Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.

Abstract:

:Peripheral nerves are composed of complex layered anatomical structures, including epineurium, perineurium, and endoneurium. Perineurium and endoneurium contain many physical barriers, including the blood-nerve barrier at endoneurial vessels and the perineurial barrier. These physical barriers help to eliminate flux penetration and thus contribute to the establishment of a stable microenvironment. In the current review, we introduce the anatomical compartments and physical barriers of peripheral nerves and then describe the cellular and molecular basis of peripheral physical barriers. We also specifically explore peripheral nerve injury-induced changes of peripheral physical barriers, including elevated endoneurial fluid pressure, increased leakage of tracer, decreased barrier-type endothelial cell ratio, and altered distributions and expressions of cellular junctional proteins. The understanding of the pathophysiological changes of physical barriers following peripheral nerve injury may provide a clue for the treatment of peripheral nerve injury.

journal_name

Front Neurosci

authors

Liu Q,Wang X,Yi S

doi

10.3389/fnins.2018.00597

subject

Has Abstract

pub_date

2018-08-23 00:00:00

pages

597

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

杂志文章,评审
  • Endocannabinoid System and Migraine Pain: An Update.

    abstract::The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00172

    authors: Greco R,Demartini C,Zanaboni AM,Piomelli D,Tassorelli C

    更新日期:2018-03-19 00:00:00

  • A core circuit module for cost/benefit decision.

    abstract::A simple circuit for cost-benefit decision derived from behavioral and neural studies of the predatory sea-slug Pleurobranchaea may closely resemble that upon which the more complex valuation and decision processes of the social vertebrates are built. The neuronal natures of the pathways in the connectionist model com...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00123

    authors: Hirayama K,Catanho M,Brown JW,Gillette R

    更新日期:2012-08-31 00:00:00

  • Reshaping of Gait Coordination by Robotic Intervention in Myelopathy Patients After Surgery.

    abstract::The Ossification of the Posterior Longitudinal Ligament (OPLL) is an idiopathic degenerative spinal disease which may cause motor deficit. For patients presenting myelopathy or severe stenosis, surgical decompression is the treatment of choice; however, despite adequate decompression residual motor impairment is found...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00099

    authors: Puentes S,Kadone H,Kubota S,Abe T,Shimizu Y,Marushima A,Sankai Y,Yamazaki M,Suzuki K

    更新日期:2018-03-02 00:00:00

  • Adaptive Wavelet Based MRI Brain Image De-noising.

    abstract::This paper presents a unique approach for wavelet-based MRI brain image de-noising. Adaptive soft and hard threshold functions are first proposed to improve the results of standard soft and hard threshold functions for image de-noising in the wavelet domain. Then, we applied the newly emerged improved adaptive general...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00728

    authors: Amiri Golilarz N,Gao H,Kumar R,Ali L,Fu Y,Li C

    更新日期:2020-07-22 00:00:00

  • Systematic Error in Hippocampal Volume Asymmetry Measurement is Minimal with a Manual Segmentation Protocol.

    abstract::Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00179

    authors: Rogers BP,Sheffield JM,Luksik AS,Heckers S

    更新日期:2012-12-13 00:00:00

  • Noncoding RNA in the transcriptional landscape of human neural progenitor cell differentiation.

    abstract::Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00392

    authors: Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

    更新日期:2015-10-23 00:00:00

  • The behavioral relevance of multisensory neural response interactions.

    abstract::Sensory information can interact to impact perception and behavior. Foods are appreciated according to their appearance, smell, taste and texture. Athletes and dancers combine visual, auditory, and somatosensory information to coordinate their movements. Under laboratory settings, detection and discrimination are like...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.009.2010

    authors: Sperdin HF,Cappe C,Murray MM

    更新日期:2010-05-15 00:00:00

  • Elk-1 a transcription factor with multiple facets in the brain.

    abstract::The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with a dimer of serum response factor (SRF) at the SRE site, and its phosphorylation occurs at specific residues in response...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00035

    authors: Besnard A,Galan-Rodriguez B,Vanhoutte P,Caboche J

    更新日期:2011-03-16 00:00:00

  • Standardized and Experimental Tools to Assess Spatial Cognition in Visually Impaired Children: A Mini-Review.

    abstract::The acquisition of spatial cognition is essential for both everyday functioning (e.g., navigation) and more specific goals (e.g., mathematics), therefore being able to assess and monitor spatial cognition from the first years of life would be essential to predict developmental outcomes and timely intervene whenever sp...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.562589

    authors: Aprile G,Cappagli G,Morelli F,Gori M,Signorini S

    更新日期:2020-09-16 00:00:00

  • Corrigendum: Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.

    abstract::[This corrects the article on p. 589 in vol. 10, PMID: 28066172.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2017.00065

    authors: Wang H,Li X,Shan L,Zhu J,Chen R,Li Y,Yuan W,Yang L,Huang J

    更新日期:2017-02-13 00:00:00

  • The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.

    abstract::Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at the early stages o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00865

    authors: Rideout HJ,Chartier-Harlin MC,Fell MJ,Hirst WD,Huntwork-Rodriguez S,Leyns CEG,Mabrouk OS,Taymans JM

    更新日期:2020-08-18 00:00:00

  • Brain Functional Interaction of Acupuncture Effects in Diarrhea-Dominant Irritable Bowel Syndrome.

    abstract::Acupuncture is a traditional Chinese medicine treatment that has widely been used to modulate gastrointestinal dysfunction caused by irritable bowel syndrome (IBS) and to alleviate the resulting pain. Recent studies have shown that gastrointestinal dysfunction caused by IBS is associated with dysregulation of the brai...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.608688

    authors: Ma K,Liu Y,Shao W,Sun J,Li J,Fang X,Li J,Wang Z,Zhang D

    更新日期:2020-12-15 00:00:00

  • In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes.

    abstract::Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00464

    authors: Chauvière L,Pothof F,Gansel KS,Klon-Lipok J,Aarts AAA,Holzhammer T,Paul O,Singer WJ,Ruther P

    更新日期:2019-05-21 00:00:00

  • The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease.

    abstract::Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid β and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction. However, AD is also accompanied by various secondary symptoms such as depression, sl...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.583097

    authors: Kim S,Nam Y,Shin SJ,Park YH,Jeon SG,Kim JI,Kim MJ,Moon M

    更新日期:2020-09-24 00:00:00

  • Decoding Speech With Integrated Hybrid Signals Recorded From the Human Ventral Motor Cortex.

    abstract::Restoration of speech communication for locked-in patients by means of brain computer interfaces (BCIs) is currently an important area of active research. Among the neural signals obtained from intracranial recordings, single/multi-unit activity (SUA/MUA), local field potential (LFP), and electrocorticography (ECoG) a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00221

    authors: Ibayashi K,Kunii N,Matsuo T,Ishishita Y,Shimada S,Kawai K,Saito N

    更新日期:2018-04-05 00:00:00

  • Experimental and Computational Methods for the Study of Cerebral Organoids: A Review.

    abstract::Cerebral (or brain) organoids derived from human cells have enormous potential as physiologically relevant downscaled in vitro models of the human brain. In fact, these stem cell-derived neural aggregates resemble the three-dimensional (3D) cytoarchitectural arrangement of the brain overcoming not only the unrealistic...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00162

    authors: Poli D,Magliaro C,Ahluwalia A

    更新日期:2019-03-05 00:00:00

  • ATP as a multi-target danger signal in the brain.

    abstract::ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00148

    authors: Rodrigues RJ,Tomé AR,Cunha RA

    更新日期:2015-04-28 00:00:00

  • Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology.

    abstract::Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00477

    authors: Barnard RA,Pomaville MB,O'Roak BJ

    更新日期:2015-12-17 00:00:00

  • The Impact of Vision Loss on Allocentric Spatial Coding.

    abstract::Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00565

    authors: Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

    更新日期:2020-06-16 00:00:00

  • Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.

    abstract::In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many similarities at the cellular and molecular level. However, upon injury durin...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.568930

    authors: Diotel N,Lübke L,Strähle U,Rastegar S

    更新日期:2020-09-23 00:00:00

  • sPyNNaker: A Software Package for Running PyNN Simulations on SpiNNaker.

    abstract::This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00816

    authors: Rhodes O,Bogdan PA,Brenninkmeijer C,Davidson S,Fellows D,Gait A,Lester DR,Mikaitis M,Plana LA,Rowley AGD,Stokes AB,Furber SB

    更新日期:2018-11-20 00:00:00

  • A Mathematical Approach to Correlating Objective Spectro-Temporal Features of Non-linguistic Sounds With Their Subjective Perceptions in Humans.

    abstract::Non-linguistic sounds (NLSs) are a core feature of our everyday life and many evoke powerful cognitive and emotional outcomes. The subjective perception of NLSs by humans has occasionally been defined for single percepts, e.g., their pleasantness, whereas many NLSs evoke multiple perceptions. There has also been very ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00794

    authors: Burns T,Rajan R

    更新日期:2019-07-31 00:00:00

  • Decreased Functional Connectivity Between the Right Precuneus and Middle Frontal Gyrus Is Related to Attentional Decline Following Acute Sleep Deprivation.

    abstract:Objectives:Acute sleep deprivation (SD) seriously affects cognitive functions, such as attention, memory, and response inhibition. Previous neuroimaging studies have demonstrated a close relationship between the functional activities of the precuneus (PC) and the function of alert attention. However, the specific effec...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.530257

    authors: Li B,Zhang L,Zhang Y,Chen Y,Peng J,Shao Y,Zhang X

    更新日期:2020-12-21 00:00:00

  • A Pilot Study of Peripheral Muscle Magnetic Stimulation as Add-on Treatment to Repetitive Transcranial Magnetic Stimulation in Chronic Tinnitus.

    abstract::While brain stimulation techniques have been examined as treatment options for chronic tinnitus for many years, they have recently been extended to multimodal treatment approaches. As chronic tinnitus is often accompanied by comorbid muscular tension in the neck and back, we performed a one-arm pilot study to explore ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00068

    authors: Vielsmeier V,Schecklmann M,Schlee W,Kreuzer PM,Poeppl TB,Rupprecht R,Langguth B,Lehner A

    更新日期:2018-02-20 00:00:00

  • Cognitive, Emotional and Psychological Manifestations in Amyotrophic Lateral Sclerosis at Baseline and Overtime: A Review.

    abstract::It is now well recognized that, in addition to motor impairment, amyotrophic lateral sclerosis (ALS) may cause extra-motor clinical signs and symptoms. These can include the alteration of certain cognitive functions, impaired social cognition, and changes in the perception and processing of emotions. Where these extra...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00951

    authors: Benbrika S,Desgranges B,Eustache F,Viader F

    更新日期:2019-09-10 00:00:00

  • Speech Discrimination Tasks: A Sensitive Sensory and Cognitive Measure in Early and Mild Multiple Sclerosis.

    abstract::There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.604991

    authors: Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

    更新日期:2020-12-23 00:00:00

  • Arousal Contributions to Resting-State fMRI Connectivity and Dynamics.

    abstract::Resting-state functional magnetic resonance imaging (rsfMRI) is being widely used for charting brain connectivity and dynamics in healthy and diseased brains. However, the resting state paradigm allows an unconstrained fluctuation of brain arousal, which may have profound effects on resting-state fMRI signals and asso...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01190

    authors: Gu Y,Han F,Liu X

    更新日期:2019-11-05 00:00:00

  • Transcutaneous Vagus Nerve Stimulation May Enhance Only Specific Aspects of the Core Executive Functions. A Randomized Crossover Trial.

    abstract:Background:Individuals are able to perform goal-directed behaviors thanks to executive functions. According to the neurovisceral integration model, executive functions are upregulated by brain areas such as the prefrontal and cingulate cortices, which are also crucially involved in controlling cardiac vagal activity. A...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00523

    authors: Borges U,Knops L,Laborde S,Klatt S,Raab M

    更新日期:2020-05-25 00:00:00

  • Rehabilitation of Upper Extremity Nerve Injuries Using Surface EMG Biofeedback: Protocols for Clinical Application.

    abstract::Motor recovery following nerve transfer surgery depends on the successful re-innervation of the new target muscle by regenerating axons. Cortical plasticity and motor relearning also play a major role during functional recovery. Successful neuromuscular rehabilitation requires detailed afferent feedback. Surface elect...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00906

    authors: Sturma A,Hruby LA,Prahm C,Mayer JA,Aszmann OC

    更新日期:2018-12-04 00:00:00

  • Altered Spatial and Temporal Brain Connectivity in the Salience Network of Sensorineural Hearing Loss and Tinnitus.

    abstract::Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00246

    authors: Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

    更新日期:2019-03-19 00:00:00