Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance.

Abstract:

:The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularly in the improvement of cognition. Since the BBB regulates the transport of insulin into the brain and thus, helps to regulate CNS levels, alterations in the BBB response to insulin could impact CNS insulin resistance. In this review, we summarize the effect of insulin on some of the cell types that make up the BBB, including endothelial cells, neurons, astrocytes, and pericytes. We broadly discuss how these changes in specific cell types could ultimately impact the BBB. We also summarize how insulin can regulate levels of the pathological hallmarks of Alzheimer's disease, including amyloid beta (Aβ) and tau within each cell type. Finally, we suggest interventional approaches to overcome detrimental effects on the BBB in regards to changes in insulin transport.

journal_name

Front Neurosci

authors

Rhea EM,Banks WA

doi

10.3389/fnins.2019.00521

subject

Has Abstract

pub_date

2019-06-04 00:00:00

pages

521

eissn

1662-4548

issn

1662-453X

journal_volume

13

pub_type

杂志文章,评审
  • A Comparative Study of Standardized Infinity Reference and Average Reference for EEG of Three Typical Brain States.

    abstract::The choice of different reference electrodes plays an important role in deciphering the functional meaning of electroencephalography (EEG) signals. In recent years, the infinity zero reference using the reference electrode standard technique (REST) has been increasingly applied, while the average reference (AR) was ge...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00158

    authors: Zheng G,Qi X,Li Y,Zhang W,Yu Y

    更新日期:2018-03-13 00:00:00

  • Manipulation of the Duration of the Initial Self-Control Task Within the Sequential-Task Paradigm: Effect on Exercise Performance.

    abstract::Self-control exertion on an initial task has been associated with impaired performance on subsequent physical tasks also requiring self-control; an effect suggested to be mediated by changes in perceptions of pain and motivation. However, the effects of spending longer on the initial self-control task are unknown. Thi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.571312

    authors: Boat R,Hunte R,Welsh E,Dunn A,Treadwell E,Cooper SB

    更新日期:2020-10-08 00:00:00

  • No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating.

    abstract::The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral pr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00738

    authors: Lukasik KM,Lehtonen M,Salmi J,Meinzer M,Joutsa J,Laine M

    更新日期:2018-01-10 00:00:00

  • Deep Brain Stimulation for Obesity: A Review and Future Directions.

    abstract::The global prevalence of obesity has been steadily increasing. Although pharmacotherapy and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may lose long-term effectiveness. Obesity result largely from unbalanced energy homeostasis. Palatable and densely caloric foods may affect th...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00323

    authors: Formolo DA,Gaspar JM,Melo HM,Eichwald T,Zepeda RJ,Latini A,Okun MS,Walz R

    更新日期:2019-04-18 00:00:00

  • Effects of Environmental Enrichment on Doublecortin and BDNF Expression along the Dorso-Ventral Axis of the Dentate Gyrus.

    abstract::Adult hippocampal neurogenesis (AHN) in the dentate gyrus is known to respond to environmental enrichment, chronic stress, and many other factors. The function of AHN may vary across the septo-temporal axis of the hippocampus, as different subdivisions are responsible for different functions. The dorsal pole regulates...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00488

    authors: Gualtieri F,Brégère C,Laws GC,Armstrong EA,Wylie NJ,Moxham TT,Guzman R,Boswell T,Smulders TV

    更新日期:2017-09-15 00:00:00

  • Novel Therapeutic Approaches for the Treatment of Retinal Degenerative Diseases: Focus on CRISPR/Cas-Based Gene Editing.

    abstract::Inherited retinal diseases encompass a highly heterogenous group of disorders caused by a wide range of genetic variants and with diverse clinical symptoms that converge in the common trait of retinal degeneration. Indeed, mutations in over 270 genes have been associated with some form of retinal degenerative phenotyp...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00838

    authors: Gallego C,Gonçalves MAFV,Wijnholds J

    更新日期:2020-08-20 00:00:00

  • Chronic Timed Sleep Restriction Attenuates LepRb-Mediated Signaling Pathways and Circadian Clock Gene Expression in the Rat Hypothalamus.

    abstract::The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying the association are unclear. Therefore, the hypothalamic-regulated mechanisms of appetite and the circadian clock gene expression w...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00909

    authors: Sun Q,Liu Y,Wei W,Wu D,Lin R,Wen D,Jia L

    更新日期:2020-09-08 00:00:00

  • Cerebellar Functional Parcellation Using Sparse Dictionary Learning Clustering.

    abstract::The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00188

    authors: Wang C,Kipping J,Bao C,Ji H,Qiu A

    更新日期:2016-05-02 00:00:00

  • Ocular Dominance Plasticity of Areas 17 and 21a in the Cat.

    abstract::The visual system is organized in a parallel and hierarchical architecture. However, the plasticity in hierarchical neural networks is controversial across different response features and at different levels. In this study, we recorded areas 17 and 21a, earlier and intermediate stages of the visual cortex in the cat, ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01039

    authors: Wang J,Ni Z,Jin A,Yu T,Yu H

    更新日期:2019-10-11 00:00:00

  • Reshaping of Gait Coordination by Robotic Intervention in Myelopathy Patients After Surgery.

    abstract::The Ossification of the Posterior Longitudinal Ligament (OPLL) is an idiopathic degenerative spinal disease which may cause motor deficit. For patients presenting myelopathy or severe stenosis, surgical decompression is the treatment of choice; however, despite adequate decompression residual motor impairment is found...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00099

    authors: Puentes S,Kadone H,Kubota S,Abe T,Shimizu Y,Marushima A,Sankai Y,Yamazaki M,Suzuki K

    更新日期:2018-03-02 00:00:00

  • Modulation on Glutamic Pathway of Frontal-Striatum-Thalamus by rs11146020 and rs3813296 Gene Polymorphism in First-Episode Negative Schizophrenia.

    abstract:Objectives:The frontal-striatum-thalamus pathway is important in the glutamic neural circuit. The hypofunction of GRIN1 and GRIA2 subunits from glutamic receptors has been hypothesized as the primary process in the etiology of schizophrenia. Identified gene polymorphism involved in the pathogenesis of schizophrenia may...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00351

    authors: Cai S,Lv Y,Huang K,Zhang W,Wang Q,Huang L,Wang J

    更新日期:2020-04-21 00:00:00

  • Increasing Our Insular World View: Interoception and Psychopathology for Psychotherapists.

    abstract::Interoception has been determined to be an elemental aspect of the neural foundations of physiological homeostasis, subjective experience, and motivated behavior. This paper reviews current neuroscience research regarding interoception and forms of interoceptive dysfunction that may result in psychopathology, focusing...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00135

    authors: Duquette P

    更新日期:2017-03-21 00:00:00

  • Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats.

    abstract::Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective therapy for obsessive compulsive disorder (OCD) and is currently under investigation as a treatment for eating disorders. DBS of this area is associated with altered food intake and pharmacological treatment of OCD is associated with the risk ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00226

    authors: Diepenbroek C,van der Plasse G,Eggels L,Rijnsburger M,Feenstra MG,Kalsbeek A,Denys D,Fliers E,Serlie MJ,la Fleur SE

    更新日期:2013-12-10 00:00:00

  • ATP as a multi-target danger signal in the brain.

    abstract::ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00148

    authors: Rodrigues RJ,Tomé AR,Cunha RA

    更新日期:2015-04-28 00:00:00

  • Erratum: Mediating Retinal Ganglion Cell Spike Rates Using High-Frequency Electrical Stimulation.

    abstract::[This corrects the article DOI: 10.3389/fnins.2019.00413.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2019.00910

    authors: Frontiers Production Office.

    更新日期:2019-08-28 00:00:00

  • Effects of Field-Map Distortion Correction on Resting State Functional Connectivity MRI.

    abstract::Magnetic field inhomogeneities cause geometric distortions of echo planar images used for functional magnetic resonance imaging (fMRI). To reduce this problem, distortion correction (DC) with field map is widely used for both task and resting-state fMRI (rs-fMRI). Although DC with field map has been reported to improv...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00656

    authors: Togo H,Rokicki J,Yoshinaga K,Hisatsune T,Matsuda H,Haga N,Hanakawa T

    更新日期:2017-12-01 00:00:00

  • Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology.

    abstract::Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00413

    authors: Browning KN

    更新日期:2015-10-29 00:00:00

  • Risk Factors and Neuropsychological Assessments of Subjective Cognitive Decline (plus) in Chinese Memory Clinic.

    abstract:Background:Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Ob...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00846

    authors: Hao L,Xing Y,Li X,Mu B,Zhao W,Wang G,Wang T,Jia J,Han Y

    更新日期:2019-08-14 00:00:00

  • Altering Opioid Neuromodulation in the Songbird Basal Ganglia Modulates Vocalizations.

    abstract::Although the interplay between endogenous opioids and dopamine (DA) in the basal ganglia (BG) is known to underlie diverse motor functions, few studies exist on their role in modulating speech and vocalization. Vocal impairment is a common symptom of Parkinson's disease (PD), wherein DA depletion affects striosomes ri...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00671

    authors: Kumar S,Mohapatra AN,Sharma HP,Singh UA,Kambi NA,Velpandian T,Rajan R,Iyengar S

    更新日期:2019-07-03 00:00:00

  • Anti-microRNAs as Novel Therapeutic Agents in the Clinical Management of Alzheimer's Disease.

    abstract::Overview- One hundred and ten years since its first description Alzheimer's disease (AD) still retains its prominent status: (i) as the industrialized world's number one cause of age-related intellectual impairment and cognitive decline; (ii) as this country's most rapidly expanding socioeconomic and healthcare concer...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00059

    authors: Zhao Y,Alexandrov PN,Lukiw WJ

    更新日期:2016-02-25 00:00:00

  • A Framework for Measuring the Progress in Exoskeleton Skills in People with Complete Spinal Cord Injury.

    abstract::For safe application of exoskeletons in people with spinal cord injury at home or in the community, it is required to have completed an exoskeleton training in which users learn to perform basic and advanced skills. So far, a framework to test exoskeleton skills is lacking. The aim of this study was to develop and tes...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00699

    authors: van Dijsseldonk RB,Rijken H,van Nes IJW,van de Meent H,Keijsers NLW

    更新日期:2017-12-12 00:00:00

  • Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.

    abstract::Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01009

    authors: Pitake S,Middleton LJ,Abdus-Saboor I,Mishra SK

    更新日期:2019-09-19 00:00:00

  • Foveal Therapy in Blue Cone Monochromacy: Predictions of Visual Potential From Artificial Intelligence.

    abstract::Novel therapeutic approaches for treating inherited retinal degenerations (IRDs) prompt a need to understand which patients with impaired vision have the anatomical potential to gain from participation in a clinical trial. We used supervised machine learning to predict foveal function from foveal structure in blue con...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00800

    authors: Sumaroka A,Cideciyan AV,Sheplock R,Wu V,Kohl S,Wissinger B,Jacobson SG

    更新日期:2020-08-03 00:00:00

  • A FPGA Implementation of the CAR-FAC Cochlear Model.

    abstract::This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear effere...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00198

    authors: Xu Y,Thakur CS,Singh RK,Hamilton TJ,Wang RM,van Schaik A

    更新日期:2018-04-10 00:00:00

  • Key factors for the emergence of collective decision in invertebrates.

    abstract::In many species of group living invertebrates, in particular arthropods, collective decisions can emerge from the combined actions of individuals and the direct or indirect interactions between individuals. These decisions allow groups of individuals to respond quickly and accurately to changes that occur in their env...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00121

    authors: Jeanson R,Dussutour A,Fourcassié V

    更新日期:2012-08-20 00:00:00

  • Fascicular Topography of the Human Median Nerve for Neuroprosthetic Surgery.

    abstract::One of the most sought-after applications of neuroengineering is the communication between the arm and an artificial prosthetic device for the replacement of an amputated hand or the treatment of peripheral nerve injuries. For that, an electrode is placed around or inside the median nerve to serve as interface for rec...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00286

    authors: Delgado-Martínez I,Badia J,Pascual-Font A,Rodríguez-Baeza A,Navarro X

    更新日期:2016-07-01 00:00:00

  • α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats.

    abstract:UNLABELLED:α2-adrenoceptors (α2AR) lower central sympathetic output and peripheral catecholamine release, and may therefore prevent sympathetic hyperactivity and hypertension. The α2AR are dysfunctional in male spontaneously hypertensive rats (SHR). Premenopausal females are less hypertensive than males. The purpose of...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00130

    authors: Berg T

    更新日期:2016-03-30 00:00:00

  • Molecular cloning, sequencing and tissue expression of vasotocin and isotocin precursor genes from Ostariophysian catfishes: phylogeny and evolutionary considerations in teleosts.

    abstract::Basic and neutral neurohypophyseal (NH) nonapeptides have evolved from vasotocin (VT) by a gene duplication at the base of the gnathostome lineage. In teleosts, VT and IT are the basic and neutral peptides, respectively. In the present study, VT and IT precursor genes of Heteropneustes fossilis and Clarias batrachus (...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00166

    authors: Banerjee P,Chaube R,Joy KP

    更新日期:2015-05-15 00:00:00

  • Toward a Bidirectional Communication Between Retinal Cells and a Prosthetic Device - A Proof of Concept.

    abstract::Background: Significant progress toward the recovery of useful vision in blind patients with severe degenerative retinal diseases caused by photoreceptor death has been achieved with the development of visual prostheses that stimulate the retina electrically. However, currently used prostheses do not provide feedback ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00367

    authors: Rincón Montes V,Gehlen J,Lück S,Mokwa W,Müller F,Walter P,Offenhäusser A

    更新日期:2019-04-30 00:00:00

  • Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia.

    abstract::We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacolo...

    journal_title:Frontiers in neuroscience

    pub_type:

    doi:10.3389/fnins.2017.00333

    authors: Gad P,Gerasimenko Y,Zdunowski S,Turner A,Sayenko D,Lu DC,Edgerton VR

    更新日期:2017-06-08 00:00:00