Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice.

Abstract:

:Orexins (also known as hypocretins) play critical roles in the regulation of sleep/wakefulness states by activating two G-protein coupled receptors (GPCRs), orexin 1 (OX1R) and orexin 2 receptors (OX2R). In order to understand the differential contribution of both receptors in regulating sleep/wakefulness states we compared the pharmacological effects of a newly developed OX2R antagonist (2-SORA), Compound 1 m (C1 m), with those of a dual orexin receptor antagonist (DORA), suvorexant, in C57BL/6J mice. After oral administration in the dark period, both C1m and suvorexant decreased wakefulness time with similar efficacy in a dose-dependent manner. While C1m primarily increased total non-rapid eye movement (NREM) sleep time without affecting episode durations and with minimal effects on REM sleep, suvorexant increased both total NREM and REM sleep time and episode durations with predominant effects on REM sleep. Fos-immunostaining showed that both compounds affected the activities of arousal-related neurons with different patterns. The number of Fos-IR noradrenergic neurons in the locus coeruleus was lower in the suvorexant group as compared with the control and C1m-treated groups. In contrast, the numbers of Fos-IR neurons in histaminergic neurons in the tuberomamillary nucleus and serotonergic neurons in the dorsal raphe were reduced to a similar extent in the suvorexant and C1m groups as compared with the vehicle-treated group. Together, these results suggest that an orexin-mediated suppression of REM sleep via potential activation of OX1Rs in the locus coeruleus may possibly contribute to the differential effects on sleep/wakefulness exerted by a DORA as compared to a 2-SORA.

journal_name

Front Neurosci

authors

Etori K,Saito YC,Tsujino N,Sakurai T

doi

10.3389/fnins.2014.00008

subject

Has Abstract

pub_date

2014-01-31 00:00:00

pages

8

eissn

1662-4548

issn

1662-453X

journal_volume

8

pub_type

杂志文章
  • Investigations Into Bioenergetic Neuroprotection of Cone Photoreceptors: Relevance to Retinitis Pigmentosa.

    abstract::Recent studies suggest cone degeneration in retinitis pigmentosa (RP) may result from intracellular energy depletion. We tested the hypothesis that cones die when depleted of energy by examining the effect of two bioenergetic, nutraceutical agents on cone survival. The study had three specific aims: firstly, we, studi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01234

    authors: Narayan DS,Chidlow G,Wood JPM,Casson RJ

    更新日期:2019-11-15 00:00:00

  • Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders.

    abstract::ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Her...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00198

    authors: Hensel N,Rademacher S,Claus P

    更新日期:2015-06-02 00:00:00

  • microRNA-Based Biomarkers in Alzheimer's Disease (AD).

    abstract::Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple biological levels, including molecular, genetic, epigenetic, cellular and large-scale brain networks. These alterations account for multiple pathophysiological me...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.585432

    authors: Zhao Y,Jaber V,Alexandrov PN,Vergallo A,Lista S,Hampel H,Lukiw WJ

    更新日期:2020-10-30 00:00:00

  • Foveal Therapy in Blue Cone Monochromacy: Predictions of Visual Potential From Artificial Intelligence.

    abstract::Novel therapeutic approaches for treating inherited retinal degenerations (IRDs) prompt a need to understand which patients with impaired vision have the anatomical potential to gain from participation in a clinical trial. We used supervised machine learning to predict foveal function from foveal structure in blue con...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00800

    authors: Sumaroka A,Cideciyan AV,Sheplock R,Wu V,Kohl S,Wissinger B,Jacobson SG

    更新日期:2020-08-03 00:00:00

  • Convergence of Cortical, Thalamocortical, and Callosal Pathways during Human Fetal Development Revealed by Diffusion MRI Tractography.

    abstract::There has been evidence that during brain development, emerging thalamocortical (TC) and corticothalamic (CT) pathways converge in some brain regions and follow each other's trajectories to their final destinations. Corpus callosal (CC) pathways also emerge at a similar developmental stage, and are known to converge w...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00576

    authors: Wang R,Wilkinson M,Kane T,Takahashi E

    更新日期:2017-11-01 00:00:00

  • Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.

    abstract:Purpose:The phantom sound of tinnitus is considered to be associated with abnormal functional coupling between the nucleus accumbens (NAc) and the prefrontal cortex, which may form a frontostriatal top-down gating system to evaluate and modulate sensory signals. Resting-state functional magnetic resonance imaging (fMRI...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01299

    authors: Xu JJ,Cui J,Feng Y,Yong W,Chen H,Chen YC,Yin X,Wu Y

    更新日期:2019-12-06 00:00:00

  • Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.

    abstract::The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly complex polarized morphology. The motor protein complex cytoplasmic dynein has an important role ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00397

    authors: Jaarsma D,Hoogenraad CC

    更新日期:2015-10-26 00:00:00

  • Gender-typical olfactory regulation of sexual behavior in goldfish.

    abstract::It is known that olfaction is essential for the occurrence of sexual behavior in male goldfish. Sex pheromones from ovulatory females elicit male sexual behavior, chasing, and sperm releasing act. In female goldfish, ovarian prostaglandin F2α (PGF) elicits female sexual behavior, egg releasing act. It has been conside...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00091

    authors: Kawaguchi Y,Nagaoka A,Kitami A,Mitsuhashi T,Hayakawa Y,Kobayashi M

    更新日期:2014-04-30 00:00:00

  • Neurobiology of inflammation-associated anorexia.

    abstract::Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system. For instance, the aforementioned pro-inflammatory factors can stimulate the activity of peripheral sensory neurons, and induc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.23.003.2009

    authors: Gautron L,Layé S

    更新日期:2010-01-08 00:00:00

  • Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics.

    abstract::Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00485

    authors: Nuno-Perez A,Tchenio A,Mameli M,Lecca S

    更新日期:2018-07-23 00:00:00

  • Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling.

    abstract::Inducing somatic cells into neural stem cells (iNSCs) in specific ways provides a new cell therapy in a variety of neurological diseases. In the past, iNSCs were generated by transcription factors which increased the risk of mutagenesis, tumor formations, and immune reactions by viral transduction vectors. Therefore, ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00867

    authors: Duan Q,Li S,Wen X,Sunnassee G,Chen J,Tan S,Guo Y

    更新日期:2019-09-04 00:00:00

  • Role of Oscillations in Auditory Temporal Processing: A General Model for Temporal Processing of Sensory Information in the Brain?

    abstract::We review the role of oscillations in the brain and in the auditory system showing that the ability of humans to distinguish changes in pitch can be explained as a precise analysis of temporal information in auditory signals by neural oscillations. The connections between auditory brain stem chopper neurons construct ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00793

    authors: Bahmer A,Gupta DS

    更新日期:2018-10-31 00:00:00

  • Memory-Efficient Synaptic Connectivity for Spike-Timing- Dependent Plasticity.

    abstract::Spike-Timing-Dependent Plasticity (STDP) is a bio-inspired local incremental weight update rule commonly used for online learning in spike-based neuromorphic systems. In STDP, the intensity of long-term potentiation and depression in synaptic efficacy (weight) between neurons is expressed as a function of the relative...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00357

    authors: Pedroni BU,Joshi S,Deiss SR,Sheik S,Detorakis G,Paul S,Augustine C,Neftci EO,Cauwenberghs G

    更新日期:2019-04-24 00:00:00

  • Topological Pattern Recognition of Severe Alzheimer's Disease via Regularized Supervised Learning of EEG Complexity.

    abstract::Alzheimer's disease (AD) is a progressive brain disorder with gradual memory loss that correlates to cognitive deficits in the elderly population. Recent studies have shown the potentials of machine learning algorithms to identify biomarkers and functional brain activity patterns across various AD stages using electro...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00685

    authors: Fan M,Yang AC,Fuh JL,Chou CA

    更新日期:2018-10-04 00:00:00

  • Expressional Profiling of Carpet Glia in the Developing Drosophila Eye Reveals Its Molecular Signature of Morphology Regulators.

    abstract::Homeostasis in the nervous system requires intricate regulation and is largely accomplished by the blood-brain barrier (BBB). The major gate keeper of the vertebrate BBB is vascular endothelial cells, which form tight junctions (TJs). To gain insight into the development of the BBB, we studied the carpet glia, a subpe...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00244

    authors: Ho TY,Wu WH,Hung SJ,Liu T,Lee YM,Liu YH

    更新日期:2019-03-29 00:00:00

  • MicroRNA Let-7i Is a Promising Serum Biomarker for Post-stroke Cognitive Impairment and Alleviated OGD-Induced Cell Damage in vitro by Regulating Bcl-2.

    abstract:Background:The mechanism of post-stroke cognitive impairment (PSCI) has not been explained. We aimed to investigate whether miR-let-7i participates in the PSCI and illuminates its underlying role in oxygen-glucose deprivation (OGD)-induced cell apoptosis. Methods:Blood samples from 36 subjects with PSCI and 38 with po...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00215

    authors: Wang ZQ,Li K,Huang J,Huo TT,Lv PY

    更新日期:2020-03-24 00:00:00

  • Safety and Efficacy of Magnetic Resonance-Guided Focused Ultrasound Surgery With Autofocusing Echo Imaging.

    abstract:Objective:Magnetic resonance-guided focused ultrasound surgery (MRgFUS) lesioning is a new treatment for brain disorders. However, the skull is a major barrier of ultrasound sonication in MRgFUS because it has an irregular surface and varies its size and shape among individuals. We recently developed the concept of sku...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.592763

    authors: Chang KW,Rachmilevitch I,Chang WS,Jung HH,Zadicario E,Prus O,Chang JW

    更新日期:2021-01-12 00:00:00

  • T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls.

    abstract::Alzheimer's disease (AD), a chronic multifactorial and complex neurodegenerative disorder is a leading cause of dementia. Recently, neuroinflammation has been hypothesized as a contributing factor to AD pathogenesis. The role of adaptive immune responses against neuronal antigens, which can either confer protection or...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00874

    authors: Dhanwani R,Pham J,Premlal ALR,Frazier A,Kumar A,Pero ME,Bartolini F,Dutra JR,Marder KS,Peters B,Sulzer D,Sette A,Lindestam Arlehamn CS

    更新日期:2020-08-27 00:00:00

  • Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice.

    abstract::There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer's disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurodegenerative and clinical features of AD. Nevertheless, how the brain in...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00476

    authors: Bonham LW,Geier EG,Steele NZR,Holland D,Miller BL,Dale AM,Desikan RS,Yokoyama JS,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2018-07-16 00:00:00

  • Supplemental Stimulation Improves Swing Phase Kinematics During Exoskeleton Assisted Gait of SCI Subjects With Severe Muscle Spasticity.

    abstract::Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00374

    authors: Ekelem A,Goldfarb M

    更新日期:2018-06-01 00:00:00

  • Coordinate transformation approach to social interactions.

    abstract::A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances toward our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-ce...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00147

    authors: Chang SW

    更新日期:2013-08-21 00:00:00

  • Identification of neural cells activated by mating stimulus in the periaqueductal gray in female rats.

    abstract::Induction of lordosis as typical female sexual behavior in rodents is dependent on a mount stimulus from males and blood levels of estrogen. Periaqueductal gray (PAG) efferent neurons have been suggested to be important for lordosis behavior; however, the neurochemical basis remains to be understood. In this study, we...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00421

    authors: Yamada S,Kawata M

    更新日期:2014-12-18 00:00:00

  • Circadian adaptations to meal timing: neuroendocrine mechanisms.

    abstract::Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli. A master circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) is directly entrained by daily light-dark (LD) cycles, and coordinates ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2013.00185

    authors: Patton DF,Mistlberger RE

    更新日期:2013-10-14 00:00:00

  • Restoration of motor function following spinal cord injury via optimal control of intraspinal microstimulation: toward a next generation closed-loop neural prosthesis.

    abstract::Movement is planned and coordinated by the brain and carried out by contracting muscles acting on specific joints. Motor commands initiated in the brain travel through descending pathways in the spinal cord to effector motor neurons before reaching target muscles. Damage to these pathways by spinal cord injury (SCI) c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2014.00296

    authors: Grahn PJ,Mallory GW,Berry BM,Hachmann JT,Lobel DA,Lujan JL

    更新日期:2014-09-17 00:00:00

  • Modulation of Illusory Auditory Perception by Transcranial Electrical Stimulation.

    abstract::The aim of the present study was to test whether transcranial electrical stimulation can modulate illusory perception in the auditory domain. In two separate experiments we applied transcranial Direct Current Stimulation (anodal/cathodal tDCS, 2 mA; N = 60) and high-frequency transcranial Random Noise Stimulation (hf-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00351

    authors: Prete G,D'Anselmo A,Tommasi L,Brancucci A

    更新日期:2017-06-20 00:00:00

  • Corrigendum: Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.

    abstract::[This corrects the article DOI: 10.3389/fnins.2019.01334.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2020.00426

    authors: Ooi LQR,Wen MC,Ng SY,Chia NS,Chew IHM,Lee W,Xu Z,Hartono S,Tan EK,Chan LL,Tan LC

    更新日期:2020-05-12 00:00:00

  • Intracortical cartography in an agranular area.

    abstract::A well-defined granular layer 4 is a defining cytoarchitectonic feature associated with sensory areas of mammalian cerebral cortex, and one with hodological significance: the local axons ascending from cells in thalamorecipient layer 4 and connecting to layer 2/3 pyramidal neurons form a major feedforward excitatory i...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.030.2009

    authors: Shepherd GM

    更新日期:2009-12-15 00:00:00

  • Discounting in Pigeons When the Choice is between Two Delayed Rewards: Implications for Species Comparisons.

    abstract::Studies of delay discounting typically have involved choices between smaller, immediate outcomes and larger, delayed outcomes. In a study of delay discounting in humans, Green et al. (2005) added a period of time prior to both outcomes, creating a delay common to both. They found that the subjective value of the more ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00096

    authors: Calvert AL,Green L,Myerson J

    更新日期:2011-08-17 00:00:00

  • A Single Dose of Methylprednisolone Improves Aversive Memory Consolidation and Extinction in Rats.

    abstract::Aversive memory is essential for survival, but in some situations its exacerbation can be potentially dangerous. There are several ways to modulate memory, among them, through stress-related hormones physiological release or administration of exogenous substances analogous to them. Recently, our group shown that a chr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01167

    authors: Gonçalves R,de Vargas LDS,Mello-Carpes PB

    更新日期:2019-10-31 00:00:00

  • Antibiotic Driven Changes in Gut Motility Suggest Direct Modulation of Enteric Nervous System.

    abstract::Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be the basis of antibiotic-induced neurophysiological and behavioral changes. However, relatively little research has addressed whether antibiotics act directly on the host nervous system to produce these changes. We aimed to identif...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00588

    authors: Delungahawatta T,Amin JY,Stanisz AM,Bienenstock J,Forsythe P,Kunze WA

    更新日期:2017-10-20 00:00:00