Exposure in vivo Induced Changes in Neural Circuitry for Pain-Related Fear: A Longitudinal fMRI Study in Chronic Low Back Pain.

abstract：:Blood-brain barrier opening (BBBO) with pulsed Focused Ultrasound (pFUS) and microbubbles (MB) has received increasing interest as a method for neurotherapeutics of the central nervous system. In general, conventional MRI [i.e., T2w, T2∗w, gadolinium (Gd) enhanced T1w] is used to monitor the effects of pFUS+MB on BBBO...

journal_title：Frontiers in neuroscience

authors： Tu TW,Kovacs ZI,Sundby M,Witko JA,Papadakis GZ,Reid WC,Hammoud DA,Frank JA

更新日期：2020-08-25 00:00:00

abstract：:Although many scholars deem non-invasive measures of neurophysiology to have promise in assessing learning, these measures are currently not widely applied, neither in educational settings nor in training. How can non-invasive neurophysiology provide insight into learning and how should research on this topic move for...

journal_title：Frontiers in neuroscience

authors： Tinga AM,de Back TT,Louwerse MM

更新日期：2020-06-05 00:00:00

abstract：:Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patt...

journal_title：Frontiers in neuroscience

authors： Luan Y,Wang C,Jiao Y,Tang T,Zhang J,Teng GJ

更新日期：2019-02-05 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive mental illness characterized by memory loss and multiple cognitive impairments. In the last several decades, significant progress has been made in understanding basic biology, molecular mechanisms, and development of biomarkers and therapeutic drugs. Multiple cellular changes ...

journal_title：Frontiers in neuroscience

authors： Amakiri N,Kubosumi A,Tran J,Reddy PH

更新日期：2019-05-03 00:00:00

abstract：:Over the past several decades, clinical studies have shown significant analgesic effects of acupuncture. The efficacy of acupuncture treatment has improved with the recent development of nanoporous needles (PN), which are produced by modifying the needle surface using nanotechnology. Herein, we showed that PN at acupo...

journal_title：Frontiers in neuroscience

authors： Bae SJ,Lim J,Lee S,Choi H,Jang JH,Kim YK,Oh JY,Park JH,Jung HS,Chae Y,In SI,Park HJ

更新日期：2019-06-20 00:00:00

abstract：:The melanocortin receptors (MCRs) are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the MCRs are only found in chordates. The presence of five genes in the family (i.e., mc1r, mc2r, mc3r, mc4r, mc5r) in representatives of...

journal_title：Frontiers in neuroscience

authors： Dores RM

更新日期：2013-04-10 00:00:00

abstract：:Aggressive behavior is associated with dysfunctional frontolimbic emotion regulation circuits. Recent findings suggest serotonin as a primary transmitter for prefrontal amygdala control. However, the association between serotonin levels, amygdala regulation, and aggression is still a matter of debate. Neurobehavioral ...

journal_title：Frontiers in neuroscience

authors： Klasen M,Wolf D,Eisner PD,Eggermann T,Zerres K,Zepf FD,Weber R,Mathiak K

更新日期：2019-02-22 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is increasingly used in both research and therapeutic settings, but its precise mechanisms remain largely unknown. At a neuronal level, tDCS modulates cortical excitability by shifting the resting membrane potential in a polarity-dependent way: anodal stimulation increase...

journal_title：Frontiers in neuroscience

authors： Varoli E,Pisoni A,Mattavelli GC,Vergallito A,Gallucci A,Mauro LD,Rosanova M,Bolognini N,Vallar G,Romero Lauro LJ

更新日期：2018-05-15 00:00:00

abstract：:Possible risks stemming from the employment of novel, micrometer-thin printed electrodes for direct current neural stimulation are discussed. To assess those risks, electrochemical methods are used, including cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Experiments were cond...

journal_title：Frontiers in neuroscience

authors： Pepłowski A,Rathi S,Piotrkowski B,Ziółkowski R,Janczak D,Krzemiński J,Brosch M,Jakubowska M

更新日期：2020-10-29 00:00:00

abstract：:Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain in mice. One week af...

journal_title：Frontiers in neuroscience

authors： Jang JH,Kim YK,Jung WM,Kim HK,Song EM,Kim HY,Oh JY,Park JY,Ryu Y,Song MY,Park HJ

更新日期：2019-09-20 00:00:00

abstract：:Recently, Parkinson's disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs neurotransmission. Here we use a single vesicle fusion assay with ms time resolut...

journal_title：Frontiers in neuroscience

authors： Hawk BJD,Khounlo R,Shin YK

更新日期：2019-03-21 00:00:00

abstract：:In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with ...

journal_title：Frontiers in neuroscience

authors： Köbe T,Witte AV,Schnelle A,Tesky VA,Pantel J,Schuchardt JP,Hahn A,Bohlken J,Grittner U,Flöel A

更新日期：2017-03-07 00:00:00

abstract：:Recent studies have shown the ability to record high-γ signals (80-160 Hz) in electroencephalogram (EEG) from traumatic brain injury (TBI) patients who have had hemicraniectomies. However, extraction of the movement-related high-γ remains challenging due to a confounding bandwidth overlap with surface electromyogram (...

journal_title：Frontiers in neuroscience

authors： Li Y,Wang PT,Vaidya MP,Flint RD,Liu CY,Slutzky MW,Do AH

更新日期：2020-11-24 00:00:00

abstract：:Beside diverse therapeutic properties of palmitoylethanolamide (PEA) including: neuroprotection, inflammation and pain alleviation, prophylactic effects have also been reported in animal models of infections, inflammation, and neurological diseases. The availability of PEA as (ultra)micronized nutraceutical formulatio...

journal_title：Frontiers in neuroscience

authors： Lerner R,Pascual Cuadrado D,Post JM,Lutz B,Bindila L

更新日期：2019-06-11 00:00:00

abstract：:Neuromorphic computing employs models of neuronal circuits to solve computing problems. Neuromorphic hardware systems are now becoming more widely available and "neuromorphic algorithms" are being developed. As they are maturing toward deployment in general research environments, it becomes important to assess and com...

journal_title：Frontiers in neuroscience

authors： Diamond A,Nowotny T,Schmuker M

更新日期：2016-01-08 00:00:00

abstract：:Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation. Abnormal regulation of 5-HT occurs in gastrointestinal disorders and Inflammatory Bowel Diseases (IBD...

journal_title：Frontiers in neuroscience

authors： Linan-Rico A,Ochoa-Cortes F,Beyder A,Soghomonyan S,Zuleta-Alarcon A,Coppola V,Christofi FL

更新日期：2016-12-19 00:00:00

abstract：Purpose:To evaluate the effect of resolution on iron content using quantitative susceptibility mapping (QSM); to verify the consistency of QSM across field strengths and manufacturers in evaluating the iron content of deep gray matter (DGM) of the human brain using subjects from multiple sites; and to establish a susce...

journal_title：Frontiers in neuroscience

authors： Li Y,Sethi SK,Zhang C,Miao Y,Yerramsetty KK,Palutla VK,Gharabaghi S,Wang C,He N,Cheng J,Yan F,Haacke EM

更新日期：2021-01-06 00:00:00

abstract：:Studies of delay discounting typically have involved choices between smaller, immediate outcomes and larger, delayed outcomes. In a study of delay discounting in humans, Green et al. (2005) added a period of time prior to both outcomes, creating a delay common to both. They found that the subjective value of the more ...

journal_title：Frontiers in neuroscience

authors： Calvert AL,Green L,Myerson J

更新日期：2011-08-17 00:00:00

abstract：:Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

journal_title：Frontiers in neuroscience

authors： Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

更新日期：2015-10-23 00:00:00

abstract：:Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronal subtypes and their placement along the three-dimensional axis. Over recent years, our knowledge of the regulatory mechanisms ...

journal_title：Frontiers in neuroscience

authors： Toma K,Hanashima C

更新日期：2015-08-11 00:00:00

abstract：:Overview- One hundred and ten years since its first description Alzheimer's disease (AD) still retains its prominent status: (i) as the industrialized world's number one cause of age-related intellectual impairment and cognitive decline; (ii) as this country's most rapidly expanding socioeconomic and healthcare concer...

journal_title：Frontiers in neuroscience

authors： Zhao Y,Alexandrov PN,Lukiw WJ

更新日期：2016-02-25 00:00:00

abstract：:The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularl...

journal_title：Frontiers in neuroscience

authors： Rhea EM,Banks WA

更新日期：2019-06-04 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive brain disorder with gradual memory loss that correlates to cognitive deficits in the elderly population. Recent studies have shown the potentials of machine learning algorithms to identify biomarkers and functional brain activity patterns across various AD stages using electro...

journal_title：Frontiers in neuroscience

authors： Fan M,Yang AC,Fuh JL,Chou CA

更新日期：2018-10-04 00:00:00

abstract：:Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infu...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Wey HY,Fox PT,Lancaster JL,Davis MD,Wang DJ,Lin AL,Bastarrachea RA,Andrade MC,Mattern V,Frost P,Higgins PB,Comuzzie AG,Voruganti VS

更新日期：2017-02-14 00:00:00

abstract：:Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead to slacking when the assistance is too supportive. Preserving the engagement of t...

journal_title：Frontiers in neuroscience

authors： Grimm F,Naros G,Gharabaghi A

更新日期：2016-11-15 00:00:00

abstract：Objective:To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods:We e...

journal_title：Frontiers in neuroscience

authors： Wang X,Guo Y,Zhang Y,Li J,Gao Z,Li Y,Zhou T,Zhang H,He J,Cong F

更新日期：2020-04-28 00:00:00

abstract：Purpose:Brain iron accumulation has been suggested as a pathomechanism in patients with type 2 diabetes mellitus (T2DM) with cognitive impairment. This research aims to examine the total-brain pattern of iron accumulation in relation to executive function decline in patients with T2DM by voxel-based quantitative suscep...

journal_title：Frontiers in neuroscience

authors： Li J,Zhang Q,Zhang N,Guo L

更新日期：2021-01-15 00:00:00

abstract：Purpose:To improve the metoprolol therapeutic effectiveness, we aimed to explore whether baseline heart rate variability (HRV) indicators before metoprolol treatment were useful for predicting its efficacy for postural tachycardia syndrome (POTS). Methods:We recruited 45 children with POTS who received metoprolol and ...

journal_title：Frontiers in neuroscience

authors： Wang Y,Zhang C,Chen S,Liu P,Wang Y,Tang C,Jin H,Du J

更新日期：2019-11-12 00:00:00

abstract：:The acute phase of stroke is accompanied by functional changes in the activity and interplay of both hemispheres. In healthy subjects, gender is known to impact the functional brain organization. We investigated whether gender influences also acute stroke functional changes. In thirty-five ischemic stroke patients, we...

journal_title：Frontiers in neuroscience

authors： Di Lazzaro V,Pellegrino G,Di Pino G,Ranieri F,Lotti F,Florio L,Capone F

更新日期：2016-01-29 00:00:00

abstract：:Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

journal_title：Frontiers in neuroscience

authors： Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

更新日期：2016-06-30 00:00:00