Analytic Methods for Evaluating Patterns of Multiple Congenital Anomalies in Birth Defect Registries.

abstract：BACKGROUND:Maternal smoking or passive smoking during gestation increases the risk of congenital birth defects, including neural tube defects (NTDs). Cigarette smoke is a recognized teratogen that causes NTDs, although the mechanisms are not well understood. METHODS:An established model of passive smoking in pregnant ...

journal_title：Birth defects research

authors： Yin C,Cai H,Yang D,Jian Y,Zhang J,Li Z,Wang D

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Most states have now passed legislation mandating pulse oximetry for all newborns, or have promulgated regulations or guidelines to encourage use of routine pulse oximetry. State-based birth defects registries may be well positioned to track and evaluate critical congenital heart disease (CCHD) screening cov...

journal_title：Birth defects research

authors： Case AP,Miller SD,McClain MR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

journal_title：Birth defects research

authors： Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

更新日期：2017-09-01 00:00:00

abstract：:The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...

journal_title：Birth defects research

authors： Radford K,Taylor RC,Hall JG,Gick B

更新日期：2019-01-15 00:00:00

abstract：:Zika virus was first identified in Uganda in 1947 but received little attention until 2015 when a large outbreak of Zika virus illness followed by an increased number of babies born with microcephaly occurred in Brazil. Zika virus spread rapidly throughout the Americas, and in 2016 was identified as a cause of microce...

journal_title：Birth defects research

authors： Rasmussen SA,Jamieson DJ

更新日期：2020-09-01 00:00:00

abstract：:Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

journal_title：Birth defects research

authors： Li J,Xia CH,Wang E,Yao K,Gong X

更新日期：2017-06-01 00:00:00

abstract：:In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mec...

journal_title：Birth defects research

authors： Rychlik KA,Sillé FCM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used ...

journal_title：Birth defects research

authors： Nasri HZ,Houde Ng K,Westgate MN,Hunt AT,Holmes LB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and ...

journal_title：Birth defects research

authors： Sheth KR,Kovar E,White JT,Chambers TM,Peckham-Gregory EC,O'Neill M,Langlois PH,Seth A,Scheurer ME,Lupo PJ,Jorgez CJ

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect newborns against pertussis infection in the months prior to their primary pertussis vaccination. Although research on the safety of the vaccine has been reassuring, most previous s...

journal_title：Birth defects research

authors： Kerr SM,Van Bennekom CM,Mitchell AA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...

journal_title：Birth defects research

authors： Rittler M,Campaña H,Poletta FA,Santos MR,Gili JA,Pawluk MS,Cosentino VR,Gimenez L,Lopez-Camelo JS

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:My career goal in 1971 was to learn about the causes of malformations. Attending the annual meetings of the Teratology Society and reading the articles in Teratology exposed me to the scientists and clinicians involved in this research and the methods being used. METHODS:Over a period of 49 years (1972-2020...

journal_title：Birth defects research

authors： Holmes LB

更新日期：2020-07-15 00:00:00

abstract：OBJECTIVES:To explore the technical aspects and clinical utility of early fetal echocardiography and screening of the fetal heart in early pregnancy. Also, to document differences in cardiac structure and function which can be demonstrated in the late first/early second trimesters. METHODS:In addition to summarizing o...

journal_title：Birth defects research

authors： McBrien A,Hornberger LK

更新日期：2019-05-01 00:00:00

abstract：:The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...

journal_title：Birth defects research

authors： Mylchreest E,Smiley MA,Ballin JD,Blauth B,Shearer J,Reece J,Ionin B,Savransky V

更新日期：2021-01-01 00:00:00

abstract：:Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...

journal_title：Birth defects research

authors： Jacobus J,Courtney KE,Hodgdon EA,Baca R

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:A cardinal feature of prenatal ethanol exposure is CNS damage, resulting in a continuum of neurological and behavioral impairments that are described by the term fetal alcohol spectrum disorders (FASD). FASDs are variable and depend on several factors, including the amount, timing, and duration of prenatal e...

journal_title：Birth defects research

authors： Buckley DM,Sidik A,Kar RD,Eberhart JK

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

journal_title：Birth defects research

authors： Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains the same. The objective of dose selection is to identify a strategy to achieve consistent system...

journal_title：Birth defects research

authors： Posobiec LM,Laffan SB

更新日期：2020-12-14 00:00:00

abstract：:Over 50% of patients with 22q11.2 deletion syndrome (DS) have a conotruncal or related cardiac defect (CTRD). We hypothesized that similar genetic variants, developmental pathways and biological functions, contribute to disease risk for CTRD in patients without a 22q11.2 deletion (ND-CTRD) and with a 22q11.2 deletion ...

journal_title：Birth defects research

authors： Xie HM,Taylor DM,Zhang Z,McDonald-McGinn DM,Zackai EH,Stambolian D,Hakonarson H,Morrow BE,Emanuel BS,Goldmuntz E

更新日期：2019-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. ...

journal_title：Birth defects research

authors： Davis NL,King CC,Kourtis AP

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

journal_title：Birth defects research

authors： Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. METHODS:...

journal_title：Birth defects research

authors： Tanaka T,Suzuki T,Inomata A,Moriyasu T

更新日期：2020-12-01 00:00:00

abstract：:In 2016, Centers for Disease Control and Prevention (CDC) established surveillance of pregnant women with Zika virus infection and their infants in the U.S. states, territories, and freely associated states. To identify cases of Zika-associated birth defects, subject matter experts review data reported from medical re...

journal_title：Birth defects research

authors： Lusk R,Zimmerman J,VanMaldeghem K,Kim S,Roth NM,Lavinder J,Fulton A,Raycraft M,Ellington SR,Galang RR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CF): vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia, renal malformations (R), and limb defects (L). Patients presentin...

journal_title：Birth defects research

authors： Zhang R,Marsch F,Kause F,Degenhardt F,Schmiedeke E,Märzheuser S,Hoppe B,Bachour H,Boemers TM,Schäfer M,Spychalski N,Neser J,Leonhardt J,Kosch F,Ure B,Gómez B,Lacher M,Deffaa OJ,Palta M,Wittekindt B,Kleine K,Schm

更新日期：2017-07-17 00:00:00

abstract：:Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

journal_title：Birth defects research

authors： Khokha MK,Mitchell LE,Wallingford JB

更新日期：2017-01-30 00:00:00

abstract：BACKGROUND:Cardiac fibrosis is a cardinal feature of multiple types of cardiovascular disease, which lead to heart failure. Multiple studies connect adverse maternal environment (AME) with cardiac fibrosis. AME does not always result in fibrosis, though. An additional "insult", such as an adult Western diet (WD), is fr...

journal_title：Birth defects research

authors： Spearman AD,Ke X,Fu Q,Lane RH,Majnik A

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...

journal_title：Birth defects research

authors： Segovia-Mendoza M,Nava-Castro KE,Palacios-Arreola MI,Garay-Canales C,Morales-Montor J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...

journal_title：Birth defects research

authors： Hrubec TC,Melin VE,Shea CS,Ferguson EE,Garofola C,Repine CM,Chapman TW,Patel HR,Razvi RM,Sugrue JE,Potineni H,Magnin-Bissel G,Hunt PA

更新日期：2017-08-15 00:00:00

abstract：:OEIS is the acronym of a malformations complex association including omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects. It has a very low prevalence, ranging from 1/82,000 to 1/200,000 live births (LB). The etiology of OEIS is unknown. Virtually all cases are sporadic, and specific asso...

journal_title：Birth defects research

authors： Arteaga-Vázquez J,Luna-Muñoz L,Morales-Suárez JJ,Mutchinick OM

更新日期：2019-07-01 00:00:00

abstract：:Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

journal_title：Birth defects research

authors： Bergman NJ

更新日期：2019-09-01 00:00:00