Potential Therapeutic Use of Neurosteroids for Hypertension.

abstract：:For many model organisms traditionally in use for cardiac electrophysiological studies, characterization of ion channel genes is lacking. We focused here on two genes encoding the inward rectifier current, KCNJ2 and KCNJ12, in the dog heart. A combination of RT-PCR, 5'-RACE, and 3'-RACE demonstrated the status of KCNJ...

journal_title：Frontiers in physiology

authors： Houtman MJ,Takanari H,Kok BG,van Eck M,Montagne DR,Vos MA,de Boer TP,van der Heyden MA

更新日期：2012-01-30 00:00:00

abstract：:A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...

journal_title：Frontiers in physiology

authors： Herrero A,Duhart JM,Ceriani MF

更新日期：2017-11-14 00:00:00

abstract：:Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenom...

journal_title：Frontiers in physiology

authors： Diaz LA,Flores FS,Quaglia A,Contigiani MS

更新日期：2013-01-11 00:00:00

abstract：:Insecticidal effects of Bacillus thuringiensis Cry toxins in hemocoel of larvae have not been properly evaluated. In the present study, hemocoelic injection of four representative Cry toxins i.e., Cry1Aa, Cry1Ab, Cry1Ac, and DOR5 to an economically important lepidopteran insect pest Achaea janata, induced larval morta...

journal_title：Frontiers in physiology

authors： Ningshen TJ,Chauhan VK,Dhania NK,Dutta-Gupta A

更新日期：2017-05-10 00:00:00

abstract：:Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity or trauma. In the context of decompression sickness (DCS), the course of which is sometimes erratic, we hypothesize that mtDNA plays a not insignificant role particularly ...

journal_title：Frontiers in physiology

authors： Blatteau JE,Gaillard S,De Maistre S,Richard S,Louges P,Gempp E,Druelles A,Lehot H,Morin J,Castagna O,Abraini JH,Risso JJ,Vallée N

更新日期：2018-11-29 00:00:00

abstract：:Skeletal muscle differentiation is an essential process for the maintenance of muscle development and homeostasis. Reactive oxygen species (ROS) are critical signaling molecules involved in muscle differentiation. Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fat...

journal_title：Frontiers in physiology

authors： Yun HR,Jo YH,Kim J,Nguyen NNY,Shin Y,Kim SS,Choi TG

更新日期：2020-10-15 00:00:00

abstract：:The free-fall of orbital spaceflight effectively removes the gravitational vector used as a primary spatial orientation reference on Earth. Sustained absence of this reference drives adaptive changes in the internal perception-action models of the central nervous system (CNS), most notably in the processing of the ves...

journal_title：Frontiers in physiology

authors： Ozdemir RA,Goel R,Reschke MF,Wood SJ,Paloski WH

更新日期：2018-11-27 00:00:00

abstract：:Objective: Chronic hypoxia causes pulmonary vasoconstriction leading to pulmonary hypertension and right ventricular hypertrophy. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis; its level increases in hypoxia (HX) concomitantly with reduced activity of dimethylarginine dim...

journal_title：Frontiers in physiology

authors： Hannemann J,Glatzel A,Hillig J,Zummack J,Schumacher U,Lüneburg N,Harbaum L,Böger R

更新日期：2020-11-12 00:00:00

abstract：:The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the dise...

journal_title：Frontiers in physiology

authors： Liu T,Xie M,Lv Q,Li Y,Fang L,Zhang L,Deng W,Wang J

更新日期：2019-01-30 00:00:00

abstract：:The paper reports application of a Markov-like stochastic process agent-based model and a "virtual farm" concept for enhancement of site-specific Integrated Pest Management. Conceptually, the model represents a "bottom-up ethological" approach and emulates behavior of the "primary IPM actors"-large cohorts of individu...

journal_title：Frontiers in physiology

authors： Lux SA,Wnuk A,Vogt H,Belien T,Spornberger A,Studnicki M

更新日期：2016-08-23 00:00:00

abstract：:One-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis), a primary pathogen of the mammalian respiratory system, while about 10% of latent infections progress to active tuberculosis (TB), indicating that host and environmental factors may determine the outcomes such as i...

journal_title：Frontiers in physiology

authors： Luo M,Liu Y,Wu P,Luo DX,Sun Q,Zheng H,Hu R,Pandol SJ,Li QF,Han YP,Zeng Y

更新日期：2017-11-17 00:00:00

abstract：:The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling param...

journal_title：Frontiers in physiology

authors： Ticcinelli V,Stankovski T,Iatsenko D,Bernjak A,Bradbury AE,Gallagher AR,Clarkson PBM,McClintock PVE,Stefanovska A

更新日期：2017-10-13 00:00:00

abstract：:Cell function and survival are controlled by intracellular signals, and modulated by surrounding cells and the extracellular environment. Connexin channels participate in these processes by mediating cell-to-cell communication. In bone cells, gap junction channels were detected in the early 1970s, and are present amon...

journal_title：Frontiers in physiology

authors： Plotkin LI

更新日期：2014-04-04 00:00:00

abstract：:In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cell can express more than one connexin isoform, the formation of hetero...

journal_title：Frontiers in physiology

authors： Zhong G,Akoum N,Appadurai DA,Hayrapetyan V,Ahmed O,Martinez AD,Beyer EC,Moreno AP

更新日期：2017-05-29 00:00:00

abstract：:Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

journal_title：Frontiers in physiology

authors： Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

更新日期：2017-08-29 00:00:00

abstract：:Extracellular vesicles (EVs) - including exosomes, microvesicles and apoptotic bodies - have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providing signals that infl...

journal_title：Frontiers in physiology

authors： Rackov G,Garcia-Romero N,Esteban-Rubio S,Carrión-Navarro J,Belda-Iniesta C,Ayuso-Sacido A

更新日期：2018-06-05 00:00:00

abstract：Background:Several mechanisms allow humans to resist the extreme conditions encountered during breath-hold diving. Available nitric oxide (NO) is one of the major contributors to such complex adaptations at depth and oxidative stress is one of the major collateral effects of diving. Due to technical difficulties, these...

journal_title：Frontiers in physiology

authors： Cialoni D,Brizzolari A,Samaja M,Bosco G,Paganini M,Pieri M,Lancellotti V,Marroni A

更新日期：2021-01-07 00:00:00

abstract：:The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the directio...

journal_title：Frontiers in physiology

authors： Bou Jawde S,Takahashi A,Bates JHT,Suki B

更新日期：2020-02-25 00:00:00

abstract：:Purpose: The mechanisms involved in the coordination of muscle activity are not completely known: to investigate adaptive changes in human motor cortex Transcranial magnetic stimulation (TMS) was often used. The sport models are frequently used to study how the training may affect the corticospinal system excitability...

journal_title：Frontiers in physiology

authors： Monda V,Valenzano A,Moscatelli F,Salerno M,Sessa F,Triggiani AI,Viggiano A,Capranica L,Marsala G,De Luca V,Cipolloni L,Ruberto M,Precenzano F,Carotenuto M,Zammit C,Gelzo M,Monda M,Cibelli G,Messina G,Messina A

更新日期：2017-09-12 00:00:00

abstract：:Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are re...

journal_title：Frontiers in physiology

authors： Cheng H,Lu T,Wang J,Xia Y,Chai X,Zhang M,Yao Y,Zhou N,Zhou S,Chen X,Su W,Liu C,Yi W,Chen Y,Yao L

更新日期：2020-03-25 00:00:00

abstract：:Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive ...

journal_title：Frontiers in physiology

authors： Nishikawa S,Abe M

更新日期：2010-11-16 00:00:00

abstract：:Laodelphax striatellus is naturally infected with the Wolbachia strain wStri, which induces strong cytoplasmic incompatibility of its host. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that play a critical role in the regulation of gene expression at post-transcriptional level in various biologic...

journal_title：Frontiers in physiology

authors： Liu L,Zhang KJ,Rong X,Li YY,Liu H

更新日期：2019-07-24 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00313.]. ...

journal_title：Frontiers in physiology

authors： Naro F,Venturelli M,Monaco L,Toniolo L,Muti E,Milanese C,Zhao J,Richardson RS,Schena F,Reggiani C

更新日期：2020-02-25 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Heart Failure (HF) is associated with significantly high morbidity and mortality. We performed a meta-analysis and updated new evidences from randomized controlled trials (RCTs) to determine the effects of Tai Chi (TC) in patients with HF. Electronic literature search of Medline, PubMed, EMBASE, the Cochrane Library, ...

journal_title：Frontiers in physiology

authors： Ren X,Li Y,Yang X,Li J,Li H,Yuan Z,Sun Y,Shang H,Xing Y,Gao Y

更新日期：2017-12-07 00:00:00

abstract：:Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expres...

journal_title：Frontiers in physiology

authors： Sasse P,Funken M,Beiert T,Bruegmann T

更新日期：2019-06-06 00:00:00

abstract：:The spinal cord demonstrates several forms of plasticity that resemble brain-dependent learning and memory. Among the most studied form of spinal plasticity is spinal memory for noxious (nociceptive) stimulation. Numerous papers have described central pain as a spinally-stored memory that enhances future responses to ...

journal_title：Frontiers in physiology

authors： Ferguson AR,Huie JR,Crown ED,Grau JW

更新日期：2012-10-04 00:00:00

abstract：:Muscle tone represents one of the important concepts for characterizing changes in the state of the developing nervous system. It can be manifested in the level of activity of flexors and extensors and in muscle reactions to its passive stretching (StR) or shortening (ShR). Here we investigated such reactions in a coh...

journal_title：Frontiers in physiology

authors： Solopova IA,Zhvansky DS,Dolinskaya IY,Keshishian ES,Selionov VA,Sylos-Labini F,Lacquaniti F,Ivanenko Y

更新日期：2019-09-13 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) caused by SARS-CoV2 is associated with various comorbidities; cardiovascular diseases, hypertension, diabetes, liver, lung diseases, and neurological ailments. The majority of the dysfunctions mentioned above are often associated with endothelial deterioration, indicating that endot...

journal_title：Frontiers in physiology

authors： Jakhmola S,Indari O,Baral B,Kashyap D,Varshney N,Das A,Chatterjee S,Jha HC

更新日期：2020-08-04 00:00:00