Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain.

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a novel eye-operated com...

journal_title：Frontiers in neuroscience

authors： Lenglet T,Mirault J,Veyrat-Masson M,Funkiewiez A,Amador MDM,Bruneteau G,Le Forestier N,Pradat PF,Salachas F,Vacher Y,Lacomblez L,Lorenceau J

更新日期：2019-05-29 00:00:00

abstract：:Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set ...

journal_title：Frontiers in neuroscience

authors： Herff C,Krusienski DJ,Kubben P

更新日期：2020-02-27 00:00:00

abstract：:The auditory cortex integrates auditory information over time to obtain neural representations of sound events, the time scale of which critically affects perception. This work investigated the species differences in the time scale of integration by comparing humans and monkeys regarding how their scalp-recorded corti...

journal_title：Frontiers in neuroscience

authors： Itoh K,Nejime M,Konoike N,Nakamura K,Nakada T

更新日期：2019-06-24 00:00:00

abstract：:Exposure in vivo (EXP) is a cognitive-behavioral treatment aimed at reducing pain-related fear in chronic pain, and has proven successful in reducing pain-related disability in patients with chronic low back pain (cLBP). The current longitudinal study aimed to reveal the neural correlates of changes in pain-related fe...

journal_title：Frontiers in neuroscience

authors： Timmers I,de Jong JR,Goossens M,Verbunt JA,Smeets RJ,Kaas AL

更新日期：2019-09-17 00:00:00

abstract：:Rodent models have opened the door to a better understanding of the neurobiology of brain disorders and increased our ability to evaluate novel treatments. Resting-state functional magnetic resonance imaging (rs-fMRI) allows for in vivo exploration of large-scale brain networks with high spatial resolution. Its applic...

journal_title：Frontiers in neuroscience

authors： Bajic D,Craig MM,Mongerson CRL,Borsook D,Becerra L

更新日期：2017-12-12 00:00:00

abstract：:Peripheral nerves are composed of complex layered anatomical structures, including epineurium, perineurium, and endoneurium. Perineurium and endoneurium contain many physical barriers, including the blood-nerve barrier at endoneurial vessels and the perineurial barrier. These physical barriers help to eliminate flux p...

journal_title：Frontiers in neuroscience

authors： Liu Q,Wang X,Yi S

更新日期：2018-08-23 00:00:00

abstract：:We previously demonstrated that, in the early stages of tau processing in Alzheimer's disease, the N-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by Alz-50. In this immunohistochemical stud...

journal_title：Frontiers in neuroscience

authors： Flores-Rodríguez P,Ontiveros-Torres MA,Cárdenas-Aguayo MC,Luna-Arias JP,Meraz-Ríos MA,Viramontes-Pintos A,Harrington CR,Wischik CM,Mena R,Florán-Garduño B,Luna-Muñoz J

更新日期：2015-02-11 00:00:00

abstract：:Transcutaneous auricular vagus nerve stimulation (taVNS) has gained growing interest as a non-invasive and non-pharmacologic treatment option in various neurological and psychiatric disorders. Animal experiments and clinical trials confirm that taVNS at the auricular concha region has beneficial effects on depression....

journal_title：Frontiers in neuroscience

authors： Li S,Wang Y,Gao G,Guo X,Zhang Y,Zhang Z,Wang Y,Zhang J,Wang J,Li L,Yang Y,Rong P

更新日期：2020-07-15 00:00:00

abstract：:The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

journal_title：Frontiers in neuroscience

authors： Zhang X,Gong Q

更新日期：2019-02-26 00:00:00

abstract：:Identifying the multiple contributors to the audiometric loss of a hearing impaired (HI) listener at a particular frequency is becoming gradually more useful as new treatments are developed. Here, we infer the contribution of inner (IHC) and outer hair cell (OHC) dysfunction to the total audiometric loss in a sample o...

journal_title：Frontiers in neuroscience

authors： Johannesen PT,Pérez-González P,Lopez-Poveda EA

更新日期：2014-07-23 00:00:00

abstract：:Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

journal_title：Frontiers in neuroscience

authors： Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

更新日期：2019-03-19 00:00:00

abstract：:Tau is an essential protein that physiologically promotes the assembly and stabilization of microtubules, and participates in neuronal development, axonal transport, and neuronal polarity. However, in a number of neurodegenerative diseases, including Alzheimer's disease (AD), tau undergoes pathological modifications i...

journal_title：Frontiers in neuroscience

authors： Pérez MJ,Jara C,Quintanilla RA

更新日期：2018-07-05 00:00:00

abstract：:Recently, Parkinson's disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs neurotransmission. Here we use a single vesicle fusion assay with ms time resolut...

journal_title：Frontiers in neuroscience

authors： Hawk BJD,Khounlo R,Shin YK

更新日期：2019-03-21 00:00:00

abstract：:Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic lateral sclerosis, are a prominent class of neurological diseases currently without a cure. They are characterized by an inexorable loss of a specific type of neurons. The selective vulnerability of specific neuronal clusters (typi...

journal_title：Frontiers in neuroscience

authors： Muddapu VR,Dharshini SAP,Chakravarthy VS,Gromiha MM

更新日期：2020-03-31 00:00:00

abstract：:Understanding the complex neural mechanisms controlling urinary bladder activity is an extremely important topic in both neuroscience and urology. Simultaneously recording of the bladder activity and neural activity in related brain regions will largely advance this field. However, such recording approach has long bee...

journal_title：Frontiers in neuroscience

authors： Yao J,Li Q,Li X,Qin H,Liang S,Liao X,Chen X,Li W,Yan J

更新日期：2019-06-25 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta. However, until recently, research on the pathogenesis and treatment of PD have progressed slowl...

journal_title：Frontiers in neuroscience

authors： Wang J,Wang F,Mai D,Qu S

更新日期：2020-11-26 00:00:00

abstract：:Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co...

journal_title：Frontiers in neuroscience

authors： Tsetsos F,Padmanabhuni SS,Alexander J,Karagiannidis I,Tsifintaris M,Topaloudi A,Mantzaris D,Georgitsi M,Drineas P,Paschou P

更新日期：2016-07-22 00:00:00

abstract：:Heterogeneity between late-onset Parkinson's disease (LOPD) and early-onset Parkinson's disease (EOPD) is mainly reflected in the following aspects including genetics, disease progression, drug response, clinical manifestation, and neuropathological change. Although many studies have investigated these differences in ...

journal_title：Frontiers in neuroscience

authors： Yue Y,Jiang Y,Shen T,Pu J,Lai HY,Zhang B

更新日期：2020-02-25 00:00:00

abstract：:The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the ide...

journal_title：Frontiers in neuroscience

authors： Eiriz MF,Valero J,Malva JO,Bernardino L

更新日期：2014-06-16 00:00:00

abstract：:Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

journal_title：Frontiers in neuroscience

authors： Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

更新日期：2015-10-23 00:00:00

abstract：:Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive performance, the effects of synthetic steroids contained in hormonal contraceptives on br...

journal_title：Frontiers in neuroscience

authors： Pletzer BA,Kerschbaum HH

更新日期：2014-08-21 00:00:00

abstract：:Attention and working memory (WM) are core components of executive functions, and they can be enhanced by training. One activity that has shown to improve executive functions is musical training, but the brain networks underlying these improvements are not well known. We aimed to identify, using functional MRI (fMRI),...

journal_title：Frontiers in neuroscience

authors： Kausel L,Zamorano F,Billeke P,Sutherland ME,Larrain-Valenzuela J,Stecher X,Schlaug G,Aboitiz F

更新日期：2020-10-08 00:00:00

abstract：:Cognitive changes after menopause are a common complaint, especially as the loss of estradiol at menopause has been hypothesized to contribute to the higher rates of dementia in women. To explore the neural processes related to subjective cognitive complaints, this study examined resting state functional connectivity ...

journal_title：Frontiers in neuroscience

authors： Vega JN,Zurkovsky L,Albert K,Melo A,Boyd B,Dumas J,Woodward N,McDonald BC,Saykin AJ,Park JH,Naylor M,Newhouse PA

更新日期：2016-09-23 00:00:00

abstract：:Background: Stress-induced cellular changes in limbic brain structures contribute to the development of various psychopathologies. In vivo detection of these microstructural changes may help us to develop objective biomarkers for psychiatric disorders. Diffusion tensor imaging (DTI) is an advanced neuroimaging techniq...

journal_title：Frontiers in neuroscience

authors： Nagy SA,Vranesics A,Varga Z,Csabai D,Bruszt N,Bali ZK,Perlaki G,Hernádi I,Berente Z,Miseta A,Dóczi T,Czéh B

更新日期：2020-06-03 00:00:00

abstract：:Background: Stroke is the second leading cause of death worldwide. Angiogenesis facilitates the formation of microvascular networks and promotes recovery after stroke. The Shh/Gli signaling pathway is implicated in angiogenesis and cerebral ischemia-reperfusion (I/R) injury. This study aimed at investigating the influ...

journal_title：Frontiers in neuroscience

authors： Peng L,Yin J,Ge M,Wang S,Xie L,Li Y,Si JQ,Ma K

更新日期：2019-04-09 00:00:00

abstract：:Prior research has shown that during development, there is increased segregation between, and increased integration within, prototypical resting-state functional brain networks. Functional networks are typically defined by static functional connectivity over extended periods of rest. However, little is known about how...

journal_title：Frontiers in neuroscience

authors： Rosenberg BM,Mennigen E,Monti MM,Kaiser RH

更新日期：2020-12-08 00:00:00

abstract：:Openness to experience (OTE) has relatively stable and heritable characteristics. Previous studies have used candidate gene approaches to explore the genetic mechanisms of OTE, but genome-wide polygenic scores have a greater genetic effect than other genetic analysis methods, and previous studies have never examined t...

journal_title：Frontiers in neuroscience

authors： Ren Z,Liu C,Meng J,Liu Q,Shi L,Wu X,Song L,Qiu J

更新日期：2021-01-11 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.01334.]. ...

journal_title：Frontiers in neuroscience

authors： Ooi LQR,Wen MC,Ng SY,Chia NS,Chew IHM,Lee W,Xu Z,Hartono S,Tan EK,Chan LL,Tan LC

更新日期：2020-05-12 00:00:00

abstract：:Williams syndrome (WS) is a clinical condition, involving cognitive deficits and an uneven language profile, which has been the object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozen genes in chromosome 7, no gene has yet been probed to account for, or contribute...

journal_title：Frontiers in neuroscience

authors： Benítez-Burraco A,Kimura R

更新日期：2019-03-26 00:00:00

abstract：:Motor neurons (MN) degeneration is a main feature of amyotrophic lateral sclerosis (ALS), a neurological disorder with a progressive course. The diagnosis of ALS is essentially a clinical one. Most common symptoms include a gradual neurological deterioration that reflect the impairment and subsequent loss of muscle fu...

journal_title：Frontiers in neuroscience

authors： Forostyak S,Sykova E

更新日期：2017-10-24 00:00:00