Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation.


:Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperfusion, inflammation, genetic factors, cerebral microbleeds, and recurrent silent cerebral ischemia. Oral anticoagulation can be used to minimize risk of cognitive decline and dementia, given that brain insults can be caused by chronic microemboli or microbleeds. However, controversy on the effects of warfarin and direct oral anticoagulants on this risk exists. This article will address these aspects, with data on the studies already published and a critical view on this subject.


Front Neurosci


Silva RMFLD,Miranda CM,Liu T,Tse G,Roever L




Has Abstract


2019-01-31 00:00:00










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    abstract::The functional characterization of crustacean neuropeptides and their cognate receptors has not kept pace with the recent advances in sequence determination and, therefore, our understanding of the physiological roles of neuropeptides in this important arthropod sub-phylum is rather limited. We identified a candidate ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Alexander J,Oliphant A,Wilcockson DC,Webster SG

    更新日期:2018-07-04 00:00:00

  • A Framework for Measuring the Progress in Exoskeleton Skills in People with Complete Spinal Cord Injury.

    abstract::For safe application of exoskeletons in people with spinal cord injury at home or in the community, it is required to have completed an exoskeleton training in which users learn to perform basic and advanced skills. So far, a framework to test exoskeleton skills is lacking. The aim of this study was to develop and tes...

    journal_title:Frontiers in neuroscience

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    authors: van Dijsseldonk RB,Rijken H,van Nes IJW,van de Meent H,Keijsers NLW

    更新日期:2017-12-12 00:00:00

  • Partial Least Squares Regression Performs Well in MRI-Based Individualized Estimations.

    abstract::Estimation of individuals' cognitive, behavioral and demographic (CBD) variables based on MRI has attracted much research interest in the past decade, and effective machine learning techniques are of great importance for these estimations. Partial least squares regression (PLSR) is an attractive machine learning techn...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Chen C,Cao X,Tian L

    更新日期:2019-11-27 00:00:00

  • Genome Wide Association Study and Next Generation Sequencing: A Glimmer of Light Toward New Possible Horizons in Frontotemporal Dementia Research.

    abstract::Frontotemporal Dementia (FTD) is a focal neurodegenerative disease, with a strong genetic background, that causes early onset dementia. The present knowledge about the risk loci and causative mutations of FTD mainly derives from genetic linkage analysis, studies of candidate genes, Genome-Wide Association Studies (GWA...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Ciani M,Benussi L,Bonvicini C,Ghidoni R

    更新日期:2019-05-16 00:00:00

  • Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: a histological perspective.

    abstract::Disruption of iron homeostasis and increased glial response are known to occur in brains afflicted by Alzheimer's disease (AD). While the APP/PS1 transgenic mouse model recapitulates the hallmark amyloid-beta plaque pathology of AD, it does so in a different neuronal mileu than humans. Understanding the iron character...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Meadowcroft MD,Connor JR,Yang QX

    更新日期:2015-07-23 00:00:00

  • Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology.

    abstract::Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Browning KN

    更新日期:2015-10-29 00:00:00

  • Depression Affects Intrinsic Brain Activity in Patients With Mild Cognitive Impairment.

    abstract::Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yu Y,Li Z,Lin Y,Yu J,Peng G,Zhang K,Jia X,Luo B

    更新日期:2019-12-17 00:00:00

  • Analysis of Interrelationships among Voluntary and Prosthetic Leg Joint Parameters Using Cyclograms.

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Jasni F,Hamzaid NA,Mohd Syah NE,Chung TY,Abu Osman NA

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  • Full Field Masking Causes Reversals in Perceived Event Order.

    abstract::We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Chota S,McLelland D,Lavergne L,Zimmermann E,Cavanagh P,VanRullen R

    更新日期:2020-03-17 00:00:00

  • Making BREAD: Biomimetic Strategies for Artificial Intelligence Now and in the Future.

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Krichmar JL,Severa W,Khan MS,Olds JL

    更新日期:2019-06-27 00:00:00

  • On the origin of rhythmic contractile activity of the esophagus in early achalasia, a clinical case study.

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    journal_title:Frontiers in neuroscience



    authors: Chen JH,Wang XY,Liu LW,Yu W,Yu Y,Zhao L,Huizinga JD

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  • Isoflurane Post-conditioning Ameliorates Cerebral Ischemia/Reperfusion Injury by Enhancing Angiogenesis Through Activating the Shh/Gli Signaling Pathway in Rats.

    abstract::Background: Stroke is the second leading cause of death worldwide. Angiogenesis facilitates the formation of microvascular networks and promotes recovery after stroke. The Shh/Gli signaling pathway is implicated in angiogenesis and cerebral ischemia-reperfusion (I/R) injury. This study aimed at investigating the influ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Peng L,Yin J,Ge M,Wang S,Xie L,Li Y,Si JQ,Ma K

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  • Simultaneous Measurement of Neuronal Activity in the Pontine Micturition Center and Cystometry in Freely Moving Mice.

    abstract::Understanding the complex neural mechanisms controlling urinary bladder activity is an extremely important topic in both neuroscience and urology. Simultaneously recording of the bladder activity and neural activity in related brain regions will largely advance this field. However, such recording approach has long bee...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yao J,Li Q,Li X,Qin H,Liang S,Liao X,Chen X,Li W,Yan J

    更新日期:2019-06-25 00:00:00

  • Pharmaco-fUS for Characterizing Drugs for Alzheimer's Disease - The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine.

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Vidal B,Droguerre M,Valdebenito M,Zimmer L,Hamon M,Mouthon F,Charvériat M

    更新日期:2020-08-12 00:00:00

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    pub_type: 杂志文章


    authors: Jackson N,Greenhouse I

    更新日期:2019-09-13 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Brown R,Kemp U,Macefield V

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  • Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.

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    journal_title:Frontiers in neuroscience

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    authors: Ma G,Yang D,Qin W,Liu Y,Jiang T,Yu C

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Isaiah S,Loots DT,Solomons R,van der Kuip M,Tutu Van Furth AM,Mason S

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Dong L,Liu X,Zhao L,Lai Y,Gong D,Liu T,Yao D

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Diamond A,Nowotny T,Schmuker M

    更新日期:2016-01-08 00:00:00

  • Increasing Our Insular World View: Interoception and Psychopathology for Psychotherapists.

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Duquette P

    更新日期:2017-03-21 00:00:00

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    abstract:Purpose:To evaluate the effect of resolution on iron content using quantitative susceptibility mapping (QSM); to verify the consistency of QSM across field strengths and manufacturers in evaluating the iron content of deep gray matter (DGM) of the human brain using subjects from multiple sites; and to establish a susce...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Li Y,Sethi SK,Zhang C,Miao Y,Yerramsetty KK,Palutla VK,Gharabaghi S,Wang C,He N,Cheng J,Yan F,Haacke EM

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Rosenfeld CS

    更新日期:2015-03-03 00:00:00

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    abstract::Silver nano-particles (Ag-NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products will almost certainly increase environmental silver levels, resulting in increased exposures and the potential for increased adverse reactions including neurotox...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Liu F,Mahmood M,Xu Y,Watanabe F,Biris AS,Hansen DK,Inselman A,Casciano D,Patterson TA,Paule MG,Slikker W Jr,Wang C

    更新日期:2015-04-08 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Neal J,Strothkamp S,Bedingar E,Cordero P,Wagner B,Vagnini V,Jiang Y

    更新日期:2019-09-25 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Panossian A,Hamm R,Kadioglu O,Wikman G,Efferth T

    更新日期:2013-02-20 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Bae SJ,Lim J,Lee S,Choi H,Jang JH,Kim YK,Oh JY,Park JH,Jung HS,Chae Y,In SI,Park HJ

    更新日期:2019-06-20 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Li S,Wang Y,Gao G,Guo X,Zhang Y,Zhang Z,Wang Y,Zhang J,Wang J,Li L,Yang Y,Rong P

    更新日期:2020-07-15 00:00:00

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    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Hirayama K,Catanho M,Brown JW,Gillette R

    更新日期:2012-08-31 00:00:00

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    abstract::Head motion is one of major concerns in current resting-state functional MRI studies. Image realignment including motion estimation and spatial resampling is often applied to achieve rigid-body motion correction. While the accurate estimation of motion parameters has been addressed in most studies, spatial resampling ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yuan L,He H,Zhang H,Zhong J

    更新日期:2016-12-27 00:00:00