Biological markers of problem drinking in homeless patients.

Abstract:

OBJECTIVE:In the search for optimal biomarkers of excessive drinking, a central limitation has been the lack of sensitivity of measures. Many patients have apparently normal values of liver markers despite a considerable alcohol intake. This study aimed to test a novel combined indicator of alcohol drinking. MATERIAL AND METHODS:Concentrations of carbohydrate-deficient transferrin (%CDT), gamma glutamyl transferase (gammaGT), aspartate aminotransferase (ASAT), and mean corpuscular volume (MCV), together with a combined index of the %CDT and gammaGT, the Antilla Index (AI), were studied in 104 homeless patients with (n = 87) or without (n = 24) problem drinking according to the Fast Alcohol Screening Test. RESULTS:Concentrations of all markers were significantly higher in the alcoholic patients than in other homeless patients. The best agreement between liver markers and self-reported status was found between the combined %CDT and gammaGT index (kappa = 0.61, p < 0.001, sensitivity = 63%, specificity = 94%). CONCLUSIONS:The combined AI is a relatively efficient measure of current drinking in homeless populations.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Thiesen H,Hesse M

doi

10.1016/j.addbeh.2009.10.005

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

260-2

issue

3

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(09)00270-6

journal_volume

35

pub_type

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