Test-Retest Reliability of Diffusion Measures Extracted Along White Matter Language Fiber Bundles Using HARDI-Based Tractography.


:High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to ascertain that the longitudinal variations observed are not related to data processing. The aims of this study were to determine the reproducibility of the reconstruction of major white matter fiber bundles of the language network using anatomically constrained probabilistic tractography with constrained spherical deconvolution based on HARDI data, as well as to assess the test-retest reliability of diffusion measures extracted along them. Eighteen right-handed participants were scanned twice, one week apart. The arcuate, inferior longitudinal, inferior fronto-occipital, and uncinate fasciculi were reconstructed in the left and right hemispheres and the following diffusion measures were extracted along each tract: fractional anisotropy, mean, axial, and radial diffusivity, number of fiber orientations, mean length of streamlines, and volume. All fiber bundles showed good morphological overlap between the two scanning timepoints and the test-retest reliability of all diffusion measures in most fiber bundles was good to excellent. We thus propose a fairly simple, but robust, HARDI-based tractography pipeline reliable for the longitudinal study of white matter language fiber bundles, which increases its potential applicability to research on the neurobiological mechanisms supporting language.


Front Neurosci


Boukadi M,Marcotte K,Bedetti C,Houde JC,Desautels A,Deslauriers-Gauthier S,Chapleau M,Boré A,Descoteaux M,Brambati SM




Has Abstract


2019-01-14 00:00:00










  • Neurotrophic effects of neudesin in the central nervous system.

    abstract::Neudesin (neuron-derived neurotrophic factor; NENF) was identified as a neurotrophic factor that is involved in neuronal differentiation and survival. It is abundantly expressed in the central nervous system, and its neurotrophic activity is exerted via the mitogen-activated protein kinase (MAPK) and phosphatidylinosi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Kimura I,Nakayama Y,Zhao Y,Konishi M,Itoh N

    更新日期:2013-06-25 00:00:00

  • A Comparison of Low-Complexity Real-Time Feature Extraction for Neuromorphic Speech Recognition.

    abstract::This paper presents a real-time, low-complexity neuromorphic speech recognition system using a spiking silicon cochlea, a feature extraction module and a population encoding method based Neural Engineering Framework (NEF)/Extreme Learning Machine (ELM) classifier IC. Several feature extraction methods with varying mem...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Acharya J,Patil A,Li X,Chen Y,Liu SC,Basu A

    更新日期:2018-03-28 00:00:00

  • Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives.

    abstract::In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Akerblom M,Sachdeva R,Jakobsson J

    更新日期:2012-02-07 00:00:00

  • A Pulsed Electromagnetic Field Protects against Glutamate-Induced Excitotoxicity by Modulating the Endocannabinoid System in HT22 Cells.

    abstract::Glutamate-induced excitotoxicity is common in the pathogenesis of many neurological diseases. A pulsed electromagnetic field (PEMF) exerts therapeutic effects on the nervous system, but its specific mechanism associated with excitotoxicity is still unknown. We investigated the role of PEMF exposure in regulating gluta...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Li X,Xu H,Lei T,Yang Y,Jing D,Dai S,Luo P,Xu Q

    更新日期:2017-02-06 00:00:00

  • Improving Real-Time Lower Limb Motor Imagery Detection Using tDCS and an Exoskeleton.

    abstract::The aim of this work was to test if a novel transcranial direct current stimulation (tDCS) montage boosts the accuracy of lower limb motor imagery (MI) detection by using a real-time brain-machine interface (BMI) based on electroencephalographic (EEG) signals. The tDCS montage designed was composed of two anodes and o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Rodríguez-Ugarte M,Iáñez E,Ortiz M,Azorín JM

    更新日期:2018-10-23 00:00:00

  • Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling of Cardiac Postganglionic Parasympathetic Neurons in the Late Stage of Heart Failure after Myocardial Infarction.

    abstract::Introduction: Ventricular arrhythmia is a major cause of sudden cardiac death in patients with chronic heart failure (CHF). Our recent study demonstrates that N-type Ca2+ currents in intracardiac ganglionic neurons are reduced in the late stage of CHF rats. Rat intracardiac ganglia are divided into the atrioventricula...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Zhang D,Tu H,Wang C,Cao L,Muelleman RL,Wadman MC,Li YL

    更新日期:2017-05-08 00:00:00

  • Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.

    abstract::Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

    更新日期:2018-06-20 00:00:00

  • Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?

    abstract::Intracranial chemical injection (ICI) methods have been used to identify the locations in the brain where feeding behavior can be controlled acutely. Scientists conducting ICI studies often document their injection site locations, thereby leaving kernels of valuable location data for others to use to further character...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Khan AM

    更新日期:2013-12-18 00:00:00

  • Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus.

    abstract::Risperidone (RIS), an atypical antipsychotic has been found to show anti-inflammatory effect against lipopolysaccharide (LPS)-induced inflammation. In vitro study has revealed that RIS inhibits the LPS-induced reactive oxygen species (ROS) formation. We investigated the antioxidant effects of RIS on LPS-induced oxidat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Al-Amin MM,Choudhury MFR,Chowdhury AS,Chowdhury TR,Jain P,Kazi M,Alkholief M,Alshehri SM,Reza HM

    更新日期:2018-06-08 00:00:00

  • Physiological and Pathological Brain Activation in the Anesthetized Rat Produces Hemodynamic-Dependent Cortical Temperature Increases That Can Confound the BOLD fMRI Signal.

    abstract::Anesthetized rodent models are ubiquitous in pre-clinical neuroimaging studies. However, because the associated cerebral morphology and experimental methodology results in a profound negative brain-core temperature differential, cerebral temperature changes during functional activation are likely to be principally dri...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Harris SS,Boorman LW,Das D,Kennerley AJ,Sharp PS,Martin C,Redgrave P,Schwartz TH,Berwick J

    更新日期:2018-08-14 00:00:00

  • Mixed Effects Models for Resampled Network Statistics Improves Statistical Power to Find Differences in Multi-Subject Functional Connectivity.

    abstract::Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Narayan M,Allen GI

    更新日期:2016-04-12 00:00:00

  • Performance Comparison of the Digital Neuromorphic Hardware SpiNNaker and the Neural Network Simulation Software NEST for a Full-Scale Cortical Microcircuit Model.

    abstract::The digital neuromorphic hardware SpiNNaker has been developed with the aim of enabling large-scale neural network simulations in real time and with low power consumption. Real-time performance is achieved with 1 ms integration time steps, and thus applies to neural networks for which faster time scales of the dynamic...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: van Albada SJ,Rowley AG,Senk J,Hopkins M,Schmidt M,Stokes AB,Lester DR,Diesmann M,Furber SB

    更新日期:2018-05-23 00:00:00

  • Effects of silver nanoparticles on human and rat embryonic neural stem cells.

    abstract::Silver nano-particles (Ag-NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products will almost certainly increase environmental silver levels, resulting in increased exposures and the potential for increased adverse reactions including neurotox...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Liu F,Mahmood M,Xu Y,Watanabe F,Biris AS,Hansen DK,Inselman A,Casciano D,Patterson TA,Paule MG,Slikker W Jr,Wang C

    更新日期:2015-04-08 00:00:00

  • Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis.

    abstract::Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by T helper (h)1 and/or Th17 CD4 T cells that drive inflammatory lesion development along with demyelination and neuronal damage. Defects in immune regulatory mechanisms are thought to play a role in the pathogenesis of MS. W...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Miller NM,Wang J,Tan Y,Dittel BN

    更新日期:2015-08-18 00:00:00

  • Stochastic Synapses Enable Efficient Brain-Inspired Learning Machines.

    abstract::Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

    更新日期:2016-06-29 00:00:00

  • Uniformity and Deviation of Intra-axonal Cross-sectional Area Coverage of the Gray-to-White Matter Interface.

    abstract::Diffusion magnetic resonance imaging (dMRI) is a compelling tool for investigating the structure and geometry of brain tissue based on indirect measurement of the diffusion anisotropy of water. Recent developments in global top-down tractogram optimizations enable the estimation of streamline weights, which characteri...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Sommer S,Kozerke S,Seifritz E,Staempfli P

    更新日期:2017-12-22 00:00:00

  • Early Disruption of Cortical Sleep-Related Oscillations in a Mouse Model of Dementia With Lewy Bodies (DLB) Expressing Human Mutant (A30P) Alpha-Synuclein.

    abstract::Changes in sleep behavior and sleep-related cortical activity have been reported in conditions associated with abnormal alpha-synuclein (α-syn) expression, in particular Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Notably, changes can occur in patients years before the onset of cognitive decline. Sle...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Stylianou M,Zaaimi B,Thomas A,Taylor JP,LeBeau FEN

    更新日期:2020-09-17 00:00:00

  • In vitro Methods to Cultivate Spiral Ganglion Cells, and Purification of Cellular Subtypes for Induced Neuronal Reprogramming.

    abstract::Hearing loss can develop as a consequence of primary auditory neuron degeneration. These neurons are present within the spiral ganglion of the inner ear and co-exist with glial cells that assist in neuronal maintenance and function. There are limited interventions for individuals with hearing impairment, hence novel b...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Meas SJ,Nishimura K,Scheibinger M,Dabdoub A

    更新日期:2018-11-13 00:00:00

  • Tamoxifen Activation of Cre-Recombinase Has No Persisting Effects on Adult Neurogenesis or Learning and Anxiety.

    abstract::Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreERT2-Lox system are widely used. In this study, we made use of a Nestin-CreERT2/R26R-YFP transgenic mouse ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Rotheneichner P,Romanelli P,Bieler L,Pagitsch S,Zaunmair P,Kreutzer C,König R,Marschallinger J,Aigner L,Couillard-Després S

    更新日期:2017-02-01 00:00:00

  • Coding of reward probability and risk by single neurons in animals.

    abstract::Probability and risk are important factors for value-based decision making and optimal foraging. In order to survive in an unpredictable world, organisms must be able to assess the probability and risk attached to future events and use this information to generate adaptive behavior. Recent studies in non-human primate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Burke CJ,Tobler PN

    更新日期:2011-10-11 00:00:00

  • When and How to Interpret Null Results in NIBS: A Taxonomy Based on Prior Expectations and Experimental Design.

    abstract::Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often d...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: de Graaf TA,Sack AT

    更新日期:2018-12-11 00:00:00

  • SAT: Free Software for the Semi-Automated Analysis of Rodent Brain Sections With 2,3,5-Triphenyltetrazolium Chloride Staining.

    abstract::Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCA...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Shi XF,Ai H,Lu W,Cai F

    更新日期:2019-02-12 00:00:00

  • The Involvement of Endogenous Neural Oscillations in the Processing of Rhythmic Input: More Than a Regular Repetition of Evoked Neural Responses.

    abstract::It is undisputed that presenting a rhythmic stimulus leads to a measurable brain response that follows the rhythmic structure of this stimulus. What is still debated, however, is the question whether this brain response exclusively reflects a regular repetition of evoked responses, or whether it also includes entraine...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Zoefel B,Ten Oever S,Sack AT

    更新日期:2018-03-07 00:00:00

  • The intense world syndrome--an alternative hypothesis for autism.

    abstract::Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the neuronal structures and cells affected, a unifying theory that co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Markram H,Rinaldi T,Markram K

    更新日期:2007-10-15 00:00:00

  • Identification of neural cells activated by mating stimulus in the periaqueductal gray in female rats.

    abstract::Induction of lordosis as typical female sexual behavior in rodents is dependent on a mount stimulus from males and blood levels of estrogen. Periaqueductal gray (PAG) efferent neurons have been suggested to be important for lordosis behavior; however, the neurochemical basis remains to be understood. In this study, we...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yamada S,Kawata M

    更新日期:2014-12-18 00:00:00

  • Reduced Oblique Effect in Children with Autism Spectrum Disorders (ASD).

    abstract::People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the "oblique ef...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Sysoeva OV,Davletshina MA,Orekhova EV,Galuta IA,Stroganova TA

    更新日期:2016-01-21 00:00:00

  • Impact of Stimulus Features on the Performance of a Gaze-Independent Brain-Computer Interface Based on Covert Spatial Attention Shifts.

    abstract::Regaining communication abilities in patients who are unable to speak or move is one of the main goals in decoding brain waves for brain-computer interface (BCI) control. Many BCI approaches designed for communication rely on attention to visual stimuli, commonly applying an oddball paradigm, and require both eye move...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Reichert C,Tellez Ceja IF,Sweeney-Reed CM,Heinze HJ,Hinrichs H,Dürschmid S

    更新日期:2020-12-01 00:00:00

  • Statistical learning analysis in neuroscience: aiming for transparency.

    abstract::Encouraged by a rise of reciprocal interest between the machine learning and neuroscience communities, several recent studies have demonstrated the explanatory power of statistical learning techniques for the analysis of neural data. In order to facilitate a wider adoption of these methods, neuroscientific research ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Hanke M,Halchenko YO,Haxby JV,Pollmann S

    更新日期:2010-05-15 00:00:00

  • Amyloid Beta and MicroRNAs in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a progressive mental illness characterized by memory loss and multiple cognitive impairments. In the last several decades, significant progress has been made in understanding basic biology, molecular mechanisms, and development of biomarkers and therapeutic drugs. Multiple cellular changes ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Amakiri N,Kubosumi A,Tran J,Reddy PH

    更新日期:2019-05-03 00:00:00

  • An Improved in vitro Model of Cortical Tissue.

    abstract::Intracortical electrodes for brain-machine interfaces rely on intimate contact with tissues for recording signals and stimulating neurons. However, the long-term viability of intracortical electrodes in vivo is poor, with a major contributing factor being the development of a glial scar. In vivo approaches for evaluat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Gilmour A,Poole-Warren L,Green RA

    更新日期:2019-12-17 00:00:00