Abstract:
:Follicle-stimulating hormone (FSH), a major regulator of spermatogenesis, has a crucial function in the development and function of the testis and it is extensively given as a fertility treatment to stimulate spermatogenesis. We analyzed the effects of different FSH preparations (α-follitropin, β-follitropin, and urofollitropin) in combination with testosterone on porcine pre-pubertal Sertoli cells. To study the effect of the different FSH treatments in the Sertoli cell function we performed Real Time PCR analysis of AMH, inhibin B, and FSH-r, an ELISA assay for AMH and inhibin B, and a high-throughput comparative proteomic analysis. We verified that all three preparations induced a reduction of AMH in terms of mRNA and secreted proteins, and an increase of inhibin B in terms of mRNA in all the FSH formulations, while solely α-follitropin produced an increase of secreted inhibin B in the culture medium. Comparative proteomic analysis of the three FSH preparations identified 46 proteins, 11 up-regulated and 2 down-regulated. Surprisingly, the combination of testosterone with β-follitropin specifically induced an up-regulation of eight specific secreted proteins. Our study, showing that the three different FSH preparations induce different effects, could offer the opportunity to shed light inside new applications to a personalized reproductive medicine.
journal_name
Front Endocrinol (Lausanne)journal_title
Frontiers in endocrinologyauthors
Arato I,Grande G,Barrachina F,Bellucci C,Lilli C,Jodar M,Aglietti MC,Mancini F,Vincenzoni F,Pontecorvi A,Calafiore R,Oliva R,Luca G,Mancuso F,Milardi Ddoi
10.3389/fendo.2020.00401subject
Has Abstractpub_date
2020-06-18 00:00:00pages
401issn
1664-2392journal_volume
11pub_type
杂志文章abstract::Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic d...
journal_title:Frontiers in endocrinology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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abstract::The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer....
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journal_title:Frontiers in endocrinology
pub_type: 杂志文章,评审
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doi:10.3389/fendo.2019.00889
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
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abstract::Thyroid nodules with ultrasound (US) cancer risk features and extra-thyroid lesions suggesting malignant lymph nodes, require prompt diagnosis, especially in children. The US pattern of intrathyroidal ectopic thymus (IET) can strongly suggest papillary thyroid carcinoma (PTC). The extra-thyroid ectopic thymic tissue (...
journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
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更新日期:2017-01-17 00:00:00