Abstract:
:The decision to transfuse a hospitalized patient must balance the known risks of transfusion with the need to provide adequate tissue oxygenation and the appropriate utilization of blood as a scarce resource. The minimum tolerated hemoglobin level is not well established, and considerable variation exists in intensivists' transfusion practices. Conventional transfusion triggers of 100 g/l have been challenged by reports indicating that aerobic metabolism is supported by hemoglobin levels of 50 g/l or less. Evidence from randomized trials also indicates that withholding transfusions may result in improved outcomes. Arbitrary numeric hemoglobin triggers, however, cannot supercede intervention based on individual physiologic need and clinical circumstances.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Marshall JCdoi
10.1186/cc2846keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
S31-3eissn
1364-8535issn
1466-609Xpii
cc2846journal_volume
8 Suppl 2pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract::Heart rate variability in the frequency domain can now be obtained at the bedside in the ICU. Promising data suggest that it may help to characterize a patient response to a spontaneous breathing trial. Refinement of the analysis could even help to predict the outcome of extubation or at least help to detect early pat...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13807
更新日期:2014-03-31 00:00:00
abstract:BACKGROUND:Atherosclerotic intracranial arterial stenosis is an important cause of stroke that is increasingly being treated with percutaneous transluminal angioplasty and stenting (PTAS) to prevent recurrent stroke. However, PTAS has not been compared with medical management in a randomized trial. METHODS:Objective: ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11326
更新日期:2012-05-09 00:00:00
abstract:BACKGROUND:Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendations have not been defined for this cohort. Our goal is to determine outcome and mortality associate...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2648-6
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. METHODS:In this work, an antibiotic cocktail was used to ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02977-5
更新日期:2020-05-27 00:00:00
abstract:INTRODUCTION:The purpose of this study was to investigate whether common variants across the nuclear factor erythroid 2-like 2 (NFE2L2) gene contribute to the development of the acute respiratory distress syndrome (ARDS) in patients with severe sepsis. NFE2L2 is involved in the response to oxidative stress, and it has ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-0981-y
更新日期:2015-06-16 00:00:00
abstract:BACKGROUND:Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hy...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1889-5
更新日期:2017-12-12 00:00:00
abstract:INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1000-z
更新日期:2015-08-27 00:00:00
abstract:INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc12598
更新日期:2013-04-25 00:00:00
abstract:INTRODUCTION:Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and delirium guidelines are incorporated into order sets at hospital...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc11390
更新日期:2012-06-18 00:00:00
abstract:INTRODUCTION:The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie2 receptor protects the vasculature from inflammation and leakage, whereas binding of Ang-2 antago...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7130
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), pro...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03423-2
更新日期:2021-01-06 00:00:00
abstract::The rationale for the provision of nitrogen from proteins given via the enteral route or from intravenous amino acids is to boost the synthesis of muscle proteins, and thereby to limit the severity of intensive care unit-acquired weakness by the prevention of muscle loss. However, the optimal timing for supplemental n...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2196-5
更新日期:2018-10-25 00:00:00
abstract::The past 15 years have seen major advances in our understanding of severity assessment in community-acquired pneumonia (CAP). Prognostic tools have been promoted to guide all major management decisions in CAP, including admission to the critical care unit. Several recent studies, including the study by Renaud and coll...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc7889
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β-cyclodextrin (SBECD). The purpose of this study was to evaluate the pharmacokinetics of SBECD, voriconazole, and voriconazole N-oxide in critically ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-0753-8
更新日期:2015-02-03 00:00:00
abstract::Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2879
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was bu...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10306
更新日期:2011-07-11 00:00:00
abstract::Patients in ICUs frequently require tracheostomy for long-term ventilator support, and the percutaneous dilatational tracheostomy (PDT) method is preferred over surgical tracheostomy. The use of ultrasound (US) imaging to guide ICU procedures and interventions has recently emerged as a simple and noninvasive tool. The...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-015-0942-5
更新日期:2015-05-18 00:00:00
abstract::Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-018-2157-z
更新日期:2018-09-23 00:00:00
abstract::The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis, leading to capillary leak, microcirculatory dysfunction, organ failure, and eventual death in many critically ill patients. The angiogenic growth f...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc7685
更新日期:2009-01-01 00:00:00
abstract::The optimal length of antimicrobial therapy has not been extensively studied for a great majority of infections and, in critically ill patients affected by ventilator-associated pneumonia, is a persisting and unsolved issue confronting clinicians. The integration of biomarkers, clinical judgment, and microbiologic era...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11899
更新日期:2013-01-21 00:00:00
abstract:INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10100
更新日期:2011-01-01 00:00:00
abstract::Institutionally based research ethics review is a form of peer review that has - for better or worse - become the norm throughout the world. The vast majority of research ethics review takes the form of protocol review alone, conducted in advance of the research. Although oversight and monitoring in clinical research ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2964
更新日期:2004-12-01 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2776-z
更新日期:2020-03-24 00:00:00
abstract::Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10067
更新日期:2011-01-01 00:00:00
abstract::Tight glycaemic control has emerged as a major focus in critical care. However, the struggle to repeat, improve and standardize the results of the initial landmark studies is ongoing. The prospective computerized glycaemic control study by Shulman et al. highlights two emerging and often overlooked aspects of intensiv...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6099
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9963
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:It has been unclear if mechanical cardiopulmonary resuscitation (CPR) is a viable alternative to manual CPR. We aimed to compare resuscitation outcomes before and after switching from manual CPR to load-distributing band (LDB) CPR in a multi-center emergency department (ED) trial. METHODS:We conducted a p...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11456
更新日期:2012-08-03 00:00:00
abstract:INTRODUCTION:Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a stimulation of heat shock protein (HSP)70. We infused either alanine-glutamine or saline during endotoxin challenge ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc7696
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the prognosis and timing of defervescence of bacteremic patients remain under debate. METHODS:In a 6-year ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2632-1
更新日期:2019-11-20 00:00:00
abstract::Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despit...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13065
更新日期:2013-10-16 00:00:00