Abstract:
:Infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac index and systemic oxygen transport. Whether or not such a vasoconstriction impedes regional blood flow and thus visceral organ function, even when low AVP is used, is still a matter of debate. Krejci and colleagues now report, in this issue of Critical Care, that infusing 'low-dose' AVP during early, short-term, normotensive and normodynamic fecal peritonitis-induced porcine septicemia markedly reduced both renal and portal blood flow, and consequently total hepatic blood flow, whereas hepatic arterial flow was not affected. This macrocirculatory response was concomitant with reduced kidney microcirculatory perfusion, whereas liver micro-circulation remained unchanged. From these findings the authors conclude that the use of AVP to treat hypotension should be cautioned against in patients with septic shock. Undoubtedly, given its powerful vasoconstrictor properties, which are not accompanied by positive inotropic qualities (in contrast with most of the equally potent standard care 'competitors', namely catecholamines), the safety of AVP is still a matter of concern. Nevertheless, the findings reported by Krejci and colleagues need to be discussed in the context of the model design, the timing and dosing of AVP as well as the complex interaction between visceral organ perfusion and function.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Bracht H,Asfar P,Radermacher P,Calzia Edoi
10.1186/cc6171subject
Has Abstractpub_date
2007-01-01 00:00:00pages
178issue
6eissn
1364-8535issn
1466-609Xpii
cc6171journal_volume
11pub_type
评论,杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:INTRODUCTION:The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements. METHODS:The subjects were 21 critically ill patients with spontaneous breathing movements receiving mechanical ventil...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4970
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (-429T/C) revealed a strong clinical relevance with sepsis morbidity rate and...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0727-2
更新日期:2015-01-09 00:00:00
abstract::The decision to transfuse a hospitalized patient must balance the known risks of transfusion with the need to provide adequate tissue oxygenation and the appropriate utilization of blood as a scarce resource. The minimum tolerated hemoglobin level is not well established, and considerable variation exists in intensivi...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2846
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Data on prehospital and trauma-room fluid management of multiple trauma patients with pelvic disruptions are rarely reported. Present trauma algorithms recommend early hemorrhage control and massive fluid resuscitation. By matching the German Pelvic Injury Register (PIR) with the TraumaRegister DGU (TR) fo...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11487
更新日期:2012-08-22 00:00:00
abstract:INTRODUCTION:The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock with respect to its ability to differentiate between infectious and noninfectious etiologies in SIR...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2386
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION:Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10551
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Bacterial infection represents a serious risk in neonates and critically ill paediatric patients. Current clinical practice is characterized by frequent antibiotic treatment despite low incidence of true infection. However, some patients escape early diagnosis and progress to septic shock. Many new markers...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/cc2971
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc9320
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Little is known about mortality rates following general surgical procedures in the United Kingdom. Deaths are most common in the 'high-risk' surgical population consisting mainly of older patients, with coexisting medical disease, who undergo major surgery. Only limited data are presently available to desc...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4928
更新日期:2006-01-01 00:00:00
abstract::Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1329-y
更新日期:2016-06-30 00:00:00
abstract:BACKGROUND:There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). METHODS:We performed a retrospective single-center cohort study of patients treat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1225-5
更新日期:2016-02-19 00:00:00
abstract:INTRODUCTION:Sepsis-related multiple organ dysfunction is a common cause of death in the intensive care unit. The effect of sepsis on markers of tissue repair is only partly understood. The aim of this study was to measure markers of collagen synthesis and degradation during sepsis and investigate the association with ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7780
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2611-6
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine hospital mortality, long-term mortality, and health service utilization among critically ill patients. We also determined whether these outcomes differed according to demographic and clinical characteristics. METHODS:We conducted a retrospective cohort study of adult...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1248-y
更新日期:2016-03-31 00:00:00
abstract::Cardiogenic shock is a lethal condition. Physicians are searching for hemodynamic markers which could help risk-stratification of patients in this picture. Torgersen and coworkers present an hourly time integral of the cardiac power index and cardiac index drops to predict outcomes in the setting of cardiogenic shock....
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8176
更新日期:2009-01-01 00:00:00
abstract::Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which when measured in combination have high predictive values, offers a paradigm shift forwards for rapid, near-pa...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13137
更新日期:2013-12-04 00:00:00
abstract::Base deficit has frequently been utilized as an informal adjunct in the initial evaluation of trauma patients to assess the extent of their physiologic derangements. However, the current Advanced Trauma Life Support (ATLS) classification system for hypovolemic shock does not include base-deficit measurements and relie...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc12513
更新日期:2013-03-13 00:00:00
abstract::Three pulse contour systems for monitoring cardiac output - LiDCO Plus™, PiCCO Plus™ and FloTrac™ - were compared in postcardiac surgery patients. None of the three methods demonstrated good trending ability according to concordance analysis. Pulse contour systems remain unreliable in the haemodynamically unstable pat...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc9381
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), pro...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03423-2
更新日期:2021-01-06 00:00:00
abstract:INTRODUCTION:B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early s...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1024-4
更新日期:2015-08-28 00:00:00
abstract:BACKGROUND:Clinical team composition for prehospital paediatric intubation may affect success and complication rates. We performed a systematic review and meta-analysis to determine the success and complication rates by type of clinical team. METHODS:We searched MEDLINE, EMBASE, and CINAHL for interventional and obser...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-020-02865-y
更新日期:2020-04-15 00:00:00
abstract::Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with ce...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc9236
更新日期:2010-01-01 00:00:00
abstract::The pulmonary artery catheter (PAC) was introduced in 1971 for the assessment of heart function at the bedside. Since then it has generated much enthusiasm and controversy regarding the benefits and potential harms caused by this invasive form of hemodynamic monitoring. This review discusses all clinical studies condu...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc4834
更新日期:2006-01-01 00:00:00
abstract::Urgent cardiac ultrasound examination in the critical care setting is clinically useful. Application of goal-directed echocardiography in this setting is quite distinct from typical exploratory diagnostic comprehensive echocardiography, because the urgent critical care setting mandates a goal-directed approach. Goal-d...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0681-z
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9061
更新日期:2010-01-01 00:00:00
abstract::Acute hyperglycaemia has been associated with complications, prolonged intensive care unit and hospital stay, and increased mortality. We made an inventory of the prevalence and prognostic value of hyperglycaemia, and of the effects of glucose control in different groups of critically ill patients. The prevalence of h...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc4957
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Ventilator-associated pneumonia (VAP) remains a common hazardous complication in mechanically ventilated patients and is associated with increased morbidity and mortality. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effect of toothbrushing as a component...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc11675
更新日期:2012-10-12 00:00:00
abstract:BACKGROUND:Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treated in the intensive care unit (ICU). METHODS:We used the prospective Finnish Intensive Care Consort...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-018-2151-5
更新日期:2018-09-20 00:00:00
abstract::Large numbers of patients who survive critical illness are left with significant new cognitive impairments that are often severe and remain years after hospital discharge. In the previous issue of Critical Care, Guerra and colleagues assessed risk factors for the development of dementia after an intensive care unit (I...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11913
更新日期:2013-02-06 00:00:00
abstract::The past 15 years have seen major advances in our understanding of severity assessment in community-acquired pneumonia (CAP). Prognostic tools have been promoted to guide all major management decisions in CAP, including admission to the critical care unit. Several recent studies, including the study by Renaud and coll...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc7889
更新日期:2009-01-01 00:00:00