Uniformity and Deviation of Intra-axonal Cross-sectional Area Coverage of the Gray-to-White Matter Interface.

Abstract:

:Diffusion magnetic resonance imaging (dMRI) is a compelling tool for investigating the structure and geometry of brain tissue based on indirect measurement of the diffusion anisotropy of water. Recent developments in global top-down tractogram optimizations enable the estimation of streamline weights, which characterize the connection between gray matter areas. In this work, the intra-axonal cross-sectional area coverage of the gray-to-white matter interface was examined by intersecting tractography streamlines with cortical regions of interest. The area coverage is the ratio of streamline weights divided by the surface area at the gray-to-white matter interface and assesses the estimated percentage which is covered by intra-axonal space. A high correlation (r = 0.935) between streamline weights and the cortical surface area was found across all regions of interest in all subjects. The variance across different cortical regions exhibits similarities to myelin maps. Additionally, we examined the effect of different diffusion gradient subsets at a lower, clinically feasible spatial resolution. Subsampling of the initial high-resolution diffusion dataset did not alter the tendency of the area coverage at the gray-to-white matter interface across cortical areas and subjects. However, single-shell acquisition schemes with lower b-values lead to a steady increase in area coverage in comparison to the full acquisition scheme at high resolution.

journal_name

Front Neurosci

authors

Sommer S,Kozerke S,Seifritz E,Staempfli P

doi

10.3389/fnins.2017.00729

subject

Has Abstract

pub_date

2017-12-22 00:00:00

pages

729

eissn

1662-4548

issn

1662-453X

journal_volume

11

pub_type

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