The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.

abstract：:Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive performance, the effects of synthetic steroids contained in hormonal contraceptives on br...

journal_title：Frontiers in neuroscience

authors： Pletzer BA,Kerschbaum HH

更新日期：2014-08-21 00:00:00

abstract：:A novel low cost interconnected architecture (LCIA) is proposed in this paper, which is an efficient solution for the neuron interconnections for the hardware spiking neural networks (SNNs). It is based on an all-to-all connection that takes each paired input and output nodes of multi-layer SNNs as the source and dest...

journal_title：Frontiers in neuroscience

authors： Luo Y,Wan L,Liu J,Harkin J,McDaid L,Cao Y,Ding X

更新日期：2018-11-21 00:00:00

abstract：:The functional characterization of crustacean neuropeptides and their cognate receptors has not kept pace with the recent advances in sequence determination and, therefore, our understanding of the physiological roles of neuropeptides in this important arthropod sub-phylum is rather limited. We identified a candidate ...

journal_title：Frontiers in neuroscience

authors： Alexander J,Oliphant A,Wilcockson DC,Webster SG

更新日期：2018-07-04 00:00:00

abstract：:An associative brain-computer-interface (BCI) that correlates in time a peripherally generated afferent volley with the peak negativity (PN) of the movement related cortical potential (MRCP) induces plastic changes in the human motor cortex. However, in this associative BCI the movement timed to a cue is not detected ...

journal_title：Frontiers in neuroscience

authors： Mrachacz-Kersting N,Aliakbaryhosseinabadi S

更新日期：2018-07-11 00:00:00

abstract：:The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging ...

journal_title：Frontiers in neuroscience

authors： Wang C,Kipping J,Bao C,Ji H,Qiu A

更新日期：2016-05-02 00:00:00

abstract：:Motor performance varies substantially between individuals. This variance is rooted in individuals' innate motor abilities, and should thus have a neural signature underlying these differences in behavior. Could these individual differences be detectable with neural measurements acquired at rest? Here, we tested the h...

journal_title：Frontiers in neuroscience

authors： Herszage J,Dayan E,Sharon H,Censor N

更新日期：2020-02-05 00:00:00

abstract：Background:The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global measures of neurodegeneration, and cognition. Methods:145 participants underwent ...

journal_title：Frontiers in neuroscience

authors： Low A,Mak E,Stefaniak JD,Malpetti M,Nicastro N,Savulich G,Chouliaras L,Markus HS,Rowe JB,O'Brien JT

更新日期：2020-03-19 00:00:00

abstract：:Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperf...

journal_title：Frontiers in neuroscience

authors： Silva RMFLD,Miranda CM,Liu T,Tse G,Roever L

更新日期：2019-01-31 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...

journal_title：Frontiers in neuroscience

authors： Pitake S,Middleton LJ,Abdus-Saboor I,Mishra SK

更新日期：2019-09-19 00:00:00

abstract：:Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

journal_title：Frontiers in neuroscience

authors： Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

更新日期：2018-06-20 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00

abstract：:Kolmer-Agduhr (KA) cells are a subgroup of interneurons positioned adjacent to the neurocoele with cilia on the apical surface protruding into the central canal of the spinal cord. Although KA cells were identified almost a century ago, their development and functions are only beginning to be unfolded. Recent studies ...

journal_title：Frontiers in neuroscience

authors： Yang L,Wang F,Strähle U

更新日期：2020-10-09 00:00:00

abstract：:Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have ...

journal_title：Frontiers in neuroscience

authors： Li W,Yu G,Liu Y,Sha L

更新日期：2019-02-20 00:00:00

abstract：:Openness to experience (OTE) has relatively stable and heritable characteristics. Previous studies have used candidate gene approaches to explore the genetic mechanisms of OTE, but genome-wide polygenic scores have a greater genetic effect than other genetic analysis methods, and previous studies have never examined t...

journal_title：Frontiers in neuroscience

authors： Ren Z,Liu C,Meng J,Liu Q,Shi L,Wu X,Song L,Qiu J

更新日期：2021-01-11 00:00:00

abstract：:Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the content of neuronal injury. As well-accepted, inflammation, and neuron...

journal_title：Frontiers in neuroscience

authors： Hohmann U,Pelzer M,Kleine J,Hohmann T,Ghadban C,Dehghani F

更新日期：2019-11-07 00:00:00

abstract：:Spinocerebellar ataxia (SCA) is a part of the cerebellar neurodegenerative disease group that is diverse in genetics and phenotypes. It usually shows autosomal dominant inheritance. SCAs, always together with the cerebellar degeneration, may exhibit clinical deficits in brainstem or eye, especially retina or optic ner...

journal_title：Frontiers in neuroscience

authors： Park JY,Joo K,Woo SJ

更新日期：2020-08-21 00:00:00

abstract：:How speech signals are analyzed and represented remains a foundational challenge both for cognitive science and neuroscience. A growing body of research, employing various behavioral and neurobiological experimental techniques, now points to the perceptual relevance of both phoneme-sized (10-40 Hz modulation frequency...

journal_title：Frontiers in neuroscience

authors： Chait M,Greenberg S,Arai T,Simon JZ,Poeppel D

更新日期：2015-06-16 00:00:00

abstract：:Non-linguistic sounds (NLSs) are a core feature of our everyday life and many evoke powerful cognitive and emotional outcomes. The subjective perception of NLSs by humans has occasionally been defined for single percepts, e.g., their pleasantness, whereas many NLSs evoke multiple perceptions. There has also been very ...

journal_title：Frontiers in neuroscience

authors： Burns T,Rajan R

更新日期：2019-07-31 00:00:00

abstract：:People generally prefer risky options, which have fully specified outcome probabilities, to ambiguous options, which have unspecified probabilities. This preference, formalized in economics, is strong enough that people will reliably prefer a risky option to an ambiguous option with a greater expected value. Explanati...

journal_title：Frontiers in neuroscience

authors： Hayden BY,Heilbronner SR,Platt ML

更新日期：2010-09-17 00:00:00

abstract：:Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol's effects, increased consumption, loss of control over drinking and the development of physical dependence. This cycle is often times punctuated by periods of abstinence, craving and relapse. The development ...

journal_title：Frontiers in neuroscience

authors： Rao PS,Bell RL,Engleman EA,Sari Y

更新日期：2015-04-23 00:00:00

abstract：:In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction. Specifically, we will describe mGluR5 studies in humans that employed Positron Emission Tomography (PET) and combined the findings w...

journal_title：Frontiers in neuroscience

authors： Terbeck S,Akkus F,Chesterman LP,Hasler G

更新日期：2015-03-18 00:00:00

abstract：:Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...

journal_title：Frontiers in neuroscience

authors： Barnard RA,Pomaville MB,O'Roak BJ

更新日期：2015-12-17 00:00:00

abstract：:Event-driven neuromorphic spiking sensors such as the silicon retina and the silicon cochlea encode the external sensory stimuli as asynchronous streams of spikes across different channels or pixels. Combining state-of-art deep neural networks with the asynchronous outputs of these sensors has produced encouraging res...

journal_title：Frontiers in neuroscience

authors： Anumula J,Neil D,Delbruck T,Liu SC

更新日期：2018-02-09 00:00:00

abstract：:We used amyotrophic lateral sclerosis (ALS) as a model of prefrontal dysfunction in order to re-assess the potential neuronal substrates of two sub processes of working memory, namely information storage and filtering. To date it is unclear which exact neuronal networks sustain these two processes and the prefrontal c...

journal_title：Frontiers in neuroscience

authors： Vellage AK,Veit M,Kobeleva X,Petri S,Vielhaber S,Müller NG

更新日期：2016-04-19 00:00:00

abstract：:A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual m...

journal_title：Frontiers in neuroscience

authors： Svob Strac D,Pivac N,Smolders IJ,Fogel WA,De Deurwaerdere P,Di Giovanni G

更新日期：2016-11-10 00:00:00

abstract：Background:Postherpetic neuralgia (PHN) is a form of long-lasting neuropathic pain that can severely affect patients' quality of life. Pulsed radiofrequency (PRF) has been proven to be effective in treating PHN, but the optimal radiofrequency parameters are still not well defined. This retrospective study aimed to comp...

journal_title：Frontiers in neuroscience

authors： Han Z,Hong T,Ding Y,Wang S,Yao P

更新日期：2020-12-18 00:00:00

abstract：:Movement is planned and coordinated by the brain and carried out by contracting muscles acting on specific joints. Motor commands initiated in the brain travel through descending pathways in the spinal cord to effector motor neurons before reaching target muscles. Damage to these pathways by spinal cord injury (SCI) c...

journal_title：Frontiers in neuroscience

authors： Grahn PJ,Mallory GW,Berry BM,Hachmann JT,Lobel DA,Lujan JL

更新日期：2014-09-17 00:00:00

abstract：:Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be the basis of antibiotic-induced neurophysiological and behavioral changes. However, relatively little research has addressed whether antibiotics act directly on the host nervous system to produce these changes. We aimed to identif...

journal_title：Frontiers in neuroscience

authors： Delungahawatta T,Amin JY,Stanisz AM,Bienenstock J,Forsythe P,Kunze WA

更新日期：2017-10-20 00:00:00

abstract：:The cerebellum is one of the most consistent sites of abnormality in autism spectrum disorder (ASD) and cerebellar damage is associated with an increased risk of ASD symptoms, suggesting that cerebellar dysfunction may play a crucial role in the etiology of ASD. The cerebellum forms multiple closed-loop circuits with ...

journal_title：Frontiers in neuroscience

authors： D'Mello AM,Stoodley CJ

更新日期：2015-11-05 00:00:00

abstract：:Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

journal_title：Frontiers in neuroscience

authors： Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

更新日期：2016-06-29 00:00:00