The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming.

abstract：:Aging is a complex natural phenomenon that is manifested by degenerative changes in the structure and function of cells and tissues. D-Galactose-induced aging mice are an artificial accelerated aging model that causes memory and learning impairment, oxidative stress, and neuroinflammation. In this study, we examined t...

journal_title：Frontiers in neuroscience

authors： Li H,Zheng L,Chen C,Liu X,Zhang W

更新日期：2019-09-18 00:00:00

abstract：:Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and protein expression, and inter-individual differences, in the valp...

journal_title：Frontiers in neuroscience

authors： Favre MR,La Mendola D,Meystre J,Christodoulou D,Cochrane MJ,Markram H,Markram K

更新日期：2015-06-02 00:00:00

abstract：:Transcutaneous Vagus Nerve Stimulation (tVNS) on the auricular branch of the vagus nerve has been receiving attention due to its therapeutic potential for neuropsychiatric disorders. Although the mechanism of tVNS is not yet completely understood, studies have demonstrated the potential role of vagal afferent nerve st...

journal_title：Frontiers in neuroscience

authors： Jin Y,Kong J

更新日期：2017-01-20 00:00:00

abstract：Background:Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fing...

journal_title：Frontiers in neuroscience

authors： Metzdorf J,Hobloss Z,Schlevogt S,Ayzenberg I,Stahlke S,Pedreiturria X,Haupeltshofer S,Gold R,Tönges L,Kleiter I

更新日期：2019-07-09 00:00:00

abstract：:Funding institutions and researchers increasingly expect that data will be shared to increase scientific integrity and provide other scientists with the opportunity to use the data with novel methods that may advance understanding in a particular field of study. In practice, sharing human subject data can be complicat...

journal_title：Frontiers in neuroscience

authors： Song X,Wang J,Wang A,Meng Q,Prescott C,Tsu L,Eckert MA

更新日期：2015-09-22 00:00:00

abstract：:Some studies identified hypo-connectivity, while others showed hyper-connectivity of the insula in the autism spectrum disorders (ASD). These contradictory findings leave open the question of whether and to what extent functional connectivity of the insula is altered and how functional connectivity of the insula is as...

journal_title：Frontiers in neuroscience

authors： Xu J,Wang H,Zhang L,Xu Z,Li T,Zhou Z,Zhou Z,Gan Y,Hu Q

更新日期：2018-04-11 00:00:00

abstract：:Despite evolutionary musicology's interdisciplinary nature, and the diverse methods it employs, the field has nevertheless tended to divide into two main positions. Some argue that music should be understood as a naturally selected adaptation, while others claim that music is a product of culture with little or no rel...

journal_title：Frontiers in neuroscience

authors： van der Schyff D,Schiavio A

更新日期：2017-09-29 00:00:00

abstract：:The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tes...

journal_title：Frontiers in neuroscience

authors： Eissa N,Khan N,Ojha SK,Łazewska D,Kieć-Kononowicz K,Sadek B

更新日期：2018-02-12 00:00:00

abstract：:Background: Gambling disorder (GD) is the most common behavioral addiction and shares pathophysiological and clinical features with substance use disorders (SUDs). Effective therapeutic interventions for GD are lacking. Non-invasive brain stimulation (NIBS) may represent a promising treatment option for GD. Objective:...

journal_title：Frontiers in neuroscience

authors： Zucchella C,Mantovani E,Federico A,Lugoboni F,Tamburin S

更新日期：2020-08-18 00:00:00

abstract：:Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm and its disappearance from the nucleus are pathological features of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) and are directly involved in the pathogenesis of these conditions. TDP-43 is an essential nuclear protein...

journal_title：Frontiers in neuroscience

authors： Sugai A,Kato T,Koyama A,Koike Y,Kasahara S,Konno T,Ishihara T,Onodera O

更新日期：2018-02-01 00:00:00

abstract：:Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

journal_title：Frontiers in neuroscience

authors： Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

更新日期：2015-10-23 00:00:00

abstract：:Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the content of neuronal injury. As well-accepted, inflammation, and neuron...

journal_title：Frontiers in neuroscience

authors： Hohmann U,Pelzer M,Kleine J,Hohmann T,Ghadban C,Dehghani F

更新日期：2019-11-07 00:00:00

abstract：:Adult hippocampal neurogenesis (AHN) in the dentate gyrus is known to respond to environmental enrichment, chronic stress, and many other factors. The function of AHN may vary across the septo-temporal axis of the hippocampus, as different subdivisions are responsible for different functions. The dorsal pole regulates...

journal_title：Frontiers in neuroscience

authors： Gualtieri F,Brégère C,Laws GC,Armstrong EA,Wylie NJ,Moxham TT,Guzman R,Boswell T,Smulders TV

更新日期：2017-09-15 00:00:00

abstract：:The increasing rate of age-related hearing loss (ARHL), with its subsequent reduction in quality of life and increase in health care costs, requires new therapeutic strategies to reduce and delay its impact. The goal of this study was to determine if ARHL could be reduced in a rat model by administering a combination ...

journal_title：Frontiers in neuroscience

authors： Alvarado JC,Fuentes-Santamaría V,Gabaldón-Ull MC,Juiz JM

更新日期：2018-07-31 00:00:00

abstract：:Anesthetized rodent models are ubiquitous in pre-clinical neuroimaging studies. However, because the associated cerebral morphology and experimental methodology results in a profound negative brain-core temperature differential, cerebral temperature changes during functional activation are likely to be principally dri...

journal_title：Frontiers in neuroscience

authors： Harris SS,Boorman LW,Das D,Kennerley AJ,Sharp PS,Martin C,Redgrave P,Schwartz TH,Berwick J

更新日期：2018-08-14 00:00:00

abstract：:Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be the basis of antibiotic-induced neurophysiological and behavioral changes. However, relatively little research has addressed whether antibiotics act directly on the host nervous system to produce these changes. We aimed to identif...

journal_title：Frontiers in neuroscience

authors： Delungahawatta T,Amin JY,Stanisz AM,Bienenstock J,Forsythe P,Kunze WA

更新日期：2017-10-20 00:00:00

abstract：INTRODUCTION:Impairments in walking speed and capacity are common problems after stroke which may benefit from treadmill training. However, standard treadmills, are unable to adapt to the slower walking speeds of stroke survivors and are unable to automate training progression. This study tests a Variable Automated Spe...

journal_title：Frontiers in neuroscience

authors： Chua KS,Chee J,Wong CJ,Lim PH,Lim WS,Hoo CM,Ong WS,Shen ML,Yu WS

更新日期：2015-07-10 00:00:00

abstract：:Micro-Graphitic Single Crystal Diamond Multi Electrode Arrays (μG-SCD-MEAs) have so far been used as amperometric sensors to detect catecholamines from chromaffin cells and adrenal gland slices. Besides having time resolution and sensitivity that are comparable with carbon fiber electrodes, that represent the gold sta...

journal_title：Frontiers in neuroscience

authors： Tomagra G,Picollo F,Battiato A,Picconi B,De Marchis S,Pasquarelli A,Olivero P,Marcantoni A,Calabresi P,Carbone E,Carabelli V

更新日期：2019-04-09 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00

abstract：:Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

journal_title：Frontiers in neuroscience

authors： Narayan M,Allen GI

更新日期：2016-04-12 00:00:00

abstract：:Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional corr...

journal_title：Frontiers in neuroscience

authors： Zhou X,Li M,Zhou H,Li L,Cui J

更新日期：2018-11-06 00:00:00

abstract：:Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

journal_title：Frontiers in neuroscience

authors： Ekelem A,Goldfarb M

更新日期：2018-06-01 00:00:00

abstract：:Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia. Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression. Ex vivo patch clamp recordings and in vivo calcium imaging demonstrated impaired ne...

journal_title：Frontiers in neuroscience

authors： Zhou C,Kong D,Xue R,Chen M,Li G,Xu Y,Liu S,Tian H,Zhuo C

更新日期：2020-06-03 00:00:00

abstract：:This study was to explore the mechanisms underlying 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of matrix metalloproteinase-2 (MMP-2) in rat astrocytes induced by 2-chloroethanol (2-CE), an intermediate metabolite of 1,2-DCE in vivo. Protein and mRNA levels of MMP-2, and the phosphorylat...

journal_title：Frontiers in neuroscience

authors： Sun Q,Liao Y,Wang T,Tang H,Wang G,Zhao F,Jin Y

更新日期：2017-01-04 00:00:00

abstract：:The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

journal_title：Frontiers in neuroscience

authors： Zhang X,Gong Q

更新日期：2019-02-26 00:00:00

abstract：:Social memory, including the ability to recognize faces and voices, is essential for social relationships. It has a large heritable component, but the knowledge about the contributing genes is sparse. The genetic variation underlying inter-individual differences in social memory was investigated in an exploratory samp...

journal_title：Frontiers in neuroscience

authors： Henningsson S,Zettergren A,Hovey D,Jonsson L,Svärd J,Cortes DS,Melke J,Ebner NC,Laukka P,Fischer H,Westberg L

更新日期：2015-10-21 00:00:00

abstract：:Previous research has provided qualitative evidence for overlap in a number of brain regions across the subjective value network (SVN) and the default mode network (DMN). In order to quantitatively assess this overlap, we conducted a series of coordinate-based meta-analyses (CBMA) of results from 466 functional magnet...

journal_title：Frontiers in neuroscience

authors： Acikalin MY,Gorgolewski KJ,Poldrack RA

更新日期：2017-01-19 00:00:00

abstract：:Stimulation of the pineal gland via its sympathetic innervation pathway results in the production of N-acetylserotonin and melatonin. Melatonin has many therapeutic roles and is heavily implicated in the regulation of the sleep-wake cycle. In addition, N-acetylserotonin has recently been reported to promote neurogenes...

journal_title：Frontiers in neuroscience

authors： Lumsden SC,Clarkson AN,Cakmak YO

更新日期：2020-04-02 00:00:00

abstract：:The GABAergic neurons in the lateral pontine tegmentum (LPT) play key roles in the regulation of sleep and locomotion. The dysfunction of the LPT is related to neurological disorders such as rapid eye movement sleep behavior disorder and ocular flutter. However, the whole-brain neural connectivity to LPT GABAergic neu...

journal_title：Frontiers in neuroscience

authors： Chen ZK,Yuan XS,Dong H,Wu YF,Chen GH,He M,Qu WM,Huang ZL

更新日期：2019-04-24 00:00:00

abstract：:The mechanisms that control the frequency and propagation velocity of colonic migrating motor complexes (CMMCs) in mammals are poorly understood. Previous in vitro studies on whole mouse colon have shown that CMMCs occur frequently (~every 1-3 min) when the colon is devoid of all fecal content. Consequently, these stu...

journal_title：Frontiers in neuroscience

authors： Barnes KJ,Beckett EA,Brookes SJ,Sia TC,Spencer NJ

更新日期：2014-05-08 00:00:00