Neuromodulation of the Pineal Gland via Electrical Stimulation of Its Sympathetic Innervation Pathway.

Abstract:

:Stimulation of the pineal gland via its sympathetic innervation pathway results in the production of N-acetylserotonin and melatonin. Melatonin has many therapeutic roles and is heavily implicated in the regulation of the sleep-wake cycle. In addition, N-acetylserotonin has recently been reported to promote neurogenesis in the brain. Upregulation of these indoleamines is possible via neuromodulation of the pineal gland. This is achieved by electrical stimulation of structures or fibres in the pineal gland sympathetic innervation pathway. Many studies have performed such pineal neuromodulation using both invasive and non-invasive methods. However, the effects of various experimental variables and stimulation paradigms has not yet been reviewed and evaluated. This review summarises these studies and presents the optimal experimental protocols and stimulation parameters necessary for maximal upregulation of melatonin metabolic output.

journal_name

Front Neurosci

authors

Lumsden SC,Clarkson AN,Cakmak YO

doi

10.3389/fnins.2020.00264

subject

Has Abstract

pub_date

2020-04-02 00:00:00

pages

264

eissn

1662-4548

issn

1662-453X

journal_volume

14

pub_type

杂志文章,评审
  • A Model of Synaptic Reconsolidation.

    abstract::Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been interpreted as reconsolidation at the synaptic level. The model implement...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00206

    authors: Kastner DB,Schwalger T,Ziegler L,Gerstner W

    更新日期:2016-05-18 00:00:00

  • Standardized and Experimental Tools to Assess Spatial Cognition in Visually Impaired Children: A Mini-Review.

    abstract::The acquisition of spatial cognition is essential for both everyday functioning (e.g., navigation) and more specific goals (e.g., mathematics), therefore being able to assess and monitor spatial cognition from the first years of life would be essential to predict developmental outcomes and timely intervene whenever sp...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.562589

    authors: Aprile G,Cappagli G,Morelli F,Gori M,Signorini S

    更新日期:2020-09-16 00:00:00

  • Full Field Masking Causes Reversals in Perceived Event Order.

    abstract::We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00217

    authors: Chota S,McLelland D,Lavergne L,Zimmermann E,Cavanagh P,VanRullen R

    更新日期:2020-03-17 00:00:00

  • Neural Dynamics of Improved Bimodal Attention and Working Memory in Musically Trained Children.

    abstract::Attention and working memory (WM) are core components of executive functions, and they can be enhanced by training. One activity that has shown to improve executive functions is musical training, but the brain networks underlying these improvements are not well known. We aimed to identify, using functional MRI (fMRI),...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.554731

    authors: Kausel L,Zamorano F,Billeke P,Sutherland ME,Larrain-Valenzuela J,Stecher X,Schlaug G,Aboitiz F

    更新日期:2020-10-08 00:00:00

  • A Hypothesis of the Co-evolution of Cooperation and Responses to Inequity.

    abstract::Recent evidence demonstrates that humans are not the only species to respond negatively to inequitable outcomes which are to their disadvantage. Several species respond negatively if they subsequently receive a less good reward than a social partner for completing the same task. While these studies suggest that the ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00043

    authors: Brosnan SF

    更新日期:2011-04-05 00:00:00

  • The Profiles of Non-stationarity and Non-linearity in the Time Series of Resting-State Brain Networks.

    abstract::The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state fMRI (rs-fMRI) time-series data from the Midnight Scan Club datasets. The degree of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00493

    authors: Guan S,Jiang R,Bian H,Yuan J,Xu P,Meng C,Biswal B

    更新日期:2020-06-11 00:00:00

  • The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.

    abstract::We previously demonstrated that, in the early stages of tau processing in Alzheimer's disease, the N-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by Alz-50. In this immunohistochemical stud...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00033

    authors: Flores-Rodríguez P,Ontiveros-Torres MA,Cárdenas-Aguayo MC,Luna-Arias JP,Meraz-Ríos MA,Viramontes-Pintos A,Harrington CR,Wischik CM,Mena R,Florán-Garduño B,Luna-Muñoz J

    更新日期:2015-02-11 00:00:00

  • Differential Circular RNA Expression Profiles Following Spinal Cord Injury in Rats: A Temporal and Experimental Analysis.

    abstract::Spinal cord injury (SCI), one of the most severe types of neurological damage, results in persistent motor and sensory dysfunction and involves complex gene alterations. Circular RNAs (circRNAs) are a recently discovered class of regulatory molecules, and their roles in SCI still need to be addressed. This study compr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01303

    authors: Wu R,Mao S,Wang Y,Zhou S,Liu Y,Liu M,Gu X,Yu B

    更新日期:2019-12-10 00:00:00

  • Comparison of IVA and GIG-ICA in Brain Functional Network Estimation Using fMRI Data.

    abstract::Spatial group independent component analysis (GICA) methods decompose multiple-subject functional magnetic resonance imaging (fMRI) data into a linear mixture of spatially independent components (ICs), some of which are subsequently characterized as brain functional networks. Group information guided independent compo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00267

    authors: Du Y,Lin D,Yu Q,Sui J,Chen J,Rachakonda S,Adali T,Calhoun VD

    更新日期:2017-05-19 00:00:00

  • Combined Brain-Perfusion SPECT and EEG Measurements Suggest Distinct Strategies for Speech Comprehension in CI Users With Higher and Lower Performance.

    abstract::Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) users, showing major limitations in speech comprehension. The current study used a ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00787

    authors: Kessler M,Schierholz I,Mamach M,Wilke F,Hahne A,Büchner A,Geworski L,Bengel FM,Sandmann P,Berding G

    更新日期:2020-08-11 00:00:00

  • The behavioral relevance of multisensory neural response interactions.

    abstract::Sensory information can interact to impact perception and behavior. Foods are appreciated according to their appearance, smell, taste and texture. Athletes and dancers combine visual, auditory, and somatosensory information to coordinate their movements. Under laboratory settings, detection and discrimination are like...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.009.2010

    authors: Sperdin HF,Cappe C,Murray MM

    更新日期:2010-05-15 00:00:00

  • Anodal Transcranial Direct Current Stimulation Increases Bilateral Directed Brain Connectivity during Motor-Imagery Based Brain-Computer Interface Control.

    abstract::Transcranial direct current stimulation (tDCS) has been shown to affect motor and cognitive task performance and learning when applied to brain areas involved in the task. Targeted stimulation has also been found to alter connectivity within the stimulated hemisphere during rest. However, the connectivity effect of th...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00691

    authors: Baxter BS,Edelman BJ,Sohrabpour A,He B

    更新日期:2017-12-07 00:00:00

  • Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

    abstract::Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00428

    authors: Alexander J,Potamianou H,Xing J,Deng L,Karagiannidis I,Tsetsos F,Drineas P,Tarnok Z,Rizzo R,Wolanczyk T,Farkas L,Nagy P,Szymanska U,Androutsos C,Tsironi V,Koumoula A,Barta C,TSGeneSEE.,Sandor P,Barr CL,Tischfield

    更新日期:2016-09-21 00:00:00

  • The intense world syndrome--an alternative hypothesis for autism.

    abstract::Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the neuronal structures and cells affected, a unifying theory that co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.1.1.006.2007

    authors: Markram H,Rinaldi T,Markram K

    更新日期:2007-10-15 00:00:00

  • Neurogenesis in the dentate gyrus: carrying the message or dictating the tone.

    abstract::The dentate gyrus (DG) is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas. One of the major differences of the DG compared to other brain regions is the finding that the dentate gyrus generates new principal neu...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00050

    authors: Piatti VC,Ewell LA,Leutgeb JK

    更新日期:2013-04-04 00:00:00

  • An Objective Estimation of Air-Bone-Gap in Cochlear Implant Recipients with Residual Hearing Using Electrocochleography.

    abstract::Although, cochlear implants (CI) traditionally have been used to treat individuals with bilateral profound sensorineural hearing loss, a recent trend is to implant individuals with residual low-frequency hearing. Notably, many of these individuals demonstrate an air-bone gap (ABG) in low-frequency, pure-tone threshold...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00210

    authors: Koka K,Saoji AA,Attias J,Litvak LM

    更新日期:2017-04-18 00:00:00

  • Ambiguity aversion in rhesus macaques.

    abstract::People generally prefer risky options, which have fully specified outcome probabilities, to ambiguous options, which have unspecified probabilities. This preference, formalized in economics, is strong enough that people will reliably prefer a risky option to an ambiguous option with a greater expected value. Explanati...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2010.00166

    authors: Hayden BY,Heilbronner SR,Platt ML

    更新日期:2010-09-17 00:00:00

  • Contralateral Inhibition of Click- and Chirp-Evoked Human Compound Action Potentials.

    abstract::Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is believed to play a role in listening in noise and protection from a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00189

    authors: Smith SB,Lichtenhan JT,Cone BK

    更新日期:2017-04-04 00:00:00

  • Cognitive, Emotional and Psychological Manifestations in Amyotrophic Lateral Sclerosis at Baseline and Overtime: A Review.

    abstract::It is now well recognized that, in addition to motor impairment, amyotrophic lateral sclerosis (ALS) may cause extra-motor clinical signs and symptoms. These can include the alteration of certain cognitive functions, impaired social cognition, and changes in the perception and processing of emotions. Where these extra...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00951

    authors: Benbrika S,Desgranges B,Eustache F,Viader F

    更新日期:2019-09-10 00:00:00

  • Autism Pathogenesis: The Superior Colliculus.

    abstract::After been exposed to the visual input, in the first year of life, the brain experiences subtle but massive changes apparently crucial for communicative/emotional and social human development. Its lack could be the explanation of the very high prevalence of autism in children with total congenital blindness. The prese...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.01029

    authors: Jure R

    更新日期:2019-01-09 00:00:00

  • No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults.

    abstract::Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00218

    authors: Forde NJ,Ronan L,Zwiers MP,Alexander-Bloch AF,Faraone SV,Oosterlaan J,Heslenfeld DJ,Hartman CA,Buitelaar JK,Hoekstra PJ

    更新日期:2017-04-20 00:00:00

  • EEG Responses to Auditory Stimuli for Automatic Affect Recognition.

    abstract::Brain state classification for communication and control has been well established in the area of brain-computer interfaces over the last decades. Recently, the passive and automatic extraction of additional information regarding the psychological state of users from neurophysiological signals has gained increased att...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00244

    authors: Hettich DT,Bolinger E,Matuz T,Birbaumer N,Rosenstiel W,Spüler M

    更新日期:2016-06-10 00:00:00

  • Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance.

    abstract::The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularl...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00521

    authors: Rhea EM,Banks WA

    更新日期:2019-06-04 00:00:00

  • The Influence of EEG References on the Analysis of Spatio-Temporal Interrelation Patterns.

    abstract::The characterization of the functional network of the brain dynamics has become a prominent tool to illuminate novel aspects of brain functioning. Due to its excellent time resolution, such research is oftentimes based on electroencephalographic recordings (EEG). However, a particular EEG-reference might cause crucial...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00941

    authors: Ríos-Herrera WA,Olguín-Rodríguez PV,Arzate-Mena JD,Corsi-Cabrera M,Escalona J,Marín-García A,Ramos-Loyo J,Rivera AL,Rivera-López D,Zapata-Berruecos JF,Müller MF

    更新日期:2019-09-12 00:00:00

  • Making predictions in a changing world-inference, uncertainty, and learning.

    abstract::To function effectively, brains need to make predictions about their environment based on past experience, i.e., they need to learn about their environment. The algorithms by which learning occurs are of interest to neuroscientists, both in their own right (because they exist in the brain) and as a tool to model parti...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00105

    authors: O'Reilly JX

    更新日期:2013-06-14 00:00:00

  • Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.

    abstract::The neurodegenerative disorder multiple system atrophy (MSA) is characterized by autonomic failure, cerebellar ataxia and parkinsonism in any combination associated with predominantly oligodendroglial α-synuclein (α-syn) aggregates (glial cytoplasmic inclusions = GCIs). To date, there is no effective disease modifying...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00099

    authors: Fellner L,Kuzdas-Wood D,Levin J,Ryazanov S,Leonov A,Griesinger C,Giese A,Wenning GK,Stefanova N

    更新日期:2016-03-10 00:00:00

  • Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

    abstract::Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegener...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00278

    authors: Mustapic M,Eitan E,Werner JK Jr,Berkowitz ST,Lazaropoulos MP,Tran J,Goetzl EJ,Kapogiannis D

    更新日期:2017-05-22 00:00:00

  • Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.

    abstract::Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01009

    authors: Pitake S,Middleton LJ,Abdus-Saboor I,Mishra SK

    更新日期:2019-09-19 00:00:00

  • Distinct Effects of Chronic Dopaminergic Stimulation on Hippocampal Neurogenesis and Striatal Doublecortin Expression in Adult Mice.

    abstract::While adult neurogenesis is considered to be restricted to the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ), recent studies in humans and rodents provide evidence for newly generated neurons in regions generally considered as non-neurogenic, e.g., the striatum. Stimulating dopaminergic neurotransmi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00077

    authors: Salvi R,Steigleder T,Schlachetzki JC,Waldmann E,Schwab S,Winner B,Winkler J,Kohl Z

    更新日期:2016-03-11 00:00:00

  • A novel biomarker of amnestic MCI based on dynamic cross-frequency coupling patterns during cognitive brain responses.

    abstract::The detection of mild cognitive impairment (MCI), the transitional stage between normal cognitive changes of aging and the cognitive decline caused by AD, is of paramount clinical importance, since MCI patients are at increased risk of progressing into AD. Electroencephalographic (EEG) alterations in the spectral cont...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00350

    authors: Dimitriadis SI,Laskaris NA,Bitzidou MP,Tarnanas I,Tsolaki MN

    更新日期:2015-10-20 00:00:00