The FMRP regulon: from targets to disease convergence.

abstract：:The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with a dimer of serum response factor (SRF) at the SRE site, and its phosphorylation occurs at specific residues in response...

journal_title：Frontiers in neuroscience

authors： Besnard A,Galan-Rodriguez B,Vanhoutte P,Caboche J

更新日期：2011-03-16 00:00:00

abstract：:Drug addiction is a chronic disease characterized by recurring episodes of abstinence and relapse. The precise mechanisms underlying this pattern are yet to be elucidated, but stress is thought to be a major factor in relapse. Recently, we reported that rats under withdrawal and exposed to a mild chronic stressor, pro...

journal_title：Frontiers in neuroscience

authors： Sedki F,Abbas Z,Angelis S,Martin J,D'Cunha T,Shalev U

更新日期：2013-06-06 00:00:00

abstract：:Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, a...

journal_title：Frontiers in neuroscience

authors： Udovin LD,Kobiec T,Herrera MI,Toro-Urrego N,Kusnier CF,Kölliker-Frers RA,Ramos-Hryb AB,Luaces JP,Otero-Losada M,Capani F

更新日期：2020-01-08 00:00:00

abstract：:The aim of our study was to evaluate the effects of chronic administration of nandrolone-decanoate (ND) or testosterone-enanthate (TE) in supraphysiological doses and a prolonged swimming protocol, alone and in combination with ND or TE, on anxiety-like behavior in rats. We investigated the immunohistochemical alterat...

journal_title：Frontiers in neuroscience

authors： Joksimovic J,Selakovic D,Jovicic N,Mitrovic S,Mihailovic V,Katanic J,Milovanovic D,Rosic G

更新日期：2019-02-26 00:00:00

abstract：:We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...

journal_title：Frontiers in neuroscience

authors： Chota S,McLelland D,Lavergne L,Zimmermann E,Cavanagh P,VanRullen R

更新日期：2020-03-17 00:00:00

abstract：:Electroencephalography (EEG) is perhaps the most widely used brain-imaging technique for pediatric populations. However, EEG signals are prone to distortion by motion. Compared to adults, infants' motion is both more frequent and less stereotypical yet motion effects on the infant EEG signal are largely undocumented. ...

journal_title：Frontiers in neuroscience

authors： Georgieva S,Lester S,Noreika V,Yilmaz MN,Wass S,Leong V

更新日期：2020-04-28 00:00:00

abstract：:Stroke patients often use trunk to compensate for impaired upper limb motor function during upper limb rehabilitation training, which results in a reduced rehabilitation training effect. Detecting trunk compensations can improve the effect of rehabilitation training. This study investigates the feasibility of a surfac...

journal_title：Frontiers in neuroscience

authors： Ma K,Chen Y,Zhang X,Zheng H,Yu S,Cai S,Xie L

更新日期：2019-11-21 00:00:00

abstract：:Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant. Given the limitations in the efficacy of current pharmacotherapies to treat these disorders, research in developing alternative pharm...

journal_title：Frontiers in neuroscience

authors： Rahman S,Engleman EA,Bell RL

更新日期：2015-01-15 00:00:00

abstract：:Intracortical electrodes for brain-machine interfaces rely on intimate contact with tissues for recording signals and stimulating neurons. However, the long-term viability of intracortical electrodes in vivo is poor, with a major contributing factor being the development of a glial scar. In vivo approaches for evaluat...

journal_title：Frontiers in neuroscience

authors： Gilmour A,Poole-Warren L,Green RA

更新日期：2019-12-17 00:00:00

abstract：:Tapping in time to a metronome beat (hereafter beat synchronization) shows considerable variability in child populations, and individual differences in beat synchronization are reliably related to reading development. Children with developmental dyslexia show impairments in beat synchronization. These impairments may ...

journal_title：Frontiers in neuroscience

authors： Colling LJ,Noble HL,Goswami U

更新日期：2017-07-12 00:00:00

abstract：:Defects in the endoplasmic reticulum (ER) membrane shaping and interaction with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 family, is implicated in SPG31, an autosomal dominant form of HSP, and ...

journal_title：Frontiers in neuroscience

authors： Napoli B,Gumeni S,Forgiarini A,Fantin M,De Filippis C,Panzeri E,Vantaggiato C,Orso G

更新日期：2019-11-19 00:00:00

abstract：:The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the ide...

journal_title：Frontiers in neuroscience

authors： Eiriz MF,Valero J,Malva JO,Bernardino L

更新日期：2014-06-16 00:00:00

abstract：:D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis "Khat." NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there is little information about the role of dopamine receptors on NP...

journal_title：Frontiers in neuroscience

authors： Kalyanasundar B,Perez CI,Arroyo B,Moreno MG,Gutierrez R

更新日期：2020-10-16 00:00:00

abstract：:Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead to slacking when the assistance is too supportive. Preserving the engagement of t...

journal_title：Frontiers in neuroscience

authors： Grimm F,Naros G,Gharabaghi A

更新日期：2016-11-15 00:00:00

abstract：:Epilepsy is a serious neurological disorder and is characterized by recurrent and unprovoked seizures. A critical pathological factor in the seizure genesis is neuronal loss. Until now, apart from the known regulatory cell death pathways, ferroptosis is a newly discovered type of cell death with the features of iron a...

journal_title：Frontiers in neuroscience

authors： Mao XY,Zhou HH,Jin WL

更新日期：2019-07-17 00:00:00

abstract：:The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions. Extracellular cues such as Reelin induce intracellular signaling cascades through the protein phosphorylation. Migrating neurons also have intrinsic machineries t...

journal_title：Frontiers in neuroscience

authors： Ohshima T

更新日期：2015-01-13 00:00:00

abstract：:The walking mechanism of a prosthetic leg user is a tightly coordinated movement of several joints and limb segments. The interaction among the voluntary and mechanical joints and segments requires particular biomechanical insight. This study aims to analyze the inter-relationship between amputees' voluntary and mecha...

journal_title：Frontiers in neuroscience

authors： Jasni F,Hamzaid NA,Mohd Syah NE,Chung TY,Abu Osman NA

更新日期：2017-04-25 00:00:00

abstract：:Heterogeneity between late-onset Parkinson's disease (LOPD) and early-onset Parkinson's disease (EOPD) is mainly reflected in the following aspects including genetics, disease progression, drug response, clinical manifestation, and neuropathological change. Although many studies have investigated these differences in ...

journal_title：Frontiers in neuroscience

authors： Yue Y,Jiang Y,Shen T,Pu J,Lai HY,Zhang B

更新日期：2020-02-25 00:00:00

abstract：:Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...

journal_title：Frontiers in neuroscience

authors： Barnard RA,Pomaville MB,O'Roak BJ

更新日期：2015-12-17 00:00:00

abstract：:This study was designed to investigate the molecular mechanism of stroke and to explore the effect of miR-224-5p in hypoxic cortical neurons. Firstly, we established a middle cerebral artery occlusion (MCAO) model with Sprague-Dawley rats. Triphenyltetrazolium chloride (TTC) staining showed the brain infarction of an ...

journal_title：Frontiers in neuroscience

authors： Liu LL,Qiao S,Wang ML,Wu HK,Su YX,Wang KM,Liu XW

更新日期：2020-06-25 00:00:00

abstract：:Spinal cord injury (SCI), one of the most severe types of neurological damage, results in persistent motor and sensory dysfunction and involves complex gene alterations. Circular RNAs (circRNAs) are a recently discovered class of regulatory molecules, and their roles in SCI still need to be addressed. This study compr...

journal_title：Frontiers in neuroscience

authors： Wu R,Mao S,Wang Y,Zhou S,Liu Y,Liu M,Gu X,Yu B

更新日期：2019-12-10 00:00:00

abstract：:The utility of premovement electroencephalography (EEG) for decoding movement intention during a reaching task has been demonstrated. However, the kind of information the brain represents regarding the intended target during movement preparation remains unknown. In the present study, we investigated which movement par...

journal_title：Frontiers in neuroscience

authors： Kim H,Yoshimura N,Koike Y

更新日期：2019-11-01 00:00:00

abstract：:To function effectively, brains need to make predictions about their environment based on past experience, i.e., they need to learn about their environment. The algorithms by which learning occurs are of interest to neuroscientists, both in their own right (because they exist in the brain) and as a tool to model parti...

journal_title：Frontiers in neuroscience

authors： O'Reilly JX

更新日期：2013-06-14 00:00:00

abstract：:Recent non-invasive brain stimulation techniques in combination with motor training can enhance neuroplasticity and learning. It is reasonable to assume that such neuroplasticity-based interventions constitute a useful rehabilitative tool for patients with Parkinson's Disease (PD). Regarding motor skill training, many...

journal_title：Frontiers in neuroscience

authors： Horiba M,Ueki Y,Nojima I,Shimizu Y,Sahashi K,Itamoto S,Suzuki A,Yamada G,Matsukawa N,Wada I

更新日期：2019-06-19 00:00:00

abstract：:Monoamine oxidase-A (MAO-A) and MAO-B have both been implicated in the pathology of Alzheimer disease (AD). We examined 60 autopsied control and AD donor brain samples to determine how well MAO function aligned with two major risk factors for AD, namely sex and APOE ε4 status. MAO-A activity was increased in AD cortic...

journal_title：Frontiers in neuroscience

authors： Quartey MO,Nyarko JNK,Pennington PR,Heistad RM,Klassen PC,Baker GB,Mousseau DD

更新日期：2018-06-26 00:00:00

abstract：:Background: Gambling disorder (GD) is the most common behavioral addiction and shares pathophysiological and clinical features with substance use disorders (SUDs). Effective therapeutic interventions for GD are lacking. Non-invasive brain stimulation (NIBS) may represent a promising treatment option for GD. Objective:...

journal_title：Frontiers in neuroscience

authors： Zucchella C,Mantovani E,Federico A,Lugoboni F,Tamburin S

更新日期：2020-08-18 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) allows studying human brain function non-invasively up to the spatial resolution of cortical columns and layers. Most fMRI acquisitions rely on the blood oxygenation level dependent (BOLD) contrast employing T(*) 2 weighted 2D multi-slice echo-planar imaging (EPI). At ultra...

journal_title：Frontiers in neuroscience

authors： Kemper VG,De Martino F,Vu AT,Poser BA,Feinberg DA,Goebel R,Yacoub E

更新日期：2015-05-05 00:00:00

abstract：:Inhibitory control, the ability to suppress an immediate dominant response, has been shown to predict academic and career success, socioemotional wellbeing, wealth, and physical health. Learning to play a musical instrument engages various sensorimotor processes and draws on cognitive capacities including inhibition a...

journal_title：Frontiers in neuroscience

authors： Hennessy SL,Sachs ME,Ilari B,Habibi A

更新日期：2019-10-16 00:00:00

abstract：:The neurohormone oxytocin (OXT) has been found to mediate the regulation of complex socioemotional cognition in multiple ways both in humans and other animals. Recent studies have investigated the effects of OXT in different levels of analysis (from genetic to behavioral) chiefly targeting its impact on the social com...

journal_title：Frontiers in neuroscience

authors： Theofanopoulou C

更新日期：2016-06-14 00:00:00

abstract：:Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great potential for combating bacterial resistance. AMPs can be both bacteriostatic and bactericidal, induce rapid killing and display a lower propensity to develop resistance than do conventional antibiotics. Despite significant progres...

journal_title：Frontiers in neuroscience

authors： Li J,Koh JJ,Liu S,Lakshminarayanan R,Verma CS,Beuerman RW

更新日期：2017-02-14 00:00:00