Abstract：
:This paper describes a rapid and systematic method of using open trials to identify medications that may be useful for the treatment of cocaine dependence. Results of these open trials can be used to prioritize medications for inclusion in subsequent double-blind, placebo-controlled trials. Preliminary results are presented from the evaluation of propranolol, nefazodone, and the combination of phentermine and fenfluramine (phen/fen). Each medication was evaluated in an open trial, and results were compared to results obtained from a group that received a multivitamin. Outcome measures included treatment retention, urine toxicology screens, self-reported cocaine use, and changes on the Addiction Severity Index (ASI). Treatment retention was significantly better in the propranolol group than in the multivitamin group. Concurrent alcohol abuse was associated with increased rates of attrition in the multivitamin group, and the phen/fen group, but not in the propranolol group. Neither the nefazodone nor the phen/fen groups showed any outcome advantages over the multivitamin group. We conclude that propranolol may enhance retention among cocaine-dependent patients, especially among those who also abuse alcohol. These results encourage a double-blind, placebo-controlled trial of propranolol.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Kampman KM,Rukstalis M,Ehrman R,McGinnis DE,Gariti P,Volpicelli JR,Pettinati H,O'Brien CPdoi
10.1016/s0306-4603(98)00040-9keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
287-91issue
2eissn
0306-4603issn
1873-6327pii
S0306-4603(98)00040-9journal_volume
24pub_type
临床试验,杂志文章abstract：:The prediction of resumption of drinking in posttreatment alcoholics was investigated as a function of five possible confounding variables: depression, anxiety, childhood symptoms of attention deficit and conduct disorders and family history of alcoholism. Male and female detoxified alcoholics (n = 103) in inpatient t...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(90)90073-7
更新日期：1990-01-01 00:00:00
abstract：:Fifth and sixth grade children randomly assigned to experimental and control groups saw videotaped television programs in which the drinking of alcoholic beverages by the principal characters appeared in the experimental condition but not the control condition. Parents' drinking and home television watching were simil...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(86)90012-2
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:In the search for optimal biomarkers of excessive drinking, a central limitation has been the lack of sensitivity of measures. Many patients have apparently normal values of liver markers despite a considerable alcohol intake. This study aimed to test a novel combined indicator of alcohol drinking. MATERIAL ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2009.10.005
更新日期：2010-03-01 00:00:00
abstract：:Smoking reduces negative affect while it increases sympathetic nervous system activity. However, theories of emotion predict that increased autonomic arousal should increase rather than reduce negative affect. One explanation for this paradox is that nicotine interferes with perception of autonomic activity. We evalua...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(86)90061-4
更新日期：1986-01-01 00:00:00
abstract：:In two experiments, nonsmoking females whose urine was acidified were more willing after smoking one cigarette to volunteer to smoke additional cigarettes than were females whose urine was made alkaline. Males did not exhibit this effect. The results indicate that physiological factors that influence nicotine intake d...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(82)90030-2
更新日期：1982-01-01 00:00:00
abstract：:Greek-affiliated college students have been found to drink more heavily and frequently than other students. With female student drinking on the rise over the past decade, sorority women may be at particular risk for heavy consumption patterns. The current study is the first to apply the Theory of Planned Behavior (TPB...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2007.11.002
更新日期：2008-04-01 00:00:00
abstract：:The present study assessed patterns of multiple drug use among a sample of university employees and students who had been identified as having moderately high drug use habits. Use of eleven categories of legal and illegal drugs was tested and subjects reported how much of each drug they currently and habitually used. ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(89)90022-1
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:College student drinkers have the propensity to engage in heavy alcohol consumption. These consumption patterns can be problematic given the well-established relationship between heavy drinking and negative consequences of alcohol consumption. Though the research on college student drinking is abundant, mu...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.02.004
更新日期：2015-07-01 00:00:00
abstract：:The notion of comorbidities within problem gambling populations has important clinical implications, particularly for appropriate treatment matching. The comorbidities most commonly cited in problem gambling literature include depression, anxiety, alcohol abuse and impulsivity. Previous research shows evidence of patt...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.07.023
更新日期：2014-12-01 00:00:00
abstract：:Little research has been conducted on symptom reductions in response to assessments in clinical trials, despite the impact such reactivity may have on interpretation of outcomes. Reactivity to data collection procedures during post-treatment follow-up may obscure treatment effects. The current study examined whether f...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2007.12.004
更新日期：2008-06-01 00:00:00
abstract：INTRODUCTION:Recently studies examined mediating psychological constructs accounting for relations between both depression and anxiety with problematic smartphone use (PSU) severity. The aim of the current study was to analyze the fear of missing out (FOMO) as a possible mediator in these relationships. METHOD:We recr...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.04.020
更新日期：2020-02-01 00:00:00
abstract：:The tendency to become addicted across a number of different substances or activities was determined for a sample of 573 subjects, including college students and their parents. Four components of addiction were defined: craving, tolerance, withdrawal and lack of control. Subjects rated the extent to which each of thes...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(93)90011-w
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:There is a lack of understanding of what contributes to attitudes toward individuals with an opioid addiction and preferences for policies that support them. METHODS:This study aimed to investigate stigmatization of an opioid addiction and support for publicly funded drug treatment. A randomized, between-su...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106784
更新日期：2021-04-01 00:00:00
abstract：:Little is known about the natural course of smoking behaviors following substance use treatment, particularly among individuals with comorbid substance use and psychiatric disorders. This study examined smoking cessation efforts among 120 substance abusers with and without psychiatric comorbidity. Participants complet...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2004.02.051
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:This study examined associations between two types of AA participation (i.e., meeting attendance, having a sponsor) and two types of post-treatment abstinence (i.e., abstinence from alcohol, abstinence from drugs). METHOD:Respondents completed measures that assessed their demographic characteristics, the se...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2011.03.011
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:To examine associations between discrete eating disordered behaviors as well as clusters of eating disordered behaviors in relation to the use and abuse of a wide spectrum of substance classes, both licit and illicit, in a female university sample. METHODS:Women with particular types of eating disordered be...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2005.12.021
更新日期：2006-10-01 00:00:00
abstract：:The present study examined plasma arginine vasopressin (AVP) levels in 18 smokers (10 men, 8 women) and in 22 non-smokers (12 men, 10 women). Non-smokers came to the laboratory once, whereas smokers came twice: while smoking freely and following 24-hr abstinence. Plasma was collected for AVP assessment; salivary cotin...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2011.06.015
更新日期：2011-11-01 00:00:00
abstract：:The present longitudinal study investigates baseline assessments of static and dynamic variables, including demographic characteristics, smoking severity, and Transtheoretical Model of Behavior Change (TTM) effort variables (Decisional Balance (i.e. Pros and Cons), Situational Temptations, and Processes of Change) of ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.11.022
更新日期：2015-03-01 00:00:00
abstract：:Skin conductance activity was monitored in male and female smokers and non-smokers during repeated presentation of high intensity auditory stimuli. Smokers, and, in particular, female smokers, exhibited significantly higher resting skin conductance levels and significantly larger skin conductance responses. The result...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(84)90057-1
更新日期：1984-01-01 00:00:00
abstract：:To better understand pathological gambling, potential risk factors were assessed within three domains--gambling behaviors, substance abuse and other problem behaviors, and sociodemographic factors. A random-digit-dial telephone survey was conducted in 1999-2000 with a representative sample of the U.S. population aged ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2003.08.007
更新日期：2004-02-01 00:00:00
abstract：:The aim of this study was to determine whether depressed alcoholics who used cocaine would display a higher prevalence of suicidal behavior and suicidal ideation than depressed alcoholics who did not use cocaine. Forty-one depressed alcoholics participated in this prospective study of consecutively admitted inpatients...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(97)00019-1
更新日期：1998-01-01 00:00:00
abstract：UNLABELLED:While smokers' ability to tolerate emotional or physical distress has been associated with length of smoking cessation, there is no measure of ability to tolerate smoking abstinence discomfort specifically, which may be more heuristic than a measure of tolerance of general emotional stress or physical discom...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.02.014
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:There has been ample research on college student risks and consequences related to 21st Birthday Drinking. To date, no studies we are aware of have examined how 21st birthday drinking impacts subsequent drinking and related consequences. This study evaluates the effect of a single night of drinking on peak dr...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2016.08.006
更新日期：2017-01-01 00:00:00
abstract：:This trial of cognitive-behavioural therapy (CBT) based amphetamine abstinence program (n=507) focused on refusal self-efficacy, improved coping, improved problem solving and planning for relapse prevention. Measures included the Severity of Dependence Scale (SDS), the General Health Questionnaire-28 (GHQ-28) and Amph...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2005.12.026
更新日期：2006-10-01 00:00:00
abstract：:To investigate the role of treatment modality in relapse prevention treatment, 32 cocaine-dependent subjects were randomly assigned by cohorts to group-based relapse prevention (G-RP) or individually based RP (I-RP). The two RP formats were identical in content, consisting of 12 outpatient treatment sessions over a 2-...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0306-4603(96)00047-0
更新日期：1997-05-01 00:00:00
abstract：:Message content in anti-smoking public service announcements (PSAs) can be delivered explicitly (directly with concrete statements) or implicitly (indirectly via metaphor), and the method of delivery may affect the efficacy of those PSAs. The purpose of this study was to conduct an initial test of this idea using toba...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2009.12.023
更新日期：2010-05-01 00:00:00
abstract：:Sensitivity to the initial smoking experience, upon initial smoking experimentation, is associated with youth smoking. We determined the association between exposure to smoking from peers and family members on the symptoms of the initial smoking experience of adolescents. Data from a survey of 3280 high school student...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.04.019
更新日期：2008-09-01 00:00:00
abstract：:This study investigated the effects of salivary stimulation on thiocyanate (SCN) levels. A device for collecting parotid saliva that allowed for the measurement of flow rate was used in stimulated and nonstimulated conditions with six subjects. Results indicated that SCN levels exhibited considerable within-subject va...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(88)90045-7
更新日期：1988-01-01 00:00:00
abstract：:Low distress tolerance has been an inconsistent predictor of alcohol-related consequences in college students, but its relationships to depression and coping motives for alcohol have received stronger support. Research on college students who drink heavily in isolation suggests that this population is more likely to h...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.06.025
更新日期：2015-11-01 00:00:00
abstract：:While it has been established that many women quit smoking during pregnancy, little is known about postpartum maintenance of smoking cessation and relapse. A sample of 567 women were surveyed at about 6 months postpartum in order to (a) describe the patterns of smoking relapse; (b) assess the perceived importance of s...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(90)90020-x
更新日期：1990-01-01 00:00:00
