Plasma Protein and MicroRNA Biomarkers of Insulin Resistance: A Network-Based Integrative -Omics Analysis.

abstract：:Prescribing the proper resistance training (RT) program is critical to optimize skeletal muscle hypertrophy and strength. Periodization is a strategy that entails planned manipulations of training variables to maximize fitness adaptations while minimizing the risk of overtraining. Multiple meta-analyses have shown per...

journal_title：Frontiers in physiology

authors： Evans JW

更新日期：2019-01-23 00:00:00

abstract：:Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling. This paper mainly explores the regulatory effect of glycogen sy...

journal_title：Frontiers in physiology

authors： Ding YJ,Li GY,Xu CD,Wu Y,Zhou ZS,Wang SG,Li C

更新日期：2020-11-25 00:00:00

abstract：:Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts. We aimed to determine its existence, molecular nature in undiseased h...

journal_title：Frontiers in physiology

authors： Wen H,Zhao Z,Fefelova N,Xie LH

更新日期：2018-12-13 00:00:00

abstract：:This study aims to investigate the embryo development potential of extending the culture of abnormally fertilized zygotes with no pronuclear (0PN), monopronuclear (1PN), and poor-quality day 3 embryos and to determine the associated clinical outcomes. This is a retrospective study performed between January 2014 and Ma...

journal_title：Frontiers in physiology

authors： Chen X,Shi S,Mao J,Zou L,Yu K

更新日期：2020-11-04 00:00:00

abstract：:Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but...

journal_title：Frontiers in physiology

authors： Amorós-Figueras G,Jorge E,García-Sánchez T,Bragós R,Rosell-Ferrer J,Cinca J

更新日期：2016-08-31 00:00:00

abstract：:In this paper, we computationally generate hypotheses for dose-finding studies in the context of desynchronizing neuromodulation techniques. Abnormally strong neuronal synchronization is a hallmark of several brain disorders. Coordinated Reset (CR) stimulation is a spatio-temporally patterned stimulation technique tha...

journal_title：Frontiers in physiology

authors： Manos T,Zeitler M,Tass PA

更新日期：2018-04-12 00:00:00

abstract：:The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within the organ, with subsequent optimization of its function. Intercellular ...

journal_title：Frontiers in physiology

authors： Segers VFM,Brutsaert DL,De Keulenaer GW

更新日期：2018-04-11 00:00:00

abstract：:Contusion injuries in skeletal muscle commonly occur in contact sport and vehicular and industrial workplace accidents. Icing has traditionally been used to treat such injuries under the premise that it alleviates pain, reduces tissue metabolism, and modifies vascular responses to decrease swelling. Previous research ...

journal_title：Frontiers in physiology

authors： Singh DP,Barani Lonbani Z,Woodruff MA,Parker TJ,Steck R,Peake JM

更新日期：2017-03-07 00:00:00

abstract：:The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

journal_title：Frontiers in physiology

authors： Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2013-12-17 00:00:00

abstract：:Background: The results from animal and human research indicate that acute intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma levels and gene expression. As BDNF is known to promote the differentiation of new neurons and the formation of synapses, it has been proposed to mediate adult neu...

journal_title：Frontiers in physiology

authors： Becke A,Müller P,Dordevic M,Lessmann V,Brigadski T,Müller NG

更新日期：2018-10-01 00:00:00

abstract：:Invasive coronary revascularization has been shown to improve prognoses in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but the optimal timing of intervention remains unclear. This meta-analysis is to evaluate the outcomes in immediate (<2 h), early (<24 h), and delayed invasive group an...

journal_title：Frontiers in physiology

authors： Li Y,Zhang Z,Xiong X,Cho WC,Hu D,Gao Y,Shang H,Xing Y

更新日期：2017-11-27 00:00:00

abstract：:Background: Constant blood flow despite changes in blood pressure, a phenomenon called autoregulation, has been demonstrated for various organ systems. We hypothesized that by changing hydrostatic pressures in peripheral arteries, we can establish these limits of autoregulation in peripheral arteries based on local pu...

journal_title：Frontiers in physiology

authors： Tripathi A,Obata Y,Ruzankin P,Askaryar N,Berkowitz DE,Steppan J,Barodka V

更新日期：2017-11-02 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:One of the key defining features of an endogenous circadian clock is that it can be entrained or set to local time. Though a number of cues can perform this role, light is the predominant environmental signal that acts to entrain circadian pacemakers in most species. For the past 20 years, a great deal of work has bee...

journal_title：Frontiers in physiology

authors： Steindal IAF,Whitmore D

更新日期：2020-08-14 00:00:00

abstract：:A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investiga...

journal_title：Frontiers in physiology

authors： Camacho-Cardenosa A,Camacho-Cardenosa M,Burtscher M,Martínez-Guardado I,Timon R,Brazo-Sayavera J,Olcina G

更新日期：2018-02-07 00:00:00

abstract：:The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications. The current study sought to investigate the antihypertensive effect of a newly synthesized pyrazole derivative ...

journal_title：Frontiers in physiology

authors： Trindade NR,Lopes PR,Naves LM,Fajemiroye JO,Alves PH,Amaral NO,Lião LM,Rebelo ACS,Castro CH,Braga VA,Menegatti R,Pedrino GR

更新日期：2018-08-07 00:00:00

abstract：:Collective behavior in the forest tent caterpillar (Malacosoma disstria) meets the thermal constraints of being an early spring folivore, but introduces other constraints in food choice. These are minimized by state-dependent, inter-individual, and ontogenetic variations in responses to social cues. Forest tent caterp...

journal_title：Frontiers in physiology

authors： Despland E

更新日期：2013-03-22 00:00:00

abstract：:Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. NC cells express many cadherin proteins, which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithel...

journal_title：Frontiers in physiology

authors： Manohar S,Camacho-Magallanes A,Echeverria C Jr,Rogers CD

更新日期：2020-10-30 00:00:00

abstract：:Heat acclimation by post-exercise hot water immersion (HWI) on six consecutive days reduces thermal strain and improves exercise performance during heat stress. However, the retention of adaptations by this method remains unknown. Typically, adaptations to short-term, exercise-heat-acclimation (<7 heat exposures) deca...

journal_title：Frontiers in physiology

authors： Zurawlew MJ,Mee JA,Walsh NP

更新日期：2019-08-28 00:00:00

abstract：:Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and inter...

journal_title：Frontiers in physiology

authors： Kurtz R,Steinberg LG,Betcher M,Fowler D,Shepard BD

更新日期：2020-10-06 00:00:00

abstract：:Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic illness of unknown etiology, classified as a neurological disorder by the World Health Organization (WHO). The symptomatology of the condition appears to emanate from a variety of sources of chronic neurological distur...

journal_title：Frontiers in physiology

authors： Glassford JA

更新日期：2017-02-17 00:00:00

abstract：:Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

journal_title：Frontiers in physiology

authors： Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

更新日期：2018-09-10 00:00:00

abstract：:Previous research has quantified the peak movement demands of elite rugby league match-play, but the peak accelerometer load or the semi-professional peak demands remain unknown. The aim of this research was to determine the peak movement demands of professional and semi-professional rugby league competition. Wearable...

journal_title：Frontiers in physiology

authors： Johnston RD,Devlin P,Wade JA,Duthie GM

更新日期：2019-10-14 00:00:00

abstract：:Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium an...

journal_title：Frontiers in physiology

authors： Knöpfel EB,Vilches C,Camargo SMR,Errasti-Murugarren E,Stäubli A,Mayayo C,Munier FL,Miroshnikova N,Poncet N,Junza A,Bhattacharya SS,Prat E,Berry V,Berger W,Heon E,Moore AT,Yanes Ó,Nunes V,Palacín M,Verrey F,Kloecke

更新日期：2019-06-04 00:00:00

abstract：:Signal transduction and gene regulation determine a major reorganization of metabolic activities in order to support cell proliferation. Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis and cellular biosynthesis, two activities shown by both...

journal_title：Frontiers in physiology

authors： Mosca E,Alfieri R,Maj C,Bevilacqua A,Canti G,Milanesi L

更新日期：2012-11-21 00:00:00

abstract：:As part of the ZOOMICS project, we set out to investigate common and diverging metabolic traits in the blood metabolome across various species by taking advantage of recent developments in high-throughput metabolomics. Here we provide the first comparative metabolomics analysis of fresh and stored human (n = 21, 10 ma...

journal_title：Frontiers in physiology

authors： Bertolone L,Shin HK,Stefanoni D,Baek JH,Gao Y,Morrison EJ,Nemkov T,Thomas T,Francis RO,Hod EA,Zimring JC,Yoshida T,Karafin M,Schwartz J,Hudson KE,Spitalnik SL,Buehler PW,D'Alessandro A

更新日期：2020-10-23 00:00:00

abstract：:Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

journal_title：Frontiers in physiology

authors： Zhang J,Ma A,Shang L

更新日期：2018-05-29 00:00:00

abstract：:Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which are ectopic nodules of nerve cells that failed to migrate appropria...

journal_title：Frontiers in physiology

authors： Vontell R,Supramaniam VG,Davidson A,Thornton C,Marnerides A,Holder-Espinasse M,Lillis S,Yau S,Jansson M,Hagberg HE,Rutherford MA

更新日期：2019-05-24 00:00:00

abstract：:Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5) from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in leng...

journal_title：Frontiers in physiology

authors： Huang Y,Han K,Ren Q

更新日期：2018-03-05 00:00:00

abstract：:Since the late 2010s, Transcranial Ultrasound Stimulation (TUS) has been used experimentally to carryout safe, non-invasive stimulation of the brain with better spatial resolution than Transcranial Magnetic Stimulation (TMS). This innovative stimulation method has emerged as a novel and valuable device for studying br...

journal_title：Frontiers in physiology

authors： Pouget P,Frey S,Ahnine H,Attali D,Claron J,Constans C,Aubry JF,Arcizet F

更新日期：2020-08-19 00:00:00