Abstract:
:This study explored how different forms of reward-based decision-making are associated with pathological gambling (PG) among abstinent individuals with prior dependence on different classes of drugs. Participants had lifetime histories of either "pure" heroin dependence (n = 64), "pure" amphetamine dependence (n = 51), or polysubstance dependence (n = 89), or had no history of substance dependence (n = 133). Decision-making was assessed via two neurocognitive tasks: (1) the Iowa Gambling Task (IGT), a measure of decision-making under ambiguity (i.e., uncertain risk contingencies); and (2) the Cambridge Gambling task (CGT), a measure of decision-making under risk (i.e., explicit risk contingencies). The main effects of neurocognitive performance and drug class on PG (defined as ≥3 DSM-IV PG symptoms) as well as their interactional effects were assessed via multiple linear regression. Two CGT indices of decision-making under risk demonstrated positive main effects on PG. Interaction effects indicated that the effects of decision-making under risk on PG were largely consistent across participant groups. Notably, a linear relationship between greater CGT Risk-Taking and PG symptoms was not observed among amphetamine users, whereas IGT performance was selectively and positively associated with PG in polysubstance users. Overall, results indicate that reward-based decision-making under risk may represent a risk factor for PG across substance users, with some variations in these relationships influenced by specific class of substance of abuse.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Wilson MJ,Vassileva Jdoi
10.3389/fpsyt.2018.00239subject
Has Abstractpub_date
2018-06-05 00:00:00pages
239issn
1664-0640journal_volume
9pub_type
杂志文章abstract::Imaging studies of major depressive disorder (MDD) have demonstrated enhanced resting-state activity of the amygdala as well as exaggerated reactivity to negative emotional stimuli relative to healthy controls (HCs). However, the abnormalities in the intrinsic connectivity of the amygdala in MDD still remain unclear. ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2014.00017
更新日期:2014-02-19 00:00:00
abstract:Background:Accumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and is used as a stabil...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00250
更新日期:2020-04-15 00:00:00
abstract::Non-suicidal self-injury (NSSI) is prevalent in adolescence and is associated with increased risk for a variety of subsequent negative mental health outcomes, necessitating an evidence-based preventive approach. This pilot study examines the potential iatrogenic effects and feasibility of an evidence-based school prog...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00437
更新日期:2020-05-29 00:00:00
abstract::This hypothesis and theory paper presents a pragmatic framework to help bridge the clinical presentation and neuroscience of intrusive memories following psychological trauma. Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD). However, key questions, including those involving etiology,...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2015.00104
更新日期:2015-07-22 00:00:00
abstract:Introduction:Mixed-specifier mood disorders are probably a different subgroup in terms of response to treatment, socio-demographic parameters, course, and family history. Here we describe the rationale and design of a clinical trial aimed to test the efficacy, safety, and tolerability of a non-pharmacological treatment...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00435
更新日期:2020-05-15 00:00:00
abstract::Objective: We previously found that chronic ketamine usages were associated with various psychotic and cognitive symptoms mimicking schizophrenia. The blockade of the NMDA receptor and subsequent nitric oxide synthase 1 (NOS1) dysfunction were found to be closely correlated with schizophrenia including NOS1 gene polym...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.580771
更新日期:2020-12-23 00:00:00
abstract::Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life. Little research has been conducted on parenting experiences of mothers in recovery from substance use, taking into account their own upbringing a...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00728
更新日期:2019-10-18 00:00:00
abstract:Background:Among Muslim patients, a common cultural concept of distress is the notion that jinn may be the cause of mental health problems, especially in the presence of hallucinations. Objective:This study examines the frequency with which this attribution style is manifest in a specific psychiatric outpatient popula...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00089
更新日期:2018-03-28 00:00:00
abstract::Aim: Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. Most patients improve if properly diagnosed and treated expediently with immunotherapy. Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00913
更新日期:2019-12-13 00:00:00
abstract:INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2012.00053
更新日期:2012-06-01 00:00:00
abstract::Background: The transition from psychiatric hospital to community is often hindered by challenges that influence community adjustment and continuity of care. Transitional interventions with bridging components are provided prior to discharge and continue beyond inpatient care. They provide continuity of care and may b...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2019.00969
更新日期:2020-01-21 00:00:00
abstract::Background: While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.584711
更新日期:2020-12-18 00:00:00
abstract::Background: Patients with schizophrenia show abnormal spontaneous oscillatory activity in scalp-level electroencephalographic (EEG) responses across multiple frequency bands. While oscillations play an essential role in the transmission of information across neural networks, few studies have assessed the frequency-spe...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.608154
更新日期:2020-11-27 00:00:00
abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2013.00128
更新日期:2013-10-14 00:00:00
abstract::Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2017.00221
更新日期:2017-11-06 00:00:00
abstract::Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single g...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2014.00053
更新日期:2014-08-04 00:00:00
abstract::Background: The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) is the most commonly used instrument to assess burnout. Although various factors have been reported to influence its validity, the influence of major depressive disorder (MDD) has not been previously considered. We developed this study to invest...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00695
更新日期:2018-12-18 00:00:00
abstract::Overt aggression, increased anxiety, and dysfunctional fear processing are often observed in individuals with conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD). Methylphenidate (MPH), a psychostimulant increasing dopamine and noradrenaline tone, is effective in reducing aggression in both CD an...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00768
更新日期:2019-10-25 00:00:00
abstract::Introduction: The loss of a loved one in a terror incident is associated with elevated risk for mental health disorders such as prolonged grief disorder (PGD) and posttraumatic stress disorder (PTSD), but the long- term adaptation after such losses are not well understood. This study aims to explore the trajectories o...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.545368
更新日期:2020-10-14 00:00:00
abstract:Objectives:Many studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (HCs), and examined ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00364
更新日期:2020-05-05 00:00:00
abstract::Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the sym...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00249
更新日期:2018-06-08 00:00:00
abstract::Background: Approach and avoidance motivation have been thoroughly studied in common mental disorders, which are prevalent in the military context. Approach/avoidance motivational dispositions underlie emotion responses and are thought to influence emotion dysregulation. However, studies on the mediating role of emoti...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00149
更新日期:2019-03-22 00:00:00
abstract::Inflammation and immune dysregulation could contribute to the pathogenesis of schizophrenia. Osteopontin (OPN) is a cytokine-like glycoprotein involved in inflammation and in modulating immune responses, and it can also directly modify the cytokine expression and survival of microglia. Furthermore, elevated gene expre...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00996
更新日期:2020-01-23 00:00:00
abstract::The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged. Proposed mechanisms underlying brain enlargement include abnormal inflammatory and neurotrophic signals that lead to excessive, abe...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2019.00165
更新日期:2019-04-10 00:00:00
abstract::Cogmed Working Memory Training (CWMT), an online cognitive training program developed for children, is an increasingly popular non-pharmacological intervention for ADHD amongst all ages, despite limited supporting evidence. The initial objective of the present work was to examine the short- and long-term impacts of CW...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00388
更新日期:2018-08-28 00:00:00
abstract::There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed wit...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2017.00124
更新日期:2017-07-11 00:00:00
abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2017.00282
更新日期:2017-12-13 00:00:00
abstract::Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. The purpose of this study was to specify overlapping symptom domains and to identify symptoms that can reliably differentiate adults with ASD (n = 53), SZ (n = 39), and typical deve...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00548
更新日期:2020-06-11 00:00:00
abstract::In the brain of female mammals, including humans, a number of physiological and behavioral changes occur as a result of sex hormone exposure. Estradiol and progesterone regulate several brain functions, including learning and memory. Sex hormones contribute to shape the central nervous system by modulating the formati...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2015.00165
更新日期:2015-11-20 00:00:00
abstract::Attention deficit hyperactivity disorder (ADHD) is a disorder most frequently diagnosed in children and adolescents. Although ADHD can be effectively treated with psychostimulants, a significant proportion of patients discontinue treatment because of adverse events or insufficient improvement of symptoms. In addition,...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00334
更新日期:2019-05-16 00:00:00