Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling.

abstract：:Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component. Compared with other cell types, PQC in neurons is particularly challenging because they have a unique cellular struct...

journal_title：Frontiers in neuroscience

authors： Ciechanover A,Kwon YT

更新日期：2017-04-06 00:00:00

abstract：:Attention and working memory (WM) are core components of executive functions, and they can be enhanced by training. One activity that has shown to improve executive functions is musical training, but the brain networks underlying these improvements are not well known. We aimed to identify, using functional MRI (fMRI),...

journal_title：Frontiers in neuroscience

authors： Kausel L,Zamorano F,Billeke P,Sutherland ME,Larrain-Valenzuela J,Stecher X,Schlaug G,Aboitiz F

更新日期：2020-10-08 00:00:00

abstract：:Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders worldwide, with age being their major risk factor. The increasing worldwide life expectancy, together with the scarcity of available treatment choices, makes it thus pressing to find the molecular basis of AD and ...

journal_title：Frontiers in neuroscience

authors： Bordone MC,Barbosa-Morais NL

更新日期：2020-12-09 00:00:00

abstract：:It is now well recognized that, in addition to motor impairment, amyotrophic lateral sclerosis (ALS) may cause extra-motor clinical signs and symptoms. These can include the alteration of certain cognitive functions, impaired social cognition, and changes in the perception and processing of emotions. Where these extra...

journal_title：Frontiers in neuroscience

authors： Benbrika S,Desgranges B,Eustache F,Viader F

更新日期：2019-09-10 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide dismutase 1 (mSOD1...

journal_title：Frontiers in neuroscience

authors： Pinto S,Cunha C,Barbosa M,Vaz AR,Brites D

更新日期：2017-05-17 00:00:00

abstract：:Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Using brain slices from mi...

journal_title：Frontiers in neuroscience

authors： Kohlmeier KA,Tyler CJ,Kalogiannis M,Ishibashi M,Kristensen MP,Gumenchuk I,Chemelli RM,Kisanuki YY,Yanagisawa M,Leonard CS

更新日期：2013-12-20 00:00:00

abstract：:Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co...

journal_title：Frontiers in neuroscience

authors： Tsetsos F,Padmanabhuni SS,Alexander J,Karagiannidis I,Tsifintaris M,Topaloudi A,Mantzaris D,Georgitsi M,Drineas P,Paschou P

更新日期：2016-07-22 00:00:00

abstract：:Inherited retinal diseases encompass a highly heterogenous group of disorders caused by a wide range of genetic variants and with diverse clinical symptoms that converge in the common trait of retinal degeneration. Indeed, mutations in over 270 genes have been associated with some form of retinal degenerative phenotyp...

journal_title：Frontiers in neuroscience

authors： Gallego C,Gonçalves MAFV,Wijnholds J

更新日期：2020-08-20 00:00:00

abstract：:While the adult human brain has approximately 8.8 × 10(10) neurons, this number is dwarfed by its 1 × 10(15) synapses. From the point of view of neuromorphic engineering and neural simulation in general this makes the simulation of these synapses a particularly complex problem. SpiNNaker is a digital, neuromorphic arc...

journal_title：Frontiers in neuroscience

authors： Knight JC,Furber SB

更新日期：2016-09-14 00:00:00

abstract：:It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the signaling of intracellular c...

journal_title：Frontiers in neuroscience

authors： Wang JM,Sun C

更新日期：2010-12-02 00:00:00

abstract：:Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimul...

journal_title：Frontiers in neuroscience

authors： Kennedy AE,Kaf WA,Ferraro JA,Delgado RE,Lichtenhan JT

更新日期：2017-07-27 00:00:00

abstract：:We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consistin...

journal_title：Frontiers in neuroscience

authors： Hori S,Mori K,Mashimo T,Seiyama A

更新日期：2017-06-09 00:00:00

abstract：:Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

journal_title：Frontiers in neuroscience

authors： Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

更新日期：2015-10-23 00:00:00

abstract：:Currently the integrity of brain function that drives behavior is predominantly measured in terms of pure motor function, yet most human behavior is visually driven. A means of easily quantifying such visually-driven brain function for comparison against population norms is lacking. Analysis of eye-hand coordination (...

journal_title：Frontiers in neuroscience

authors： Junghans BM,Khuu SK

更新日期：2019-07-10 00:00:00

abstract：:The cerebellum is one of the most consistent sites of abnormality in autism spectrum disorder (ASD) and cerebellar damage is associated with an increased risk of ASD symptoms, suggesting that cerebellar dysfunction may play a crucial role in the etiology of ASD. The cerebellum forms multiple closed-loop circuits with ...

journal_title：Frontiers in neuroscience

authors： D'Mello AM,Stoodley CJ

更新日期：2015-11-05 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.00117.]. ...

journal_title：Frontiers in neuroscience

authors： Zuo XN,Biswal BB,Poldrack RA

更新日期：2019-04-16 00:00:00

abstract：:The molecular mechanism underlying Parkinson's disease (PD), an increasingly common neurodegenerative disease, remains unclear. Long non-coding RNA (lncRNA) plays essential roles in gene expression and human diseases. We hypothesize that lncRNAs are involved in neuronal degeneration of PD. Using microarray, we identif...

journal_title：Frontiers in neuroscience

authors： Fan Y,Li J,Yang Q,Gong C,Gao H,Mao Z,Yuan X,Zhu S,Xue Z

更新日期：2019-12-13 00:00:00

abstract：:Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and i...

journal_title：Frontiers in neuroscience

authors： Mondello SE,Kasten MR,Horner PJ,Moritz CT

更新日期：2014-02-27 00:00:00

abstract：:Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) users, showing major limitations in speech comprehension. The current study used a ...

journal_title：Frontiers in neuroscience

authors： Kessler M,Schierholz I,Mamach M,Wilke F,Hahne A,Büchner A,Geworski L,Bengel FM,Sandmann P,Berding G

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Cortical modulation is likely to be involved in the various therapeutic effects of deep brain stimulation (DBS). However, it is currently difficult to predict the changes of cortical modulation during clinical adjustment of DBS. Therefore, we present a novel quantitative approach to estimate anatomical regio...

journal_title：Frontiers in neuroscience

authors： Hartmann CJ,Chaturvedi A,Lujan JL

更新日期：2015-02-10 00:00:00

abstract：:While the transient receptor potential vanilloid 1 (TRPV1) ion channel, a non-selective calcium-permeable cation channel with high Ca2+ permeability, mainly integrates physical and chemical stimuli for nociception, recent studies suggest that it has a role beyond a noxious thermal sensor. In fact, TRPV1 is presently b...

journal_title：Frontiers in neuroscience

authors： Zhang M,Ruwe D,Saffari R,Kravchenko M,Zhang W

更新日期：2020-02-07 00:00:00

abstract：:The right orbitofrontal cortex (rOFC) has been proposed as the region where conscious olfactory perception arises; however, evidence supporting this hypothesis has all been collected from neuroimaging and lesion studies in which only correlation and not a temporal pattern can be established. Continuous theta burst sti...

journal_title：Frontiers in neuroscience

authors： Villafuerte G,Miguel-Puga A,Arias-Carrión O

更新日期：2019-06-05 00:00:00

abstract：:Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patt...

journal_title：Frontiers in neuroscience

authors： Luan Y,Wang C,Jiao Y,Tang T,Zhang J,Teng GJ

更新日期：2019-02-05 00:00:00

abstract：Purpose:Brain iron accumulation has been suggested as a pathomechanism in patients with type 2 diabetes mellitus (T2DM) with cognitive impairment. This research aims to examine the total-brain pattern of iron accumulation in relation to executive function decline in patients with T2DM by voxel-based quantitative suscep...

journal_title：Frontiers in neuroscience

authors： Li J,Zhang Q,Zhang N,Guo L

更新日期：2021-01-15 00:00:00

abstract：:Background: Stroke is the second leading cause of death worldwide. Angiogenesis facilitates the formation of microvascular networks and promotes recovery after stroke. The Shh/Gli signaling pathway is implicated in angiogenesis and cerebral ischemia-reperfusion (I/R) injury. This study aimed at investigating the influ...

journal_title：Frontiers in neuroscience

authors： Peng L,Yin J,Ge M,Wang S,Xie L,Li Y,Si JQ,Ma K

更新日期：2019-04-09 00:00:00

abstract：:Opioid abuse is now the primary cause of accidental deaths in the United States. Studies over several decades established the cyclical nature of abused drugs of choice, with a current resurgence of heroin abuse and, more recently, fentanyl's emergence as a major precipitant of drug-related deaths. To better understand...

journal_title：Frontiers in neuroscience

authors： Saad MH,Savonen CL,Rumschlag M,Todi SV,Schmidt CJ,Bannon MJ

更新日期：2018-10-23 00:00:00

abstract：:Self-control exertion on an initial task has been associated with impaired performance on subsequent physical tasks also requiring self-control; an effect suggested to be mediated by changes in perceptions of pain and motivation. However, the effects of spending longer on the initial self-control task are unknown. Thi...

journal_title：Frontiers in neuroscience

authors： Boat R,Hunte R,Welsh E,Dunn A,Treadwell E,Cooper SB

更新日期：2020-10-08 00:00:00

abstract：:Natural experience can cause complex changes in gene expression in brain centers for cognition and perception, but the mechanisms that link perceptual experience and neurogenomic regulation are not understood. MicroRNAs (miRNAs or miRs) have the potential to regulate large gene expression networks, and a previous stud...

journal_title：Frontiers in neuroscience

authors： Lin YC,Balakrishnan CN,Clayton DF

更新日期：2014-12-16 00:00:00

abstract：:Here, we present the first description of an isolation syndrome in a patient who suffered prolonged cardiac arrest and underwent a standard therapeutic hypothermia protocol. Two years after the arrest, the patient demonstrated no motor responses to commands, communication capabilities, or visual tracking at the bedsid...

journal_title：Frontiers in neuroscience

authors： Forgacs PB,Fridman EA,Goldfine AM,Schiff ND

更新日期：2016-06-09 00:00:00

abstract：:Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

journal_title：Frontiers in neuroscience

authors： Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

更新日期：2016-06-30 00:00:00