Neuroprotective Potential of Cell-Based Therapies in ALS: From Bench to Bedside.

abstract：:Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

journal_title：Frontiers in neuroscience

authors： Macefield VG

更新日期：2011-12-06 00:00:00

abstract：:Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis (protein homeostasis) is an essential factor in maintaining a persistent environment for neuronal activ...

journal_title：Frontiers in neuroscience

authors： Lehtonen Š,Sonninen TM,Wojciechowski S,Goldsteins G,Koistinaho J

更新日期：2019-05-10 00:00:00

abstract：:This paper introduces Pyff, the Pythonic feedback framework for feedback applications and stimulus presentation. Pyff provides a platform-independent framework that allows users to develop and run neuroscientific experiments in the programming language Python. Existing solutions have mostly been implemented in C++, wh...

journal_title：Frontiers in neuroscience

authors： Venthur B,Scholler S,Williamson J,Dähne S,Treder MS,Kramarek MT,Müller KR,Blankertz B

更新日期：2010-12-02 00:00:00

abstract：:SpiNNaker is a digital neuromorphic architecture, designed specifically for the low power simulation of large-scale spiking neural networks at speeds close to biological real-time. Unlike other neuromorphic systems, SpiNNaker allows users to develop their own neuron and synapse models as well as specify arbitrary conn...

journal_title：Frontiers in neuroscience

authors： Mikaitis M,Pineda García G,Knight JC,Furber SB

更新日期：2018-02-27 00:00:00

abstract：:Inducing somatic cells into neural stem cells (iNSCs) in specific ways provides a new cell therapy in a variety of neurological diseases. In the past, iNSCs were generated by transcription factors which increased the risk of mutagenesis, tumor formations, and immune reactions by viral transduction vectors. Therefore, ...

journal_title：Frontiers in neuroscience

authors： Duan Q,Li S,Wen X,Sunnassee G,Chen J,Tan S,Guo Y

更新日期：2019-09-04 00:00:00

abstract：:It has long been suggested that sound plays a role in the postural control process. Few studies however have explored sound and posture interactions. The present paper focuses on the specific impact of audition on posture, seeking to determine the attributes of sound that may be useful for postural purposes. We invest...

journal_title：Frontiers in neuroscience

authors： Gandemer L,Parseihian G,Kronland-Martinet R,Bourdin C

更新日期：2017-06-26 00:00:00

abstract：:Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

journal_title：Frontiers in neuroscience

authors： Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

更新日期：2019-03-19 00:00:00

abstract：:Decisions are faster and less accurate when conditions favor speed, and are slower and more accurate when they favor accuracy. This phenomenon is referred to as the speed-accuracy trade-off (SAT). Behavioral studies of the SAT have a long history, and the data from these studies are well characterized within the frame...

journal_title：Frontiers in neuroscience

authors： Standage D,Blohm G,Dorris MC

更新日期：2014-08-13 00:00:00

abstract：:The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a homolog that is incorrectly spliced. Primary treatment strategies for SM...

journal_title：Frontiers in neuroscience

authors： Borg R,Cauchi RJ

更新日期：2014-10-15 00:00:00

abstract：:The utility of premovement electroencephalography (EEG) for decoding movement intention during a reaching task has been demonstrated. However, the kind of information the brain represents regarding the intended target during movement preparation remains unknown. In the present study, we investigated which movement par...

journal_title：Frontiers in neuroscience

authors： Kim H,Yoshimura N,Koike Y

更新日期：2019-11-01 00:00:00

abstract：:In the event-related potential (ERP) of scalp electroencephalography (EEG) studies, the vertex reference (Cz), linked mastoids or ears (LM), and average reference (AVG) are popular reference methods, and the reference electrode standardization technique (REST) is increasingly applied. Because scalp EEG recordings are ...

journal_title：Frontiers in neuroscience

authors： Dong L,Liu X,Zhao L,Lai Y,Gong D,Liu T,Yao D

更新日期：2019-10-11 00:00:00

abstract：:Diffusion magnetic resonance imaging (dMRI) allows to reconstruct the main pathways of axons within the white matter of the brain as a set of polylines, called streamlines. The set of streamlines of the whole brain is called the tractogram. Organizing tractograms into anatomically meaningful structures, called tracts,...

journal_title：Frontiers in neuroscience

authors： Sharmin N,Olivetti E,Avesani P

更新日期：2018-02-06 00:00:00

abstract：:Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed ...

journal_title：Frontiers in neuroscience

authors： Oliva MK,Pérez-Moreno JJ,O'Shaughnessy J,Wardill TJ,O'Kane CJ

更新日期：2020-08-10 00:00:00

abstract：:The neurohormone oxytocin (OXT) has been found to mediate the regulation of complex socioemotional cognition in multiple ways both in humans and other animals. Recent studies have investigated the effects of OXT in different levels of analysis (from genetic to behavioral) chiefly targeting its impact on the social com...

journal_title：Frontiers in neuroscience

authors： Theofanopoulou C

更新日期：2016-06-14 00:00:00

abstract：:In this work, we propose a Spiking Neural Network (SNN) consisting of input neurons sparsely connected by plastic synapses to a randomly interlinked liquid, referred to as Liquid-SNN, for unsupervised speech and image recognition. We adapt the strength of the synapses interconnecting the input and liquid using Spike T...

journal_title：Frontiers in neuroscience

authors： Srinivasan G,Panda P,Roy K

更新日期：2018-08-23 00:00:00

abstract：:The neuropeptide oxytocin plays a central role in prosocial and parental behavior in non-human mammals as well as humans. It has been suggested that oxytocin may affect visual processing of infant faces and emotional reaction to infants. Healthy male volunteers (N = 13) were tested for their ability to detect infant o...

journal_title：Frontiers in neuroscience

authors： Saito A,Hamada H,Kikusui T,Mogi K,Nagasawa M,Mitsui S,Higuchi T,Hasegawa T,Hiraki K

更新日期：2014-07-29 00:00:00

abstract：:The mechanisms underlying the beneficial effects of deep brain stimulation (DBS) for Parkinson's disease (PD) remain poorly understood and are still under debate. This has hindered the development of adaptive DBS (aDBS). For further progress in aDBS, more insight into the dynamics of PD is needed, which can be obtaine...

journal_title：Frontiers in neuroscience

authors： Mohammed A,Bayford R,Demosthenous A

更新日期：2020-05-19 00:00:00

abstract：:Huntington Disease (HD) is a genetic neurodegenerative disorder characterized by broad types of cellular and molecular dysfunctions that may affect both neuronal and non-neuronal cell populations. Among all the molecular mechanisms underlying the complex pathogenesis of the disease, alteration of sphingolipids has bee...

journal_title：Frontiers in neuroscience

authors： Di Pardo A,Amico E,Maglione V

更新日期：2016-10-06 00:00:00

abstract：Background:A number of mental illness is often re-diagnosed to be bipolar disorder (BD). Furthermore, the prefronto-limbic-striatal regions seem to be associated with the main dysconnectivity of BD. Functional connectivity is potentially an appropriate objective neurobiological marker that can assist with BD diagnosis....

journal_title：Frontiers in neuroscience

authors： Chen YL,Tu PC,Huang TH,Bai YM,Su TP,Chen MH,Wu YT

更新日期：2020-10-20 00:00:00

abstract：:In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different gene...

journal_title：Frontiers in neuroscience

authors： Fernández-Marmiesse A,Roca I,Díaz-Flores F,Cantarín V,Pérez-Poyato MS,Fontalba A,Laranjeira F,Quintans S,Moldovan O,Felgueroso B,Rodríguez-Pedreira M,Simón R,Camacho A,Quijada P,Ibanez-Mico S,Domingno MR,Benito C,Calvo

更新日期：2019-11-08 00:00:00

abstract：:The diterpenoid compound, Oridonin, extracted from the Chinese herb, Rabdosia rubescens, possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition of the Notch pa...

journal_title：Frontiers in neuroscience

authors： Xu L,Li L,Zhang CY,Schluesener H,Zhang ZY

更新日期：2019-04-02 00:00:00

abstract：:Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music trai...

journal_title：Frontiers in neuroscience

authors： Miendlarzewska EA,Trost WJ

更新日期：2014-01-20 00:00:00

abstract：:The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying the association are unclear. Therefore, the hypothalamic-regulated mechanisms of appetite and the circadian clock gene expression w...

journal_title：Frontiers in neuroscience

authors： Sun Q,Liu Y,Wei W,Wu D,Lin R,Wen D,Jia L

更新日期：2020-09-08 00:00:00

abstract：:In situ hybridization (ISH) is a powerful technique that is used to detect the localization of specific nucleic acid sequences for understanding the organization, regulation, and function of genes. However, in most cases, RNA probes are obtained by in vitro transcription from plasmids containing specific promoter elem...

journal_title：Frontiers in neuroscience

authors： Hua R,Yu S,Liu M,Li H

更新日期：2018-05-02 00:00:00

abstract：:Head motion is one of major concerns in current resting-state functional MRI studies. Image realignment including motion estimation and spatial resampling is often applied to achieve rigid-body motion correction. While the accurate estimation of motion parameters has been addressed in most studies, spatial resampling ...

journal_title：Frontiers in neuroscience

authors： Yuan L,He H,Zhang H,Zhong J

更新日期：2016-12-27 00:00:00

abstract：:Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set ...

journal_title：Frontiers in neuroscience

authors： Herff C,Krusienski DJ,Kubben P

更新日期：2020-02-27 00:00:00

abstract：:A novel low cost interconnected architecture (LCIA) is proposed in this paper, which is an efficient solution for the neuron interconnections for the hardware spiking neural networks (SNNs). It is based on an all-to-all connection that takes each paired input and output nodes of multi-layer SNNs as the source and dest...

journal_title：Frontiers in neuroscience

authors： Luo Y,Wan L,Liu J,Harkin J,McDaid L,Cao Y,Ding X

更新日期：2018-11-21 00:00:00

abstract：:Background: Tinnitus is a very common symptom that often causes distress and decreases the patient's quality of life. Apart from the well-known causes, tinnitus can in some cases be elicited by dysfunctions of the cervical spine or the temporomandibular joint (TMJ). To date however, it is unclear whether alleviation o...

journal_title：Frontiers in neuroscience

authors： Michiels S,Naessens S,Van de Heyning P,Braem M,Visscher CM,Gilles A,De Hertogh W

更新日期：2016-11-29 00:00:00

abstract：:Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been however shown that repe...

journal_title：Frontiers in neuroscience

authors： Aubonnet R,Banea OC,Sirica R,Wassermann EM,Yassine S,Jacob D,Magnúsdóttir BB,Haraldsson M,Stefansson SB,Jónasson VD,Ívarsson E,Jónasson AD,Hassan M,Gargiulo P

更新日期：2020-11-20 00:00:00

abstract：:While brain stimulation techniques have been examined as treatment options for chronic tinnitus for many years, they have recently been extended to multimodal treatment approaches. As chronic tinnitus is often accompanied by comorbid muscular tension in the neck and back, we performed a one-arm pilot study to explore ...

journal_title：Frontiers in neuroscience

authors： Vielsmeier V,Schecklmann M,Schlee W,Kreuzer PM,Poeppl TB,Rupprecht R,Langguth B,Lehner A

更新日期：2018-02-20 00:00:00