Craving patterns in methadone maintenance treatment with dextromoramide as adjuvant.

Abstract:

:A study was performed to establish the effect on opiate craving among six long-term opiate-dependent subjects in methadone maintenance treatment. Subjects currently stabilised on methadone, received 5 or 10 mg dextromoramide besides methadone. During the study the usual methadone dose was diminished according to the individual subject's expectation of the effect of dextromoramide addition. A clear drug-effect relationship between the increment of dextromoramide plasma concentration and decrement of opiate craving could be seen. A craving increase before drug administration was seen in three cases. The results could imply beneficial effects of a short-acting opiate on diminishing craving in opiate addicts who are difficult to stabilise with methadone maintenance treatment.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

de Vos JW,Ufkes JG,van den Brink W,van Brussel GH,de Wolff FA

doi

10.1016/s0306-4603(98)00081-1

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

707-13

issue

5

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(98)00081-1

journal_volume

24

pub_type

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