Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation.

Abstract:

:Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperfusion, inflammation, genetic factors, cerebral microbleeds, and recurrent silent cerebral ischemia. Oral anticoagulation can be used to minimize risk of cognitive decline and dementia, given that brain insults can be caused by chronic microemboli or microbleeds. However, controversy on the effects of warfarin and direct oral anticoagulants on this risk exists. This article will address these aspects, with data on the studies already published and a critical view on this subject.

journal_name

Front Neurosci

authors

Silva RMFLD,Miranda CM,Liu T,Tse G,Roever L

doi

10.3389/fnins.2019.00018

subject

Has Abstract

pub_date

2019-01-31 00:00:00

pages

18

eissn

1662-4548

issn

1662-453X

journal_volume

13

pub_type

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