Typhoid hepatitis in children.

Abstract:

:Liver involvement is commonly observed in patients with typhoid fever. However, a hepatitis-like picture with fever and jaundice is unusual and infrequently reported in the paediatric literature. Our aim was to characterize the clinical picture, biochemical features, and prognosis of typhoid hepatitis. One hundred cases of typhoid fever (age 0 to 12 years), proven by positive blood cultures to Salmonella typhi, were studied with special reference to hepatic dysfunction. Of these, eight patients were found to have hepatitis during the course of their illness. All had high fever, tender hepatomegaly, elevated serum bilirubin (in the range of 2.5-5.8 mg/dl), and elevated serum alanine transaminase levels (in the range 100-620 IU/l). All the eight patients showed complete clinical and biochemical recovery in response to appropriate antibiotics. The clinical picture of typhoid hepatitis frequently mimics acute viral hepatitis. In tropical areas, the differential diagnosis of a child presenting with fever and jaundice should include typhoid hepatitis.

journal_name

J Trop Pediatr

authors

Shetty AK,Mital SR,Bahrainwala AH,Khubchandani RP,Kumta NB

doi

10.1093/tropej/45.5.287

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

287-90

issue

5

eissn

0142-6338

issn

1465-3664

journal_volume

45

pub_type

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