Abstract:
:Distribution of anti-malarials at the community level is one of the interventions recommended to reduce mortality from febrile illnesses. Inappropriate treatment of fever with anti-malarials may result in missed diagnosis and delays in appropriate treatments including consideration of other illnesses than malaria. We report the case of an 8-year-old black girl receiving prophylaxis with sulfadoxine-pyrimethamine from the caretaker of the community during her holidays in Ivory Coast. A persistent fever suspected to be due to malaria was treated inappropriately with atovaquone-proguanil and then with sulfadoxine-pyrimethamine again. Cumulative toxicity of anti-malarials leads to irreversible hepatic damages requiring hepatic transplantation. Community caretakers must be aware of the potential side effects and the contraindications of anti-malarials. Early identification of drug-induced toxicity and immediate discontinuation of the drug are the more effective tools to limit the progression of tissue damage.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Orostegui L,Balu L,Chevret L,Habes D,Pussard Edoi
10.1093/tropej/fmq074subject
Has Abstractpub_date
2011-06-01 00:00:00pages
225-6issue
3eissn
0142-6338issn
1465-3664pii
fmq074journal_volume
57pub_type
杂志文章abstract::A community-based study was undertaken to determine the prevalence and types of intestinal parasites in the pediatric population of Al-Baha region, Saudi Arabia. Stool samples were randomly collected from 19,939 children of whom 4208 (21.1%) were found to harbour intestinal parasites. The most affected age group was 5...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/41.1.47
更新日期:1995-02-01 00:00:00
abstract::The aim of this study was to investigate the effects of different doses of iron on haematological status of breastfed infants. One hundred and thirteen infants were randomized into four groups at 5 months of age. Iron supplementation was given at doses of 1 mg/kg/day, 2 mg/kg/day, and 2 mg/kg/every other day in the fi...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/tropej/48.5.280
更新日期:2002-10-01 00:00:00
abstract::A prospective cohort study was carried out to determine the factors affecting initiation of breastfeeding, and describe patterns of breastfeeding and supplemental feeding in the multiethnically and culturally diverse population of Al Ain, UAE. Two-hundred-and-twenty-one infants completed the 4 weeks of follow up. None...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/43.5.304
更新日期:1997-10-01 00:00:00
abstract::Neonatal hyperbilirubinemia continues to be a leading cause of morbidity and mortality in resource-limited countries. The aim of this study was to measure the effectiveness of existing phototherapy units at a local hospital in Cameroon using an irradiance meter. Phototherapy units (n = 4) in one newborn nursery in Cam...
journal_title:Journal of tropical pediatrics
pub_type: 信件
doi:10.1093/tropej/fmt110
更新日期:2014-06-01 00:00:00
abstract::The present study describes the use of a home-based antenatal card in a sample of 120 consecutive women who were giving birth at a large teaching hospital in the city of León, Nicaragua. Information was obtained by interviews with the women before leaving hospital and all data on their antenatal cards and regarding de...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/40.3.133
更新日期:1994-06-01 00:00:00
abstract::A protocol of nutritional rehabilitation using fermented milk, vegetable oil, and castor sugar has been tested on 54 Senegalese children age 6-36 months admitted with acute diarrhoea and malnutrition. At time of admission, 39 per cent of children were dehydrated and 26 per cent had sugar intolerance. In the course of ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.6.281
更新日期:1989-12-01 00:00:00
abstract::The study was designed to determine the prevalence of congenital malaria, cord blood and placental malaria parasitaemia and the prevalence of clinical manifestations of congenital malaria. Ile-Ife is a holoendemic area for malaria. Placental, cord and peripheral blood smears of 120 newborn babies were examined for mal...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmi003
更新日期:2005-08-01 00:00:00
abstract::Cassia occidentalis toxicity is thought to be uncommon; however, several cases have been described with acute hepatomyoencephalopathy with a high-mortality rate. We report a previously healthy, 2-year-old girl who developed acute liver failure after fresh seed ingestion. Without a specific antidote, we decided to impl...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa087
更新日期:2020-11-23 00:00:00
abstract::Of 511 young (1-19 years of age) Jamaicans sampled for IgG antibodies to Toxoplasma by the ELISA method, there was an overall prevalence of 45 per cent. Seropositivity ranged from 24-26 per cent in the 2-year-olds, up to 54 per cent in the 5-9-year-olds. There was no significant difference in prevalence between the se...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.5.234
更新日期:1989-10-01 00:00:00
abstract::Lymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmq024
更新日期:2010-12-01 00:00:00
abstract::This paper reports the results of a cross-sectional study of the growth of Fulani children, aged 1-16 years, living in the Jos Plateau of northern Nigeria. This particular population of Fulani are semi-nomadic pastoralists whose economy and culture are centered on cattle. We measured the heights and weights of 176 gir...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/49.5.313
更新日期:2003-10-01 00:00:00
abstract::The effects of iron deficiency anemia (IDA) on nerve conduction and efficiency of iron therapy were investigated by peripheral nerve-electrophysiological measurements. Eighteen children (10 boys, eight girls; mean age 31 +/- 1.3 months) with IDA and 12 healthy children (six boys, six girls; mean age 29 +/- 1.3 months)...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1093/tropej/48.4.204
更新日期:2002-08-01 00:00:00
abstract::Screening for enteric pathogens in stool samples from 249 children under the age of 36 months, admitted to hospital for non-gastrointestinal disorders, was positive at admission in 41 (16.4 per cent) in a prospective study of enteric pathogen acquisition and diarrhoea in hospitalized children. Infection with multiple ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/47.1.46
更新日期:2001-02-01 00:00:00
abstract:AIM:There is insufficient knowledge on the * duodenal histology and Helicobacter pylori infection in malnourished Bangladeshi children. Therefore, we attempted to explore the prevalence of H. pylori infection and duodenal histopathology in 2-year-old chronic malnourished Bangladeshi slum-dwelling children and investiga...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa079
更新日期:2020-10-25 00:00:00
abstract:AIM:To assess the knowledge of HIV/AIDS prevention and factors associated with condom use among adolescent. METHODS:A cross-sectional study was conducted among 410 outpatient adolescents. Association between knowledge on the transmission of HIV/AIDS and variables were analyzed using the chi-square test. Logistic regre...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmr074
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates. METHODS:This case-control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmz021
更新日期:2019-12-01 00:00:00
abstract::Tests for renal function were performed in 75 smear positive children with acute malaria together with 10 control children. Plasmodium vivax and Plasmodium falciparum accounted for 52 and 46 per cent cases, respectively. Renal impairment in the form of decreased endogenous creatine clearance (less than 65 ml/min/m2) w...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.6.291
更新日期:1989-12-01 00:00:00
abstract::beta-thalassaemia major, an autosomal recessive hemoglobinopathy, is one of the most common single gene disorders in multi-racial Malaysia. The control of beta-thalassaemia major requires a multi-disciplinary approach that includes population screening, genetic counselling, prenatal diagnosis and the option of termina...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmi052
更新日期:2005-12-01 00:00:00
abstract::The aim of the present study was to study the epidemiological and clinical profile of patients attending an exclusive pediatric Emergency Department (ED). Data was retrieved from records of the patients seen over a 6-year period from 1995 to 2000. Descriptive analysis was done to define demographic and clinical detail...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/49.4.207
更新日期:2003-08-01 00:00:00
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journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fml044
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the importance of food supplementation as incentive in improving preantiretroviral therapy (pre-ART) adherence, and second its impact on health of HIV-infected children by a clinic-based observational study. METHODS:HIV-seropositive children aged between 2 and 12 years were followed-up sequential...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmr026
更新日期:2012-02-01 00:00:00
abstract::One thousand children with cerebral palsy (CP) were reviewed to study their clinical profile, etiological factors and associated problems. Spastic quadriplegia constituted the predominant group (61 per cent), followed by spastic diplegia (22 per cent). Dyskinetic CP was present in 7.8 per cent of the cases. Acquired C...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/48.3.162
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Early data regarding the outcome of human immunodeficiency virus (HIV)-infected children in paediatric intensive care units (PICU) suggested mortality as high as 100%. Recent studies report mortality of 38%. Survival depends on the indication for admission. OBJECTIVES:To describe the prevalence, duration of...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmm036
更新日期:2007-08-01 00:00:00
abstract::The aim of the study was to determine the etiology of meningitis and sepsis in the newborn at the State University Hospital of Haiti and evaluate the susceptibility 'in vitro' of the pathogens to the antibiotics commonly used. This was a prospective case series study over a 10-month period (May 1997-February 1998) of ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/50.1.48
更新日期:2004-02-01 00:00:00
abstract::Transversal study conducted in a Human Milk Bank to evaluate the factors associated with the use of artificial nipples (pacifier and/or nursing bottle) among Brazilian infants. Analyses were performed using the χ2 test and logistic regression analysis. A total of 6017 nursing mothers were evaluated and the use of arti...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa007
更新日期:2020-10-01 00:00:00
abstract::A total of 74 multitransfused (MT) children of beta thalassaemia major were analysed for prevalent viral markers transmitted through transfusion. A higher incidence of serological markers for Hepatitis B virus (HBV), cytomegalovirus (CMV) could be observed in the group of MT children compared to control group. There w...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/39.4.243
更新日期:1993-08-01 00:00:00
abstract::One-hundred-and-eighty-eight ostensibly normal, pubertal schoolchildren, aged 9-16 years, residing in Chinamora Communal Land, Zimbabwe, had blood taken to assess thyroid function. Total goitre rate in the area was 44 per cent in primary schoolchildren: 91 of the subjects tested were goitrous. Thyroid stimulating horm...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/37.4.199
更新日期:1991-08-01 00:00:00
abstract::Lysozyme level was measured in the fluid and serum of 42 tuberculous (25 pleural, 11 ascites and 6 pericardial) and 29 non-tuberculous (5 malignant, 9 empyema thoracis, 10 transudative ascites and 5 pyopericardium) effusions. The mean fluid lysozyme level was significantly raised in tuberculous pleural, ascites, and p...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1093/tropej/46.5.296
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Preterm constitutes a major part of neonatal mortality, particularly in India. Due to dermal immaturity, preterm neonates are susceptible to various complications like infection, hypothermia, etc. Emollient application is a traditional practice in our subcontinent. AIMS:To find out the efficacy of coconut o...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1093/tropej/fmz041
更新日期:2020-04-01 00:00:00
abstract::Fasciolosis is a chronic parasitic disease caused by two species of liver trematodes, Fasciola hepatica and Fasciola gigantica, which infest ruminants and rarely humans. The disease is spread all over the world, but more common in Asia in areas with extensive livestock farming and can be imported cases in Europe and A...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmz043
更新日期:2020-04-01 00:00:00