Effects of Environmental Enrichment on Doublecortin and BDNF Expression along the Dorso-Ventral Axis of the Dentate Gyrus.

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson's disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intriguingly, the presenc...

journal_title：Frontiers in neuroscience

authors： Dues DJ,Moore DJ

更新日期：2020-07-08 00:00:00

abstract：:Musicians have considerable experience naming pitch-classes with verbal (e.g., Doh, Ré, and Mi) and semiotic tags (e.g., musical notation). On the one end of the spectrum, musicians can identify the pitch of a piano tone or quality of a chord without a reference tone [i.e., absolute pitch (AP) or relative pitch], whic...

journal_title：Frontiers in neuroscience

authors： Sharma VV,Thaut M,Russo F,Alain C

更新日期：2019-09-06 00:00:00

abstract：:L-DOPA-induced dyskinesia (LID) represents one of the major problems of the long-term therapy of patients with Parkinson's disease (PD). Although, the pathophysiologic mechanisms underlying LID are not completely understood, activation of the extracellular signal regulated kinase (ERK) is recognized to play a key role...

journal_title：Frontiers in neuroscience

authors： Chen G,Nie S,Han C,Ma K,Xu Y,Zhang Z,Papa SM,Cao X

更新日期：2017-03-09 00:00:00

abstract：:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCA...

journal_title：Frontiers in neuroscience

authors： Shi XF,Ai H,Lu W,Cai F

更新日期：2019-02-12 00:00:00

abstract：:Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

journal_title：Frontiers in neuroscience

authors： Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

更新日期：2016-06-30 00:00:00

abstract：:Funding institutions and researchers increasingly expect that data will be shared to increase scientific integrity and provide other scientists with the opportunity to use the data with novel methods that may advance understanding in a particular field of study. In practice, sharing human subject data can be complicat...

journal_title：Frontiers in neuroscience

authors： Song X,Wang J,Wang A,Meng Q,Prescott C,Tsu L,Eckert MA

更新日期：2015-09-22 00:00:00

abstract：Introduction:Low back pain (LBP) is a complex and growing global health problem in need of more effective pain management strategies. Spinal mobilization (SM) is a non-pharmacological approach recommended by most clinical guidelines for LBP, but greater utilization and treatment optimization are hampered by a lack of m...

journal_title：Frontiers in neuroscience

authors： Reed WR,Little JW,Lima CR,Sorge RE,Yarar-Fisher C,Eraslan M,Hurt CP,Ness TJ,Gu JG,Martins DF,Li P

更新日期：2020-04-30 00:00:00

abstract：:Experiment was carried out to study the proprioception accuracy of elderly (61-83 years old) and young (22-36 years old) subjects during contralateral elbow matching in sagittal plane. The subjects performed the task under ordinary condition and under experimental condition (matching forearm attached to the rocking cy...

journal_title：Frontiers in neuroscience

authors： Talis VL,Levik YS

更新日期：2016-11-16 00:00:00

abstract：:We performed this study to investigate the possibility of a definitive pattern of Galectin-3 (Gal-3) expression in the cerebrospinal fluid (CSF) and serum of Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) patients. In our study, we collected the CSF and serum samples of 31 AD patients, 19 ALS patient...

journal_title：Frontiers in neuroscience

authors： Ashraf GM,Baeesa SS

更新日期：2018-06-29 00:00:00

abstract：:The aim of the present study was to test whether transcranial electrical stimulation can modulate illusory perception in the auditory domain. In two separate experiments we applied transcranial Direct Current Stimulation (anodal/cathodal tDCS, 2 mA; N = 60) and high-frequency transcranial Random Noise Stimulation (hf-...

journal_title：Frontiers in neuroscience

authors： Prete G,D'Anselmo A,Tommasi L,Brancucci A

更新日期：2017-06-20 00:00:00

abstract：:The GABAergic neurons in the lateral pontine tegmentum (LPT) play key roles in the regulation of sleep and locomotion. The dysfunction of the LPT is related to neurological disorders such as rapid eye movement sleep behavior disorder and ocular flutter. However, the whole-brain neural connectivity to LPT GABAergic neu...

journal_title：Frontiers in neuroscience

authors： Chen ZK,Yuan XS,Dong H,Wu YF,Chen GH,He M,Qu WM,Huang ZL

更新日期：2019-04-24 00:00:00

abstract：:Williams syndrome (WS) is a clinical condition, involving cognitive deficits and an uneven language profile, which has been the object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozen genes in chromosome 7, no gene has yet been probed to account for, or contribute...

journal_title：Frontiers in neuroscience

authors： Benítez-Burraco A,Kimura R

更新日期：2019-03-26 00:00:00

abstract：:Alzheimer's dementia commonly impacts the health of older adults and lacks any preventative therapy. While Alzheimer's dementia risk has a substantial genetic component, the specific molecular mechanisms and neuropathologies triggered by most of the known genetic variants are unclear. Resultantly, they have shown limi...

journal_title：Frontiers in neuroscience

authors： Tasaki S,Gaiteri C,Mostafavi S,De Jager PL,Bennett DA

更新日期：2018-10-08 00:00:00

abstract：Background:Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects...

journal_title：Frontiers in neuroscience

authors： Hollis A,Zewdie E,Nettel-Aguirre A,Hilderley A,Kuo HC,Carlson HL,Kirton A

更新日期：2020-05-19 00:00:00

abstract：:How speech signals are analyzed and represented remains a foundational challenge both for cognitive science and neuroscience. A growing body of research, employing various behavioral and neurobiological experimental techniques, now points to the perceptual relevance of both phoneme-sized (10-40 Hz modulation frequency...

journal_title：Frontiers in neuroscience

authors： Chait M,Greenberg S,Arai T,Simon JZ,Poeppel D

更新日期：2015-06-16 00:00:00

abstract：:Available evidence suggests that diabetes mellitus (DM) is a non-genetic risk factor for Parkinson's disease (PD). PD and DM have shared similarities in pathogenetic mechanisms, including age, environmental factors, inflammatory reaction, and protein aggregation, etc. α-Synuclein is the primary protein component in th...

journal_title：Frontiers in neuroscience

authors： Sun Y,Guo C,Yuan L,Li W,Wang ZY,Yue F,Li JY

更新日期：2020-02-07 00:00:00

abstract：:Concerns regarding a drought in psychopharmacology have risen from many quarters. From one perspective, the wellspring of bedrock medications for anxiety disorders, depression, and schizophrenia was serendipitously discovered over 30 year ago, the swell of pharmaceutical investment in drug discovery has receded, and t...

journal_title：Frontiers in neuroscience

authors： Macdonald K,Feifel D

更新日期：2013-03-15 00:00:00

abstract：:The functional characterization of crustacean neuropeptides and their cognate receptors has not kept pace with the recent advances in sequence determination and, therefore, our understanding of the physiological roles of neuropeptides in this important arthropod sub-phylum is rather limited. We identified a candidate ...

journal_title：Frontiers in neuroscience

authors： Alexander J,Oliphant A,Wilcockson DC,Webster SG

更新日期：2018-07-04 00:00:00

abstract：:The ability to delegate control over repetitive tasks from higher to lower neural centers may be a fundamental innovation in human cognition. Plausibly, the massive neurocomputational challenges associated with the mastery of balance during the evolution of bipedality in proto-humans provided a strong selective advant...

journal_title：Frontiers in neuroscience

authors： Shine JM,Shine R

更新日期：2014-04-29 00:00:00

abstract：:The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system. Under normal conditions, the continuous activation of these neurons during bladder distension goes mostly unnoticed. However, for ...

journal_title：Frontiers in neuroscience

authors： Grundy L,Caldwell A,Brierley SM

更新日期：2018-12-12 00:00:00

abstract：:Intracortical electrodes for brain-machine interfaces rely on intimate contact with tissues for recording signals and stimulating neurons. However, the long-term viability of intracortical electrodes in vivo is poor, with a major contributing factor being the development of a glial scar. In vivo approaches for evaluat...

journal_title：Frontiers in neuroscience

authors： Gilmour A,Poole-Warren L,Green RA

更新日期：2019-12-17 00:00:00

abstract：:Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...

journal_title：Frontiers in neuroscience

authors： Barnard RA,Pomaville MB,O'Roak BJ

更新日期：2015-12-17 00:00:00

abstract：:Neurologic Music Therapy (NMT) is a novel impairment-focused behavioral intervention system whose techniques are based on the clinical neuroscience of music perception, cognition, and production. Auditory Stimulation (RAS) is one of the NMT techniques, which aims to develop and maintain a physiological rhythmic motor ...

journal_title：Frontiers in neuroscience

authors： Buard I,Dewispelaere WB,Thaut M,Kluger BM

更新日期：2019-02-19 00:00:00

abstract：:The acquisition of spatial cognition is essential for both everyday functioning (e.g., navigation) and more specific goals (e.g., mathematics), therefore being able to assess and monitor spatial cognition from the first years of life would be essential to predict developmental outcomes and timely intervene whenever sp...

journal_title：Frontiers in neuroscience

authors： Aprile G,Cappagli G,Morelli F,Gori M,Signorini S

更新日期：2020-09-16 00:00:00

abstract：:Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

journal_title：Frontiers in neuroscience

authors： Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

更新日期：2016-06-29 00:00:00

abstract：:Silymarin is a bioactive constituent isolated from milk thistle (Silybum marinum). Since its discovery, silymarin has been considered a gold standard drug in treating ailments related to the liver, resulting from alcohol consumption and viral hepatitis. This hepatoprotective nature of silymarin arises out of antioxida...

journal_title：Frontiers in neuroscience

authors： Rathore P,Arora I,Rastogi S,Akhtar M,Singh S,Samim M

更新日期：2020-10-26 00:00:00

abstract：:The mean diffusivity (MD) value has been used to describe microstructural properties in Diffusion Tensor Imaging (DTI) in cortical gray matter (GM). Recently, researchers have applied a cortical surface generated from the T1-weighted volume. When the DTI data are analyzed using the cortical surface, it is important to...

journal_title：Frontiers in neuroscience

authors： Kwon OH,Park H,Seo SW,Na DL,Lee JM

更新日期：2015-07-14 00:00:00

abstract：:The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in ...

journal_title：Frontiers in neuroscience

authors： Fernández E,Rajan N,Bagni C

更新日期：2013-10-24 00:00:00

abstract：:Astrocytes are the most abundant type of glial cell in the central nervous system and perform a myriad of vital functions, however, the nature of their diversity remains a longstanding question in neuroscience. Using transcription factor motif discovery analysis on region-specific gene signatures from astrocytes we un...

journal_title：Frontiers in neuroscience

authors： Lozzi B,Huang TW,Sardar D,Huang AY,Deneen B

更新日期：2020-02-21 00:00:00

abstract：:After been exposed to the visual input, in the first year of life, the brain experiences subtle but massive changes apparently crucial for communicative/emotional and social human development. Its lack could be the explanation of the very high prevalence of autism in children with total congenital blindness. The prese...

journal_title：Frontiers in neuroscience

authors： Jure R

更新日期：2019-01-09 00:00:00