Three Research Strategies of Neuroscience and the Future of Legal Imaging Evidence.

abstract：:Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Using brain slices from mi...

journal_title：Frontiers in neuroscience

authors： Kohlmeier KA,Tyler CJ,Kalogiannis M,Ishibashi M,Kristensen MP,Gumenchuk I,Chemelli RM,Kisanuki YY,Yanagisawa M,Leonard CS

更新日期：2013-12-20 00:00:00

abstract：:Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by in...

journal_title：Frontiers in neuroscience

authors： Dobryakova YV,Volobueva MN,Manolova AO,Medvedeva TM,Kvichansky AA,Gulyaeva NV,Markevich VA,Stepanichev MY,Bolshakov AP

更新日期：2019-03-12 00:00:00

abstract：:Learning a new language requires the use of extensive neural networks and can represent a powerful tool to reorganize brain neuroplasticity. In this study, we analyze how a 4 months long second language learning program (16, 2 h sessions) can lead to functional changes in the brain of healthy elderly individuals. A la...

journal_title：Frontiers in neuroscience

authors： Bubbico G,Chiacchiaretta P,Parenti M,di Marco M,Panara V,Sepede G,Ferretti A,Perrucci MG

更新日期：2019-05-15 00:00:00

abstract：:Over the past several decades, clinical studies have shown significant analgesic effects of acupuncture. The efficacy of acupuncture treatment has improved with the recent development of nanoporous needles (PN), which are produced by modifying the needle surface using nanotechnology. Herein, we showed that PN at acupo...

journal_title：Frontiers in neuroscience

authors： Bae SJ,Lim J,Lee S,Choi H,Jang JH,Kim YK,Oh JY,Park JH,Jung HS,Chae Y,In SI,Park HJ

更新日期：2019-06-20 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.00413.]. ...

journal_title：Frontiers in neuroscience

authors： Frontiers Production Office.

更新日期：2019-08-28 00:00:00

abstract：:We previously demonstrated that, in the early stages of tau processing in Alzheimer's disease, the N-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by Alz-50. In this immunohistochemical stud...

journal_title：Frontiers in neuroscience

authors： Flores-Rodríguez P,Ontiveros-Torres MA,Cárdenas-Aguayo MC,Luna-Arias JP,Meraz-Ríos MA,Viramontes-Pintos A,Harrington CR,Wischik CM,Mena R,Florán-Garduño B,Luna-Muñoz J

更新日期：2015-02-11 00:00:00

abstract：:Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended specifically for the management of tinnitus. Whilst some of the curre...

journal_title：Frontiers in neuroscience

authors： McFerran DJ,Stockdale D,Holme R,Large CH,Baguley DM

更新日期：2019-08-06 00:00:00

abstract：:Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component. Compared with other cell types, PQC in neurons is particularly challenging because they have a unique cellular struct...

journal_title：Frontiers in neuroscience

authors： Ciechanover A,Kwon YT

更新日期：2017-04-06 00:00:00

abstract：Purpose:The phantom sound of tinnitus is considered to be associated with abnormal functional coupling between the nucleus accumbens (NAc) and the prefrontal cortex, which may form a frontostriatal top-down gating system to evaluate and modulate sensory signals. Resting-state functional magnetic resonance imaging (fMRI...

journal_title：Frontiers in neuroscience

authors： Xu JJ,Cui J,Feng Y,Yong W,Chen H,Chen YC,Yin X,Wu Y

更新日期：2019-12-06 00:00:00

abstract：:The hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their associa...

journal_title：Frontiers in neuroscience

authors： Ma G,Yang D,Qin W,Liu Y,Jiang T,Yu C

更新日期：2017-01-10 00:00:00

abstract：:Neural stem cells-based therapies have shown great potential for central nervous system regeneration, with three-dimensional (3D) culture systems representing a key technique for tissue engineering applications, as well as disease modeling and drug screenings. Self-assembling peptides (SAPs), providing biomimetic synt...

journal_title：Frontiers in neuroscience

authors： Marchini A,Favoino C,Gelain F

更新日期：2020-05-05 00:00:00

abstract：:The combination of electromyography (EMG) and transcranial magnetic stimulation (TMS) offers a powerful non-invasive approach for investigating corticospinal excitability in both humans and animals. Acquiring and analyzing the data produced with this combination of tools requires overcoming multiple technical hurdles....

journal_title：Frontiers in neuroscience

authors： Jackson N,Greenhouse I

更新日期：2019-09-13 00:00:00

abstract：:The visual system is organized in a parallel and hierarchical architecture. However, the plasticity in hierarchical neural networks is controversial across different response features and at different levels. In this study, we recorded areas 17 and 21a, earlier and intermediate stages of the visual cortex in the cat, ...

journal_title：Frontiers in neuroscience

authors： Wang J,Ni Z,Jin A,Yu T,Yu H

更新日期：2019-10-11 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple biological levels, including molecular, genetic, epigenetic, cellular and large-scale brain networks. These alterations account for multiple pathophysiological me...

journal_title：Frontiers in neuroscience

authors： Zhao Y,Jaber V,Alexandrov PN,Vergallo A,Lista S,Hampel H,Lukiw WJ

更新日期：2020-10-30 00:00:00

abstract：:Precise diagnosis of psychiatric diseases and a comprehensive assessment of a patient's symptom severity are important in order to establish a successful treatment strategy for each patient. Although great efforts have been devoted to searching for diagnostic biomarkers of schizophrenia over the past several decades, ...

journal_title：Frontiers in neuroscience

authors： Kim DW,Lee SH,Shim M,Im CH

更新日期：2017-08-03 00:00:00

abstract：:Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 contributes to altered energy metabolism that appears to be a strong determinant in the development of...

journal_title：Frontiers in neuroscience

authors： Dierssen M,Fructuoso M,Martínez de Lagrán M,Perluigi M,Barone E

更新日期：2020-07-08 00:00:00

abstract：:Accumulation of misfolded proteins results in cellular stress, and is detected by specific sensors in the endoplasmic reticulum, collectively known as the unfolded protein response (UPR). It has been prominently proposed that the UPR is involved in the pathophysiology of Parkinson's disease (PD). In the present study,...

journal_title：Frontiers in neuroscience

authors： Baek JH,Mamula D,Tingstam B,Pereira M,He Y,Svenningsson P

更新日期：2019-07-05 00:00:00

abstract：:The neuronal cascade related to the perception of either purely olfactory or trigeminal airborne chemicals has been investigated using electroencephalography (EEG) microstate analyses and source localization. However, most airborne chemicals are bimodal in nature, encompassing both properties. Moreover, there is an on...

journal_title：Frontiers in neuroscience

authors： Hucke CI,Heinen RM,Pacharra M,Wascher E,van Thriel C

更新日期：2021-01-13 00:00:00

abstract：:For safe application of exoskeletons in people with spinal cord injury at home or in the community, it is required to have completed an exoskeleton training in which users learn to perform basic and advanced skills. So far, a framework to test exoskeleton skills is lacking. The aim of this study was to develop and tes...

journal_title：Frontiers in neuroscience

authors： van Dijsseldonk RB,Rijken H,van Nes IJW,van de Meent H,Keijsers NLW

更新日期：2017-12-12 00:00:00

abstract：:Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation. Abnormal regulation of 5-HT occurs in gastrointestinal disorders and Inflammatory Bowel Diseases (IBD...

journal_title：Frontiers in neuroscience

authors： Linan-Rico A,Ochoa-Cortes F,Beyder A,Soghomonyan S,Zuleta-Alarcon A,Coppola V,Christofi FL

更新日期：2016-12-19 00:00:00

abstract：:The comprehension of fluent speech in one's native language requires that listeners integrate the detailed acoustic-phonetic information available in the sound signal with linguistic knowledge. This interplay is especially apparent in the phoneme restoration effect, a phenomenon in which a missing phoneme is "restored...

journal_title：Frontiers in neuroscience

authors： Del Tufo SN,Myers EB

更新日期：2014-06-04 00:00:00

abstract：:Central sleep apnea is a sudden arrest of breathing during sleep caused by the central commands to the thoracoabdominal muscles. It is a widespread phenomenon in both healthy and diseased people, as well as in some animals. However, there is an ongoing debate whether it can be considered as a pathological deviation of...

journal_title：Frontiers in neuroscience

authors： Limanskaya AV,Busygina II,Levichkina EV,Pigarev IN

更新日期：2020-06-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.00117.]. ...

journal_title：Frontiers in neuroscience

authors： Zuo XN,Biswal BB,Poldrack RA

更新日期：2019-04-16 00:00:00

abstract：:High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to asc...

journal_title：Frontiers in neuroscience

authors： Boukadi M,Marcotte K,Bedetti C,Houde JC,Desautels A,Deslauriers-Gauthier S,Chapleau M,Boré A,Descoteaux M,Brambati SM

更新日期：2019-01-14 00:00:00

abstract：:The choice of different reference electrodes plays an important role in deciphering the functional meaning of electroencephalography (EEG) signals. In recent years, the infinity zero reference using the reference electrode standard technique (REST) has been increasingly applied, while the average reference (AR) was ge...

journal_title：Frontiers in neuroscience

authors： Zheng G,Qi X,Li Y,Zhang W,Yu Y

更新日期：2018-03-13 00:00:00

abstract：:How speech signals are analyzed and represented remains a foundational challenge both for cognitive science and neuroscience. A growing body of research, employing various behavioral and neurobiological experimental techniques, now points to the perceptual relevance of both phoneme-sized (10-40 Hz modulation frequency...

journal_title：Frontiers in neuroscience

authors： Chait M,Greenberg S,Arai T,Simon JZ,Poeppel D

更新日期：2015-06-16 00:00:00

abstract：:A lack of sleep is linked with a range of inner ear diseases, including hearing loss and tinnitus. Here, we used a mouse model to investigate the effects of sleep deprivation (SD) on noise vulnerability, and explored the mechanisms that might be involved in vitro, focusing particularly corticosterone levels and autoph...

journal_title：Frontiers in neuroscience

authors： Li P,Bing D,Wang S,Chen J,Du Z,Sun Y,Qi F,Zhang Y,Chu H

更新日期：2019-11-29 00:00:00

abstract：:Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

journal_title：Frontiers in neuroscience

authors： Ekelem A,Goldfarb M

更新日期：2018-06-01 00:00:00

abstract：Background and Purpose:Oncological neurosurgery relies heavily on making continuous, intra-operative tumor-brain delineations based on image-guidance. Limitations of currently available imaging techniques call for the development of real-time image-guided resection tools, which allow for reliable functional and anatomi...

journal_title：Frontiers in neuroscience

authors： Soloukey S,Vincent AJPE,Satoer DD,Mastik F,Smits M,Dirven CMF,Strydis C,Bosch JG,van der Steen AFW,De Zeeuw CI,Koekkoek SKE,Kruizinga P

更新日期：2020-01-09 00:00:00

abstract：:Heterogeneity between late-onset Parkinson's disease (LOPD) and early-onset Parkinson's disease (EOPD) is mainly reflected in the following aspects including genetics, disease progression, drug response, clinical manifestation, and neuropathological change. Although many studies have investigated these differences in ...

journal_title：Frontiers in neuroscience

authors： Yue Y,Jiang Y,Shen T,Pu J,Lai HY,Zhang B

更新日期：2020-02-25 00:00:00