Therapeutic Effect of Platelet-Rich Plasma in Rat Spinal Cord Injuries.

Abstract:

:Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are an abundant source of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), and epithelial growth factor (EGF). The complex mechanisms underlying spinal cord injury (SCI) diminish intrinsic repair and neuronal regeneration. Several studies have suggested that growth factor-promoted axonal regeneration can occur for an extended period after injury. More importantly, the delivery of exogenous growth factors contained in PRP, such as EGF, IGF-1, and TGF-β, has neurotrophic effects on central nervous system (CNS) injuries and neurodegenerative diseases. However, only a few studies have investigated the effects of PRP on CNS injuries or neurodegenerative diseases. According to our review of relevant literature, no study has investigated the effect of intrathecal (i.t.) PRP injection into the injured spinal cord and activation of intrinsic mechanisms. In the present study, we directly injected i.t. PRP into rat spinal cords and examined the effects of PRP on normal and injured spinal cords. In rats with normal spinal cords, PRP induced microglia and astrocyte activation and PDGF-B and ICAM-1 expression. In rats with SCIs, i.t. PRP enhanced the locomotor recovery and spared white matter, promoted angiogenesis and neuronal regeneration, and modulated blood vessel size. Furthermore, a sustained treatment (a bolus of PRP followed by a 1/3 dose of initial PRP concentration) exerted more favorable therapeutic effects than a single dose of PRP. Our findings suggest by i.t. PRP stimulate angiogenesis, enhancing neuronal regeneration after SCI in rats. Although PRP induces minor inflammation in normal and injured spinal cords, it has many advantages. It is an autologous, biocompatible, nontoxic material that does not result in a major immune response. In addition, based on its safety and ease of preparation, we hypothesize that PRP is a promising therapeutic agent for SCI.

journal_name

Front Neurosci

authors

Chen NF,Sung CS,Wen ZH,Chen CH,Feng CW,Hung HC,Yang SN,Tsui KH,Chen WF

doi

10.3389/fnins.2018.00252

subject

Has Abstract

pub_date

2018-04-23 00:00:00

pages

252

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

杂志文章
  • Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.

    abstract::The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly complex polarized morphology. The motor protein complex cytoplasmic dynein has an important role ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00397

    authors: Jaarsma D,Hoogenraad CC

    更新日期:2015-10-26 00:00:00

  • The Influence of EEG References on the Analysis of Spatio-Temporal Interrelation Patterns.

    abstract::The characterization of the functional network of the brain dynamics has become a prominent tool to illuminate novel aspects of brain functioning. Due to its excellent time resolution, such research is oftentimes based on electroencephalographic recordings (EEG). However, a particular EEG-reference might cause crucial...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00941

    authors: Ríos-Herrera WA,Olguín-Rodríguez PV,Arzate-Mena JD,Corsi-Cabrera M,Escalona J,Marín-García A,Ramos-Loyo J,Rivera AL,Rivera-López D,Zapata-Berruecos JF,Müller MF

    更新日期:2019-09-12 00:00:00

  • GRP78 Level Is Altered in the Brain, but Not in Plasma or Cerebrospinal Fluid in Parkinson's Disease Patients.

    abstract::Accumulation of misfolded proteins results in cellular stress, and is detected by specific sensors in the endoplasmic reticulum, collectively known as the unfolded protein response (UPR). It has been prominently proposed that the UPR is involved in the pathophysiology of Parkinson's disease (PD). In the present study,...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00697

    authors: Baek JH,Mamula D,Tingstam B,Pereira M,He Y,Svenningsson P

    更新日期:2019-07-05 00:00:00

  • Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring.

    abstract::Recently, the putative association between selective serotonin reuptake inhibitor (SSRI) exposure during pregnancy and the development of social disorders in children has gained increased attention. However, clinical studies struggle with the confounding effects of maternal depression typically co-occurring with antid...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00229

    authors: Houwing DJ,Staal L,Swart JM,Ramsteijn AS,Wöhr M,de Boer SF,Olivier JDA

    更新日期:2019-03-12 00:00:00

  • Bisphenol A and phthalate endocrine disruption of parental and social behaviors.

    abstract::Perinatal exposure to endocrine disrupting chemicals (EDCs) can induce promiscuous neurobehavioral disturbances. Bisphenol A and phthalates are two widely prevalent and persistent EDCs reported to lead to such effects. Parental and social behaviors are especially vulnerable to endocrine disruption, as these traits are...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00057

    authors: Rosenfeld CS

    更新日期:2015-03-03 00:00:00

  • Glucocorticoid Regulation of Food-Choice Behavior in Humans: Evidence from Cushing's Syndrome.

    abstract::The mechanisms by which glucocorticoids regulate food intake and resulting body mass in humans are not well-understood. One potential mechanism could involve modulation of reward processing, but human stress models examining effects of glucocorticoids on behavior contain important confounds. Here, we studied individua...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00021

    authors: Moeller SJ,Couto L,Cohen V,Lalazar Y,Makotkine I,Williams N,Yehuda R,Goldstein RZ,Geer EB

    更新日期:2016-02-05 00:00:00

  • Model-based Vestibular Afferent Stimulation: Modular Workflow for Analyzing Stimulation Scenarios in Patient Specific and Statistical Vestibular Anatomy.

    abstract::Our sense of balance and spatial orientation strongly depends on the correct functionality of our vestibular system. Vestibular dysfunction can lead to blurred vision and impaired balance and spatial orientation, causing a significant decrease in quality of life. Recent studies have shown that vestibular implants offe...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00713

    authors: Handler M,Schier PP,Fritscher KD,Raudaschl P,Johnson Chacko L,Glueckert R,Saba R,Schubert R,Baumgarten D,Baumgartner C

    更新日期:2017-12-19 00:00:00

  • Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.

    abstract::Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating work from both the locomotor and animal behavioral fields, we can now...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00581

    authors: Kim LH,Sharma S,Sharples SA,Mayr KA,Kwok CHT,Whelan PJ

    更新日期:2017-10-18 00:00:00

  • How musical training affects cognitive development: rhythm, reward and other modulating variables.

    abstract::Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music trai...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2013.00279

    authors: Miendlarzewska EA,Trost WJ

    更新日期:2014-01-20 00:00:00

  • Combining Robotic Training and Non-Invasive Brain Stimulation in Severe Upper Limb-Impaired Chronic Stroke Patients.

    abstract::Previous studies suggested that both robot-assisted rehabilitation and non-invasive brain stimulation can produce a slight improvement in severe chronic stroke patients. It is still unknown whether their combination can produce synergistic and more consistent improvements. Safety and efficacy of this combination has b...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00088

    authors: Di Lazzaro V,Capone F,Di Pino G,Pellegrino G,Florio L,Zollo L,Simonetti D,Ranieri F,Brunelli N,Corbetto M,Miccinilli S,Bravi M,Milighetti S,Guglielmelli E,Sterzi S

    更新日期:2016-03-08 00:00:00

  • Dystrophin Is Required for the Proper Timing in Retinal Histogenesis: A Thorough Investigation on the mdx Mouse Model of Duchenne Muscular Dystrophy.

    abstract::Duchenne muscular dystrophy (DMD) is a lethal X-linked muscular disease caused by defective expression of the cytoskeletal protein dystrophin (Dp427). Selected autonomic and central neurons, including retinal neurons, express Dp427 and/or dystrophin shorter isoforms. Because of this, DMD patients may also experience d...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00760

    authors: Persiconi I,Cosmi F,Guadagno NA,Lupo G,De Stefano ME

    更新日期:2020-08-31 00:00:00

  • Evaluating auditory stream segregation of SAM tone sequences by subjective and objective psychoacoustical tasks, and brain activity.

    abstract::Auditory stream segregation refers to a segregated percept of signal streams with different acoustic features. Different approaches have been pursued in studies of stream segregation. In psychoacoustics, stream segregation has mostly been investigated with a subjective task asking the subjects to report their percept....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00119

    authors: Dolležal LV,Brechmann A,Klump GM,Deike S

    更新日期:2014-06-06 00:00:00

  • Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice.

    abstract::Poor postoperative pain (POP) control increases perioperative morbidity, prolongs hospitalization days, and causes chronic pain. However, the specific mechanism(s) underlying POP is unclear and the identification of optimal perioperative treatment remains elusive. Akt and mammalian target of rapamycin (mTOR) are expre...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00766

    authors: Xu B,Liu SS,Wei J,Jiao ZY,Mo C,Lv CM,Huang AL,Chen QB,Ma L,Guan XH

    更新日期:2020-07-22 00:00:00

  • No Differential Effects of Two Different Alpha-Band Electrical Stimulation Protocols Over Fronto-Parietal Regions on Spatial Attention.

    abstract::In a previous study using transcranial alternating current stimulation (tACS), we found preliminary evidence that phase coherence in the alpha band (8-12 Hz) within the fronto-parietal network may critically support top-down control of spatial attention (van Schouwenburg et al., 2017). Specifically, synchronous alpha-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00433

    authors: van Schouwenburg MR,Sörensen LKA,de Klerk R,Reteig LC,Slagter HA

    更新日期:2018-07-03 00:00:00

  • Brain Functional Interaction of Acupuncture Effects in Diarrhea-Dominant Irritable Bowel Syndrome.

    abstract::Acupuncture is a traditional Chinese medicine treatment that has widely been used to modulate gastrointestinal dysfunction caused by irritable bowel syndrome (IBS) and to alleviate the resulting pain. Recent studies have shown that gastrointestinal dysfunction caused by IBS is associated with dysregulation of the brai...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.608688

    authors: Ma K,Liu Y,Shao W,Sun J,Li J,Fang X,Li J,Wang Z,Zhang D

    更新日期:2020-12-15 00:00:00

  • Manipulation of the Duration of the Initial Self-Control Task Within the Sequential-Task Paradigm: Effect on Exercise Performance.

    abstract::Self-control exertion on an initial task has been associated with impaired performance on subsequent physical tasks also requiring self-control; an effect suggested to be mediated by changes in perceptions of pain and motivation. However, the effects of spending longer on the initial self-control task are unknown. Thi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.571312

    authors: Boat R,Hunte R,Welsh E,Dunn A,Treadwell E,Cooper SB

    更新日期:2020-10-08 00:00:00

  • Functional genomic analysis and neuroanatomical localization of miR-2954, a song-responsive sex-linked microRNA in the zebra finch.

    abstract::Natural experience can cause complex changes in gene expression in brain centers for cognition and perception, but the mechanisms that link perceptual experience and neurogenomic regulation are not understood. MicroRNAs (miRNAs or miRs) have the potential to regulate large gene expression networks, and a previous stud...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00409

    authors: Lin YC,Balakrishnan CN,Clayton DF

    更新日期:2014-12-16 00:00:00

  • The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb.

    abstract::In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important role in odor information processing by adjusting the neuronal network to changing environmental conditions. Olfactory bulb neurogenesis...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2016.00149

    authors: Gengatharan A,Bammann RR,Saghatelyan A

    更新日期:2016-04-05 00:00:00

  • Phase-II Clinical Validation of a Powered Exoskeleton for the Treatment of Elbow Spasticity.

    abstract::Introduction: Spasticity is a typical motor disorder in patients affected by stroke. Typically post-stroke rehabilitation consists of repetition of mobilization exercises on impaired limbs, aimed to reduce muscle hypertonia and mitigate spastic reflexes. It is currently strongly debated if the treatment's effectivenes...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00261

    authors: Crea S,Cempini M,Mazzoleni S,Carrozza MC,Posteraro F,Vitiello N

    更新日期:2017-05-12 00:00:00

  • Rare Variants in 48 Genes Account for 42% of Cases of Epilepsy With or Without Neurodevelopmental Delay in 246 Pediatric Patients.

    abstract::In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different gene...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01135

    authors: Fernández-Marmiesse A,Roca I,Díaz-Flores F,Cantarín V,Pérez-Poyato MS,Fontalba A,Laranjeira F,Quintans S,Moldovan O,Felgueroso B,Rodríguez-Pedreira M,Simón R,Camacho A,Quijada P,Ibanez-Mico S,Domingno MR,Benito C,Calvo

    更新日期:2019-11-08 00:00:00

  • Case Report: Concurrent Resistance and Aerobic Training Regulate Adiponectin Expression and Disease Severity in Multiple Sclerosis: A Case Study.

    abstract::Adapted exercise is an effective non-pharmacological tool to improve functional, cognitive, and psychological parameters in multiple sclerosis (MS), in association with increased quality of life (QoL) and decreased disease severity. Adipose tissue, through the production of different adipokines, is involved in regulat...

    journal_title:Frontiers in neuroscience

    pub_type:

    doi:10.3389/fnins.2020.567302

    authors: Grazioli E,Nigro E,Cerulli C,Borriello G,Mancini A,Tranchita E,Polito R,Parisi A,Buono P,Daniele A

    更新日期:2020-12-22 00:00:00

  • sEMG-Based Trunk Compensation Detection in Rehabilitation Training.

    abstract::Stroke patients often use trunk to compensate for impaired upper limb motor function during upper limb rehabilitation training, which results in a reduced rehabilitation training effect. Detecting trunk compensations can improve the effect of rehabilitation training. This study investigates the feasibility of a surfac...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01250

    authors: Ma K,Chen Y,Zhang X,Zheng H,Yu S,Cai S,Xie L

    更新日期:2019-11-21 00:00:00

  • Nicotinic receptor modulation to treat alcohol and drug dependence.

    abstract::Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant. Given the limitations in the efficacy of current pharmacotherapies to treat these disorders, research in developing alternative pharm...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2014.00426

    authors: Rahman S,Engleman EA,Bell RL

    更新日期:2015-01-15 00:00:00

  • A Preliminary Study of Knowledge Transfer in Multi-Classification Using Gene Expression Programming.

    abstract::Gene Expression Programming (GEP), a variant of Genetic Programming (GP), is a well established technique for automatic generation of computer programs. Due to the flexible representation, GEP has long been concerned as a classification algorithm for various applications. Whereas, GEP cannot be extended to multi-class...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01396

    authors: Wei T,Zhong J

    更新日期:2020-01-17 00:00:00

  • The intense world syndrome--an alternative hypothesis for autism.

    abstract::Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the neuronal structures and cells affected, a unifying theory that co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.1.1.006.2007

    authors: Markram H,Rinaldi T,Markram K

    更新日期:2007-10-15 00:00:00

  • How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?

    abstract::Despite advances in the field of dynamic connectivity, fixed sliding window approaches for the detection of fluctuations in functional connectivity are still widely used. The use of conventional connectivity metrics in conjunction with a fixed sliding window comes with the arbitrariness of the chosen window lengths. I...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00797

    authors: Liuzzi L,Quinn AJ,O'Neill GC,Woolrich MW,Brookes MJ,Hillebrand A,Tewarie P

    更新日期:2019-08-02 00:00:00

  • Direct Regulation of Aromatase B Expression by 17β-Estradiol and Dopamine D1 Receptor Agonist in Adult Radial Glial Cells.

    abstract::Aromatase cytochrome P450arom (cyp19) is the only enzyme that has the ability to convert androgens into estrogens. Estrogens, which are produced locally in the vertebrate brain play many fundamental roles in neuroendocrine functions, reproductive functions, socio-sexual behaviors, and neurogenesis. Radial glial cells ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00504

    authors: Xing L,Esau C,Trudeau VL

    更新日期:2016-01-12 00:00:00

  • The Involvement of Endogenous Neural Oscillations in the Processing of Rhythmic Input: More Than a Regular Repetition of Evoked Neural Responses.

    abstract::It is undisputed that presenting a rhythmic stimulus leads to a measurable brain response that follows the rhythmic structure of this stimulus. What is still debated, however, is the question whether this brain response exclusively reflects a regular repetition of evoked responses, or whether it also includes entraine...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00095

    authors: Zoefel B,Ten Oever S,Sack AT

    更新日期:2018-03-07 00:00:00

  • Expressional Profiling of Carpet Glia in the Developing Drosophila Eye Reveals Its Molecular Signature of Morphology Regulators.

    abstract::Homeostasis in the nervous system requires intricate regulation and is largely accomplished by the blood-brain barrier (BBB). The major gate keeper of the vertebrate BBB is vascular endothelial cells, which form tight junctions (TJs). To gain insight into the development of the BBB, we studied the carpet glia, a subpe...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00244

    authors: Ho TY,Wu WH,Hung SJ,Liu T,Lee YM,Liu YH

    更新日期:2019-03-29 00:00:00

  • Supplemental Stimulation Improves Swing Phase Kinematics During Exoskeleton Assisted Gait of SCI Subjects With Severe Muscle Spasticity.

    abstract::Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00374

    authors: Ekelem A,Goldfarb M

    更新日期:2018-06-01 00:00:00