Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case-Control Study.

Abstract:

OBJECTIVE:To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates. METHODS:This case-control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and neonatal demography, clinical examination and investigations were recorded. Correlation of vitamin-D deficiency (<20 ng/ml) with LOS was assessed. RESULTS:Total 225 term neonates including 175 cases and 50 controls were included. Maternal and neonatal demographic profile was comparable. The mean vitamin-D level in cases (12.28 ± 6.11 ng/ml) was significantly lower than that in controls (14.88 ± 7.2 ng/ml) (p = 0.002). Total 151 (86.29%) neonates out of 175 cases and 37 (74%) out of 50 controls had the vitamin-D deficiency (p = 0.00003). On multiple regression analysis, neonatal sepsis (p = 0.00003) was found to be significantly associated with vitamin-D deficiency. CONCLUSION:This study shows that vitamin-D deficiency in term neonates may predispose them to LOS.

journal_name

J Trop Pediatr

authors

Agrawal A,Gupta A,Shrivastava J

doi

10.1093/tropej/fmz021

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

609-616

issue

6

eissn

0142-6338

issn

1465-3664

pii

5475886

journal_volume

65

pub_type

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