Rickets and protein malnutrition in northern Nigeria.

Abstract:

:The aim of the study was to explore the relationship between protein nutritional status and the development of rickets in children living in northern Nigeria. The diagnosis of rickets in 16 children between the ages of 10 months and 7 years was confirmed using established, and recently developed clinical and biochemical parameters. Twenty-seven children devoid of skeletal stigmata were age- and sex-matched to the rachitic patients. A battery of clinical laboratory and anthropometric measurements designed to assess calcium homeostasis, skeletal growth, the extent of bone remodeling or resorption, and protein nutritional status were performed on all subjects. Our central finding was that although the rachitic children were moderately malnourished, their protein nutritional status was significantly better as measured by the serum prealbumin concentration (15.4 v. 12.5 mg/dl, P = 0.0012) when compared with the severely malnourished children who were devoid of any indication of rickets. This may be due, in part, to the fact that actively growing children are more likely to develop rickets than are children whose linear growth is impeded. Unexpectedly, we found that the mean concentrations of serum 1,25-dihydroxyvitamin D in both the rachitic and control group were higher than any values for the active vitamin D metabolite previously reported in the literature.

journal_name

J Trop Pediatr

authors

Walter EA,Scariano JK,Easington CR,Polaco AM,Hollis BW,Dasgupta A,Pam S,Glew RH

doi

10.1093/tropej/43.2.98

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

98-102

issue

2

eissn

0142-6338

issn

1465-3664

journal_volume

43

pub_type

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