Effect of Vitamin D and Calcium Supplementation on Bone Mineral Content in Children with Thalassemia.

Abstract:

OBJECTIVE:To evaluate the effect of vitamin D and calcium supplementation for osteoprotection in thalassemia. METHODS:29 children (age 2-12 y) were supplemented with oral vitamin D (1000 IU/d) and calcium (500 mg/d) for 1 year. The dual energy X-ray absorptiometry (DXA) was done to assess bone mineral content at baseline and 12 months. Serum 25-hydroxy vitamin D, intact parathyroid hormone, osteocalcin, calcium, phosphate, alkaline phosphatase, and spot urine deoxypyridinoline (DPD)/creatinine were done at baseline, 6 months and 12 months. RESULTS:The mean (SD) bone mineral content increased from baseline value of 8.4 (2.8) g to 10.8 (3.5) g (P<0.001). The mean (SD) vitamin D level increased from baseline value of 16.0 (5.8) ng/mL to 23.4 (6.6) ng/mL (P<0.001). The change in serum osteocalcin and spot urine DPD/creatinine ratio were not significant (P=0.062). CONCLUSION:Oral vitamin D and calcium supplementation increases bone mineral content in children with thalassemia.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Thiagarajan NR,Kumar CGD,Sahoo J,Krishnamurthy S

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

307-310

issue

4

eissn

0019-6061

issn

0974-7559

journal_volume

56

pub_type

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