Abstract:
:Possible risks stemming from the employment of novel, micrometer-thin printed electrodes for direct current neural stimulation are discussed. To assess those risks, electrochemical methods are used, including cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Experiments were conducted in non-deoxidized phosphate-buffered saline to better emulate living organism conditions. Since preliminary results obtained have shown unexpected oxidation peaks in 0-0.4 V potential range, the source of those was further investigated. Hypothesized redox activity of printing paste components was disproven, supporting further development of proposed fabrication technology of stimulating electrodes. Finally, partial permeability and resulting electrochemical activity of underlying silver-based printed layers of the device were pointed as the source of potential tissue irritation or damage. Employing this information, electrodes with corrected design were investigated, yielding no undesired redox processes.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Pepłowski A,Rathi S,Piotrkowski B,Ziółkowski R,Janczak D,Krzemiński J,Brosch M,Jakubowska Mdoi
10.3389/fnins.2020.594235subject
Has Abstractpub_date
2020-10-29 00:00:00pages
594235eissn
1662-4548issn
1662-453Xjournal_volume
14pub_type
杂志文章abstract::Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in neuroscience
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