Malformations among infants of mothers with insulin-dependent diabetes: Is there a recognizable pattern of abnormalities?

abstract：BACKGROUND:Maternal smoking or passive smoking during gestation increases the risk of congenital birth defects, including neural tube defects (NTDs). Cigarette smoke is a recognized teratogen that causes NTDs, although the mechanisms are not well understood. METHODS:An established model of passive smoking in pregnant ...

journal_title：Birth defects research

authors： Yin C,Cai H,Yang D,Jian Y,Zhang J,Li Z,Wang D

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and ...

journal_title：Birth defects research

authors： Sheth KR,Kovar E,White JT,Chambers TM,Peckham-Gregory EC,O'Neill M,Langlois PH,Seth A,Scheurer ME,Lupo PJ,Jorgez CJ

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...

journal_title：Birth defects research

authors： Kronenfeld N,Berlin M,Shaniv D,Berkovitch M

更新日期：2017-07-17 00:00:00

abstract：:Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

journal_title：Birth defects research

authors： Li J,Xia CH,Wang E,Yao K,Gong X

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Congenital malformations are a leading cause of infant mortality in the United States, and risk for some congenital malformations varies by socioeconomic status (SES). Medicaid provides health insurance for people with low income, and covers approximately half of all live births in the United States. Income ...

journal_title：Birth defects research

authors： Richardson SD,Josberger RE

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...

journal_title：Birth defects research

authors： Segovia-Mendoza M,Nava-Castro KE,Palacios-Arreola MI,Garay-Canales C,Morales-Montor J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect newborns against pertussis infection in the months prior to their primary pertussis vaccination. Although research on the safety of the vaccine has been reassuring, most previous s...

journal_title：Birth defects research

authors： Kerr SM,Van Bennekom CM,Mitchell AA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...

journal_title：Birth defects research

authors： Abdelaziz MH,Salah El-Din EY,El-Dakdoky MH,Ahmed TA

更新日期：2019-08-01 00:00:00

abstract：:Over 50% of patients with 22q11.2 deletion syndrome (DS) have a conotruncal or related cardiac defect (CTRD). We hypothesized that similar genetic variants, developmental pathways and biological functions, contribute to disease risk for CTRD in patients without a 22q11.2 deletion (ND-CTRD) and with a 22q11.2 deletion ...

journal_title：Birth defects research

authors： Xie HM,Taylor DM,Zhang Z,McDonald-McGinn DM,Zackai EH,Stambolian D,Hakonarson H,Morrow BE,Emanuel BS,Goldmuntz E

更新日期：2019-08-01 00:00:00

abstract：:Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

journal_title：Birth defects research

authors： Bergman NJ

更新日期：2019-09-01 00:00:00

abstract：:In 2016, Centers for Disease Control and Prevention (CDC) established surveillance of pregnant women with Zika virus infection and their infants in the U.S. states, territories, and freely associated states. To identify cases of Zika-associated birth defects, subject matter experts review data reported from medical re...

journal_title：Birth defects research

authors： Lusk R,Zimmerman J,VanMaldeghem K,Kim S,Roth NM,Lavinder J,Fulton A,Raycraft M,Ellington SR,Galang RR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...

journal_title：Birth defects research

authors： D'Oria L,Apicella M,De Luca C,Licameli A,Neri C,Pellegrino M,Simeone D,De Santis M

更新日期：2018-03-01 00:00:00

abstract：:Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

journal_title：Birth defects research

authors： Wu YL,Lo CW

更新日期：2017-06-01 00:00:00

abstract：:The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain dev...

journal_title：Birth defects research

authors： Saili KS,Zurlinden TJ,Schwab AJ,Silvin A,Baker NC,Hunter ES 3rd,Ginhoux F,Knudsen TB

更新日期：2017-12-01 00:00:00

abstract：:Antibody-like biopharmaceuticals cross the placenta by utilizing existing transport pathways (e.g., FcRn receptor). There are limited data evaluating this transfer during organogenesis in any species. Understanding placental transfer of antibody-like biopharmaceuticals can help to predict risk of developmental toxicit...

journal_title：Birth defects research

authors： Catlin NR,Mitchell AZ,Potchoiba MJ,O'Hara DM,Wang M,Zhang M,Weinbauer GF,Bowman CJ

更新日期：2020-01-01 00:00:00

abstract：:Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...

journal_title：Birth defects research

authors： Jacobus J,Courtney KE,Hodgdon EA,Baca R

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). METHODS:Data for IHPS cases (n = 29,554) delivered from 1999-2010 a...

journal_title：Birth defects research

authors： Kapoor R,Kancherla V,Cao Y,Oleson J,Suhl J,Canfield MA,Druschel CM,Kirby RS,Meyer RE,Romitti PA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Most states have now passed legislation mandating pulse oximetry for all newborns, or have promulgated regulations or guidelines to encourage use of routine pulse oximetry. State-based birth defects registries may be well positioned to track and evaluate critical congenital heart disease (CCHD) screening cov...

journal_title：Birth defects research

authors： Case AP,Miller SD,McClain MR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

journal_title：Birth defects research

authors： Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

更新日期：2017-05-01 00:00:00

abstract：:Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovari...

journal_title：Birth defects research

authors： Qi J,Liu L,Yang J,Gao X,Zhang W

更新日期：2020-12-01 00:00:00

abstract：:In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mec...

journal_title：Birth defects research

authors： Rychlik KA,Sillé FCM

更新日期：2019-03-01 00:00:00

abstract：:The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...

journal_title：Birth defects research

authors： Radford K,Taylor RC,Hall JG,Gick B

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Recent advances in genomics methodologies, in particular the availability of next-generation sequencing approaches have made it possible to identify risk loci throughout the genome, in particular the exome. In the current study, we present findings from an exome study conducted in five affected individuals o...

journal_title：Birth defects research

authors： Liu H,Busch T,Eliason S,Anand D,Bullard S,Gowans LJJ,Nidey N,Petrin A,Augustine-Akpan EA,Saadi I,Dunnwald M,Lachke SA,Zhu Y,Adeyemo A,Amendt B,Roscioli T,Cornell R,Murray J,Butali A

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. METHODS:In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymera...

journal_title：Birth defects research

authors： Bagheri F,Ebadifar A,Khorram Khorshid HR,Kamali K

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from...

journal_title：Birth defects research

authors： Somerville NJ,Chen X,Heinke D,Stone SL,Higgins C,Manning SE,Pagnano S,Yazdy MM,Anderka M

更新日期：2018-03-15 00:00:00

abstract：:The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...

journal_title：Birth defects research

authors： Mylchreest E,Smiley MA,Ballin JD,Blauth B,Shearer J,Reece J,Ionin B,Savransky V

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development. We intended to discover the crucial long noncoding RNAs (lncRNAs) regulating autophagy from the gene expression profile of the genital tubercle (GT) of dib...

journal_title：Birth defects research

authors： Feng X,Huang E,Gao Y,Zhang Y,Zhou Y

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:There is considerable variability in the prevalence of birth defects among racial/ethnic groups. This study estimated birth defect prevalence among the less studied non-Hispanic (NH) Asian/Pacific Islander (PI) and American Indian/Alaska Native (AI/AN) populations in Texas relative to NH Whites. METHODS:Dat...

journal_title：Birth defects research

authors： Le MT,Shumate CJ,Hoyt AT,Wilkinson AV,Canfield MA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

journal_title：Birth defects research

authors： Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

更新日期：2018-06-01 00:00:00

abstract：:As a result of human socio-economic activity, industrial wastes have increased alarmingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. Two broad classes of plastic-related chemicals are of critical concern for human health-bisphenol-A or BPA, and additiv...

journal_title：Birth defects research

authors： Solleiro-Villavicencio H,Gomez-De León CT,Del Río-Araiza VH,Morales-Montor J

更新日期：2020-10-01 00:00:00