Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.

Abstract:

:Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-related damage in the sensitive hilar region of hippocampal dentate gyrus (DG). However, the complex mechanisms by which E2 empowers the genomic fabrics of neurotransmission to resist damaging effects of status epilepticus (SE) are still unclear. We determined the protective effects of the estradiol replacement against kainic acid-induced SE-associated transcriptomic alterations in the DG of OVX rats. Without E2 replacement, SE altered expression of 44% of the DG genes. SE affected all major functional pathways, including apoptosis (61%), Alzheimer's disease (47%), cell cycle (59%), long-term potentiation (62%), and depression (55%), as well as synaptic vesicle cycle (62%), glutamatergic (53%), GABAergic (49%), cholinergic (52%), dopaminergic (55%), and serotonergic (49%) neurotransmission. However, in rats with E2 replacement the percentage of significantly affected genes after SE was reduced to the average 11% (from 8% for apoptosis to 32% for GABAergic synapse). Interestingly, while SE down-regulated most of the synaptic receptor genes in oil-injected females it had little effect on these receptors after E2-replacement. Our novel Pathway Protection analysis indicated that the E2-replacement prevented SE-related damage from 50% for GABA to 75% for dopaminergic transmission. The 15% synergistic expression between genes involved in estrogen signaling (ESG) and neurotransmission explains why low E2 levels result in down-regulation of neurotransmission. Interestingly, in animals with E2-replacement, SE switched 131 synergistically expressed ESG-neurotransmission gene pairs into antagonistically expressed gene pairs. Thus, the ESG pathway acts like a buffer against SE-induced alteration of neurotransmission that may contribute to the E2-mediated maintenance of brain function after the SE injury in postmenopausal women. We also show that the long-term potentiation is lost in OVX rats following SE but not in those with E2 replacement. The electrophysiological findings in OVX female rats with SE are corroborated by the high percentage of long-term potentiation regulated genes (62%) in oil-injected while only 13% of genes were regulated following SE in E2-replaced rats.

journal_name

Front Neurosci

authors

Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

doi

10.3389/fnins.2018.00332

subject

Has Abstract

pub_date

2018-06-20 00:00:00

pages

332

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

杂志文章
  • Neurotrophic effects of neudesin in the central nervous system.

    abstract::Neudesin (neuron-derived neurotrophic factor; NENF) was identified as a neurotrophic factor that is involved in neuronal differentiation and survival. It is abundantly expressed in the central nervous system, and its neurotrophic activity is exerted via the mitogen-activated protein kinase (MAPK) and phosphatidylinosi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00111

    authors: Kimura I,Nakayama Y,Zhao Y,Konishi M,Itoh N

    更新日期:2013-06-25 00:00:00

  • A PCR-Based Method for RNA Probes and Applications in Neuroscience.

    abstract::In situ hybridization (ISH) is a powerful technique that is used to detect the localization of specific nucleic acid sequences for understanding the organization, regulation, and function of genes. However, in most cases, RNA probes are obtained by in vitro transcription from plasmids containing specific promoter elem...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00266

    authors: Hua R,Yu S,Liu M,Li H

    更新日期:2018-05-02 00:00:00

  • Systemic Low-Frequency Oscillations in BOLD Signal Vary with Tissue Type.

    abstract::Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00313

    authors: Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

    更新日期:2016-06-30 00:00:00

  • No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating.

    abstract::The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral pr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00738

    authors: Lukasik KM,Lehtonen M,Salmi J,Meinzer M,Joutsa J,Laine M

    更新日期:2018-01-10 00:00:00

  • Hybrid Functional Brain Network With First-Order and Second-Order Information for Computer-Aided Diagnosis of Schizophrenia.

    abstract::Brain functional connectivity network (BFCN) analysis has been widely used in the diagnosis of mental disorders, such as schizophrenia. In BFCN methods, brain network construction is one of the core tasks due to its great influence on the diagnosis result. Most of the existing BFCN construction methods only consider t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00603

    authors: Zhu Q,Li H,Huang J,Xu X,Guan D,Zhang D

    更新日期:2019-06-14 00:00:00

  • Non-parametric statistical thresholding for sparse magnetoencephalography source reconstructions.

    abstract::Uncovering brain activity from magnetoencephalography (MEG) data requires solving an ill-posed inverse problem, greatly confounded by noise, interference, and correlated sources. Sparse reconstruction algorithms, such as Champagne, show great promise in that they provide focal brain activations robust to these confoun...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00186

    authors: Owen JP,Sekihara K,Nagarajan SS

    更新日期:2012-12-26 00:00:00

  • Pharmaco-fUS for Characterizing Drugs for Alzheimer's Disease - The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine.

    abstract::Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the proteins involved in astrocyte network organization, potentiates donepe...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00835

    authors: Vidal B,Droguerre M,Valdebenito M,Zimmer L,Hamon M,Mouthon F,Charvériat M

    更新日期:2020-08-12 00:00:00

  • On the number of preganglionic neurons driving human postganglionic sympathetic neurons: a comparison of modeling and empirical data.

    abstract::Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00132

    authors: Macefield VG

    更新日期:2011-12-06 00:00:00

  • Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.

    abstract::Posttraumatic stress disorder (PTSD) is an anxiety disorder characterized by intrusive recollections of a severe traumatic event and hyperarousal following exposure to the event. Human and animal studies have shown that the change of amygdala activity after traumatic stress may contribute to occurrences of some sympto...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00387

    authors: Fang Q,Li Z,Huang GD,Zhang HH,Chen YY,Zhang LB,Ding ZB,Shi J,Lu L,Yang JL

    更新日期:2018-08-21 00:00:00

  • Modulation of feedback-related negativity during trial-and-error exploration and encoding of behavioral shifts.

    abstract::The feedback-related negativity (FRN) is a mid-frontal event-related potential (ERP) recorded in various cognitive tasks and associated with the onset of sensory feedback signaling decision outcome. Some properties of the FRN are still debated, notably its sensitivity to positive and negative reward prediction error (...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00209

    authors: Sallet J,Camille N,Procyk E

    更新日期:2013-11-14 00:00:00

  • The Effects of Leptin on Glial Cells in Neurological Diseases.

    abstract::It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice. The leptin receptors in the hypothalamus are the main target for the homeostat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00828

    authors: Fujita Y,Yamashita T

    更新日期:2019-08-07 00:00:00

  • Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face.

    abstract::The neuropeptide oxytocin plays a central role in prosocial and parental behavior in non-human mammals as well as humans. It has been suggested that oxytocin may affect visual processing of infant faces and emotional reaction to infants. Healthy male volunteers (N = 13) were tested for their ability to detect infant o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00217

    authors: Saito A,Hamada H,Kikusui T,Mogi K,Nagasawa M,Mitsui S,Higuchi T,Hasegawa T,Hiraki K

    更新日期:2014-07-29 00:00:00

  • Modulation of Illusory Auditory Perception by Transcranial Electrical Stimulation.

    abstract::The aim of the present study was to test whether transcranial electrical stimulation can modulate illusory perception in the auditory domain. In two separate experiments we applied transcranial Direct Current Stimulation (anodal/cathodal tDCS, 2 mA; N = 60) and high-frequency transcranial Random Noise Stimulation (hf-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00351

    authors: Prete G,D'Anselmo A,Tommasi L,Brancucci A

    更新日期:2017-06-20 00:00:00

  • Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain.

    abstract::Astrocytes are the most abundant type of glial cell in the central nervous system and perform a myriad of vital functions, however, the nature of their diversity remains a longstanding question in neuroscience. Using transcription factor motif discovery analysis on region-specific gene signatures from astrocytes we un...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00061

    authors: Lozzi B,Huang TW,Sardar D,Huang AY,Deneen B

    更新日期:2020-02-21 00:00:00

  • Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia.

    abstract::Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01345

    authors: Udovin LD,Kobiec T,Herrera MI,Toro-Urrego N,Kusnier CF,Kölliker-Frers RA,Ramos-Hryb AB,Luaces JP,Otero-Losada M,Capani F

    更新日期:2020-01-08 00:00:00

  • Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice.

    abstract::Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain in mice. One week af...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00995

    authors: Jang JH,Kim YK,Jung WM,Kim HK,Song EM,Kim HY,Oh JY,Park JY,Ryu Y,Song MY,Park HJ

    更新日期:2019-09-20 00:00:00

  • Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis.

    abstract::Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional corr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00817

    authors: Zhou X,Li M,Zhou H,Li L,Cui J

    更新日期:2018-11-06 00:00:00

  • sPyNNaker: A Software Package for Running PyNN Simulations on SpiNNaker.

    abstract::This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00816

    authors: Rhodes O,Bogdan PA,Brenninkmeijer C,Davidson S,Fellows D,Gait A,Lester DR,Mikaitis M,Plana LA,Rowley AGD,Stokes AB,Furber SB

    更新日期:2018-11-20 00:00:00

  • Altered Spatial and Temporal Brain Connectivity in the Salience Network of Sensorineural Hearing Loss and Tinnitus.

    abstract::Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00246

    authors: Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

    更新日期:2019-03-19 00:00:00

  • Evolution of Orexin Neuropeptide System: Structure and Function.

    abstract::Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They are multitasking peptides involved in many physiological functions, including regulation of feeding behavior, wakefulness and autonomic/neuroen...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00691

    authors: Soya S,Sakurai T

    更新日期:2020-07-10 00:00:00

  • Sub-millimeter T2 weighted fMRI at 7 T: comparison of 3D-GRASE and 2D SE-EPI.

    abstract::Functional magnetic resonance imaging (fMRI) allows studying human brain function non-invasively up to the spatial resolution of cortical columns and layers. Most fMRI acquisitions rely on the blood oxygenation level dependent (BOLD) contrast employing T(*) 2 weighted 2D multi-slice echo-planar imaging (EPI). At ultra...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00163

    authors: Kemper VG,De Martino F,Vu AT,Poser BA,Feinberg DA,Goebel R,Yacoub E

    更新日期:2015-05-05 00:00:00

  • A Hypothesis of the Co-evolution of Cooperation and Responses to Inequity.

    abstract::Recent evidence demonstrates that humans are not the only species to respond negatively to inequitable outcomes which are to their disadvantage. Several species respond negatively if they subsequently receive a less good reward than a social partner for completing the same task. While these studies suggest that the ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00043

    authors: Brosnan SF

    更新日期:2011-04-05 00:00:00

  • Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide dismutase 1 (mSOD1...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00273

    authors: Pinto S,Cunha C,Barbosa M,Vaz AR,Brites D

    更新日期:2017-05-17 00:00:00

  • Modulation on Glutamic Pathway of Frontal-Striatum-Thalamus by rs11146020 and rs3813296 Gene Polymorphism in First-Episode Negative Schizophrenia.

    abstract:Objectives:The frontal-striatum-thalamus pathway is important in the glutamic neural circuit. The hypofunction of GRIN1 and GRIA2 subunits from glutamic receptors has been hypothesized as the primary process in the etiology of schizophrenia. Identified gene polymorphism involved in the pathogenesis of schizophrenia may...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00351

    authors: Cai S,Lv Y,Huang K,Zhang W,Wang Q,Huang L,Wang J

    更新日期:2020-04-21 00:00:00

  • Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.

    abstract::Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and i...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00021

    authors: Mondello SE,Kasten MR,Horner PJ,Moritz CT

    更新日期:2014-02-27 00:00:00

  • Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia.

    abstract::Alzheimer disease (AD) and vascular dementia (VaD) together represent the majority of dementia cases. Since their neuropsychological profiles often overlap and white matter lesions are observed in elderly subjects including AD, differentiating between VaD and AD can be difficult. Characterization of these different fo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00274

    authors: Palesi F,De Rinaldis A,Vitali P,Castellazzi G,Casiraghi L,Germani G,Bernini S,Anzalone N,Ramusino MC,Denaro FM,Sinforiani E,Costa A,Magenes G,D'Angelo E,Gandini Wheeler-Kingshott CAM,Micieli G

    更新日期:2018-04-25 00:00:00

  • Using Minimal-Redundant and Maximal-Relevant Whole-Brain Functional Connectivity to Classify Bipolar Disorder.

    abstract:Background:A number of mental illness is often re-diagnosed to be bipolar disorder (BD). Furthermore, the prefronto-limbic-striatal regions seem to be associated with the main dysconnectivity of BD. Functional connectivity is potentially an appropriate objective neurobiological marker that can assist with BD diagnosis....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.563368

    authors: Chen YL,Tu PC,Huang TH,Bai YM,Su TP,Chen MH,Wu YT

    更新日期:2020-10-20 00:00:00

  • Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

    abstract::Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegener...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00278

    authors: Mustapic M,Eitan E,Werner JK Jr,Berkowitz ST,Lazaropoulos MP,Tran J,Goetzl EJ,Kapogiannis D

    更新日期:2017-05-22 00:00:00

  • An Intelligent EEG Classification Methodology Based on Sparse Representation Enhanced Deep Learning Networks.

    abstract::The classification of electroencephalogram (EEG) signals is of significant importance in brain-computer interface (BCI) systems. Aiming to achieve intelligent classification of EEG types with high accuracy, a classification methodology using sparse representation (SR) and fast compression residual convolutional neural...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00808

    authors: Huang JS,Li Y,Chen BQ,Lin C,Yao B

    更新日期:2020-09-30 00:00:00

  • Neuroprotective Potential of Cell-Based Therapies in ALS: From Bench to Bedside.

    abstract::Motor neurons (MN) degeneration is a main feature of amyotrophic lateral sclerosis (ALS), a neurological disorder with a progressive course. The diagnosis of ALS is essentially a clinical one. Most common symptoms include a gradual neurological deterioration that reflect the impairment and subsequent loss of muscle fu...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00591

    authors: Forostyak S,Sykova E

    更新日期:2017-10-24 00:00:00