Abstract:
OBJECTIVE:To evaluate the efficacy of therapeutic hypothermia (TH) using gel packs in reducing mortality and morbidity in term neonates with HIE and study the associated problems with TH. METHODS:Hypoxic ischaemic encephalopathy babies were randomized into TH and control group. Babies in TH group were cooled for first 72 h of birth using cloth covered cooling gel packs to maintain target rectal temperature of 33-34°C. Infants were followed up to 6 months and were assessed using Baroda Developmental Screening Test. RESULTS:There were no significant differences in baseline parameters. TH group showed significant reduction in the combined rate of death or developmental delay at 6 months of age by 21% (8.1% in the TH group vs. 29% in the control, RR 0.28, 95% CI: 0.11-0.70; p = 0.003). CONCLUSIONS:TH using gel packs reduces the risk of death or developmental delay at 6 months of age in infants with HIE.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Bharadwaj SK,Bhat BVdoi
10.1093/tropej/fms005subject
Has Abstractpub_date
2012-10-01 00:00:00pages
382-8issue
5eissn
0142-6338issn
1465-3664pii
fms005journal_volume
58pub_type
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