal cyst in children below 12 years of age. DESIGN:Descriptive study. SETTING:Tertiary care hospital. METHODS:Twenty three children with choledochal cysts were managed between January 1991 to September 1997 and their clinical details, investigations ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::We conducted this study to ascertain whether health workers can routinely administer verbal autopsy (VA) to determine the cause of death in their area. The health workers were trained to administer verbal autopsy tool on the deaths occurring in the population under them. All the verbal autopsies of under-five deaths b...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::We evaluated 50 mothers of children with Down syndrome attending Genetic Clinic of the Institute of Child Health and Hospital for Children, Madras, with special reference to their knowledge, belief and attitudes in the care of these children. After evaluation, they were educated individually and in groups with demonst...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Acute interstitial nephritis (AIN) should be ruled out in children with unexplained acute renal failure. We present a 4 1/2 year old girl who presented with oliguric acute renal failure preceded by a febrile illness. Renal histopathology revealed features of drug induced AIN. She recovered with dialysis, other support...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::In this cohort study, neurodevelopmental outcome of 20 of 24 surviving very low birth weight infants with sepsis followed up between 2008 and 2009 was compared with 20 control (uninfected infants). We found that plasma interleukin 6 and C reactive protein values were negatively correlated with mental developmental ind...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0091-3
更新日期:2013-03-01 00:00:00
abstract::Five hundred ninety two children (6.0%) were diagnosed as persistent diarrhea (PD) out of a total attendance of 9795 cases in the Diarrhea Training and Treatment Unit (DTU) over a period of 1 year. Most of the cases were initially managed as outpatients on dietary advice and treatment of associated infections. Eighty ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:(i) To assess the severity of Iodine Deficiency Disorders (DD) in Baroda and Dang Districts of Gujarat, using biochemical prevalence indicators of IDD; and (ii) To establish a biochemical baseline, in a sub-sample of the large population of Gujarat, that could be used to monitor the effectiveness of iodine re...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To evaluate efficacy of polymerase chain reaction (PCR), using the insertion sequence IS6110 as target for DNA, to detect Mycobacterium tuberculosis in body fluids of children with suspected tuberculosis (TB). SETTING:Hospitalized patients. METHODS:A comparison of PCR on body fluids, Acid Fast Bacilli stai...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Eighteen cyanotic congenital heart disease (CCHD) and 17 acyanotic congenital heart disease (ACHD) patients in the age range of 2 months to 10 years along with their age and nutrition matched controls were studied for bactericidal, chemotactic and phagocytic functions. Bactericidal and phagocytic functions were signif...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To document bone mineral density of children and adolescents with cystic fibrosis. DESIGN:Cross-sectional study. SETTING:Tertiary-care center of Northern India, July 2012 to August 2015. PARTICIPANTS:52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. METHODS:B...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1065-7
更新日期:2017-07-15 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-12-15 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::The prevalence of Attention deficit hyperactivity disorder was estimated in 500 adolescents using Conners' parents and teachers rating scales. Thirty six (7.2%) adolescents had positive scores on both the scales. The parents and teachers also completed a Diagnostic and Statistical Manual-IV based questionnaire which s...
journal_title:Indian pediatrics
pub_type: 信件
doi:10.1007/s13312-014-0350-y
更新日期:2014-02-01 00:00:00
abstract::30 MEDLINE indexed Indian journals publishing clinical trials were identified and their editorial policies on trial registration were assessed. Trial registration number was required in 9 journals (30%).16 journals (53.33%) encouraged adherence to the CONSORT Statement, while 22 (73.33%) mentioned ICMJE Guidelines. ...
journal_title:Indian pediatrics
pub_type: 信件
doi:10.1007/s13312-013-0092-2
更新日期:2013-03-01 00:00:00
abstract::One hundred nine patients presenting with ambiguous genitalia over the past 10 years (year 1995 to 2004) to Pediatric Endocrine Service of our hospital were reviewed. On the basis of clinical and investigative evaluation like hormonal and biochemical estimations, imaging studies, karyotype and invasive techniques like...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::The morbidity pattern and nutritional profile was evaluated of school children who resided around Mosaboni Copper Mines and in surrounding villages of Ghatsila subdivision in Singhbhum district of Bihar State, India. A total of 1424 school children (816 boys and 608 girls) between 5-17 years old were studied. Children...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India. METHODS:ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0505-x
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Blue rubber bleb nevus syndrome is a rare clinical entity. CASE CHARACTERISTICS:A 13-year-old Indian boy presented with characteristic cutaneous lesions, gastrointestinal malformations, skeletal involvement and pulmonary stenosis. OBSERVATIONS:Diagnosis was confirmed on skin biopsy, radiographic evaluation...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-016-0884-2
更新日期:2016-06-08 00:00:00
abstract::Ensuring quality in healthcare today has become extremely essential to ensure adequate utilization of healthcare services and improved outcomes. In addition to essential infrastructure in terms of safe and adequate space, knowledgeable and skilled health workers, and essential equipment and supply, the healthcare team...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2018-09-15 00:00:00
abstract::We report a 6 year old female child, who presented with history of right sided recurrent headache for four months. On diagnostic nasal endoscopy, a metallic foreign body was seen impacted between superior turbinate, middle turbinate and nasal septum which was removed using pediatric nasal endoscope. Following removal,...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract::Atypical celiac disease (ACD) presenting in childhood has rarely been documented from India. The present retrospective study analyzed features of atypical celiac disease over a 5-year period. Patients were diagnosed to have Celiac Disease (CD) as per the standard ESPGHAN criteria. The biochemical and hematological par...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::In Kumbakonam, Tamil Nadu State in India, 384 final-year female students attending the Government College for Women completed a questionnaire so the researcher could assess their knowledge of prenatal and childhood immunizations, breast feeding, weaning, oral rehydration solution (ORS), and feeding during diarrhea. 5...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of vitamin D and calcium supplementation for osteoprotection in thalassemia. METHODS:29 children (age 2-12 y) were supplemented with oral vitamin D (1000 IU/d) and calcium (500 mg/d) for 1 year. The dual energy X-ray absorptiometry (DXA) was done to assess bone mineral content at basel...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-04-15 00:00:00
abstract::We studied the actual time taken to document temperature in a stable neonate by an electronic digital skin thermometer with automatic time beeper. We studied 100 neonates after initial stabilization. The mean time required for documenting the temperature by a electronic thermometer in axilla was 56.34+/-1.54 secs for ...
journal_title:Indian pediatrics
pub_type: 信件
doi:
更新日期:2009-12-01 00:00:00