Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.

abstract：:Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarbo...

journal_title：Frontiers in neuroscience

authors： Hertz L,Gibbs ME,Dienel GA

更新日期：2014-09-09 00:00:00

abstract：:To ensure survival, animals must update the internal representations of their environment in a trial-and-error fashion. Psychological studies of associative learning and neurophysiological analyses of dopaminergic neurons have suggested that this updating process involves the temporal-difference (TD) method in the bas...

journal_title：Frontiers in neuroscience

authors： Wen C,Ogura Y,Matsushima T

更新日期：2016-11-08 00:00:00

abstract：:Encouraged by a rise of reciprocal interest between the machine learning and neuroscience communities, several recent studies have demonstrated the explanatory power of statistical learning techniques for the analysis of neural data. In order to facilitate a wider adoption of these methods, neuroscientific research ne...

journal_title：Frontiers in neuroscience

authors： Hanke M,Halchenko YO,Haxby JV,Pollmann S

更新日期：2010-05-15 00:00:00

abstract：:Although flight is regarded as a key behavior of birds this review argues that the perceptual demands for its control are met within constraints set by the perceptual demands of two other key tasks: the control of bill (or feet) position, and the detection of food items/predators. Control of bill position, or of the f...

journal_title：Frontiers in neuroscience

authors： Martin GR

更新日期：2017-11-07 00:00:00

abstract：:Basic and neutral neurohypophyseal (NH) nonapeptides have evolved from vasotocin (VT) by a gene duplication at the base of the gnathostome lineage. In teleosts, VT and IT are the basic and neutral peptides, respectively. In the present study, VT and IT precursor genes of Heteropneustes fossilis and Clarias batrachus (...

journal_title：Frontiers in neuroscience

authors： Banerjee P,Chaube R,Joy KP

更新日期：2015-05-15 00:00:00

abstract：:HIGHLIGHTS Many AD target combinations are being explored for multi-target drug design.New databases and models increase the potential of computational drug designLiraglutide and other antidiabetics are strong candidates for repurposing to AD.Donecopride a dual 5-HT/AChE inhibitor shows promise in pre-clinical studies...

journal_title：Frontiers in neuroscience

authors： Hughes RE,Nikolic K,Ramsay RR

更新日期：2016-04-25 00:00:00

abstract：:Recent increases in attention deficit hyperactivity disorder (ADHD) diagnoses, and the escalation of stimulant prescriptions, has raised concern about diversion and abuse of stimulants, as well as the ethics of using these drugs as "cognitive enhancers."Such concern appears misplaced in the face of substantial evidenc...

journal_title：Frontiers in neuroscience

authors： Advokat C,Scheithauer M

更新日期：2013-05-29 00:00:00

abstract：:State-of-the-art large-scale neuromorphic systems require sophisticated spike event communication between units of the neural network. We present a high-speed communication infrastructure for a waferscale neuromorphic system, based on application-specific neuromorphic communication ICs in an field programmable gate ar...

journal_title：Frontiers in neuroscience

authors： Scholze S,Schiefer S,Partzsch J,Hartmann S,Mayr CG,Höppner S,Eisenreich H,Henker S,Vogginger B,Schüffny R

更新日期：2011-10-12 00:00:00

abstract：:Alzheimer's disease (AD), a chronic multifactorial and complex neurodegenerative disorder is a leading cause of dementia. Recently, neuroinflammation has been hypothesized as a contributing factor to AD pathogenesis. The role of adaptive immune responses against neuronal antigens, which can either confer protection or...

journal_title：Frontiers in neuroscience

authors： Dhanwani R,Pham J,Premlal ALR,Frazier A,Kumar A,Pero ME,Bartolini F,Dutra JR,Marder KS,Peters B,Sulzer D,Sette A,Lindestam Arlehamn CS

更新日期：2020-08-27 00:00:00

abstract：:Central pattern generator (CPG) networks coordinate the generation of rhythmic activity such as locomotion and respiration. Their development is driven by various transcription factors, one of which is the Wilms tumor protein (Wt1). It is present in dI6 neurons of the mouse spinal cord, and involved in the coordinatio...

journal_title：Frontiers in neuroscience

authors： Schnerwitzki D,Hayn C,Perner B,Englert C

更新日期：2020-11-30 00:00:00

abstract：:Throughout development, neural stem cells (NSCs) give rise to differentiated neurons, astrocytes, and oligodendrocytes which together modulate perception, memory, and behavior in the adult nervous system. To understand how NSCs contribute to postnatal/adult brain remodeling and repair after injury, the lateral ventric...

journal_title：Frontiers in neuroscience

authors： Adlaf EW,Mitchell-Dick A,Kuo CT

更新日期：2016-03-24 00:00:00

abstract：:Recent progress in tissue engineering has led to increasingly complex approaches to investigate human neurodegenerative diseases in vitro, such as Alzheimer's disease, aiming to provide more functional and physiological models for the study of their pathogenesis, and possibly the identification of novel diagnostic bio...

journal_title：Frontiers in neuroscience

authors： Brighi C,Cordella F,Chiriatti L,Soloperto A,Di Angelantonio S

更新日期：2020-06-17 00:00:00

abstract：:Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually t...

journal_title：Frontiers in neuroscience

authors： Rogers BP,Sheffield JM,Luksik AS,Heckers S

更新日期：2012-12-13 00:00:00

abstract：:Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

journal_title：Frontiers in neuroscience

authors： Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

更新日期：2016-06-29 00:00:00

abstract：:Nocturnal secretion of melatonin from the pineal gland may affect central and peripheral timing, in addition to its well-known involvement in the control of seasonal physiology. The Syrian hamster is a photoperiodic species, which displays gonadal atrophy and increased adiposity when adapted to short (winter-like) pho...

journal_title：Frontiers in neuroscience

authors： Chakir I,Dumont S,Pévet P,Ouarour A,Challet E,Vuillez P

更新日期：2015-05-27 00:00:00

abstract：:Accumulation of misfolded proteins results in cellular stress, and is detected by specific sensors in the endoplasmic reticulum, collectively known as the unfolded protein response (UPR). It has been prominently proposed that the UPR is involved in the pathophysiology of Parkinson's disease (PD). In the present study,...

journal_title：Frontiers in neuroscience

authors： Baek JH,Mamula D,Tingstam B,Pereira M,He Y,Svenningsson P

更新日期：2019-07-05 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00

abstract：Background:Cochlear implants (CIs), which have been designed primarily to support spoken communication of persons with severe to profound hearing loss, are highly effective in supporting speech perception in quiet listening conditions. CI users as a group achieve significantly poorer perception and appraisal of music, ...

journal_title：Frontiers in neuroscience

authors： Gfeller K,Driscoll V,Schwalje A

更新日期：2019-11-21 00:00:00

abstract：:The feedback-related negativity (FRN) is a mid-frontal event-related potential (ERP) recorded in various cognitive tasks and associated with the onset of sensory feedback signaling decision outcome. Some properties of the FRN are still debated, notably its sensitivity to positive and negative reward prediction error (...

journal_title：Frontiers in neuroscience

authors： Sallet J,Camille N,Procyk E

更新日期：2013-11-14 00:00:00

abstract：:To function effectively, brains need to make predictions about their environment based on past experience, i.e., they need to learn about their environment. The algorithms by which learning occurs are of interest to neuroscientists, both in their own right (because they exist in the brain) and as a tool to model parti...

journal_title：Frontiers in neuroscience

authors： O'Reilly JX

更新日期：2013-06-14 00:00:00

abstract：Background:Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiolo...

journal_title：Frontiers in neuroscience

authors： Vega-Torres JD,Azadian M,Rios-Orsini RA,Reyes-Rivera AL,Ontiveros-Angel P,Figueroa JD

更新日期：2020-06-30 00:00:00

abstract：:Speech perception under audiovisual (AV) conditions is well known to confer benefits to perception such as increased speed and accuracy. Here, we investigated how AV training might benefit or impede auditory perceptual learning of speech degraded by vocoding. In Experiments 1 and 3, participants learned paired associa...

journal_title：Frontiers in neuroscience

authors： Bernstein LE,Auer ET Jr,Eberhardt SP,Jiang J

更新日期：2013-03-18 00:00:00

abstract：:Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis (protein homeostasis) is an essential factor in maintaining a persistent environment for neuronal activ...

journal_title：Frontiers in neuroscience

authors： Lehtonen Š,Sonninen TM,Wojciechowski S,Goldsteins G,Koistinaho J

更新日期：2019-05-10 00:00:00

abstract：:Experiment was carried out to study the proprioception accuracy of elderly (61-83 years old) and young (22-36 years old) subjects during contralateral elbow matching in sagittal plane. The subjects performed the task under ordinary condition and under experimental condition (matching forearm attached to the rocking cy...

journal_title：Frontiers in neuroscience

authors： Talis VL,Levik YS

更新日期：2016-11-16 00:00:00

abstract：:Event-related potential (ERP) studies using the task-switching paradigm show that multiple ERP components are modulated by activation of proactive control processes involved in preparing to repeat or switch task and reactive control processes involved in implementation of the current or new task. Our understanding of ...

journal_title：Frontiers in neuroscience

authors： Wong ASW,Cooper PS,Conley AC,McKewen M,Fulham WR,Michie PT,Karayanidis F

更新日期：2018-03-08 00:00:00

abstract：:Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been interpreted as reconsolidation at the synaptic level. The model implement...

journal_title：Frontiers in neuroscience

authors： Kastner DB,Schwalger T,Ziegler L,Gerstner W

更新日期：2016-05-18 00:00:00

abstract：:The dynamical systems view of movement generation in motor cortical areas has emerged as an effective way to explain the firing properties of populations of neurons recorded from these regions. Recently, many studies have focused on finding low-dimensional representations of these dynamical systems during voluntary re...

journal_title：Frontiers in neuroscience

authors： Xing D,Aghagolzadeh M,Truccolo W,Borton D

更新日期：2019-10-04 00:00:00

abstract：:The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in ...

journal_title：Frontiers in neuroscience

authors： Fernández E,Rajan N,Bagni C

更新日期：2013-10-24 00:00:00

abstract：:Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

journal_title：Frontiers in neuroscience

authors： Macefield VG

更新日期：2011-12-06 00:00:00

abstract：:Alzheimer's disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running behavior both early and late in disease progression in a novel dual Tg m...

journal_title：Frontiers in neuroscience

authors： Lippi SLP,Kakalec PA,Smith ML,Flinn JM

更新日期：2020-08-14 00:00:00