Impact of Gonadotropin-Releasing Hormone Agonist Pre-treatment on the Cumulative Live Birth Rate in Infertile Women With Adenomyosis Treated With IVF/ICSI: A Retrospective Cohort Study.

Abstract:

:Introduction: Although pre-treatment with a GnRH agonist can reduce the size of adenomyosis lesions, the supra-physiological hormone level induced by controlled ovarian hyperstimulation (COH) may negate the usefulness of the GnRH agonist in patients with adenomyosis lesions, leading to continued poor outcomes in fresh embryo transfer cycles during in vitro fertilization (IVF). It is unclear whether GnRH agonist pre-treatment before starting the long GnRH agonist protocol for IVF/ICSI (intracytoplasmic sperm injection) can improve cumulative live birth rate (CLBR) of infertile women with adenomyosis. Method: In this retrospective cohort study, a total of 374 patients diagnosed as adenomyosis (477 cycles) underwent IVF/ICSI with long GnRH agonist protocol with or without GnRH agonist pre-treatment between January 2009 and June 2018. Logistic regression was used to assess the association between GnRH agonist pre-treatment and pregnancy outcome after adjusting for confounding factors. Results: The live birth rate in fresh embryo transfer cycles was higher in the non-pre-treatment group than in the GnRH agonist pre-treatment group (37.7 vs. 21.2%, P = 0.028); the adjusted odds ratio (OR) for the long agonist protocol without pre-treatment was 1.966 (95% CI: 0.9-4.296, P = 0.09). The CLBR was higher in the non-pre-treatment group than in the GnRH agonist pre-treatment group (40.50 vs. 27.90%, P = 0.019); the adjusted OR for the long agonist protocol without pre-treatment was 1.361 (95% CI: 0.802-2.309, P = 0.254). Conclusion: Our results indicated that GnRH agonist pre-treatment before starting the long GnRH agonist protocol does not improve the live birth rate in fresh embryo transfer cycles or CLBR in infertile women with adenomyosis after IVF/ICSI treatment when compared to that in non-pre-treated patients. A subsequent prospective randomized controlled study is needed to confirm these results.

authors

Chen M,Luo L,Wang Q,Gao J,Chen Y,Zhang Y,Zhou C

doi

10.3389/fendo.2020.00318

subject

Has Abstract

pub_date

2020-05-29 00:00:00

pages

318

issn

1664-2392

journal_volume

11

pub_type

杂志文章
  • Incretin hormones as immunomodulators of atherosclerosis.

    abstract::Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00112

    authors: Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

    更新日期:2012-09-07 00:00:00

  • Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.

    abstract::Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, sp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2016.00047

    authors: Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

    更新日期:2016-06-03 00:00:00

  • Evaluating All Potential Oral Complications of Diabetes Mellitus.

    abstract::Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistanc...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00056

    authors: Verhulst MJL,Loos BG,Gerdes VEA,Teeuw WJ

    更新日期:2019-02-18 00:00:00

  • The Efficacy of PTH and Abaloparatide to Counteract Immobilization-Induced Osteopenia Is in General Similar.

    abstract::Immobilization results in a substantial bone loss and increased fracture risk. Powerful bone anabolic therapies are necessary to counteract the bone loss and reduce fracture risk during periods with immobilization. Intermittent parathyroid hormone 1-34 (PTH) (teriparatide) and PTH related peptide analog abaloparatide ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.588773

    authors: Brent MB,Thomsen JS,Brüel A

    更新日期:2020-10-09 00:00:00

  • Androgen Receptor in Breast Cancer: From Bench to Bedside.

    abstract::Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes. Accumulating evidence has revealed that AR might be a predictive or prognostic factor and a drug target in BC. AR expression and A...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00573

    authors: Chen M,Yang Y,Xu K,Li L,Huang J,Qiu F

    更新日期:2020-09-02 00:00:00

  • Effects of Obesity and Thrombophilia on the Risk of Abortion in Women Undergoing In Vitro Fertilization.

    abstract:Introduction:Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF. Methods:Patient...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.594867

    authors: Candeloro M,Di Nisio M,Ponzano A,Tiboni GM,Potere N,Tana M,Rutjes AWS,Porreca E

    更新日期:2020-12-23 00:00:00

  • Adiponectin, Leptin and Visfatin in Hypoxia and its Effect for Weight Loss in Obesity.

    abstract::Rationale: Hypoxia induces leptin gene expression in human adipocytes via hypoxia-inducible factors (HIF-α/β). Under ambient moderate hypoxia, leptin in adipocytes is elevated for at least 14 days. Leptin is supposedly involved in the reduced food intake, increased utilization of fatty acids for energy production and ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00615

    authors: Rausch LK,Hofer M,Pramsohler S,Kaser S,Ebenbichler C,Haacke S,Gatterer H,Netzer NC

    更新日期:2018-10-18 00:00:00

  • Efficacy of Vandetanib in Treating Locally Advanced or Metastatic Medullary Thyroid Carcinoma According to RECIST Criteria: A Systematic Review and Meta-Analysis.

    abstract:Background:Vandetanib is the most largely used tyrosine kinase inhibitor (TKI) in patients with locally advanced and/or metastatic medullary thyroid cancer (MTC). Here, we conducted a systematic review on its efficacy and attempted to perform a meta-analysis adopting standardized RECIST criteria as end-points. Methods...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00224

    authors: Trimboli P,Castellana M,Virili C,Giorgino F,Giovanella L

    更新日期:2018-05-03 00:00:00

  • Clinical Application of AMH Measurement in Assisted Reproduction.

    abstract::Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.606744

    authors: Li HWR,Nelson SM

    更新日期:2020-12-09 00:00:00

  • Sterol Metabolism and Transport in Atherosclerosis and Cancer.

    abstract::Cholesterol is a vital lipid molecule for mammalian cells, regulating fluidity of biological membranes, and serving as an essential constituent of lipid rafts. Mammalian cells acquire cholesterol from extracellular lipoproteins and from de novo synthesis. Cholesterol biosynthesis generates various precursor sterols. C...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00509

    authors: Yamauchi Y,Rogers MA

    更新日期:2018-09-19 00:00:00

  • Determination of Ghrelin Structure in the Barfin Flounder (Verasper moseri) and Involvement of Ingested Fatty Acids in Ghrelin Acylation.

    abstract::Ghrelin is a peptide hormone that is acylated with a fatty acid, usually n-octanoic acid, at the third amino acid (aa) residue (usually a serine or threonine), and this acylation is known to be essential for ghrelin activity not only in mammals but also in non-mammals, such as fish. However, the modification mechanism...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2013.00117

    authors: Kaiya H,Andoh T,Ichikawa T,Amiya N,Matsuda K,Kangawa K,Miyazato M

    更新日期:2013-09-03 00:00:00

  • "In vitro" Effect of Different Follicle-Stimulating Hormone Preparations on Sertoli Cells: Toward a Personalized Treatment for Male Infertility.

    abstract::Follicle-stimulating hormone (FSH), a major regulator of spermatogenesis, has a crucial function in the development and function of the testis and it is extensively given as a fertility treatment to stimulate spermatogenesis. We analyzed the effects of different FSH preparations (α-follitropin, β-follitropin, and urof...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00401

    authors: Arato I,Grande G,Barrachina F,Bellucci C,Lilli C,Jodar M,Aglietti MC,Mancini F,Vincenzoni F,Pontecorvi A,Calafiore R,Oliva R,Luca G,Mancuso F,Milardi D

    更新日期:2020-06-18 00:00:00

  • Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?

    abstract::Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00433

    authors: Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

    更新日期:2020-07-03 00:00:00

  • Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis.

    abstract::Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.599255

    authors: Ruiz-Sánchez JG,Núñez-Gil IJ,Cuesta M,Rubio MA,Maroun-Eid C,Arroyo-Espliguero R,Romero R,Becerra-Muñoz VM,Uribarri A,Feltes G,Trabattoni D,Molina M,García Aguado M,Pepe M,Cerrato E,Alfonso E,Castro Mejía AF,Roubin SR,

    更新日期:2020-11-30 00:00:00

  • A Rare Case of Pituitary Melanoma Metastasis: A Dramatic and Prolonged Response to Dabrafenib-Trametinib Therapy.

    abstract::Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.00471

    authors: Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

    更新日期:2020-07-23 00:00:00

  • The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research.

    abstract::The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within li...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00102

    authors: Wafer R,Tandon P,Minchin JEN

    更新日期:2017-05-22 00:00:00

  • Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles.

    abstract:Objective:To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design:Retrospective observational study. Setting:Tertiary-care academic medical center. Participants:4465 infertile women undergoing their f...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.546232

    authors: Ye J,Zhang J,Gao H,Zhu Y,Wang Y,Cai R,Kuang Y

    更新日期:2020-10-29 00:00:00

  • Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?

    abstract::As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical ex...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00729

    authors: Zheng J,Cheng J,Zheng S,Zhang L,Guo X,Zhang J,Xiao X

    更新日期:2018-12-03 00:00:00

  • Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner.

    abstract::Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia-the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial activation. Previously, we observed that hypothalamic microglial cells ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00424

    authors: Milanova IV,Kalsbeek MJT,Wang XL,Korpel NL,Stenvers DJ,Wolff SEC,de Goede P,Heijboer AC,Fliers E,la Fleur SE,Kalsbeek A,Yi CX

    更新日期:2019-06-26 00:00:00

  • Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.

    abstract::The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00030

    authors: De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

    更新日期:2015-03-06 00:00:00

  • Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants.

    abstract::Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00248

    authors: De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

    更新日期:2017-09-25 00:00:00

  • Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

    abstract::At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00276

    authors: Wallet MA,Santostefano KE,Terada N,Brusko TM

    更新日期:2017-10-18 00:00:00

  • Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer.

    abstract::Initially identified as monomers, G protein-coupled receptors (GPCRs) can also form functional homo- and heterodimers that act as distinct signaling hubs for cellular signal integration. We previously found that the angiotensin II (Ang II) type 1 receptor (AT1R) and the prostaglandin F2α (PGF2α) receptor (FP), both im...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00162

    authors: Fillion D,Devost D,Sleno R,Inoue A,Hébert TE

    更新日期:2019-03-18 00:00:00

  • A Pilot Randomized-Controlled Trial on the Effect of CPAP Treatment on Glycemic Control in Gestational Diabetes: Study Design and Methods.

    abstract::Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00659

    authors: Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

    更新日期:2018-11-16 00:00:00

  • The Regulation of Peripheral Metabolism by Gut-Derived Hormones.

    abstract::Enteroendocrine cells lining the gut epithelium constitute the largest endocrine organ in the body and secrete over 20 different hormones in response to cues from ingested foods and changes in nutritional status. Not only do these hormones convey signals from the gut to the brain via the gut-brain axis, they also act ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00754

    authors: Sun EWL,Martin AM,Young RL,Keating DJ

    更新日期:2019-01-04 00:00:00

  • Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.

    abstract::Objective: Circulating free DNA (cfDNA) in general and circulating tumor DNA (ctDNA) in particular is becoming an increasingly used form of liquid biopsy biomarkers. In this study, we are investigating the ability to detect ctDNA from the plasma of pituitary adenoma (PA) patients. Design: Tumor tissue samples were obt...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00615

    authors: Megnis K,Peculis R,Rovite V,Laksa P,Niedra H,Balcere I,Caune O,Breiksa A,Nazarovs J,Stukens J,Konrade I,Pirags V,Klovins J

    更新日期:2019-09-18 00:00:00

  • Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation.

    abstract::GPER-1 is a novel membrane sited G protein-coupled estrogen receptor. Clinical studies have shown that patients suffering an estrogen receptor α (ERα)/GPER-1 positive, breast cancer have a lower survival rate than those who have developed ERα-positive/GPER-1 negative tumors. Moreover, absence of GPER-1 improves the pr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.563165

    authors: Molina L,Bustamante F,Ortloff A,Ramos I,Ehrenfeld P,Figueroa CD

    更新日期:2020-09-30 00:00:00

  • Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs Outbreak.

    abstract::The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic. The circadian day-night is the rhythmic clue to organisms for their synchronized body functions. The "development for mankind" escalated the use of artificial light at night (ALAN). In this article, we tried to focus on the possible influence ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00622

    authors: Khan ZA,Yumnamcha T,Mondal G,Devi SD,Rajiv C,Labala RK,Sanjita Devi H,Chattoraj A

    更新日期:2020-09-10 00:00:00

  • Does Hypoxia Decrease the Metabolic Rate?

    abstract::In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00668

    authors: Gu C,Jun JC

    更新日期:2018-11-13 00:00:00

  • GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

    abstract::Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2015.00191

    authors: Martin B,Chadwick W,Janssens J,Premont RT,Schmalzigaug R,Becker KG,Lehrmann E,Wood WH,Zhang Y,Siddiqui S,Park SS,Cong WN,Daimon CM,Maudsley S

    更新日期:2016-01-18 00:00:00