Migration and tuberculosis transmission in a middle-income country: a cross-sectional study in a central area of São Paulo, Brazil.

abstract：BACKGROUND:Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replaceme...

journal_title：BMC medicine

authors： Tulloch HE,Pipe AL,Els C,Clyde MJ,Reid RD

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...

journal_title：BMC medicine

authors： Witzel TC,Eshun-Wilson I,Jamil MS,Tilouche N,Figueroa C,Johnson CC,Reid D,Baggaley R,Siegfried N,Burns FM,Rodger AJ,Weatherburn P

更新日期：2020-12-03 00:00:00

abstract：:The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...

journal_title：BMC medicine

authors： Moore DA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...

journal_title：BMC medicine

authors： Ferreira JP,Girerd N,Pellicori P,Duarte K,Girerd S,Pfeffer MA,McMurray JJ,Pitt B,Dickstein K,Jacobs L,Staessen JA,Butler J,Latini R,Masson S,Mebazaa A,Rocca HP,Delles C,Heymans S,Sattar N,Jukema JW,Cleland JG,Za

更新日期：2016-11-10 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) called for global action towards the elimination of cervical cancer. One of the main strategies is to screen 70% of women at the age between 35 and 45 years and 90% of women managed appropriately by 2030. So far, approximately 85% of cervical cancers occur in low- and midd...

journal_title：BMC medicine

authors： Xue P,Ng MTA,Qiao Y

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：:Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and e...

journal_title：BMC medicine

authors： Brick T,Peters MJ

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS:Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were ...

journal_title：BMC medicine

authors： Luo Q,Zhang L,Huang CC,Zheng Y,Kanen JW,Zhao Q,Yao Y,Quinlan EB,Jia T,Banaschewski T,Bokde ALW,Bromberg U,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Martinot MP,Nees F,Orfanos

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...

journal_title：BMC medicine

authors： Larsson SC,Burgess S,Michaëlsson K

更新日期：2018-05-17 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSI...

journal_title：BMC medicine

authors： Tomiyama AJ,Carr D,Granberg EM,Major B,Robinson E,Sutin AR,Brewis A

更新日期：2018-08-15 00:00:00

abstract：:The approval of sorafenib and active development of many other molecularly targeted agents in hepatocellular carcinoma (HCC) have presented a challenge to understand the mechanism of action of sorafenib and identify predictive biomarkers to select patients more likely to benefit from sorafenib. The preclinical study b...

journal_title：BMC medicine

authors： Zhu AX

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy, miscarriage, induced abortion, and stillbirth w...

journal_title：BMC medicine

authors： Peters SAE,Yang L,Guo Y,Chen Y,Bian Z,Tian X,Chang L,Zhang S,Liu J,Wang T,Chen J,Li L,Woodward M,Chen Z,China Kadoorie Biobank collaboration group.

更新日期：2017-08-08 00:00:00

abstract：:Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhea that occurs in individuals exposed over time to poor sanitation and hygiene. It is implicated as a cause of stunting and malnutrition, oral vaccine failure and impaired development in children from low-income cou...

journal_title：BMC medicine

authors： Petri WA Jr,Naylor C,Haque R

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus, we analyze...

journal_title：BMC medicine

authors： Al-Daghri NM,Cagliani R,Forni D,Alokail MS,Pozzoli U,Alkharfy KM,Sabico S,Clerici M,Sironi M

更新日期：2012-11-15 00:00:00

abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...

journal_title：BMC medicine

authors： Goldwater PN,Bettelheim KA

更新日期：2012-02-02 00:00:00

abstract：BACKGROUND:The ability to do online searches for health information has led to concerns that patients find the results confusing and that they often lead to expectations for treatments that have little supportive evidence. At the same time, the science of summarizing research evidence has advanced to the point where it...

journal_title：BMC medicine

authors： Elwyn G,Quinlan C,Mulley A,Agoritsas T,Vandvik PO,Guyatt G

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...

journal_title：BMC medicine

authors： He W,Eriksson L,Törnberg S,Strand F,Hall P,Czene K

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...

journal_title：BMC medicine

authors： Kelley GA,Kelley KS,Roberts S,Haskell W

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:Pendred syndrome, a common autosomal-recessive disorder characterized by congenital deafness and goiter, is caused by mutations of SLC26A4, which codes for pendrin. We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-). M...

journal_title：BMC medicine

authors： Wangemann P,Itza EM,Albrecht B,Wu T,Jabba SV,Maganti RJ,Lee JH,Everett LA,Wall SM,Royaux IE,Green ED,Marcus DC

更新日期：2004-08-20 00:00:00

abstract：BACKGROUND:Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to accurate differentiation of patients with higher and lower risk for mortality. This study explored th...

journal_title：BMC medicine

authors： van Loo HM,van den Heuvel ER,Schoevers RA,Anselmino M,Carney RM,Denollet J,Doyle F,Freedland KE,Grace SL,Hosseini SH,Parakh K,Pilote L,Rafanelli C,Roest AM,Sato H,Steeds RP,Kessler RC,de Jonge P

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presen...

journal_title：BMC medicine

authors： Meagher DJ,Morandi A,Inouye SK,Ely W,Adamis D,Maclullich AJ,Rudolph JL,Neufeld K,Leonard M,Bellelli G,Davis D,Teodorczuk A,Kreisel S,Thomas C,Hasemann W,Timmons S,O'Regan N,Grover S,Jabbar F,Cullen W,Dunne C,Kam

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...

journal_title：BMC medicine

authors： Meyer AC,Drefahl S,Ahlbom A,Lambe M,Modig K

更新日期：2020-03-20 00:00:00

abstract：:The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...

journal_title：BMC medicine

authors： Taft A,Colombini M

更新日期：2017-07-12 00:00:00