Environmental exposures during pregnancy: Mechanistic effects on immunity.


:In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mechanisms governing long-term effects of prenatal exposures are coming to light and providing the opportunity for intervention and risk reduction. For instance, human association studies have provided a foundation for the association of prenatal exposure to particulate matter with early immunosuppression and later allergic disease in the offspring. Only recently, the mechanisms mediating this response have been revealed and there is much we have yet to discover. Although cellular immune response is understood for many exposure scenarios, molecular pathways are still unidentified. This review will provide commentary and synthesis of the current literature regarding environmental exposures during pregnancy and mechanisms determining immune outcomes. Shared mechanistic features and current gaps in the state of the science are identified and discussed. To such purpose, we address exposures by their immune effect type: immunosuppression, autoimmunity, inflammation and tissue damage, hypersensitivity, and general immunomodulation.


Birth Defects Res


Birth defects research


Rychlik KA,Sillé FCM




Has Abstract


2019-03-01 00:00:00










  • Early fetal echocardiography.

    abstract:OBJECTIVES:To explore the technical aspects and clinical utility of early fetal echocardiography and screening of the fetal heart in early pregnancy. Also, to document differences in cardiac structure and function which can be demonstrated in the late first/early second trimesters. METHODS:In addition to summarizing o...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: McBrien A,Hornberger LK

    更新日期:2019-05-01 00:00:00

  • Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010.

    abstract:BACKGROUND:Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). METHODS:Data for IHPS cases (n = 29,554) delivered from 1999-2010 a...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Kapoor R,Kancherla V,Cao Y,Oleson J,Suhl J,Canfield MA,Druschel CM,Kirby RS,Meyer RE,Romitti PA

    更新日期:2019-02-01 00:00:00

  • How microplastic components influence the immune system and impact on children health: Focus on cancer.

    abstract:BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Segovia-Mendoza M,Nava-Castro KE,Palacios-Arreola MI,Garay-Canales C,Morales-Montor J

    更新日期:2020-10-01 00:00:00

  • Case series: Amniotic band sequence with craniofacial abnormalities.

    abstract:BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Lies S,Beckwith T,Mills J,Butler L,Ezaki M,Oishi S

    更新日期:2019-11-15 00:00:00

  • Understanding how the concentration of neighborhood advantage and disadvantage affects spina bifida risk among births to non-Hispanic white and Hispanic women, Texas, 1999-2014.

    abstract:BACKGROUND:This is the first study to utilize the index of concentration at the extremes (ICE) to examine risk factors for spina bifida in Texas. The ICE is a useful measure for providing the degree to which residents in a certain area are concentrated into groups at the extremes of disadvantage and privilege. We intro...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Shumate C,Hoyt A,Liu C,Kleinert A,Canfield M

    更新日期:2019-08-15 00:00:00

  • The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate.

    abstract:BACKGROUND:Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development. We intended to discover the crucial long noncoding RNAs (lncRNAs) regulating autophagy from the gene expression profile of the genital tubercle (GT) of dib...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Feng X,Huang E,Gao Y,Zhang Y,Zhou Y

    更新日期:2021-01-15 00:00:00

  • Cannabis and the developing brain: What does the evidence say?

    abstract::Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Jacobus J,Courtney KE,Hodgdon EA,Baca R

    更新日期:2019-10-15 00:00:00

  • Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome.

    abstract:BACKGROUND:Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Dimopoulos A,Sicko RJ,Kay DM,Rigler SL,Druschel CM,Caggana M,Browne ML,Fan R,Romitti PA,Brody LC,Mills JL

    更新日期:2017-01-20 00:00:00

  • Developmental and reproductive safety evaluation of AV7909 anthrax vaccine candidate in rats.

    abstract::The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Mylchreest E,Smiley MA,Ballin JD,Blauth B,Shearer J,Reece J,Ionin B,Savransky V

    更新日期:2021-01-01 00:00:00

  • Accuracy of birth certificate head circumference measurements: Massachusetts, 2012-2013.

    abstract:BACKGROUND:Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Somerville NJ,Chen X,Heinke D,Stone SL,Higgins C,Manning SE,Pagnano S,Yazdy MM,Anderka M

    更新日期:2018-03-15 00:00:00

  • Screening, genetics, risk factors, and treatment of neonatal cataracts.

    abstract::Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Li J,Xia CH,Wang E,Yao K,Gong X

    更新日期:2017-06-01 00:00:00

  • Blood-brain barrier development: Systems modeling and predictive toxicology.

    abstract::The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain dev...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Saili KS,Zurlinden TJ,Schwab AJ,Silvin A,Baker NC,Hunter ES 3rd,Ginhoux F,Knudsen TB

    更新日期:2017-12-01 00:00:00

  • Using State Birth Defects Registries to Evaluate Regional Critical Congenital Heart Disease Newborn Screening.

    abstract:BACKGROUND:Most states have now passed legislation mandating pulse oximetry for all newborns, or have promulgated regulations or guidelines to encourage use of routine pulse oximetry. State-based birth defects registries may be well positioned to track and evaluate critical congenital heart disease (CCHD) screening cov...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Case AP,Miller SD,McClain MR

    更新日期:2017-11-01 00:00:00

  • Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents.

    abstract:BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Hrubec TC,Melin VE,Shea CS,Ferguson EE,Garofola C,Repine CM,Chapman TW,Patel HR,Razvi RM,Sugrue JE,Potineni H,Magnin-Bissel G,Hunt PA

    更新日期:2017-08-15 00:00:00

  • Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester.

    abstract::The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester. This may soon change to recommending artemisinin-based combination therapies (standard duration of dosing = 3 days). The non-artemisinin partner drugs include amodiaquine, lumefantrine, mefloquine, pi...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Clark RL

    更新日期:2017-08-15 00:00:00

  • Tetanus, diphtheria, and pertussis vaccine (Tdap) in pregnancy and risk of major birth defects in the offspring.

    abstract:BACKGROUND:The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect newborns against pertussis infection in the months prior to their primary pertussis vaccination. Although research on the safety of the vaccine has been reassuring, most previous s...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Kerr SM,Van Bennekom CM,Mitchell AA

    更新日期:2020-03-01 00:00:00

  • Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish.

    abstract:BACKGROUND:A cardinal feature of prenatal ethanol exposure is CNS damage, resulting in a continuum of neurological and behavioral impairments that are described by the term fetal alcohol spectrum disorders (FASD). FASDs are variable and depend on several factors, including the amount, timing, and duration of prenatal e...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Buckley DM,Sidik A,Kar RD,Eberhart JK

    更新日期:2019-07-15 00:00:00

  • Exploratory analysis of machine learning approaches for surveillance of Zika-associated birth defects.

    abstract::In 2016, Centers for Disease Control and Prevention (CDC) established surveillance of pregnant women with Zika virus infection and their infants in the U.S. states, territories, and freely associated states. To identify cases of Zika-associated birth defects, subject matter experts review data reported from medical re...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Lusk R,Zimmerman J,VanMaldeghem K,Kim S,Roth NM,Lavinder J,Fulton A,Raycraft M,Ellington SR,Galang RR

    更新日期:2020-11-01 00:00:00

  • Phenotyping cardiac and structural birth defects in fetal and newborn mice.

    abstract::Mouse models are invaluable for investigating the developmental etiology and molecular pathogenesis of structural birth defects. While this has been deployed for studying a wide spectrum of birth defects, mice are particularly valuable for modeling congenital heart disease, given they have the same four-chamber cardia...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Liu X,Kim AJ,Reynolds W,Wu Y,Lo CW

    更新日期:2017-06-01 00:00:00

  • Dose range finding approach for rodent preweaning juvenile animal studies.

    abstract:OBJECTIVES:Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains the same. The objective of dose selection is to identify a strategy to achieve consistent system...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Posobiec LM,Laffan SB

    更新日期:2020-12-14 00:00:00

  • Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism.

    abstract:BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

    更新日期:2017-04-17 00:00:00

  • Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries.

    abstract:BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

    更新日期:2017-09-01 00:00:00

  • White paper on the study of birth defects.

    abstract::Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Khokha MK,Mitchell LE,Wallingford JB

    更新日期:2017-01-30 00:00:00

  • Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate.

    abstract:BACKGROUND:Recent advances in genomics methodologies, in particular the availability of next-generation sequencing approaches have made it possible to identify risk loci throughout the genome, in particular the exome. In the current study, we present findings from an exome study conducted in five affected individuals o...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Liu H,Busch T,Eliason S,Anand D,Bullard S,Gowans LJJ,Nidey N,Petrin A,Augustine-Akpan EA,Saadi I,Dunnwald M,Lachke SA,Zhu Y,Adeyemo A,Amendt B,Roscioli T,Cornell R,Murray J,Butali A

    更新日期:2017-01-20 00:00:00

  • Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods.

    abstract:BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Rittler M,Campaña H,Poletta FA,Santos MR,Gili JA,Pawluk MS,Cosentino VR,Gimenez L,Lopez-Camelo JS

    更新日期:2019-03-01 00:00:00

  • Combined effects of maternal exposure to fungicides on behavioral development in F1 -generation mice: 2. Fixed-dose study of thiabendazole.

    abstract:BACKGROUND:Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tanaka T,Suzuki T,Inomata A,Moriyasu T

    更新日期:2020-12-01 00:00:00

  • Chronic exposure to high doses of selenium in the first trimester of pregnancy: Case report and brief literature review.

    abstract:BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: D'Oria L,Apicella M,De Luca C,Licameli A,Neri C,Pellegrino M,Simeone D,De Santis M

    更新日期:2018-03-01 00:00:00

  • Malformations among infants of mothers with insulin-dependent diabetes: Is there a recognizable pattern of abnormalities?

    abstract:BACKGROUND:Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Nasri HZ,Houde Ng K,Westgate MN,Hunt AT,Holmes LB

    更新日期:2018-01-01 00:00:00

  • High Ratios of C20:4n-6/C20:5n-3 and Thromboxane B2 /6-Keto-Prostaglandin F1α in Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case-Control Study in Shanxi Province, China.

    abstract:BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

    更新日期:2017-05-01 00:00:00

  • Analytic Methods for Evaluating Patterns of Multiple Congenital Anomalies in Birth Defect Registries.

    abstract:BACKGROUND:It is estimated that 20 to 30% of infants with birth defects have two or more birth defects. Among these infants with multiple congenital anomalies (MCA), co-occurring anomalies may represent either chance (i.e., unrelated etiologies) or pathogenically associated patterns of anomalies. While some MCA pattern...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Agopian AJ,Evans JA,Lupo PJ

    更新日期:2018-01-15 00:00:00