Abstract：
:We previously demonstrated that GLUT2, a facilitated-diffusion glucose transporter isoform known to play critical roles in the regulation of systemic blood glucose level, is present at the apical ends of Müller cells in the rat retina. As a means of elucidating the ontogeny and possible role(s) of GLUT2 in the developing retina, this study examined its expression at various stages of retinal development by immunofluorescence staining using GLUT2-specific antibody. Evidence of GLUT2 expression first appeared at embryonic day 14 (E14) as linear staining along the boundary between the inner and outer layers of the optic cup, with this staining pattern being present throughout subsequent embryonic and neonatal stages. After the development of photoreceptor cell inner and outer segments (i.e., photoreceptor layer), GLUT2 immunoreactivity was localized along the boundary between the outer nuclear layer and photoreceptor layer. Localization of GLUT2 expression and the timing of its appearance, which coincided with the formation of choriocapillaries, together suggest that GLUT2 is involved in the anterior transport of glucose supplied by choroidal circulation from the early stages of retinal development.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Watanabe T,Nagamatsu S,Matsushima S,Kondo K,Motobu H,Hirosawa K,Mabuchi K,Kirino T,Uchimura Hdoi
10.1007/s004419900099keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
217-23issue
2eissn
0302-766Xissn
1432-0878journal_volume
298pub_type
杂志文章abstract：:The endothelial layer of blood vessels controls the passage of cells and solutes from the blood into the surrounding tissue. Crucial for this regulation is the integrity of endothelial cell-cell junctions. Various molecular mechanisms control junctional integrity of the endothelial layer including GTPases, modulation ...
journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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更新日期：1983-01-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：1985-01-01 00:00:00
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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