Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline.

Abstract:

:Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarboxylate transporters that carry out net transmembrane transport of lactate only until intra- and extracellular levels reach equilibrium. Astrocytes have much faster lactate uptake than neurons and shuttle more lactate among gap junction-coupled astrocytes than to nearby neurons. Lactate diffusion within syncytia can provide precursors for oxidative metabolism and glutamate synthesis and facilitate its release from endfeet to perivascular space to stimulate blood flow. Lactate efflux from brain during activation underlies the large underestimation of CMRglc with labeled glucose and fall in CMRO2/CMRglc ratio. Receptor-mediated effects of lactate on locus coeruleus neurons include noradrenaline release in cerebral cortex and c-AMP-mediated stimulation of astrocytic gap junctional coupling, thereby enhancing its dispersal and release from brain. Lactate transport is essential for its multifunctional roles.

journal_name

Front Neurosci

authors

Hertz L,Gibbs ME,Dienel GA

doi

10.3389/fnins.2014.00261

subject

Has Abstract

pub_date

2014-09-09 00:00:00

pages

261

eissn

1662-4548

issn

1662-453X

journal_volume

8

pub_type

杂志文章,评审
  • Laminin and Environmental Cues Act in the Inhibition of the Neuronal Differentiation of Enteric Glia in vitro.

    abstract::The enteric glia, a neural crest-derived cell type that composes the Enteric Nervous System, is involved in controlling gut functions, including motility, gut permeability, and neuronal communication. Moreover this glial cell could to give rise to new neurons. It is believed that enteric neurons are generated up to 21...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00914

    authors: Veríssimo CP,Carvalho JDS,da Silva FJM,Campanati L,Moura-Neto V,Coelho-Aguiar JM

    更新日期:2019-09-03 00:00:00

  • Hybrid Functional Brain Network With First-Order and Second-Order Information for Computer-Aided Diagnosis of Schizophrenia.

    abstract::Brain functional connectivity network (BFCN) analysis has been widely used in the diagnosis of mental disorders, such as schizophrenia. In BFCN methods, brain network construction is one of the core tasks due to its great influence on the diagnosis result. Most of the existing BFCN construction methods only consider t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00603

    authors: Zhu Q,Li H,Huang J,Xu X,Guan D,Zhang D

    更新日期:2019-06-14 00:00:00

  • A FPGA Implementation of the CAR-FAC Cochlear Model.

    abstract::This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear effere...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00198

    authors: Xu Y,Thakur CS,Singh RK,Hamilton TJ,Wang RM,van Schaik A

    更新日期:2018-04-10 00:00:00

  • Synapse-Centric Mapping of Cortical Models to the SpiNNaker Neuromorphic Architecture.

    abstract::While the adult human brain has approximately 8.8 × 10(10) neurons, this number is dwarfed by its 1 × 10(15) synapses. From the point of view of neuromorphic engineering and neural simulation in general this makes the simulation of these synapses a particularly complex problem. SpiNNaker is a digital, neuromorphic arc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00420

    authors: Knight JC,Furber SB

    更新日期:2016-09-14 00:00:00

  • Retraction: Atorvastatin May Attenuate Recurrence of Chronic Subdural Hematoma.

    abstract::[This retracts the article on p. 303 in vol. 10, PMID: 27445673.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,撤回出版物

    doi:10.3389/fnins.2016.00465

    authors: Frontiers Editorial Office.

    更新日期:2016-10-07 00:00:00

  • Comparison of IVA and GIG-ICA in Brain Functional Network Estimation Using fMRI Data.

    abstract::Spatial group independent component analysis (GICA) methods decompose multiple-subject functional magnetic resonance imaging (fMRI) data into a linear mixture of spatially independent components (ICs), some of which are subsequently characterized as brain functional networks. Group information guided independent compo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00267

    authors: Du Y,Lin D,Yu Q,Sui J,Chen J,Rachakonda S,Adali T,Calhoun VD

    更新日期:2017-05-19 00:00:00

  • Evaluating auditory stream segregation of SAM tone sequences by subjective and objective psychoacoustical tasks, and brain activity.

    abstract::Auditory stream segregation refers to a segregated percept of signal streams with different acoustic features. Different approaches have been pursued in studies of stream segregation. In psychoacoustics, stream segregation has mostly been investigated with a subjective task asking the subjects to report their percept....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00119

    authors: Dolležal LV,Brechmann A,Klump GM,Deike S

    更新日期:2014-06-06 00:00:00

  • Altered Spatial and Temporal Brain Connectivity in the Salience Network of Sensorineural Hearing Loss and Tinnitus.

    abstract::Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00246

    authors: Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

    更新日期:2019-03-19 00:00:00

  • 50 years of hormonal contraception-time to find out, what it does to our brain.

    abstract::Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive performance, the effects of synthetic steroids contained in hormonal contraceptives on br...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00256

    authors: Pletzer BA,Kerschbaum HH

    更新日期:2014-08-21 00:00:00

  • Closed-Loop Neuromorphic Benchmarks.

    abstract::Evaluating the effectiveness and performance of neuromorphic hardware is difficult. It is even more difficult when the task of interest is a closed-loop task; that is, a task where the output from the neuromorphic hardware affects some environment, which then in turn affects the hardware's future input. However, close...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00464

    authors: Stewart TC,DeWolf T,Kleinhans A,Eliasmith C

    更新日期:2015-12-15 00:00:00

  • Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis.

    abstract::Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00340

    authors: Tsetsos F,Padmanabhuni SS,Alexander J,Karagiannidis I,Tsifintaris M,Topaloudi A,Mantzaris D,Georgitsi M,Drineas P,Paschou P

    更新日期:2016-07-22 00:00:00

  • Attention to Emotional Information Is Associated With Cytokine Responses to Psychological Stress.

    abstract::This study aimed to investigate the impact of mental stress on salivary cytokines and attention to emotional stimuli, as well as associations between stress-induced changes of immune and cognitive parameters. In a randomized order a total of 60 young adults were assigned to one of two stress conditions with varying st...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00687

    authors: Maydych V,Claus M,Watzl C,Kleinsorge T

    更新日期:2018-10-02 00:00:00

  • A Preliminary Study of Knowledge Transfer in Multi-Classification Using Gene Expression Programming.

    abstract::Gene Expression Programming (GEP), a variant of Genetic Programming (GP), is a well established technique for automatic generation of computer programs. Due to the flexible representation, GEP has long been concerned as a classification algorithm for various applications. Whereas, GEP cannot be extended to multi-class...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01396

    authors: Wei T,Zhong J

    更新日期:2020-01-17 00:00:00

  • MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis.

    abstract::The finding that the adult mammalian brain is still capable of producing neurons has ignited a new field of research aiming to identify the molecular mechanisms regulating adult neurogenesis. An improved understanding of these mechanisms could lead to the development of novel approaches to delay cognitive decline and ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00707

    authors: Stappert L,Klaus F,Brüstle O

    更新日期:2018-11-05 00:00:00

  • Key factors for the emergence of collective decision in invertebrates.

    abstract::In many species of group living invertebrates, in particular arthropods, collective decisions can emerge from the combined actions of individuals and the direct or indirect interactions between individuals. These decisions allow groups of individuals to respond quickly and accurately to changes that occur in their env...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00121

    authors: Jeanson R,Dussutour A,Fourcassié V

    更新日期:2012-08-20 00:00:00

  • RAPA-ConvNets: Modified Convolutional Networks for Accelerated Training on Architectures With Analog Arrays.

    abstract::Analog arrays are a promising emerging hardware technology with the potential to drastically speed up deep learning. Their main advantage is that they employ analog circuitry to compute matrix-vector products in constant time, irrespective of the size of the matrix. However, ConvNets map very unfavorably onto analog a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00753

    authors: Rasch MJ,Gokmen T,Rigotti M,Haensch W

    更新日期:2019-07-30 00:00:00

  • Frequency-Following Responses to Complex Tones at Different Frequencies Reflect Different Source Configurations.

    abstract::The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00130

    authors: Zhang X,Gong Q

    更新日期:2019-02-26 00:00:00

  • Corrigendum: Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.

    abstract::[This corrects the article on p. 589 in vol. 10, PMID: 28066172.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2017.00065

    authors: Wang H,Li X,Shan L,Zhu J,Chen R,Li Y,Yuan W,Yang L,Huang J

    更新日期:2017-02-13 00:00:00

  • Arousal Contributions to Resting-State fMRI Connectivity and Dynamics.

    abstract::Resting-state functional magnetic resonance imaging (rsfMRI) is being widely used for charting brain connectivity and dynamics in healthy and diseased brains. However, the resting state paradigm allows an unconstrained fluctuation of brain arousal, which may have profound effects on resting-state fMRI signals and asso...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01190

    authors: Gu Y,Han F,Liu X

    更新日期:2019-11-05 00:00:00

  • Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy.

    abstract::Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Using brain slices from mi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00246

    authors: Kohlmeier KA,Tyler CJ,Kalogiannis M,Ishibashi M,Kristensen MP,Gumenchuk I,Chemelli RM,Kisanuki YY,Yanagisawa M,Leonard CS

    更新日期:2013-12-20 00:00:00

  • Functional Identification and Characterization of the Diuretic Hormone 31 (DH31) Signaling System in the Green Shore Crab, Carcinus maenas.

    abstract::The functional characterization of crustacean neuropeptides and their cognate receptors has not kept pace with the recent advances in sequence determination and, therefore, our understanding of the physiological roles of neuropeptides in this important arthropod sub-phylum is rather limited. We identified a candidate ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00454

    authors: Alexander J,Oliphant A,Wilcockson DC,Webster SG

    更新日期:2018-07-04 00:00:00

  • Human Summating Potential Using Continuous Loop Averaging Deconvolution: Response Amplitudes Vary with Tone Burst Repetition Rate and Duration.

    abstract::Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimul...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00429

    authors: Kennedy AE,Kaf WA,Ferraro JA,Delgado RE,Lichtenhan JT

    更新日期:2017-07-27 00:00:00

  • The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence.

    abstract::Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfun...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00493

    authors: Zuccoli GS,Saia-Cereda VM,Nascimento JM,Martins-de-Souza D

    更新日期:2017-09-07 00:00:00

  • Fingolimod for Irradiation-Induced Neurodegeneration.

    abstract:Background:Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fing...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00699

    authors: Metzdorf J,Hobloss Z,Schlevogt S,Ayzenberg I,Stahlke S,Pedreiturria X,Haupeltshofer S,Gold R,Tönges L,Kleiter I

    更新日期:2019-07-09 00:00:00

  • Combined Brain-Perfusion SPECT and EEG Measurements Suggest Distinct Strategies for Speech Comprehension in CI Users With Higher and Lower Performance.

    abstract::Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) users, showing major limitations in speech comprehension. The current study used a ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00787

    authors: Kessler M,Schierholz I,Mamach M,Wilke F,Hahne A,Büchner A,Geworski L,Bengel FM,Sandmann P,Berding G

    更新日期:2020-08-11 00:00:00

  • Test-Retest Reliability of Diffusion Measures Extracted Along White Matter Language Fiber Bundles Using HARDI-Based Tractography.

    abstract::High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to asc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.01055

    authors: Boukadi M,Marcotte K,Bedetti C,Houde JC,Desautels A,Deslauriers-Gauthier S,Chapleau M,Boré A,Descoteaux M,Brambati SM

    更新日期:2019-01-14 00:00:00

  • On event-based optical flow detection.

    abstract::Event-based sensing, i.e., the asynchronous detection of luminance changes, promises low-energy, high dynamic range, and sparse sensing. This stands in contrast to whole image frame-wise acquisition by standard cameras. Here, we systematically investigate the implications of event-based sensing in the context of visua...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00137

    authors: Brosch T,Tschechne S,Neumann H

    更新日期:2015-04-20 00:00:00

  • Comparative Analysis of C9orf72 and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of C9orf72 Positive Patients.

    abstract::We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, comorbidities, and prognosis in patients with amyotrophic lateral sclerosis (ALS). A cohort of 1417 ALS patients, diagnosed between January 1, 2009 and December 31, 2013 by 13 Italian ALS Referral Centers, was screened ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00485

    authors: Trojsi F,Siciliano M,Femiano C,Santangelo G,Lunetta C,Calvo A,Moglia C,Marinou K,Ticozzi N,Ferro C,Scialò C,Sorarù G,Conte A,Falzone YM,Tortelli R,Russo M,Sansone VA,Chiò A,Mora G,Silani V,Volanti P,Caponnetto C

    更新日期:2019-05-17 00:00:00

  • Virtual Balancing for Studying and Training Postural Control.

    abstract::Postural control during free stance has been frequently interpreted in terms of balancing an inverted pendulum. This even holds, if subjects do not balance their own, but an external body weight. We introduce here a virtual balancing apparatus, which produces torque in the ankle joint as a function of ankle angle rese...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00531

    authors: Buettner D,Dalin D,Wiesmeier IK,Maurer C

    更新日期:2017-09-26 00:00:00

  • The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming.

    abstract::Oligodendrocyte precursor cells (OPCs), also known as NG2 glia, arise from neural progenitor cells in the embryonic ganglionic eminences that also generate inhibitory neurons. They are ubiquitously distributed in the central nervous system, remain proliferative through life, and generate oligodendrocytes in both gray ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00829

    authors: Boshans LL,Factor DC,Singh V,Liu J,Zhao C,Mandoiu I,Lu QR,Casaccia P,Tesar PJ,Nishiyama A

    更新日期:2019-08-08 00:00:00