Xkr8 Modulates Bipolar Cell Number in the Mouse Retina.

Abstract:

:The present study interrogated a quantitative trait locus (QTL) on Chr 4 associated with the population sizes of two types of bipolar cell in the mouse retina. This locus was identified by quantifying the number of rod bipolar cells and Type 2 cone bipolar cells across a panel of recombinant inbred (RI) strains of mice derived from two inbred laboratory strains, C57BL/6J (B6/J) and A/J, and mapping a proportion of that variation in cell number, for each cell type, to this shared locus. There, we identified the candidate gene X Kell blood group precursor related family member 8 homolog (Xkr8). While Xkr8 has no documented role in the retina, we localize robust expression in the mature retina via in situ hybridization, confirm its developmental presence via immunolabeling, and show that it is differentially regulated during the postnatal period between the B6/J and A/J strains using qPCR. Microarray analysis, derived from whole eye mRNA from the entire RI strain set, demonstrates significant negative correlation of Xkr8 expression with the number of each of these two types of bipolar cells, and the variation in Xkr8 expression across the strains maps a cis-eQTL, implicating a regulatory variant discriminating the parental genomes. Xkr8 plasmid electroporation during development yielded a reduction in the number of bipolar cells in the retina, while sequence analysis of Xkr8 in the two parental strain genomes identified a structural variant in the 3' UTR that may disrupt mRNA stability, and two SNPs in the promoter that create transcription factor binding sites. We propose that Xkr8, via its participation in mediating cell death, plays a role in the specification of bipolar cell number in the retina.

journal_name

Front Neurosci

authors

Kautzman AG,Keeley PW,Ackley CR,Leong S,Whitney IE,Reese BE

doi

10.3389/fnins.2018.00876

subject

Has Abstract

pub_date

2018-12-03 00:00:00

pages

876

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

杂志文章
  • The Detection of Phase Amplitude Coupling during Sensory Processing.

    abstract::There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00487

    authors: Seymour RA,Rippon G,Kessler K

    更新日期:2017-09-01 00:00:00

  • Whole brain functional connectivity using phase locking measures of resting state magnetoencephalography.

    abstract::The analysis of spontaneous functional connectivity (sFC) reveals the statistical connections between regions of the brain consistent with underlying functional communication networks within the brain. In this work, we describe the implementation of a complete all-to-all network analysis of resting state neuronal acti...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00141

    authors: Schmidt BT,Ghuman AS,Huppert TJ

    更新日期:2014-06-11 00:00:00

  • STDP and STDP variations with memristors for spiking neuromorphic learning systems.

    abstract::In this paper we review several ways of realizing asynchronous Spike-Timing-Dependent-Plasticity (STDP) using memristors as synapses. Our focus is on how to use individual memristors to implement synaptic weight multiplications, in a way such that it is not necessary to (a) introduce global synchronization and (b) to ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00002

    authors: Serrano-Gotarredona T,Masquelier T,Prodromakis T,Indiveri G,Linares-Barranco B

    更新日期:2013-02-18 00:00:00

  • The Profiles of Non-stationarity and Non-linearity in the Time Series of Resting-State Brain Networks.

    abstract::The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state fMRI (rs-fMRI) time-series data from the Midnight Scan Club datasets. The degree of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00493

    authors: Guan S,Jiang R,Bian H,Yuan J,Xu P,Meng C,Biswal B

    更新日期:2020-06-11 00:00:00

  • Comparative Analysis of C9orf72 and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of C9orf72 Positive Patients.

    abstract::We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, comorbidities, and prognosis in patients with amyotrophic lateral sclerosis (ALS). A cohort of 1417 ALS patients, diagnosed between January 1, 2009 and December 31, 2013 by 13 Italian ALS Referral Centers, was screened ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00485

    authors: Trojsi F,Siciliano M,Femiano C,Santangelo G,Lunetta C,Calvo A,Moglia C,Marinou K,Ticozzi N,Ferro C,Scialò C,Sorarù G,Conte A,Falzone YM,Tortelli R,Russo M,Sansone VA,Chiò A,Mora G,Silani V,Volanti P,Caponnetto C

    更新日期:2019-05-17 00:00:00

  • Human Summating Potential Using Continuous Loop Averaging Deconvolution: Response Amplitudes Vary with Tone Burst Repetition Rate and Duration.

    abstract::Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimul...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00429

    authors: Kennedy AE,Kaf WA,Ferraro JA,Delgado RE,Lichtenhan JT

    更新日期:2017-07-27 00:00:00

  • Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism.

    abstract::Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and protein expression, and inter-individual differences, in the valp...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00127

    authors: Favre MR,La Mendola D,Meystre J,Christodoulou D,Cochrane MJ,Markram H,Markram K

    更新日期:2015-06-02 00:00:00

  • Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.

    abstract::Posttraumatic stress disorder (PTSD) is an anxiety disorder characterized by intrusive recollections of a severe traumatic event and hyperarousal following exposure to the event. Human and animal studies have shown that the change of amygdala activity after traumatic stress may contribute to occurrences of some sympto...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00387

    authors: Fang Q,Li Z,Huang GD,Zhang HH,Chen YY,Zhang LB,Ding ZB,Shi J,Lu L,Yang JL

    更新日期:2018-08-21 00:00:00

  • Habituation of the Interlimb Reflex (ILR) Over the Biceps Brachii Muscle After Electrical Stimuli Over the Sural Nerve.

    abstract::Up to now relatively little is known about interlimb reflexes (ILR). Especially it is not well known whether ILR may habituate or not to subsequent stimuli. The main aim of the present investigation was to explore the short term habituation behavior of ILR. The electromyogram was recorded over the tonically active bic...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01130

    authors: Alaid S,Emmer A,Kornhuber ME

    更新日期:2019-10-23 00:00:00

  • Fingolimod for Irradiation-Induced Neurodegeneration.

    abstract:Background:Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fing...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00699

    authors: Metzdorf J,Hobloss Z,Schlevogt S,Ayzenberg I,Stahlke S,Pedreiturria X,Haupeltshofer S,Gold R,Tönges L,Kleiter I

    更新日期:2019-07-09 00:00:00

  • MiR224-5p Inhibitor Restrains Neuronal Apoptosis by Targeting NR4A1 in the Oxygen-Glucose Deprivation (OGD) Model.

    abstract::This study was designed to investigate the molecular mechanism of stroke and to explore the effect of miR-224-5p in hypoxic cortical neurons. Firstly, we established a middle cerebral artery occlusion (MCAO) model with Sprague-Dawley rats. Triphenyltetrazolium chloride (TTC) staining showed the brain infarction of an ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00613

    authors: Liu LL,Qiao S,Wang ML,Wu HK,Su YX,Wang KM,Liu XW

    更新日期:2020-06-25 00:00:00

  • Change of cystine/glutamate antiporter expression in ethanol-dependent rats.

    abstract:BACKGROUND:Some drugs of abuse down regulate the expression of cystine/glutamate (xCT) antiporter in the nucleus accumbens (Acb) after extinction or withdrawal. The altered level of xCT exchanger in Acb, a structure involved in ethanol reinforcement, may contribute to the pathological glutamatergic signaling, linked to...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00311

    authors: Peana AT,Muggironi G,Bennardini F

    更新日期:2014-10-06 00:00:00

  • In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes.

    abstract::Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00464

    authors: Chauvière L,Pothof F,Gansel KS,Klon-Lipok J,Aarts AAA,Holzhammer T,Paul O,Singer WJ,Ruther P

    更新日期:2019-05-21 00:00:00

  • Discounting in Pigeons When the Choice is between Two Delayed Rewards: Implications for Species Comparisons.

    abstract::Studies of delay discounting typically have involved choices between smaller, immediate outcomes and larger, delayed outcomes. In a study of delay discounting in humans, Green et al. (2005) added a period of time prior to both outcomes, creating a delay common to both. They found that the subjective value of the more ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00096

    authors: Calvert AL,Green L,Myerson J

    更新日期:2011-08-17 00:00:00

  • Differentially expressed genes in major depression reside on the periphery of resilient gene coexpression networks.

    abstract::The structure of gene coexpression networks reflects the activation and interaction of multiple cellular systems. Since the pathology of neuropsychiatric disorders is influenced by diverse cellular systems and pathways, we investigated gene coexpression networks in major depression, and searched for putative unifying ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00095

    authors: Gaiteri C,Sibille E

    更新日期:2011-08-30 00:00:00

  • Toward the Understanding of Topographical and Spectral Signatures of Infant Movement Artifacts in Naturalistic EEG.

    abstract::Electroencephalography (EEG) is perhaps the most widely used brain-imaging technique for pediatric populations. However, EEG signals are prone to distortion by motion. Compared to adults, infants' motion is both more frequent and less stereotypical yet motion effects on the infant EEG signal are largely undocumented. ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00352

    authors: Georgieva S,Lester S,Noreika V,Yilmaz MN,Wass S,Leong V

    更新日期:2020-04-28 00:00:00

  • Systemic Low-Frequency Oscillations in BOLD Signal Vary with Tissue Type.

    abstract::Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00313

    authors: Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

    更新日期:2016-06-30 00:00:00

  • Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation.

    abstract::Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead to slacking when the assistance is too supportive. Preserving the engagement of t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00518

    authors: Grimm F,Naros G,Gharabaghi A

    更新日期:2016-11-15 00:00:00

  • Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.

    abstract::Progranulin (PGRN) is a tightly regulated, secreted glycoprotein involved in a wide range of biological processes that is of tremendous interest to the scientific community due to its involvement in neoplastic, neurodevelopmental, and neurodegenerative diseases. In particular, progranulin haploinsufficiency leads to f...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.602235

    authors: Gururaj S,Sampognaro PJ,Argouarch AR,Kao AW

    更新日期:2020-12-14 00:00:00

  • Modulation on Glutamic Pathway of Frontal-Striatum-Thalamus by rs11146020 and rs3813296 Gene Polymorphism in First-Episode Negative Schizophrenia.

    abstract:Objectives:The frontal-striatum-thalamus pathway is important in the glutamic neural circuit. The hypofunction of GRIN1 and GRIA2 subunits from glutamic receptors has been hypothesized as the primary process in the etiology of schizophrenia. Identified gene polymorphism involved in the pathogenesis of schizophrenia may...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00351

    authors: Cai S,Lv Y,Huang K,Zhang W,Wang Q,Huang L,Wang J

    更新日期:2020-04-21 00:00:00

  • Decoding continuous variables from neuroimaging data: basic and clinical applications.

    abstract::The application of statistical machine learning techniques to neuroimaging data has allowed researchers to decode the cognitive and disease states of participants. The majority of studies using these techniques have focused on pattern classification to decode the type of object a participant is viewing, the type of co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00075

    authors: Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

    更新日期:2011-06-15 00:00:00

  • Striatal and Tegmental Neurons Code Critical Signals for Temporal-Difference Learning of State Value in Domestic Chicks.

    abstract::To ensure survival, animals must update the internal representations of their environment in a trial-and-error fashion. Psychological studies of associative learning and neurophysiological analyses of dopaminergic neurons have suggested that this updating process involves the temporal-difference (TD) method in the bas...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00476

    authors: Wen C,Ogura Y,Matsushima T

    更新日期:2016-11-08 00:00:00

  • Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRP.

    abstract:Introduction:Low back pain (LBP) is a complex and growing global health problem in need of more effective pain management strategies. Spinal mobilization (SM) is a non-pharmacological approach recommended by most clinical guidelines for LBP, but greater utilization and treatment optimization are hampered by a lack of m...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00385

    authors: Reed WR,Little JW,Lima CR,Sorge RE,Yarar-Fisher C,Eraslan M,Hurt CP,Ness TJ,Gu JG,Martins DF,Li P

    更新日期:2020-04-30 00:00:00

  • Speech Discrimination Tasks: A Sensitive Sensory and Cognitive Measure in Early and Mild Multiple Sclerosis.

    abstract::There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.604991

    authors: Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

    更新日期:2020-12-23 00:00:00

  • 2-Chloroethanol Induced Upregulation of Matrix Metalloproteinase-2 in Primary Cultured Rat Astrocytes Via MAPK Signal Pathways.

    abstract::This study was to explore the mechanisms underlying 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of matrix metalloproteinase-2 (MMP-2) in rat astrocytes induced by 2-chloroethanol (2-CE), an intermediate metabolite of 1,2-DCE in vivo. Protein and mRNA levels of MMP-2, and the phosphorylat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00593

    authors: Sun Q,Liao Y,Wang T,Tang H,Wang G,Zhao F,Jin Y

    更新日期:2017-01-04 00:00:00

  • Coding of reward probability and risk by single neurons in animals.

    abstract::Probability and risk are important factors for value-based decision making and optimal foraging. In order to survive in an unpredictable world, organisms must be able to assess the probability and risk attached to future events and use this information to generate adaptive behavior. Recent studies in non-human primate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00121

    authors: Burke CJ,Tobler PN

    更新日期:2011-10-11 00:00:00

  • No Differential Effects of Two Different Alpha-Band Electrical Stimulation Protocols Over Fronto-Parietal Regions on Spatial Attention.

    abstract::In a previous study using transcranial alternating current stimulation (tACS), we found preliminary evidence that phase coherence in the alpha band (8-12 Hz) within the fronto-parietal network may critically support top-down control of spatial attention (van Schouwenburg et al., 2017). Specifically, synchronous alpha-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00433

    authors: van Schouwenburg MR,Sörensen LKA,de Klerk R,Reteig LC,Slagter HA

    更新日期:2018-07-03 00:00:00

  • Non-parametric statistical thresholding for sparse magnetoencephalography source reconstructions.

    abstract::Uncovering brain activity from magnetoencephalography (MEG) data requires solving an ill-posed inverse problem, greatly confounded by noise, interference, and correlated sources. Sparse reconstruction algorithms, such as Champagne, show great promise in that they provide focal brain activations robust to these confoun...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2012.00186

    authors: Owen JP,Sekihara K,Nagarajan SS

    更新日期:2012-12-26 00:00:00

  • Experimental Traumatic Brain Injury Induces Chronic Glutamatergic Dysfunction in Amygdala Circuitry Known to Regulate Anxiety-Like Behavior.

    abstract::Up to 50% of traumatic brain injury (TBI) survivors demonstrate persisting and late-onset anxiety disorders indicative of limbic system dysregulation, yet the pathophysiology underlying the symptoms is unclear. We hypothesize that the development of TBI-induced anxiety-like behavior in an experimental model of TBI is ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01434

    authors: Beitchman JA,Griffiths DR,Hur Y,Ogle SB,Bromberg CE,Morrison HW,Lifshitz J,Adelson PD,Thomas TC

    更新日期:2020-01-21 00:00:00

  • Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a novel eye-operated com...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00538

    authors: Lenglet T,Mirault J,Veyrat-Masson M,Funkiewiez A,Amador MDM,Bruneteau G,Le Forestier N,Pradat PF,Salachas F,Vacher Y,Lacomblez L,Lorenceau J

    更新日期:2019-05-29 00:00:00