Anti-microRNAs as Novel Therapeutic Agents in the Clinical Management of Alzheimer's Disease.

abstract：:Sensory information can interact to impact perception and behavior. Foods are appreciated according to their appearance, smell, taste and texture. Athletes and dancers combine visual, auditory, and somatosensory information to coordinate their movements. Under laboratory settings, detection and discrimination are like...

journal_title：Frontiers in neuroscience

authors： Sperdin HF,Cappe C,Murray MM

更新日期：2010-05-15 00:00:00

abstract：:Learning a new language requires the use of extensive neural networks and can represent a powerful tool to reorganize brain neuroplasticity. In this study, we analyze how a 4 months long second language learning program (16, 2 h sessions) can lead to functional changes in the brain of healthy elderly individuals. A la...

journal_title：Frontiers in neuroscience

authors： Bubbico G,Chiacchiaretta P,Parenti M,di Marco M,Panara V,Sepede G,Ferretti A,Perrucci MG

更新日期：2019-05-15 00:00:00

abstract：:In our complex acoustic environment, we are confronted with a mixture of sounds produced by several simultaneous sources. However, we rarely perceive these sounds as incomprehensible noise. Our brain uses perceptual organization processes to independently follow the emission of each sound source over time. If the acou...

journal_title：Frontiers in neuroscience

authors： Bidet-Caulet A,Bertrand O

更新日期：2009-09-15 00:00:00

abstract：:Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

journal_title：Frontiers in neuroscience

authors： Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

更新日期：2020-06-16 00:00:00

abstract：:Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and i...

journal_title：Frontiers in neuroscience

authors： Mondello SE,Kasten MR,Horner PJ,Moritz CT

更新日期：2014-02-27 00:00:00

abstract：:The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

journal_title：Frontiers in neuroscience

authors： Zhang X,Gong Q

更新日期：2019-02-26 00:00:00

abstract：:Several studies of semantic memory in non-musical domains involving recognition of items from long-term memory have shown an age-related shift from the medial temporal lobe structures to the frontal lobe. However, the effects of aging on musical semantic memory remain unexamined. We compared activation associated with...

journal_title：Frontiers in neuroscience

authors： Sikka R,Cuddy LL,Johnsrude IS,Vanstone AD

更新日期：2015-10-06 00:00:00

abstract：:The mechanisms underlying the beneficial effects of deep brain stimulation (DBS) for Parkinson's disease (PD) remain poorly understood and are still under debate. This has hindered the development of adaptive DBS (aDBS). For further progress in aDBS, more insight into the dynamics of PD is needed, which can be obtaine...

journal_title：Frontiers in neuroscience

authors： Mohammed A,Bayford R,Demosthenous A

更新日期：2020-05-19 00:00:00

abstract：:This paper developed a cognitive task-load (CTL) classification algorithm and allocation strategy to sustain the optimal operator CTL levels over time in safety-critical human-machine integrated systems. An adaptive human-machine system is designed based on a non-linear dynamic CTL classifier, which maps a set of elec...

journal_title：Frontiers in neuroscience

authors： Zhang J,Yin Z,Wang R

更新日期：2017-03-17 00:00:00

abstract：:Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

journal_title：Frontiers in neuroscience

authors： Browning KN

更新日期：2015-10-29 00:00:00

abstract：:Traumatic brain injury (TBI) is a kind of severe brain injury characterized with a high incidence rate and a high disability rate. Low-intensity transcranial ultrasound stimulation (LITUS) is a promising neuroprotective method for improving the functional prognosis of TBI. The fractional anisotropy (FA) value and mean...

journal_title：Frontiers in neuroscience

authors： Zheng T,Du J,Yuan Y,Wu S,Jin Y,Wang Z,Liu D,Shi Q,Wang X,Liu L

更新日期：2020-03-10 00:00:00

abstract：:Identifying the multiple contributors to the audiometric loss of a hearing impaired (HI) listener at a particular frequency is becoming gradually more useful as new treatments are developed. Here, we infer the contribution of inner (IHC) and outer hair cell (OHC) dysfunction to the total audiometric loss in a sample o...

journal_title：Frontiers in neuroscience

authors： Johannesen PT,Pérez-González P,Lopez-Poveda EA

更新日期：2014-07-23 00:00:00

abstract：:Aging is a complex natural phenomenon that is manifested by degenerative changes in the structure and function of cells and tissues. D-Galactose-induced aging mice are an artificial accelerated aging model that causes memory and learning impairment, oxidative stress, and neuroinflammation. In this study, we examined t...

journal_title：Frontiers in neuroscience

authors： Li H,Zheng L,Chen C,Liu X,Zhang W

更新日期：2019-09-18 00:00:00

abstract：:Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent diseases in the elderly population worldwide. A growing body of epidemiological studies suggest that people with T2DM are at a higher risk of developing AD. Likewise, AD brains are less capable of glucose uptake from the surroun...

journal_title：Frontiers in neuroscience

authors： Chatterjee S,Mudher A

更新日期：2018-06-08 00:00:00

abstract：:Micro-Graphitic Single Crystal Diamond Multi Electrode Arrays (μG-SCD-MEAs) have so far been used as amperometric sensors to detect catecholamines from chromaffin cells and adrenal gland slices. Besides having time resolution and sensitivity that are comparable with carbon fiber electrodes, that represent the gold sta...

journal_title：Frontiers in neuroscience

authors： Tomagra G,Picollo F,Battiato A,Picconi B,De Marchis S,Pasquarelli A,Olivero P,Marcantoni A,Calabresi P,Carbone E,Carabelli V

更新日期：2019-04-09 00:00:00

abstract：:In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with ...

journal_title：Frontiers in neuroscience

authors： Köbe T,Witte AV,Schnelle A,Tesky VA,Pantel J,Schuchardt JP,Hahn A,Bohlken J,Grittner U,Flöel A

更新日期：2017-03-07 00:00:00

abstract：:Neuroscientific imaging evidence (NIE) has become an integral part of the criminal justice system in the United States. However, in most legal cases, NIE is submitted and used only to mitigate penalties because the court does not recognize it as substantial evidence, considering its lack of reliability. Nevertheless, ...

journal_title：Frontiers in neuroscience

authors： Jun J,Yoo S

更新日期：2018-03-01 00:00:00

abstract：:Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm and its disappearance from the nucleus are pathological features of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) and are directly involved in the pathogenesis of these conditions. TDP-43 is an essential nuclear protein...

journal_title：Frontiers in neuroscience

authors： Sugai A,Kato T,Koyama A,Koike Y,Kasahara S,Konno T,Ishihara T,Onodera O

更新日期：2018-02-01 00:00:00

abstract：:Whereas major insights into the neuronal basis of adaptive behavior have been gained from the study of automatic behaviors, including reflexive and rhythmic motor acts, the neural substrates for goal-directed behaviors in which decision-making about action selection and initiation are crucial, remain poorly understood...

journal_title：Frontiers in neuroscience

authors： Nargeot R,Simmers J

更新日期：2012-07-26 00:00:00

abstract：:Recently, the putative association between selective serotonin reuptake inhibitor (SSRI) exposure during pregnancy and the development of social disorders in children has gained increased attention. However, clinical studies struggle with the confounding effects of maternal depression typically co-occurring with antid...

journal_title：Frontiers in neuroscience

authors： Houwing DJ,Staal L,Swart JM,Ramsteijn AS,Wöhr M,de Boer SF,Olivier JDA

更新日期：2019-03-12 00:00:00

abstract：:The menstrual cycle has attracted research interest ever since the 1930s. For many researchers the menstrual cycle is an excellent model of ovarian steroid influence on emotion, behavior, and cognition. Over the past years methodological improvements in menstrual cycle studies have been noted, and this review summariz...

journal_title：Frontiers in neuroscience

authors： Sundström Poromaa I,Gingnell M

更新日期：2014-11-24 00:00:00

abstract：:Modern high field and ultra high field magnetic resonance imaging (MRI) experiments routinely collect multi-dimensional data with high spatial resolution, whether multi-parametric structural, diffusion or functional MRI. While diffusion and functional imaging have benefited from recent advances in multi-dimensional si...

journal_title：Frontiers in neuroscience

authors： Bazin PL,Alkemade A,van der Zwaag W,Caan M,Mulder M,Forstmann BU

更新日期：2019-10-09 00:00:00

abstract：:Chronic glial activation is characterized by an increased number of activated microglia and astroglia; these secrete free radicals and cytotoxic cytokines, subsequently causing neuronal damage. This study investigated the hypothesis that a soy-lecithin based phytosomal curcumin formulation can decrease glial activatio...

journal_title：Frontiers in neuroscience

authors： Ullah F,Liang H,Niedermayer G,Münch G,Gyengesi E

更新日期：2020-03-12 00:00:00

abstract：:Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis (protein homeostasis) is an essential factor in maintaining a persistent environment for neuronal activ...

journal_title：Frontiers in neuroscience

authors： Lehtonen Š,Sonninen TM,Wojciechowski S,Goldsteins G,Koistinaho J

更新日期：2019-05-10 00:00:00

abstract：:Background: The relationship between awareness and attention is complex and controversial. A growing body of literature has shown that the neural bases of consciousness and endogenous attention (voluntary attention) are independent. The important role of exogenous attention (reflexive attention) on conscious experienc...

journal_title：Frontiers in neuroscience

authors： Chen Y,Wang X,Yu Y,Liu Y

更新日期：2017-11-13 00:00:00

abstract：:The comprehension of fluent speech in one's native language requires that listeners integrate the detailed acoustic-phonetic information available in the sound signal with linguistic knowledge. This interplay is especially apparent in the phoneme restoration effect, a phenomenon in which a missing phoneme is "restored...

journal_title：Frontiers in neuroscience

authors： Del Tufo SN,Myers EB

更新日期：2014-06-04 00:00:00

abstract：:How speech signals are analyzed and represented remains a foundational challenge both for cognitive science and neuroscience. A growing body of research, employing various behavioral and neurobiological experimental techniques, now points to the perceptual relevance of both phoneme-sized (10-40 Hz modulation frequency...

journal_title：Frontiers in neuroscience

authors： Chait M,Greenberg S,Arai T,Simon JZ,Poeppel D

更新日期：2015-06-16 00:00:00

abstract：:Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, a...

journal_title：Frontiers in neuroscience

authors： Udovin LD,Kobiec T,Herrera MI,Toro-Urrego N,Kusnier CF,Kölliker-Frers RA,Ramos-Hryb AB,Luaces JP,Otero-Losada M,Capani F

更新日期：2020-01-08 00:00:00

abstract：:Background: Tinnitus is a very common symptom that often causes distress and decreases the patient's quality of life. Apart from the well-known causes, tinnitus can in some cases be elicited by dysfunctions of the cervical spine or the temporomandibular joint (TMJ). To date however, it is unclear whether alleviation o...

journal_title：Frontiers in neuroscience

authors： Michiels S,Naessens S,Van de Heyning P,Braem M,Visscher CM,Gilles A,De Hertogh W

更新日期：2016-11-29 00:00:00

abstract：:Mu/beta rhythms are well-studied brain activities that originate from sensorimotor cortices. These rhythms reveal spectral changes in alpha and beta bands induced by movements of different body parts, e.g., hands and limbs, in electroencephalography (EEG) signals. However, less can be revealed in them about movements ...

journal_title：Frontiers in neuroscience

authors： Xiao R,Ding L

更新日期：2015-09-01 00:00:00