Interleukin-6 in Schizophrenia-Is There a Therapeutic Relevance?

abstract：:This study explored how different forms of reward-based decision-making are associated with pathological gambling (PG) among abstinent individuals with prior dependence on different classes of drugs. Participants had lifetime histories of either "pure" heroin dependence (n = 64), "pure" amphetamine dependence (n = 51)...

journal_title：Frontiers in psychiatry

authors： Wilson MJ,Vassileva J

更新日期：2018-06-05 00:00:00

abstract：:Background: More information is needed about the efficacy and safety of long-term baclofen in the treatment of alcohol use disorders. The objective of this study was to assess the effect of treatment with tailored-dose baclofen on alcohol consumption in patients with alcohol use disorders followed for 3 years after fi...

journal_title：Frontiers in psychiatry

authors： Pinot J,Rigal L,Granger B,Sidorkiewicz S,Jaury P

更新日期：2018-10-08 00:00:00

abstract：:Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate-dependent individuals. The current study sought to confirm these effects ...

journal_title：Frontiers in psychiatry

authors： Hogarth L,Hardy L,Bakou A,Mahlberg J,Weidemann G,Cashel S,Moustafa AA

更新日期：2019-05-15 00:00:00

abstract：Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

journal_title：Frontiers in psychiatry

authors： Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

更新日期：2020-08-14 00:00:00

abstract：:The gut hormone ghrelin has been implicated in a variety of functional roles in the central nervous system through the brain-gut axis, one of which is an anti-inflammatory effect. An aberrant brain-gut axis producing immune dysfunction has been implicated in the pathobiology of autism spectrum disorder (ASD), and elev...

journal_title：Frontiers in psychiatry

authors： Yamashita Y,Makinodan M,Toritsuka M,Yamauchi T,Ikawa D,Kimoto S,Komori T,Takada R,Kayashima Y,Hamano-Iwasa K,Tsujii M,Matsuzaki H,Kishimoto T

更新日期：2019-03-26 00:00:00

abstract：:Objective: During the outbreak of the COVID-19 epidemic in China, breast cancer (BC) patients and healthcare workers faced several challenges, resulting in great psychological stress. We measured the psychological status of BC patients and female nurses and compared the severity within the two groups at the peak time-...

journal_title：Frontiers in psychiatry

authors： Cui Q,Cai Z,Li J,Liu Z,Sun S,Chen C,Wang G

更新日期：2020-12-15 00:00:00

abstract：:Pharmacological approaches to cognitive enhancement have received considerable attention but have not had considerable success in improving their cognitive and functional targets. Other intervention strategies, such as cognitive remediation therapy (CRT), have been shown to enhance cognitive performance but have not b...

journal_title：Frontiers in psychiatry

authors： Harvey PD,Sand M

更新日期：2017-09-25 00:00:00

abstract：:Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate ...

journal_title：Frontiers in psychiatry

authors： Jones JL,Mateus CF,Malcolm RJ,Brady KT,Back SE

更新日期：2018-07-24 00:00:00

abstract：Background:Gastric necrosis following acute gastric dilatation is rare but more common in females with eating disorders, such as anorexia nervosa or bulimia, during which patients often alternate restriction and binge eating behaviors. Case Presentation:A 37-year old female patient with a history of 15 years of bulimi...

journal_title：Frontiers in psychiatry

authors： Achamrah N,Grigioni S,Coëffier M,Ainseba N,Déchelotte P

更新日期：2020-07-31 00:00:00

abstract：:Background: Over the past 15 years, comparative assessments of psychoactive substance harms to both users and others have been compiled by addiction experts. None of these rankings however have included synthetic cannabinoids or non-opioid prescription analgesics (NOAs, e.g., gabapentinoids) despite evidence of increa...

journal_title：Frontiers in psychiatry

authors： Bonnet U,Specka M,Soyka M,Alberti T,Bender S,Grigoleit T,Hermle L,Hilger J,Hillemacher T,Kuhlmann T,Kuhn J,Luckhaus C,Lüdecke C,Reimer J,Schneider U,Schroeder W,Stuppe M,Wiesbeck GA,Wodarz N,McAnally H,Scherbaum N

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Evidence indicates that early life stress (ELS) can induce persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis to respond to stress in the adult life that leads to depression. These appear to be related to the impairment of HPA hormones through binding to glucocorticoid (GR) and mineralocorti...

journal_title：Frontiers in psychiatry

authors： Baes Cv,Martins CM,Tofoli SM,Juruena MF

更新日期：2014-01-24 00:00:00

abstract：Background:Depression is pervasive in the military context and is likely to elicit lasting negative effects on health. Based on interpersonal models, social-interpersonal stressors are significantly associated with the development and maintenance of depression. However, little is known about the mechanisms by which the...

journal_title：Frontiers in psychiatry

authors： Wang J,Cheng X,Xu K,Xu H,Wang H,Feng Z

更新日期：2020-06-18 00:00:00

abstract：:Criminal responsibility assessment is undertaken by psychologists or psychiatrists to assess offenders' legal capacities, which vary among countries or regional legislations. There are two psychometric tools (i.e., checklists) validated for criminal responsibility assessment: the Roger Criminal Responsibility Scale, a...

journal_title：Frontiers in psychiatry

authors： Meyer LF,Leal CCS,Omena AAS,Mecler K,Valença AM

更新日期：2020-11-27 00:00:00

abstract：:As established in a wealth of studies subtle motor and sensory neurological abnormalities or neurological soft signs (NSS) are frequently found in patients with schizophrenia at any stage of their illness. However, the potential impact of chronicity and age on NSS was scarcely investigated. Therefore, we assessed NSS ...

journal_title：Frontiers in psychiatry

authors： Herold CJ,Lässer MM,Seidl UW,Hirjak D,Thomann PA,Schröder J

更新日期：2018-03-26 00:00:00

abstract：Background:Epidemiologic evidence highlights the harmful consequences of unemployment on health and well-being. This emphasizes the need to design low-cost interventions to prevent the adverse mental health effects of unemployment. The main aim of this study was to create expert-consensus regarding development and impl...

journal_title：Frontiers in psychiatry

authors： Santos O,Lopes E,Virgolino A,Stefanovska-Petkovska M,Dinis A,Ambrósio S,Heitor MJ

更新日期：2018-02-07 00:00:00

abstract：Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

journal_title：Frontiers in psychiatry

authors： Holper L

更新日期：2020-07-28 00:00:00

abstract：:Butyrylcholinesterase (BChE) efficiently hydrolyzes acetylcholine (ACh) at high concentrations when acetylcholinesterase (AChE) is substrate-inhibited. Recent studies have shown that BChE also has a function that is independent of ACh, but it has not been fully explored. Low BChE expression is accompanied with higher ...

journal_title：Frontiers in psychiatry

authors： Chen S,Lin Z,Tan KL,Chen R,Su W,Zhao H,Tan Q,Tan W

更新日期：2020-09-11 00:00:00

abstract：Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...

journal_title：Frontiers in psychiatry

authors： Zhong S,Zhu X,Chen Y,Guo H,Luo C,Liang X,Wang F,Chen H,Zhou J,Wang X

更新日期：2020-04-14 00:00:00

abstract：Background:The amygdala has been proposed to be involved in the pathophysiology of pediatric and adult bipolar disorder (BD). The goal of this structural magnetic resonance imaging (sMRI) study was to investigate the morphometric characteristics of amygdala subnuclei in patients with pediatric bipolar disorder (PBD) co...

journal_title：Frontiers in psychiatry

authors： Cui D,Guo Y,Cao W,Gao W,Qiu J,Su L,Jiao Q,Lu G

更新日期：2020-06-26 00:00:00

abstract：:The issues that confront families when a parent experiences mental illness are complex. This often means that multiple service systems must be engaged to meet families' needs, including those related to intergenerational experiences of mental health and illness. A multisystem approach to public mental health care is w...

journal_title：Frontiers in psychiatry

authors： Isobel S,Allchin B,Goodyear M,Gladstone BM

更新日期：2019-05-08 00:00:00

abstract：:Introduction: Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrat...

journal_title：Frontiers in psychiatry

authors： Antunes LC,Elkfury JL,Parizotti CS,Brietzke AP,Bandeira JS,Torres ILDS,Fregni F,Caumo W

更新日期：2020-10-14 00:00:00

abstract：:Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise...

journal_title：Frontiers in psychiatry

authors： Cui G,Ou Y,Chen Y,Lv D,Jia C,Zhong Z,Yang R,Wang Y,Meng X,Cui H,Li C,Sun Z,Wang X,Guo W,Li P

更新日期：2020-03-03 00:00:00

abstract：:Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brai...

journal_title：Frontiers in psychiatry

authors： Dai XJ,Jiang J,Zhang Z,Nie X,Liu BX,Pei L,Gong H,Hu J,Lu G,Zhan Y

更新日期：2018-06-27 00:00:00

abstract：:Introduction: Chronic recreational methamphetamine use causes dopaminergic neurotoxicity, which has been linked to impairments in executive functioning. Within this functional domain, response selection and the resolution of associated conflicts have repeatedly been demonstrated to be strongly modulated by dopamine. Y...

journal_title：Frontiers in psychiatry

authors： Bensmann W,Ernst J,Rädle M,Opitz A,Beste C,Stock AK

更新日期：2019-11-19 00:00:00

abstract：:Previous studies have reported an association between verbal abuse in early childhood and structural and functional alterations in the young adult brain, supporting the existence of critical periods in human brain development. In addition, exposure to verbal abuse in early childhood is strongly correlated with lifetim...

journal_title：Frontiers in psychiatry

authors： Shin DW,Yoon T,Jeong B

更新日期：2019-04-16 00:00:00

abstract：:Research has demonstrated the short- and long-term impacts of maternal mental health and well-being on children's emotional and behavioral outcomes. It is thus important to better understand the antecedents of maternal depression and stress. The aim of this study was to determine whether the contribution of perceived ...

journal_title：Frontiers in psychiatry

authors： deMontigny F,Gervais C,Pierce T,Lavigne G

更新日期：2020-11-02 00:00:00

abstract：:Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, and it refers to both a state symptom in various psychiatric disorders and a personality trait. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Anhedonia...

journal_title：Frontiers in psychiatry

authors： Hatzigiakoumis DS,Martinotti G,Giannantonio MD,Janiri L

更新日期：2011-03-17 00:00:00

abstract：:Virtual reality (VR) offers children with autism spectrum disorder (ASD) an inexpensive and motivating medium to learn and practice skills in a personalized, controlled, and safe setting; however, outcomes of VR interventions can vary widely. In particular, there is a need to understand the predictors of VR experience...

journal_title：Frontiers in psychiatry

authors： Malihi M,Nguyen J,Cardy RE,Eldon S,Petta C,Kushki A

更新日期：2020-08-04 00:00:00

abstract：:In clinical settings, nitrous oxide gas is a safe anesthetic used during childbirth, in dentistry, and to relieve anxiety in emergencies. Colloquially known as "hippy crack"' or "laughing gas," it is increasingly taken recreationally for its euphoric and relaxing effects and hallucinogenic properties. Using a self-rep...

journal_title：Frontiers in psychiatry

authors： Ehirim EM,Naughton DP,Petróczi A

更新日期：2018-01-22 00:00:00

abstract：:The present study aims to analyze the clinical and socio-demographic characteristics of patients with obsessive-compulsive disorder (OCD) in comorbidity with schizotypal personality disorder (SPD), as well as the response rate to pharmacological treatments. OCD+SPD patients had a younger age at onset, a higher probabi...

journal_title：Frontiers in psychiatry

authors： Perris F,Fabrazzo M,De Santis V,Luciano M,Sampogna G,Fiorillo A,Catapano F

更新日期：2019-06-17 00:00:00