Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.

abstract：:Changing gait is crucial for adaptive and smooth animal locomotion. Although it remains unclear what makes animals decide on a specific gait, energy efficiency is an important factor. It has been reported that the relationship of oxygen consumption with speed is U-shaped for each horse gait and that different gaits ha...

journal_title：Frontiers in neuroscience

authors： Toeda M,Aoi S,Fujiki S,Funato T,Tsuchiya K,Yanagihara D

更新日期：2020-01-17 00:00:00

abstract：:The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here, we review recent discoveries regarding ...

journal_title：Frontiers in neuroscience

authors： Kishi Y,Gotoh Y

更新日期：2018-12-11 00:00:00

abstract：:The default mode network (DMN) has been used to study disruptions of functional connectivity in a wide variety of psychiatric and neurological conditions, including posttraumatic stress disorder (PTSD). Studies indicate that the serotonin system exerts a modulatory influence on DMN connectivity; however, no prior stud...

journal_title：Frontiers in neuroscience

authors： Miller MW,Sperbeck E,Robinson ME,Sadeh N,Wolf EJ,Hayes JP,Logue M,Schichman SA,Stone A,Milberg W,McGlinchey R

更新日期：2016-06-28 00:00:00

abstract：:Possible risks stemming from the employment of novel, micrometer-thin printed electrodes for direct current neural stimulation are discussed. To assess those risks, electrochemical methods are used, including cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Experiments were cond...

journal_title：Frontiers in neuroscience

authors： Pepłowski A,Rathi S,Piotrkowski B,Ziółkowski R,Janczak D,Krzemiński J,Brosch M,Jakubowska M

更新日期：2020-10-29 00:00:00

abstract：:Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

journal_title：Frontiers in neuroscience

authors： Browning KN

更新日期：2015-10-29 00:00:00

abstract：:The global prevalence of obesity has been steadily increasing. Although pharmacotherapy and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may lose long-term effectiveness. Obesity result largely from unbalanced energy homeostasis. Palatable and densely caloric foods may affect th...

journal_title：Frontiers in neuroscience

authors： Formolo DA,Gaspar JM,Melo HM,Eichwald T,Zepeda RJ,Latini A,Okun MS,Walz R

更新日期：2019-04-18 00:00:00

abstract：Purpose:The study is conducted to identify the best corpus callosum (CC) sub-region that corresponds to highest callosal tissue alteration occurred due to Parkinsonism. In this regard the efficacy of local binary pattern (LBP) based texture analysis (TA) of CC is performed to quantify the changes in topographical distr...

journal_title：Frontiers in neuroscience

authors： Bhattacharya D,Sinha N,Prasad S,Pal PK,Saini J,Mangalore S

更新日期：2020-05-28 00:00:00

abstract：:Calcium imaging using fluorescent reporters is the most widely used optical approach to investigate activity in intact neuronal circuits with single-cell resolution. Calcium signals, however, are often difficult to interpret, especially if the desired output quantity is membrane voltage or instantaneous firing rates. ...

journal_title：Frontiers in neuroscience

authors： Moreaux L,Laurent G

更新日期：2008-12-15 00:00:00

abstract：:A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances toward our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-ce...

journal_title：Frontiers in neuroscience

authors： Chang SW

更新日期：2013-08-21 00:00:00

abstract：:The prevalence of depressive disorders is growing worldwide, notably due to stagnation in the development of drugs with greater antidepressant efficacy, the continuous large proportion of patients who do not respond to conventional antidepressants, and the increasing rate of chronic medical conditions associated with ...

journal_title：Frontiers in neuroscience

authors： Vancassel S,Capuron L,Castanon N

更新日期：2018-07-24 00:00:00

abstract：:Abdominal obesity is important for understanding obesity, which is a worldwide medical problem. We explored structural and functional brain differences in people with abdominal and non-abdominal obesity by using multimodal neuroimaging and up-to-date analysis methods. A total of 274 overweight people, whose body mass ...

journal_title：Frontiers in neuroscience

authors： Park BY,Lee MJ,Kim M,Kim SH,Park H

更新日期：2018-10-11 00:00:00

abstract：:Rodent models have opened the door to a better understanding of the neurobiology of brain disorders and increased our ability to evaluate novel treatments. Resting-state functional magnetic resonance imaging (rs-fMRI) allows for in vivo exploration of large-scale brain networks with high spatial resolution. Its applic...

journal_title：Frontiers in neuroscience

authors： Bajic D,Craig MM,Mongerson CRL,Borsook D,Becerra L

更新日期：2017-12-12 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a major type of cerebrovascular disease with poor prognosis. Recent studies have shown that Glycyl-l-histidyl-l-lysine (GHK) is a kind of natural human tripeptide which could inhibit inflammation and against neurodegenerative diseases, but neither its role nor the mechanisms in ICH ha...

journal_title：Frontiers in neuroscience

authors： Zhang H,Wang Y,Lian L,Zhang C,He Z

更新日期：2020-10-28 00:00:00

abstract：:Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrPC) is highly expressed on exosomes. In neurodegenerative diseases, PrPC has at least two functions: It is the substrate for the generation of pathological prion protein (PrPSc), a key player in the pathophysiology of...

journal_title：Frontiers in neuroscience

authors： Hartmann A,Muth C,Dabrowski O,Krasemann S,Glatzel M

更新日期：2017-04-19 00:00:00

abstract：:The finding that the adult mammalian brain is still capable of producing neurons has ignited a new field of research aiming to identify the molecular mechanisms regulating adult neurogenesis. An improved understanding of these mechanisms could lead to the development of novel approaches to delay cognitive decline and ...

journal_title：Frontiers in neuroscience

authors： Stappert L,Klaus F,Brüstle O

更新日期：2018-11-05 00:00:00

abstract：:The ability to precisely monitor and manipulate neural circuits is essential to understand the brain. Advancements over the last decade in optical techniques such as calcium imaging and optogenetics have empowered researchers to gain insight into brain function by systematically manipulating or monitoring defined neur...

journal_title：Frontiers in neuroscience

authors： Stamatakis AM,Schachter MJ,Gulati S,Zitelli KT,Malanowski S,Tajik A,Fritz C,Trulson M,Otte SL

更新日期：2018-07-24 00:00:00

abstract：:The comprehension of fluent speech in one's native language requires that listeners integrate the detailed acoustic-phonetic information available in the sound signal with linguistic knowledge. This interplay is especially apparent in the phoneme restoration effect, a phenomenon in which a missing phoneme is "restored...

journal_title：Frontiers in neuroscience

authors： Del Tufo SN,Myers EB

更新日期：2014-06-04 00:00:00

abstract：:A new paradigm in neuroscience has recently emerged - the brain-gut axis (BGA). The contemporary focus in this paradigm has been gut → brain ("bottom-up"), in which the gut-microbiome, and its perturbations, affects one's psychological state-of-mind and behavior, and is pivotal in neurodegenerative disorders. The emer...

journal_title：Frontiers in neuroscience

authors： Isaiah S,Loots DT,Solomons R,van der Kuip M,Tutu Van Furth AM,Mason S

更新日期：2020-04-21 00:00:00

abstract：:Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarbo...

journal_title：Frontiers in neuroscience

authors： Hertz L,Gibbs ME,Dienel GA

更新日期：2014-09-09 00:00:00

abstract：:Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes chronic and may be caused, among other factors, by the sensitization of higher-order neurons. The aim of this study is to describe psychologi...

journal_title：Frontiers in neuroscience

authors： Baroni A,Severini G,Straudi S,Buja S,Borsato S,Basaglia N

更新日期：2020-11-12 00:00:00

abstract：:Women and men differ in a wide variety of behavioral traits and in their vulnerability to developing certain mental disorders. This review endeavors to explore how recent preclinical and clinical research findings have enhanced our understanding of the factors that underlie these disparities. We start with a brief ove...

journal_title：Frontiers in neuroscience

authors： Viveros MP,Mendrek A,Paus T,López-Rodríguez AB,Marco EM,Yehuda R,Cohen H,Lehrner A,Wagner EJ

更新日期：2012-06-12 00:00:00

abstract：:Sensory information can interact to impact perception and behavior. Foods are appreciated according to their appearance, smell, taste and texture. Athletes and dancers combine visual, auditory, and somatosensory information to coordinate their movements. Under laboratory settings, detection and discrimination are like...

journal_title：Frontiers in neuroscience

authors： Sperdin HF,Cappe C,Murray MM

更新日期：2010-05-15 00:00:00

abstract：:Several studies of semantic memory in non-musical domains involving recognition of items from long-term memory have shown an age-related shift from the medial temporal lobe structures to the frontal lobe. However, the effects of aging on musical semantic memory remain unexamined. We compared activation associated with...

journal_title：Frontiers in neuroscience

authors： Sikka R,Cuddy LL,Johnsrude IS,Vanstone AD

更新日期：2015-10-06 00:00:00

abstract：:Up to 50% of traumatic brain injury (TBI) survivors demonstrate persisting and late-onset anxiety disorders indicative of limbic system dysregulation, yet the pathophysiology underlying the symptoms is unclear. We hypothesize that the development of TBI-induced anxiety-like behavior in an experimental model of TBI is ...

journal_title：Frontiers in neuroscience

authors： Beitchman JA,Griffiths DR,Hur Y,Ogle SB,Bromberg CE,Morrison HW,Lifshitz J,Adelson PD,Thomas TC

更新日期：2020-01-21 00:00:00

abstract：:Cellular respiration is a vital process for the existence of life. Any condition that results in deprivation of oxygen (also termed as hypoxia) may eventually lead to deleterious effects on the functioning of tissues. Brain being the highest consumer of oxygen is prone to increased risk of hypoxia-induced neurological...

journal_title：Frontiers in neuroscience

authors： Minhas G,Mathur D,Ragavendrasamy B,Sharma NK,Paanu V,Anand A

更新日期：2017-07-11 00:00:00

abstract：:In situ hybridization (ISH) is a powerful technique that is used to detect the localization of specific nucleic acid sequences for understanding the organization, regulation, and function of genes. However, in most cases, RNA probes are obtained by in vitro transcription from plasmids containing specific promoter elem...

journal_title：Frontiers in neuroscience

authors： Hua R,Yu S,Liu M,Li H

更新日期：2018-05-02 00:00:00

abstract：:Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

journal_title：Frontiers in neuroscience

authors： Ekelem A,Goldfarb M

更新日期：2018-06-01 00:00:00

abstract：:Interaural time differences (ITD) and interaural level differences (ILD) both signal horizontal sound source location. To achieve a unified percept of our acoustic environment, these two cues require integration. In the present study, we tested this integration of ITD and ILD with electroencephalography (EEG) by measu...

journal_title：Frontiers in neuroscience

authors： Altmann CF,Ueda R,Furukawa S,Kashino M,Mima T,Fukuyama H

更新日期：2017-07-06 00:00:00

abstract：Background:Individuals are able to perform goal-directed behaviors thanks to executive functions. According to the neurovisceral integration model, executive functions are upregulated by brain areas such as the prefrontal and cingulate cortices, which are also crucially involved in controlling cardiac vagal activity. A...

journal_title：Frontiers in neuroscience

authors： Borges U,Knops L,Laborde S,Klatt S,Raab M

更新日期：2020-05-25 00:00:00

abstract：:In functional magnetic resonance imaging (fMRI), functional connectivity is conventionally characterized by correlations between fMRI time series, which are intrinsically undirected measures of connectivity. Yet, some information about the directionality of network connections can nevertheless be extracted from the ma...

journal_title：Frontiers in neuroscience

authors： Lennartz C,Schiefer J,Rotter S,Hennig J,LeVan P

更新日期：2018-05-08 00:00:00