Abstract:
:Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in the elderly, such as atherosclerosis, coronary atherosclerotic heart disease, hypertension, calcific aortic valve disease, heart failure and atrial fibrillation. In this review, we discuss the apelin-APJ signal transduction pathway related to age-associated cardiovascular diseases.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Zhou Y,Wang Y,Qiao S,Yin Ldoi
10.3389/fphys.2017.01035subject
Has Abstractpub_date
2017-12-12 00:00:00pages
1035issn
1664-042Xjournal_volume
8pub_type
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pub_type: 已发布勘误
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pub_type: 杂志文章,评审
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