Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin.

Abstract:

:The present study examined plasma arginine vasopressin (AVP) levels in 18 smokers (10 men, 8 women) and in 22 non-smokers (12 men, 10 women). Non-smokers came to the laboratory once, whereas smokers came twice: while smoking freely and following 24-hr abstinence. Plasma was collected for AVP assessment; salivary cotinine and expired carbon monoxide levels confirmed smoking status. Among non-smokers, men had higher AVP levels than did women (p<0.05). Among smokers, however, women displayed higher AVP levels than did men both while smoking and following abstinence (p's<0.05). Among men, smoking resulted in lower AVP levels compared to non-smoking men. In contrast, women who smoked displayed higher AVP levels compared to their non-smoking counterparts. AVP levels were not affected by 24-hr abstinence among smokers, regardless of sex, which suggests that dysregulation in AVP levels in tobacco smokers continues even following 24-hr abstinence. Findings are consistent with previous reports of elevated Th1/Th2 immune function among female smokers compared to male smokers and to male and female non-smokers. Data suggest sex-dependent AVP changes during smoking that could contribute to negative impact of smoking on cardiovascular health.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Guaderrama MM,Corwin EJ,Kapelewski CH,Klein LC

doi

10.1016/j.addbeh.2011.06.015

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1106-9

issue

11

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(11)00195-X

journal_volume

36

pub_type

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