Age-related changes in rat testicular oxidative stress parameters by hexachlorocyclohexane.

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in APAP-induced liver injury; however, growth arrest and DNA damage-inducible 45 beta (GADD45β) is known to inhibit JNK phosphorylation. The orphan nuclear recep...

journal_title：Archives of toxicology

authors： Kim YH,Noh JR,Hwang JH,Kim KS,Choi DH,Kim JH,Moon SJ,Choi JH,Hérault Y,Lee TG,Choi HS,Lee CH

更新日期：2018-08-01 00:00:00

abstract：:Milacemide (2-n-pentylaminoacetamide) hydrochloride was administered by continuous i.v. infusion for up to 7 days, at 300 and 600 mg/kg per day to male Sprague-Dawley rats. This was intended to provide high and sustained exposure to evaluate the effect of a preterminal 24-h fast on liver lipid content. Liver lipid con...

journal_title：Archives of toxicology

authors： Rakotoamboa JL,Masson M,Palate B,Carleer J,Roba J

更新日期：1994-01-01 00:00:00

abstract：:Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...

journal_title：Archives of toxicology

authors： Malik DE,David RM,Gooderham NJ

更新日期：2019-10-01 00:00:00

abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...

journal_title：Archives of toxicology

authors： Gijbels E,Vilas-Boas V,Annaert P,Vanhaecke T,Devisscher L,Vinken M

更新日期：2020-04-01 00:00:00

abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...

journal_title：Archives of toxicology

authors： Lutter S,Schmalbach K,Esch HL,Lehmann L

更新日期：2014-02-01 00:00:00

abstract：:The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...

journal_title：Archives of toxicology

authors： Daston G,Knight DJ,Schwarz M,Gocht T,Thomas RS,Mahony C,Whelan M

更新日期：2015-01-01 00:00:00

abstract：:Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...

journal_title：Archives of toxicology

authors： Basaure P,Guardia-Escote L,Cabré M,Peris-Sampedro F,Sánchez-Santed F,Domingo JL,Colomina MT

更新日期：2019-03-01 00:00:00

abstract：:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...

journal_title：Archives of toxicology

authors： Silva MJ,Hilton D,Furr J,Gray LE,Preau JL,Calafat AM,Ye X

更新日期：2016-03-01 00:00:00

abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

journal_title：Archives of toxicology

authors： Holmes E,Bonner FW,Nicholson JK

更新日期：1995-01-01 00:00:00

abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

journal_title：Archives of toxicology

authors： Camacho IA,Nagarkatti M,Nagarkatti PS

更新日期：2004-05-01 00:00:00

abstract：:Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...

journal_title：Archives of toxicology

authors： Soukup ST,Müller DR,Kurrat A,Diel P,Kulling SE

更新日期：2017-04-01 00:00:00

abstract：:Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...

journal_title：Archives of toxicology

authors： Martin TJ,Whalen MM

更新日期：2017-04-01 00:00:00

abstract：:The present study has investigated the ability of amitraz, a widely used formamidine pesticide, to modulate serum concentrations and liver microsomal metabolism of 17beta-estradiol (E2) and testosterone in rats. Amitraz was administered intraperitoneally to male rats for 4 days and to intact female rats or ovariectomi...

journal_title：Archives of toxicology

authors： Chou CP,Lu SY,Ueng TH

更新日期：2008-10-01 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00

abstract：:Quinolone-induced arthropathy is probably caused by a lack of functionally available magnesium in immature joint cartilage. We used an in vitro assay to study the effects of fluoroquinolones on cartilage formation in mouse limb buds from 12-day-old mouse embryos in regular and in magnesium-deficient medium. Omission o...

journal_title：Archives of toxicology

authors： Förster C,Rücker M,Shakibaei M,Baumann-Wilschke I,Vormann J,Stahlmann R

更新日期：1998-06-01 00:00:00

abstract：:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...

journal_title：Archives of toxicology

authors： Appenroth D,Fröb S,Kersten L,Splinter FK,Winnefeld K

更新日期：1997-01-01 00:00:00

abstract：:We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electro-chem...

journal_title：Archives of toxicology

authors： Schwabe R,Thiel R,Chahoud I,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:Neuropathy Target Esterase (NTE) was initially identified as the primary target esterase of some organophosphorus compounds that cause delayed neuropathy. Some studies in vivo suggest that this protein may also perform a function in embryonic development and therefore also in cell differentiation. The aim of this work...

journal_title：Archives of toxicology

authors： Pamies D,Reig JA,Vilanova E,Sogorb MA

更新日期：2010-06-01 00:00:00

abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...

journal_title：Archives of toxicology

authors： Hwang JM,Wang CJ,Chou FP,Tseng TH,Hsieh YS,Lin WL,Chu CY

更新日期：2002-11-01 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:The role of the functional substituents on the pyridinium ring of bisquaternary pyridinium compounds, mostly oximes, in exerting reversible and irreversible inhibition of binding of [3H]-N-methyl-4-piperidyl benzilate [( 3H]-4NMPB) to rat brain stem muscarinic receptors was studied. The drugs tested, i.e. HGG-42, HGG-...

journal_title：Archives of toxicology

authors： Kloog Y,Galron R,Balderman D,Sokolovsky M

更新日期：1985-10-01 00:00:00

abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

journal_title：Archives of toxicology

authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

更新日期：2020-06-01 00:00:00

abstract：:The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...

journal_title：Archives of toxicology

authors： Wagner C,Vargas AP,Roos DH,Morel AF,Farina M,Nogueira CW,Aschner M,Rocha JB

更新日期：2010-02-01 00:00:00

abstract：:Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. It has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known ...

journal_title：Archives of toxicology

authors： Kuehner S,Holzmann K,Speit G

更新日期：2013-11-01 00:00:00

abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...

journal_title：Archives of toxicology

authors： Hansjosten I,Rapp J,Reiner L,Vatter R,Fritsch-Decker S,Peravali R,Palosaari T,Joossens E,Gerloff K,Macko P,Whelan M,Gilliland D,Ojea-Jimenez I,Monopoli MP,Rocks L,Garry D,Dawson K,Röttgermann PJF,Murschhauser A,Rädl

更新日期：2018-02-01 00:00:00

abstract：:During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...

journal_title：Archives of toxicology

authors： Sammarco PW,Kolian SR,Warby RA,Bouldin JL,Subra WA,Porter SA

更新日期：2016-04-01 00:00:00

abstract：:Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...

journal_title：Archives of toxicology

authors： Uesawa Y,Staines AG,Lockley D,Mohri K,Burchell B

更新日期：2007-03-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:Brominated flame retardants (BFRs) are abundant persistent organic pollutants with well-studied toxicity. The toxicological and ecological concerns associated with BFRs argue for replacement by safe(r) alternatives. Though previous research identified the nervous system as a sensitive target organ for BFRs, the (neuro...

journal_title：Archives of toxicology

authors： Hendriks HS,Meijer M,Muilwijk M,van den Berg M,Westerink RH

更新日期：2014-04-01 00:00:00